This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.
Women Writers in the United States is a celebration of the many forms of work - written and social, tangible and intangible - produced by American women. Furthering their work in The Oxford Companion to Women's Writing in the United States, Davis and West document the variety and volume of women's work in the United States in a clear and accessible timeline format. They present information on the full spectrum of women's writing - including fiction, poetry, biography, political manifestos, essays, advice columns, and cookbooks - alongside a chronology of developments in social and cultural history that are especially pertinent to women's lives. This extensive chronology illustrates the diversity of women who have lived and written in the United States and creates a sense of the full trajectory of individual careers. A valuable and rich source of information on women's studies, literature, and history, Women Writers in the United States will enable readers to locate familiar and unfamiliar women's texts and to place them in the context out of which they emerged.
Multiple scholars and practitioners provide models and theories to understand the inter-organizational relationships between businesses and higher education. This work illuminates the complexities, expectations and long-term impact of such relationships.
This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.
A spellbinding account of the rapacious pursuit of the most exquisite paintings in the world In the Gilded Age, newly wealthy and culturally ambitious Americans began to compete for Europe's extraordinary Old Master pictures, causing a major migration of art across the Atlantic. Old Masters, New World is a backstage look at the cutthroat competition, financial maneuvering, intrigue, and double-dealing often involved in these purchases, not to mention the seductive power of the ravishing paintings that drove these collectors-including financier J. Pierpont Morgan, sugar king H. O. Havemeyer, Boston aesthete Isabella Stewart Gardner, and industrialist Henry Clay Frick. Packed with stunning reproductions, this is an ideal gift book for art lovers and history buffs alike.
When hurricanes, earthquakes, wildfires, and other disasters strike, we count our losses, search for causes, commiserate with victims, and initiate relief efforts. Amply illustrated and expansively researched, Inventing Disaster explains the origins and development of this predictable, even ritualized, culture of calamity over three centuries, exploring its roots in the revolutions in science, information, and emotion that were part of the Age of Enlightenment in Europe and America. Beginning with the collapse of the early seventeenth-century Jamestown colony, ending with the deadly Johnstown flood of 1889, and highlighting fires, epidemics, earthquakes, and exploding steamboats along the way, Cynthia A. Kierner tells horrific stories of culturally significant calamities and their victims and charts efforts to explain, prevent, and relieve disaster-related losses. Although how we interpret and respond to disasters has changed in some ways since the nineteenth century, Kierner demonstrates that, for better or worse, the intellectual, economic, and political environments of earlier eras forged our own twenty-first-century approach to disaster, shaping the stories we tell, the precautions we ponder, and the remedies we prescribe for disaster-ravaged communities.
A compelling compilation of short entries, longer topical essays, and primary source documents that chronicles the historical development of the United States from an economic perspective. Based on a work originally published in 2003, The American Economy: A Historical Encyclopedia has been thoroughly updated with information on the accounting scandals of the early 2000s and the recession of 2008, including the government stimulus and bailout programs and the recession's impact on key markets. With more than 600 short entries, 31 longer essays, and 32 primary source documents, the encyclopedia spans American history from colonial times to the present. Researchers will discover detailed information on people, events, and government actions that have shaped our economy, with entries on such seminal issues as slavery, migration patterns, the welfare state, the rise of the city, and the development of financial institutions. Throughout, special attention is paid to the interdependence of economics with political, social, and cultural forces. Covering everything from the national debt to monetary policy, law, unemployment, inflation, and government/business relations, this work is the ideal go-to resource for quick answers, in-depth analysis, or direction for further research.
Mind, Brain, and Education science is a very young field, though it has roots in thousands of years of academic reflection. This book is a brief but critical look into the key turning points in the field’s evolution and the existing initiatives in order to project its future directions. It draws on information from all major branches of the learning sciences, including philosophy and history, and more modern constructs such as cognitive psychology and neuroscience. First and foremost, it is a textbook for early graduate training programs in Mind, Brain, and Education science and Educational Neuroscience and those who would like to have Learning Sciences as their main area of study, but the book will also serve as an introduction for those educational policymakers who would like to ground decision-making in evidence from the Learning Sciences, and neuroscientists who need to have knowledge about mind and education.
