Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.
Reporting on the latest advances made in treating multiple sclerosis (MS) and continuing the high standards set by earlier editions, the Handbook of Multiple Sclerosis, Third Edition examines a wide range of topics from etiology to treatment options. Analyzes recent developments in the natural history, immunopathology, lesion evolution, and
Hispanics are embracing the gospel in record numbers, swelling to well over 150 million believers today. In light of such unprecedented growth, evangelicals need resources to better understand their new Latino brothers and sisters. Then Came Hispangelicals delivers. This much-needed primer surveys the history, philosophical antecedents, cultural developments, and religious heritage of the Hispanic world. Far from blind to the potential challenges, Dr. Rudolph Gonzalez proffers a thoughtful and balanced evaluation of Hispanic cultures from a Christ-centered, evangelical perspective. Without apology, he makes a case for the gospel as the only historical message with the power to resolve the Latino's perpetual search for a satisfying identity. Hispanic evangelicals will be encouraged and empowered as they wrestle with the magnitude of the challenge they face, committing to living under the rule of the mind of Christ. A must-read for all evangelicals in this current cultural moment.
V. 1. "This gorgeous book, the first of a four-volume definitive catalogue, features Chase's stunning paintings in pastel, which constitute a major and previously understudied body of work by the artist; monotypes; painted tiles and plates; watercolors; and prints. Reconstructing Chase's oeuvre is a daunting task, as the artist left few records of any kind, and no documentation of his individual works exists. Furthermore, Chase's paintings and pastels have been forged in great numbers throughout the years, and many of these works still surface on the art market. Making this long-awaited volume even more valuable is a list of every known exhibition of Chase's work during the artist's lifetime, selected examples of major post-1917 exhibitions, and an essay on Chase's innovative pastel technique"--Jacket.
This book presents theoretical expositions of the various group topics and descriptions of existing research, emphasizing performance and interaction issues. It discusses some specific groups, of workplace groups, juries, computer-based groups, and other unique groups.
This comprehensive study ranges from Irving's Knickerbockers, Emerson's Transcendentalists, and Garrison's abolitionists to the popular serial fiction writers for Robert Bonner's New York Ledger to unearth surprising convergences between such seemingly disparate circles.
Six feet water in the hold, sir! That would not have been a pleasant announcement to the captain of the 'Aurora' at any time, but its unpleasantness was vastly increased by the fact that it greeted him near the termination of what had been, up to that point of time, an exceedingly prosperous voyage. "Are you sure, Davis?" asked the captain; "try again." He gave the order under the influence of that feeling which is styled "hoping against hope," and himself accompanied the ship's carpenter to see it obeyed. "Six feet two inches," was the result of this investigation. The vessel, a large English brig, had sprung a leak, and was rolling heavily in a somewhat rough sea off the east coast of Africa.
We teach our students of behavioural science that one first defines a research problem, and then the most appropriate animal is selected to investigate hypotheses. The reverse order of events is improper: a particular class of animals should not be studied for its own sake. In the case of the Pinnipeds (seals, sea lions, fur seals and walruses) the organism and the problem are essentially the same. The research questions presented in this volume in one way or another relate to survival in two worlds, the ocean for foraging, and the terrain at its edge or frozen above it for breeding. The evolution of Pinniped behaviour and the mechanisms which underlie it are a consequence of having to cope with two seemingly incompatible sets of environmental constraints. The physiological adaptations for concomitant functioning in two media with very different physical characteristics have produced correlated behav ioural modifications. The energetic demands of reproduction and foraging are idiosyncratic because each activity occurs on opposite sides of the air/water interface. As a result, the mating system must reconcile aquatic design for such functions as locomotion and thermoregulation, with the terrestrial requirements for successful pupping. Similarly, the ecology of this dual habitat prescribes the rules governing the behaviour of the neonate and its interactions with its mother.
