Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.
New York Times bestseller Cory Doctorow's The Bezzle is a high stakes thriller where the lives of the hundreds of thousands of inmates in California’s prisons are traded like stock shares. The year is 2006. Martin Hench is at the top of his game as a self-employed forensic accountant, a veteran of the long guerrilla war between people who want to hide money, and people who want to find it. He spends his downtime on Catalina Island, where scenic, imported bison wander the bluffs and frozen, reheated fast food burgers cost 25$. Wait, what? When Marty disrupts a seemingly innocuous scheme during a vacation on Catalina Island, he has no idea he’s kicked off a chain of events that will overtake the next decade of his life. Martin has made his most dangerous mistake yet: trespassed into the playgrounds of the ultra-wealthy and spoiled their fun. To them, money is a tool, a game, and a way to keep score, and they’ve found their newest mark—California’s Department of Corrections. Secure in the knowledge that they’re living behind far too many firewalls of shell companies and investors ever to be identified, they are interested not in the lives they ruin, but only in how much money they can extract from the government and the hundreds of thousands of prisoners they have at their mercy. A seething rebuke of the privatized prison system that delves deeply into the arcane and baroque financial chicanery involved in the 2008 financial crash, The Bezzle is a sizzling follow-up to Red Team Blues. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
The debut photography collection from the internationally renowned photographer, filmmaker, speaker, and mental health advocate, featuring 300 curated images from his global adventure features, climbing expeditions, portraiture, and early fashion and fine art work. An artist and storyteller who passionately explores the human experience, Cory Richards began working for National Geographic shooting adventure features in the most remote corners of the globe. As a professional climber, he spent his early career on high-risk expeditions that tested his unique ability to capture stories that were largely out of reach to others. Bi-Polar, a title that refers to Richards’s own diagnosis with Bipolar 2 at age fourteen and the career that has literally taken him to both ends of the earth, presents 300 of the most compelling images of Richards’s career. Organized by the emotional polarities that exist in his life and work, including hope and fear, pride and shame, awe and contempt, and finally, the singular, love, this stunning visual collection is a celebration of the tempests of the mind and how our greatest hurdles, when seen through a different lens, can become our greatest strengths. Spotlighting jaw-dropping landscapes, disappearing ways of life, the intersection of humans and animals, and more, Bi-Polar invites us to consider how art can connect us to ourselves, others, and the beautiful world we live in.
Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.
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