Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
One of the most difficult questions facing us today is that of the proper attitude toward possessions. In wealthy nations such as Britain and the USA, individuals accumulate much and yet are daily exposed to the plight of the poor, whether the homeless on their own city streets or starving children on their TV screens. What action should they take on behalf of the poor? What should they do with their own possessions? In Neither Poverty nor Riches Craig Blomberg asks what the Bible has to say to these issues. He avoids easy answers, and instead seeks a comprehensive biblical theology of possessions. Beginning with the groundwork laid by the Old Testament and the ideas developed in the intertestamental period, he draws out what the whole New Testament has to say on the subject and finally offers conclusions and applications relevant to the modern world. This is a book that all concerned with issues of poverty and wealth should read.
The richness of Detroit’s music history has by now been well established. We know all about Motown, the MC5, and Iggy and the Stooges. We also know about the important part the Motor City has played in the history of jazz. But there are stories about the music of Detroit that remain untold. One of the lesser known but nonetheless fascinating histories is contained within Detroit’s country music roots. At last, Craig Maki and Keith Cady bring to light Detroit’s most important country and western and bluegrass stars, such as Chief Redbird, the York Brothers, and Roy Hall. Beyond the individuals, Maki and Cady also map out the labels, radio programs, and performance venues that sustained Detroit’s vibrant country and bluegrass music scene. In the process, Detroit Country Music examines how and why the city’s growth in the early twentieth century, particularly the southern migration tied to the auto industry, led to this vibrant roots music scene. This is the first book—the first resource of any kind—to tell the story of Detroit’s contributions to country music. Craig Maki and Keith Cady have spent two decades collecting music and images, and visiting veteran musicians to amass more than seventy interviews about country music in Detroit. Just as astounding as the book’s revelations are the photographs, most of which have never been published before. Detroit Country Music will be essential reading for music historians, record collectors, roots music fans, and Detroit music aficionados.
The second edition of Craig Deegan and Jeffrey Unerman’s market leading text presents the various theories of financial accounting through a balanced and dynamic approach. Students are given all the tools to engage with these theories and are encouraged to critically evaluate and challenge them. Clearly written and user friendly, this new edition provides comprehensive coverage of internationally developed accounting theories from a European perspective.
Managing Tourism Enterprises: Start-up, Growth and Resilience brings a new contribution to the literature on tourism management. It presents a comprehensive, educational text on the initiation, management, growth, performance and resilience of tourism enterprises in the age of digital disruption and global uncertainty. The book addresses the unique characteristics of tourism enterprises, how they are created, how they are managed, the factors that drive business performance, and how they must be innovative, resilient and adaptable in order to succeed. The content draws on empirical research, grey literature, government data and case studies to present theoretical and practical knowledge on the successful management of tourism enterprises and their role in tourism destinations. This is an essential book for undergraduate students completing 2nd and 3rd year courses on tourism management, with a focus on managing tourism enterprises; and postgraduate students undertaking courses specific to strategy and performance of tourism firms.
A Melbourne sound that is at once both rakish and debonair. So what specifically is it about Melbourne that, according to the Sydney Morning Herald, it’s able to support around 465 live music venues as compared to 453 in New York, 385 in Tokyo and 245 in London despite its population being a fraction of those major world cities? Despite the flaky weather, the footy and Netflix, Melbournians are committed to going out at night and in great numbers in heat or hail to listen to live music and to find those bands and singers they’ve heard on Spotify or discovered on Soundcloud.
Here's what reviewers are saying about Bill Craig's new Chandler mystery series: "A gritty urban fast-paced investigative mystery..." "Quick action, intertwining plots and lots of reason to turn the next page...." The investigation flies at a pace that kept me turning the pages ..." "Written in a "Pulp Fiction" style that flits from character to character, showing what's happening away from the eyes of the hero and then touches base back at his investigation before charging into the villains' action again. And in that same writing style, the story comes together and the pieces of the puzzle start clicking together. The book is well crafted, keeping the investigator just a step behind the madness of the evil that pervades an Indiana city." "The 'Circle' is definitely made up of hell-on-wheels criminals. Bad guys you will love to hate, and dames in distress. A hero worth launching a series for. Five stars." "Very readable ..." Phillip Chandler is a hardboiled private eye working Indianapolis -- called Circle City for the towering war memorial in the circular drive at its center. Here he sets out to prove a pro basketball player didn't kill his girlfriend. As it turns out, there are lots of other suspects to pick from, dangerous bad guys who inhabit Circle City.