A Doody's Core Title 2012 Brain Injury Medicine: Principles and Practice is a comprehensive guide to all aspects of the management issues involved in caring for the person with brain injury - from early diagnosis and evaluation through the post-acute period and rehabilitation. It is the definitive core text needed by all practitioners in this area, including physiatrists, neurologists, psychologists, nurses, and other health care professionals. Written by over 100 acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, the text deals with issues of neuroimaging and neurodiagnostic testing, prognosis and outcome, acute care, rehabilitative care, treatment of specific populations, neurologic problems following injury, neuromusculoskeletal problems, and general management issues. Key features include: Emphasis on a disease state management approach to patient assessment and treatment Promotion of a holistic, biopsychosocial model of patient assessment and care Review of current expert consensus on practice guidelines Exploration of epidemiologic and basic pathophysiologic aspects of brain injury Examination of clinical issues throughout the continuum of rehabilitative care Cutting edge, practical information based on the authors' extensive clinical experience that will positively impact patients and families following brain injury
Capital, Accumulation, and Money: An Integration of Capital, Growth, and Monetary Theory is a book about capital and money. A root concept of capital is formulated that allows for most existing concepts of capital to be unified and related to one another in consistent fashion. Capital and monetary theory are integrated in a non-mathematical framework that imposes a number of constraints on the macro behavior of an economy, constraints which make for the straightforward understanding of such concepts as the real stock of money, real-balance effects, and the general price level. New and illuminating insights are also provided into aggregate supply and demand, natural and money rates of interest, the relationship between real and monetary economies, and economic growth and development. This fully expanded, revised, and updated edition features important new material on a variety of timely topics, including: * Factors leading to the financial meltdown and turmoil of 2007-09; * Why bubbles form in asset markets and how these impact on the real economy; * The importance of a lender-of-last-resort in times of financial stress; * Future financing and funding of the U. S. Social Security System. Additionally, the author offers a number of ideas for alleviating the severity, if not the avoidance altogether, of financial crises in the future. This is a book for those -- students (both graduate and undergraduate) and their teachers, investors, and the informed public -- who want an understanding of how economies and financial markets function, without an advanced degree in mathematics.
This groundbreaking core textbook offers a comprehensive overview of different approaches to the causes, assessment and treatment of psychological disorders. The book includes important diagnostic frameworks, including the new DSM-5-TR, ICD-11 and PDM, but also widens the scope of coverage beyond mainstream psychiatric models to include psychological, biological, historical, sociocultural and therapeutic approaches. Contemporary and well-balanced, this book provides an even-handed and holistic foundation, allowing students to develop a strong critical mindset while retaining a robust research-driven orientation. This new edition: - features an innovative structure organized by presenting problem, examining each in a broad context of traditional psychiatric and alternative approaches - is grounded in lived experience of disorder: shining a spot-light on service-users through 'Case Examples' scenarios and 'Lived Experience' perspective pieces - Supports student learning and critical thinking through engaging 'Controversial Question' and 'In Depth' features - Features an attractive new layout and plenty of colour illustrations - Is supported by impressive online support features including lecture slides, a test bank, instructor manual, video library, student study questions, self-test quizzes, flashcard activities and more. Now thoroughly updated to include the latest developments in research and clinical practice, along with enhanced in-text and online pedagogy to support instructors and learners, this book is ideal for undergraduate and graduate students on abnormal psychology, psychopathology, mental health or clinical psychology courses.
Stability constants are fundamental to understanding the behavior of metal ions in aqueous solution. Such understanding is important in a wide variety of areas, such as metal ions in biology, biomedical applications, metal ions in the environment, extraction metallurgy, food chemistry, and metal ions in many industrial processes. In spite of this importance, it appears that many inorganic chemists have lost an appreciation for the importance of stability constants, and the thermodynamic aspects of complex formation, with attention focused over the last thirty years on newer areas, such as organometallic chemistry. This book is an attempt to show the richness of chemistry that can be revealed by stability constants, when measured as part of an overall strategy aimed at understanding the complexing properties of a particular ligand or metal ion. Thus, for example, there are numerous crystal structures of the Li+ ion with crown ethers. What do these indicate to us about the chemistry of Li+ with crown ethers? In fact, most of these crystal structures are in a sense misleading, in that the Li+ ion forms no complexes, or at best very weak complexes, with familiar crown ethers such as l2-crown-4, in any known solvent. Thus, without the stability constants, our understanding of the chemistry of a metal ion with any particular ligand must be regarded as incomplete. In this book we attempt to show how stability constants can reveal factors in ligand design which could not readily be deduced from any other physical technique.
