This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.
The most complete, trusted reference-text covering the full span of medical toxicology Market: Students, toxicologists, and pharmacologists Focuses on the principles, concepts, and modes of thought that are the foundation of the discipline New to this edition: updated throughout to reflect new understanding of cell death and drug metabolism, new content on chemical terrorism, many new contributors
This book explores the different functions and metaphorical concepts of alchemy in fourteenth- and fifteenth-century Middle English poetry and bridges them together with the exempla tradition in late medieval English literature. Such poetic narratives function as exemplary models which directly address the ambiguity of medieval English alchemical practice. This book examines the foundation of this relationship between alchemical narrative and exemplum in the poetry of Gower and Chaucer in the fourteenth century before exploring its diffusion in lesser-known anonymous poems and recipes in the fifteenth century, namely alchemical dialogues between Morienus and Merlin, Albertus Magnus and the Queen of Elves, and an alchemical version of John Lydgate’s poem The Churl and the Bird. It investigates how this exemplarity can be read as inherent to understanding poetic narratives containing alchemy, as well as enabling the reader to reassess the understanding and expectations of science and narrative within medieval English poetry.
This study examines expectations of imminent judgment that energized reform movements in Late Medieval and Reformation Europe. It probes the apocalyptic vision of the Lollards, followers of the Oxford professor John Wycliff (1384). The Lollards repudiated the medieval church and established conventicles despite officially sanctioned prosecution. While exploring the full spectrum of late medieval apocalypticism, this work focuses on the diverse range of Wycliffite literature, political and religious treatises, sermons, biblical commentaries, including trial records, to reveal a dynamic strain of apocalyptic discourse. It shows that sixteenth-century English apocalypticism was fed by vibrant, indigenous Wycliffite well springs. The rhetoric of Lollard apocalypticism is analyzed and its effect on carriers and audiences is investigated, illuminating the rise of evil in church and society as perceived by the Lollards and their radical reform program.
Develop a strong foundation in the concepts and principles of toxicology with this concise and accessible resource Doody's Core Titles for 2023! For more than 25 years, Casarett & Doull’s Toxicology: The Basics of Poison has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Distilling the major principles and concepts from that renowned text, Casarett & Doull’s Essentials of Toxicology delivers an accessible and highly readable introduction to the science and clinical field of medical toxicology. The book reflects the expertise of more than 60 renowned contributors. Presented in full-color, this new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient. Casarett and Doull’s Essentials of Toxicology is organized into seven units: General Principles of Toxicology Disposition of Toxicants Non-organ-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents—from pesticides to radiation.
Understand the essential principles of toxicology and how poisons affect the human body with this accessible and engaging summary A Doody's Core Title for 2017! General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text. Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material. Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections: Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.
Emergency and Trauma Care is written for Australian emergency care providers including paramedics, emergency nurses, pre-hospital care providers, nurse practitioners, general practice nurses and allied health practitioners including occupational therapists and physiotherapists who are caring for trauma patients.This book follows the patient journey from pre-hospital to definitive care. Using a body systems approach, each chapter provides comprehensive coverage of all aspects of adult and paediatric emergencies. Implications for clinical practice is supported by chapters of professional practice, clinical skills, research, evidence-based practice, and legal, ethical and cultural issues. Clinical assessment, physiology, management and rationale for intervention of common and not so common emergency presentations are provided, with each chapter providing clear and relevant examples for both Paramedics and Nurses.Emergency and Trauma Care brings together a team of highly respected clinical practitioners and academics to deliver the most up-to-date text dealing with the practical procedures and evidence experienced by emergency and trauma care providers every day. - Chapter 2 Pre-hospital care overview in Australia and NZ - Chapter 10 Scene assessment, management and rescue - Chapter 11 Pre-Hospital Clinical Reasoning, Triage and Communication - Pre-hospital and emergency nursing considerations included in all relevant chapters - Chapter 5 Cultural Considerations in Emergency Care addresses cultural diversity, beliefs and values and focuses on Aboriginal and Torres Strait Islander health and Maori health - Chapter 19 Resuscitation includes advanced life support, airway management and incorporates the 2010 Australian Resuscitation Council guidelines - Chapter 37 People with disabilities provides assessment, examination and communication strategies for working with clients with intellectual and physical disabilities - Section 5 focuses on examination and communication strategies for working with unique population groups, including the elderly, disabled, obstetric and paediatric patients - Section 6 details major trauma assessment and management, blast injury, and trauma to specific body regions - Essentials outline the main points addressed in each chapter - Practice tips assist with communication skills, procedures and assessment - Case studies supported by questions throughout - Summaries and Key points, review questions, web links and references provide for consolidation and further research. - Evolve resources include Power point slides, 30 additional Case studies, image bank, web links - Three paramedic specific chapters (including scene assessment and management)
The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date,revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references. NEW to the Eighth Edition FULL-COLOR design to allow for a clearer interpretationof the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals areupdated with state-of-the-art standards that makes thisedition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories"and "Toxic Effects of Nanoparticles
Toxicology’s gold-standard text - completely updated to reflect the latest breakthroughs and discoveries A Doody’s Core Title for 2021! Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections: General Principles of Toxicology Disposition of Toxicants Non-Organ Directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Many new contributors capture the progress made in toxicology over the past few years: This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book. Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals. A true “essential” If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology - written by experts, and presented in full color, your search ends here.
The most concise and authoritative introduction to the principles of toxicology and how poisons affect the human body – now in full color A Doody's Core Title ESSENTIAL PURCHASE for 2011! Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the field’s gold-standard text Casarett & Doull’s Toxicology: The Basic Science of Poisons. Presented in full color for the first time, the book combines an accessible and engaging approach with coverage of essential introductory concepts to provide you with a solid grounding in basic and medical toxicology. Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents – from pesticides to radiation. Features: A complete basic overview of poisons and their clinical management Reflects the expertise of more than fifty renowned contributors A summary of important points is included at the beginning of each chapter and multiple-choice review questions appear at the conclusion Important chapters on forefront topics such as Analytic/Forensic Toxicology, Clinical Toxicology, Occupational Toxicology, Air Pollution, and Ecotoxicology Condensed Table of Contents: General Principles of Toxicology, Disposition of Toxicants, Nonorgan-Directed Toxicity, Target Organ Toxicity, Toxic Agents, Environmental Toxicology, Applications of Toxicology.
The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date,revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references. NEW to the Eighth Edition FULL-COLOR design to allow for a clearer interpretationof the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals areupdated with state-of-the-art standards that makes thisedition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories"and "Toxic Effects of Nanoparticles
Understand the essential principles of toxicology and how poisons affect the human body with this accessible and engaging summary A Doody's Core Title for 2017! General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text. Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material. Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections: Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.
The most complete, trusted reference-text covering the full span of medical toxicology Market: Students, toxicologists, and pharmacologists Focuses on the principles, concepts, and modes of thought that are the foundation of the discipline New to this edition: updated throughout to reflect new understanding of cell death and drug metabolism, new content on chemical terrorism, many new contributors
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