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with Mycobacterium tuberculosis and M. leprae subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity the latest developments in technology, for the next steps in the study of intracellularity All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
- Expanded coverage of zoonoses, zoonotic potential, and precautions helps you effectively monitor and treat zoonotic infections. - Fully updated drug formulary reflects the most current pharmacokinetics, indications, contraindications, handling and administration guidelines, and dosage recommendations available. - Updated content throughout the text details current diagnostic testing regimens and therapeutic and preventive considerations for all pathogens you're likely to encounter in the clinical setting. - Special focus on disease incidence and susceptibility in traveling animals helps you alert animal owners to potential risks associated with pet travel.
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
The Fourth Edition retains the elements of the text that have contributed to its success while also broadening its appeal. Written in an informal, accessible style, author Craig E. Johnson takes an interdisciplinary approach to leadership ethics while blending research and theory with practical application. This unique text promotes ethical decision-making and action through skill development, self-assessment, and application exercises. In the Fourth Edition: - A new chapter, Ethical Crisis Leadership, explains five ethical principles and strategies that are essential to fulfilling moral duties during times of crisis. - 'Leadership Ethics at the Movies' features present short summaries of feature films that portray ethical dilemmas. Discussion starters are included to prompt readers to draw ethical implications and applications from the films. - 'Self-Assessment' features measure the reader's performance on an important behaviour, skill, or concept discussed in the chapter - 'Implications and Applications' review key ideas and their ramifications for the reader as a leader - 'For Further Exploration, Challenge, and Assessment' encourages readers to engage in extended reflection and self-analysis - 'Focus on Follower Ethics' boxes that broaden coverage of the text and introduce concepts students can apply to their role as followers - Three cases per chapter offer real-world examples for anlaysis and reflection - A lengthy reference section at the end of the book serves as a starting point for further research and exploration Instructors Resources include teaching strategies, a test bank, sample syllabi, assignment descriptions, and more.
This work is an examination of all aspects of the science in developing effective dosage form for drug delivery Pharmaceutics refers to the subfield of pharmaceutical sciences that develops drug delivery products or devices to optimize the drug's performance once administered. This multidisciplinary field draws on physical chemistry, organic chemistry, and biophysics to generate and refine these crucial elements of medical care. Moreover, incorporating such disparate dimensions of drug product design as material properties and legal regulation bridges the gap between effective chemicals and viable medical treatments. Integrated Pharmaceutics provides a comprehensive introduction to the creation and manufacture of effective dosage forms for drug delivery. It presents its subject following the principles of physical pharmacy, product design, and drug regulations. This tripartite structure allows readers to move from theory to practice, beginning from a firm foundation of physical pharmacy principles, including drug solubility and stability estimation, rheology, and interfacial properties. From there, it proceeds to discussions of drug product design and of harmonizing pharmaceutical design with the regulatory regimens and technological standards of the United States, European Union, and Japan. Readers of the second edition of Integrated Pharmaceutics will also find: A glossary defining key terms, extensive informative appendices, and a list of references leading to the primary literature in the field for each chapter Earlier chapters are expanded, with additional new chapters including one entitled “Biotechnology Products” Supplementary instructor guide with questions and solutions available online for registered professors Updated regulatory guidelines including quality by design, design space analysis, process analytical technology, polymorphism characterization, blend sample uniformity, and stability protocols Integrated Pharmaceutics is a useful textbook for graduate students in pharmaceutical sciences, drug formulation and design, and biomedical engineering. In addition, professionals in the pharmaceutical industry, including regulatory bodies, will find it a helpful reference guide.