As various contemporary groups use the language of motherhood to advance their political causes, maternal rhetoric has become very visible in the American political discourse of late. Yet while it has long been recognized that women have invoked their political status as mothers to organize and authorize their political action in the past, scholars have only just begun to examine the recent reemergence of this frame. This book describes the wide variety of political causes that mothers are organizing to address, and analyses whether ideologically conservative organizations are disproportionately represented among groups using motherhood to mobilize women. Stavrianos examines the use of maternal discourses in closer detail through a comparative case study of five groups using motherhood as their primary frame for collective political action: Mothers Against Drunk Driving, Million Mom March, Mothers Against Illegal Aliens, Mainstreet Moms Organize or Bust, and Mothers in Charge. Scholars interested in women and politics, interest group politics, social movements, political behavior, women’s studies, motherhood studies, and framing strategies will find this book noteworthy, as it adds to a growing body of literature exploring the use of motherhood as an emerging political frame, and to the interdisciplinary discussion of contemporary discourses of motherhood.
1689: the Resoration enabled the Morland family to restore their own fortune, but now the Jacobite rebellion brings another threat to their security. Annuciata Morland, fiercely loyal to the Stuart cause, follows her beloved king, James II, into exile. She leaves her gentle grandson, Matt, to oversee Morland Place in her absence. Without her wise presence, Matt finds himself in an arranged marriage to India Neville and at the mercy of a woman as heartless as she is beautiful. After a lonely and sheltered life he lurches between the exquisite pain of love and the torment of deep despair. When James III - the Chevalier - returns to claim the Stuart throne, the Morlands are reunited in one country. Death and defeat threaten them, but their loves and loyalty prove stronger than kingly ambitions...
Endorsed by the American Association of Sleep Technologists (AAST) and widely used as the go-to text in the field , Fundamentals of Sleep Technology, 3rd Edition, provides comprehensive, up-to-date coverage of polysomnography and other technologies in the evaluation and management of sleep disorders in adults and children. This edition has been extensively updated and expanded to reflect current practice, the latest technology, and the broader roles and responsibilities of the sleep technologist. Content is enhanced with new illustrations, tables, and treatment algorithms. This textbook, written by and for sleep technologists, is the ideal resource for those practicing in the field of sleep medicine or preparing for licensing exams in sleep technology.
During World War II, nations raced to construct the worldOCOs first nuclear weapon that would determine the future of the world. The Manhattan Project, one of the most significant achievements of the 20th century, was the culmination of AmericaOCOs war effort. Today, although the issue of nuclear weapons frequently dominates world politics, few are aware of the history behind its development. Part I of this book, comprised of papers from the Atomic Heritage FoundationOCOs Symposium on the Manhattan Project, recounts the history of this remarkable effort and reflects upon its legacy. Most of the original structures of the Manhattan Project have been inaccessible to the public and in recent years, have been stripped of their equipment and slated for demolition. Part II proposes a strategy for preserving these historical artifacts for the public and future generations.
Basic Laboratory Methods for Biotechnology, Third Edition is a versatile textbook that provides students with a solid foundation to pursue employment in the biotech industry and can later serve as a practical reference to ensure success at each stage in their career. The authors focus on basic principles and methods while skillfully including recent innovations and industry trends throughout. Fundamental laboratory skills are emphasized, and boxed content provides step by step laboratory method instructions for ease of reference at any point in the students’ progress. Worked through examples and practice problems and solutions assist student comprehension. Coverage includes safety practices and instructions on using common laboratory instruments. Key Features: Provides a valuable reference for laboratory professionals at all stages of their careers. Focuses on basic principles and methods to provide students with the knowledge needed to begin a career in the Biotechnology industry. Describes fundamental laboratory skills. Includes laboratory scenario-based questions that require students to write or discuss their answers to ensure they have mastered the chapter content. Updates reflect recent innovations and regulatory requirements to ensure students stay up to date. Tables, a detailed glossary, practice problems and solutions, case studies and anecdotes provide students with the tools needed to master the content.