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
For more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.
The definitive bible for the field of biomedical engineering, this collection of volumes is a major reference for all practicing biomedical engineers and students. Now in its fourth edition, this work presents a substantial revision, with all sections updated to offer the latest research findings. New sections address drugs and devices, personalized medicine, and stem cell engineering. Also included is a historical overview as well as a special section on medical ethics. This set provides complete coverage of biomedical engineering fundamentals, medical devices and systems, computer applications in medicine, and molecular engineering.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of
This timely publication brings together into a single volume an overview of the extensive published data on cereal and legume phytates. It presents important information regarding historical background, physiological functions, and uses. Biosynthesis and dephosphorylation, phytase enzyme, and methods for analysis are covered. Also included is invaluable information on occurrence, distribution, content, and dietary intake; and interactions with minerals, proteins, carbohydrates and enzymes. Digestion and bioavailability, nutritional consequences, and technologies for removal of phytates from cereals and legumes are discussed. There are numerous tables and illustrations included. This volume is indispensable for researchers and food scientists in phytate research and the technology/processing of cereals and legumes.
The conference that is recorded in this volume derived its initial impetus and choice of subject from the Jubilee of the Swedish Riksbank which was being celebrated in 1975. AJ part of that celebration, the International Economic Association was invited to organise a conference on the very topical subject of inflation-a subject of great concern to the banking community in all countries-and the Riksbankens Jubileumsfund bore the largest share of its expenses. We are greatly indebted to Mr Kristen Rickman, Governor of the Sviriges Riksbank, for his interest and support in all the work of the con-ference.
Systematically solve tough diagnostic challenges in gynecologic pathology with this new title in the Differential Diagnoses in Surgical Pathology series. This practical, full-color reference uses select images of clinical and pathological findings, together with succinct, expert instructions, to guide you through the decision-making process by distinguishing between commonly confused lesions of the gynecologic tract. By presenting material according to the way pathologists actually work, this user-friendly volume helps you quickly differentiate entities that have overlapping morphologic features.
Volume II picks up in 1943-44, right where Volume I left off, with Hank’s courtship and marriage to first wife, Audrey (Sheppard) Guy Williams, his rise to fame at the Louisiana Hayride, 1948-49, and at the Grand Ole Opry, 1949-50, before success began closing in on him by December 1950. Hank was only 27 years old at the time, and no one knew that he had only two more years to live. Despite Hank’s growing alcoholism, marital and health problems, and eventual addiction to prescription drugs, his last two years were perhaps the most productive and successful of his career. “A special feature of Volume II is that Dr. Nail devotes an entire chapter to the art and craft of songwriting. Here, Nail provides what I believe is the most accurate and comprehensive analysis to date of the relative contributions of Hank and his publisher/song editor, Fred Rose, to Hank’s songs. Like Volume I, Volume II is a must-read for anyone seeking greater understanding and insight into the short but fabulous life and career of the legendary Hank Williams. I wholeheartedly recommend it.” – Ed Guy, noted Hank Williams expert
**Selected for Doody's Core Titles® 2024 in Patient Education** Research shows that what makes or breaks the success of a health care professional is more than the ability to provide accurate diagnosis and treatment. An HCP's success hinges on their ability to satisfy patients' main concerns about HCPs namely, "do they care about me?" and "will the procedure hurt?" The Mindful Health Care Professional teaches HCPs how to train the mind to be calm, focused, and compassionate in ways that enhance their own well-being and their ability to provide patient-centered care. This book offers the core communication skills needed to convey care and build trust with a novel model that helps navigate challenging procedures and consultations. Finally, it contains many simple, evidence-based techniques for managing pain and anxiety during medical and dental procedures, allowing procedures to unfold more easily for all. Written by Dr. Carmelina D'Arro, a