First published in 1987, The Illustrated History of Canada was the first comprehensive, authoritative one-volume history of the country. It featured chapters by seven of Canada's leading historians and hundreds of engravings, lithographs, cartoons, maps, posters, and photographs. Together, these elements created a sweeping chronicle of Canada from its earliest times to yesterday's news. Now The Illustrated History of Canada has been fully updated to bring readers into the twenty-first century, with new material on such topics as the rise of small government, the recognition of Native land claims, Canada's role in the post-Cold War "peace," and the 2011 federal election. More than ever, The Illustrated History of Canada is a must-have reference guide for all Canadians interested in the history - and the future - of our country. Contributors include Ramsay Cook (emeritus, York University), Christopher Moore (Toronto writer), Desmond Morton (McGill University), Arthur Ray (emeritus, University of British Columbia), Peter Waite (emeritus, Dalhousie University), and Graeme Wynn (University of British Columbia).
Ninety photos starting from 1963, including maybe the rarest one ever, 33 interviews, 266 questions and answers and a look at 121 live shows and sixty unreleased studio treasures.
Thoughtful and accessible. An up-to-date, comprehensive overview of the most important issues in dispensationalism, underpinned with accurate scholarship and summarized with clarity.
They are motivators, key strategists, tough bosses, and choreographers. They can be branded as heroes, ousted as scapegoats, quietly valued as friends, and everything in between. It's all in the job description for an NHL head coach. In Behind the Bench, ESPN's Craig Custance sits down for film sessions and candid conversations with some of the game's most notable modern luminaries—names like Mike Babcock, Joel Quenneville, Dan Bylsma, Todd McLellan, Ken Hitchcock, and Claude Julien—all of whom share their singular views on topics ranging from leadership secrets to on-ice game plans. Dissect some of hockey's greatest moments with the men who set the pieces in motion. Go straight to the source on what it's like to manage a dressing room full of the league's top stars or execute line changes with everything at stake. Signature games, including Stanley Cup finals, Olympic gold medal clashes, and World Championship contests—both wins and losses—are reflected upon and broken down in detail, making this essential reading for current and aspiring coaches, players, and hockey fans alike.
Following the publication of C. S. Holling's seminal work on the relationship between animal body mass patterns and scale-specific landscape structure, ecologists began to explore the theoretical and applied consequences of discontinuities in ecosystems and other complex systems. Are ecosystems and their components continuously distributed and do they adhere to scaling laws, or are they discontinuous and more complex than early models would have us believe? The resulting propositions over the structure of complex systems sparked an ongoing debate regarding the mechanisms generating discontinuities and the statistical methods used for their detection. This volume takes the view that ecosystems and other complex systems are inherently discontinuous and that such fields as ecology, economics, and urban studies greatly benefit from this paradigm shift. Contributors present evidence of the ubiquity of discontinuous distributions in ecological and social systems and how their analysis provides insight into complex phenomena. The book is divided into three sections. The first focuses on background material and contrasting views concerning the discontinuous organization of complex systems. The second discusses discontinuous patterns detected in a number of different systems and methods for detecting them, and the third touches on the potential significance of discontinuities in complex systems. Science is still dominated by a focus on power laws, but the contributors to this volume are convinced power laws often mask the interesting dynamics of systems and that those dynamics are best revealed by investigating deviations from assumed power law distributions. In 2008, a grand conference on resilience was held in Stockholm, hosting 600 participants from around the world. There are now three big centers established with resilience, the most recent one being the Stockholm Resilience Center, with others in Australia (an international coral reef center), Arizona State University's new sustainability center focusing on anthropology, and Canada's emerging social sciences and resilience center. Activity continues to flourish in Alaska, South Africa, and the Untied Kingdom, and a new center is forming in Uruguay.