A complete reference to the latest understanding of lymphocytic infiltrates The Cutaneous Lymphoid Proliferations provides a complete, authoritative treatment of the clinical features, phenotypes, pathogenesis, histopathology, diagnosis, and treatment of lymphocytic infiltrates of the skin. Incorporating the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry, the book brings readers up to date on the most current thinking in the field. Those readers familiar with the authors' critically acclaimed The Melanocytic Proliferations will find a similar structure and the same attention to detail and quality in this latest reference. The book starts off with a clinical atlas and introduction to the ontogeny and biology of the lymphoid system. Next, the authors explore novel molecular approaches to the diagnosis of cutaneous lymphoid proliferations and benign lymphocytic infiltrates. The remaining chapters concentrate on major inflammatory skin diseases and lymphoproliferative disorders, including chronic lymphocytic leukemia, lupus, adult T cell leukemia, and primary cutaneous Hodgkin's disease. As a reference to lymphocytic infiltrates, this book is unsurpassed. Novice and experienced practitioners alike will gain important insights into the field, including: The role of the immune system in the pathogenesis of cutaneous disease Relationships between therapeutic drugs and cutaneous eruptions Important drug reactions Hundreds of full-color, high-quality clinical and histologic photographs help readers visualize the various infiltrates and their treatments. Having this reference on hand is essential for all dermatologists, dermatopathologists, oncologists, and general pathologists who need a synthesis of the current thinking in the field.
′The 4th edition of this extensive text is an outstanding resource prepared by nurses (and a librarian) for nurses. In a structured and helpful style it presents thousands of items from the literature - published papers, reports, books and electronic resources - as a clear, accessible, and most of all useful collection. The efforts to signpost and lead the reader to the sought-for information are effective and well-conceived, and the "How to use this book" section is remarkably simple...the book should be found in every nursing and health library, every research institute and centre, and close to many career researchers′ desks′ - RCN Research This latest edition of Resources for Nursing Research provides a comprehensive bibliography of sources on nursing research, and includes references for books, journal papers and Internet resources. Designed to act as a ′signpost′ to available literature in the area, this Fourth Edition covers the disciplines of nursing, health care and the social sciences. Entries are concise, informative and accessible, and are arranged under three main sections: · ′Sources of Literature′ covers the process of literature searching, including using libraries and other tools for accessing literature · ′Methods of Inquiry′ includes an introduction to research, how to conceptualize and design nursing and health research, measurement and data collection, and the interpretation and presentation of data · ′The Background to Research in Nursing′ encompasses the development of nursing research; the profession′s responsibilities; the role of government; funding; research roles and careers; and education for research. Fully revised and updated, the Fourth Edition includes just under 3000 entries, of which 90% are new. It has extensive coverage of US, UK literature and other international resources. This new edition will be an essential guide for all those with an interest in nursing research, including students, teachers, librarians, practitioners and researchers.
An account of eminent women landscape architects who flourished in the golden age of country estates. This beautiful book covers in depth the work of six designers Beatrix Farrand, Martha Hutcheson, Marian Coffin, Ellen Shipman, Ruth Dean, and Annette Hoyt Flanders and looks at a dozen other less-well-known women. It focuses on the Long Island projects that constituted a large part of their work and brings these pioneering women to life as people and as professionals.
Development is best understood as a fusion of biological, social, and psychological processes interacting in the unique medium of human culture. [In this text, the authors] have tried to show not only the role of each of these factors considered separately but also how they interact in diverse cultural contexts to create whole, unique human beings.-Pref.
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