seasoned health care professional and qualified mindfulness teacher, this state-of-the-art guide is designed for students in all areas of health care and includes a fully searchable eBook version with each print purchase that provides links to numerous videos. - Patient-centered care approach utilizes the ISLEEP (Introduce, Solicit, Listen, Empathize, Explain, and Power) model which encompasses not only consultations but also hands-on procedures. - Trauma-sensitive mindfulness practices are tailored to health care professionals and patients, and help in integrating EASE (equanimity, attentiveness, self-awareness, and empathy) into practice. - Evidence-based interventions are based on current pain theory, and include mindfulness techniques, non-pain stimuli, and active distraction. - Case studies highlight challenging situations faced by health care professionals and patients and how to navigate them with ISLEEP communication skills. - Procedure videos provide step-by-step instructions on how to practice mindfulness and other mind-training techniques. - Focus on practical application includes opportunities for observation (videos), practice (simulation exercises), and self-evaluation (clinical tools). - More than 20 videos demonstrate the ISLEEP method and how to implement it with patients and staff. - Over 20 videos demonstrate interventions for procedural pain and anxiety. - Tables and Figures highlight key research and concepts throughout the book. - eBook version is included with print purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. It also includes videos of meditation practices, communication skills, and interventions for procedural pain and anxiety.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine. More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.
This comprehensive update on irritable bowel syndrome addresses both the state of art diagnosis and treatment as well as emerging therapies and future directions. Worldwide authority, Dr. Eammon Quigley, contributes an article on Therapies Aimed at the Gut Microflora and Inflammation. Other highlights include articles devoted to genetics, biomarkers, and symptom-based diagnostic criteria.
American slaveholders used the wealth and leisure that slave labor provided to cultivate lives of gentility and refinement. This study provides a vivid portrait of slaveholders at home and at play as they built a tragic world of both 'sweetness' and slavery.
Updated and expanded coverage of the latest trends and developments in fiber composite materials, processes, and applications Analysis and Performance of Fiber Composites, Fourth Edition features updated and expanded coverage of all technical aspects of fiber composites, including the latest trends and developments in materials, manufacturing processes, and materials applications, as well as the latest experimental characterization methods. Fiber reinforced composite materials have become a fundamental part of modern product manufacturing. Routinely used in such high-tech fields as electronics, automobiles, aircraft, and space vehicles, they are also essential to everyday staples of modern life, such as containers, piping, and appliances. Little wonder, when one considers their ease of fabrication, outstanding mechanical properties, design versatility, light weight, corrosion and impact resistance, and excellent fatigue strength. This Fourth Edition of the classic referencethe standard text for composite materials courses, worldwideoffers an unrivalled review of such an important class of engineering materials. Still the most comprehensive, up-to-date treatment of the mechanics, materials, performance, analysis, fabrication, and characterization of fiber composite materials available, Analysis and Performance of Fiber Composites, Fourth Edition features: Expanded coverage of materials and manufacturing, with additional information on materials, processes, and material applications Updated and expanded information on experimental characterization methodsincluding many industry specific tests Discussions of damage identification techniques using nondestructive evaluation (NDE) Coverage of the influence of moisture on performance of polymer matrix composites, stress corrosion of glass fibers and glass reinforced plastics, and damage due to low-velocity impact New end-of-chapter problems and exercises with solutions found on an accompanying website Computer analysis of laminates No other reference provides such exhaustive coverage of fiber composites with such clarity and depth. Analysis and Performance of Fiber Composites, Fourth Edition is, without a doubt, an indispensable resource for practicing engineers, as well as students of mechanics, mechanical engineering, and aerospace engineering. Visit the Companion Website at: https://www.wiley.com/WileyCDA/Section/id-830336.html
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