I have knocked on flyscreens and said to mothers of kidnapped toddlers, ‘Don’t you feel guilty for leaving your child in the front yard alone?’ I have shamed them to tears for the photographer. I have gatecrashed funerals, linked innocent corpses to local crime syndicates. Or feigned empathy to the grief-stricken to make copy from their hard-luck stories. I enjoyed the kudos of my name beneath headlines on front pages and became used to the heartlessness as if blank inside. I was doing it for my family—it was worth the cruelty. That line of work gives your eyes a plastic appearance. I’ve noticed it in the mirror, a dead glitter. Callum Smith—Wordsmith, Words for short—is a newspaper journalist of the old school. He knows how to write a story that sings, knows all the tricks of the tabloid trade. And he likes to drink with his colleagues, sometimes to flirt dangerously with young women. When his marriage blows up after a night of drinking goes way too far, Words is forced to leave the family home. Desperate to impress his estranged wife and feckless teenage son, he quits his job, taking a pay cut to work with a new online publication covering local crime. There the plum role of editor will soon be his, he reasons. To Words, ‘Honesty is a thief—it steals your life.’ Better to do whatever it takes to get back in someone’s good books. And that is what he sets out to do, in a series of ever more calamitous, destructive and amoral adventures. Will the irredeemable Words win back his family? Or is comeuppance around the corner? A satirical novel by Miles Franklin Literary Award shortlisted author Craig Sherborne, Off the Record stylishly skewers tabloid journalism and male vanity. Craig Sherborne’s memoir Hoi Polloi (2005) was shortlisted for the Queensland Premier’s and Victorian Premier’s Literary Awards. The follow-up, Muck (2007), won the Queensland Premier’s Literary Award for Non-fiction. Craig’s first novel, The Amateur Science of Love (2011), won the Melbourne Prize for Literature’s Best Writing Award, and was shortlisted for a Victorian Premier’s Literary Award and a NSW Premier’s Literary Award. His second novel, Tree Palace (2014), was shortlisted for the Miles Franklin Award. Craig has also written two volumes of poetry, Bullion (1995) and Necessary Evil (2005), and a verse drama, Look at Everything Twice for Me (1999). He lives outside Melbourne. ‘It’s pacy, sleek, muscled—a mesmerising portrait of how a creep of a guy (who can look very much like you or me) can weave a web in which he finds himself.’ Peter Craven, Australian ’Sharp, taut and sizzlingly mean, Off The Record paints a biting portrait of a hard-boiled hack you would not want on your back...It is an expertly crafted almost-satire, that, though billed as dark comedy, is a cautionary tale about the true cost of selling your professional and creative soul, and of unbridled vanity. Ruthlessly riveting.’ Herald Sun ‘Ambiguous, funny, and refreshingly unwise.’ Monthly ‘This novel is a demonstration of Sherborne’s virtuosity as a writer.’ Australian Book Review ‘Monstrous yet moving.’ New Zealand Herald ‘A satirical romp through the seedy undergrowth of a headline hunter.’ North & South ‘Certain of his skewed world view, there’s a perverse delight in watching Words work, and an even greater one in watching him unravel...A smug satire of old school journalism and male pride.’ AU Review ‘Reading this novel is like watching a rabbit caught in the headlights of a vehicle. There’s an awful fascination, almost a voyeuristic delight, in watching a man dig himself deeper into a hole of amoral sensationalism.’ Good Reading
An “impressively researched and useful study” of the golden age of radio and its role in American democracy (Journal of American History). In Fireside Politics, Douglas B. Craig provides the first detailed and complete examination of radio’s changing role in American political culture between 1920 and 1940—the medium’s golden age, when it commanded huge national audiences without competition from television. Craig follows the evolution of radio into a commercialized, networked, and regulated industry, and ultimately into an essential tool for winning political campaigns and shaping American identity in the interwar period. Finally, he draws thoughtful comparisons of the American experience of radio broadcasting and political culture with those of Australia, Britain, and Canada. “The best general study yet published on the development of radio broadcasting during this crucial period when key institutional and social patterns were established.” ?Technology and Culture
Giving comprehensive, soup-to-nuts coverage of database administration, this guide is written from a platform-independent viewpoint, emphasizing best practices.
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