An engaging conceptualizing chapter opens Civil Rights and Liberties: Cases and Readings in Constitutional Law and American Democracy, introducing civil liberties within their constitutional framework, illuminating their nature and sources through enlightening Supreme Court deliberations that show the underlying debates about constitutional interpretation. A distinctive approach to themes and principles encourages students to develop their own views on civil liberties in general and on the specific controversies such as abortion, gay rights, and hate speech. Extensive, intriguing excerpts from a highly focused set of cases and other readings from contemporary theory highlight conflicting opinions among the justices. They provide depth of understanding of the Constitution and of the disputes that have shaped its meaning, including the basis and nature of judicial authority. The text's thematic organization reveals the structural and normative features of the Constitution and constitutional law by linking them to contemporary issues and controversies. Key historical elements lend context and depth. A logical chapter structure offers probing overviews of the topics, constitutional arguments, and chapter readings followed by a broad range of theoretical and historical writings leading up to the cases. This multidimensional perspective draws on a wide array of resources such as case excerpts, concurring and dissenting opinions, law journal and articles, general publications, published letters, and other documents. Probing case comprehension, discussion, and synthesis questions punctuate and reinforce content. Features: an engaging conceptualizing opening chapter introduces civil liberties within constitutional framework illuminates their nature and sources through enlightening Supreme Court disputes shows underlying debates about constitutional interpretation a distinctive approach to themes and principles encourages students to develop their own views on civil liberties engages students in specific controversies--abortion, gay rights, and hate speech, etc. intriguing excerpts from a highly focused set of cases and other readings highlight disputes among the justices provide depth of understanding of the Constitution and interpretive disputes explore the basis and nature of judicial authority thematic organization shows structural and normative features of the Constitution and constitutional law links the Constitution to contemporary issues and controversies provides key historical elements for context logical chapter structure author's overviews of topics, constitutional arguments, and chapter readings a broad range of theoretical and historical writings key cases a multidimensional perspective draws on a wide array of resources case excerpts concurring and dissenting opinions law journal articles general publications published letters and other documents probing case comprehension, discussion, and synthesis questions reinforce content
A deep dive into the twisted mind of “The Sunday Morning Slasher” from the Los Angeles Times–bestselling author, “the leading voice of true crime” (Dennis McDougal). More victims than Bundy . . . In Houston, Texas, on a Sunday morning in spring, Carl “Coral” Eugene Watts trapped two young women in their apartment. Only hours before, he’d killed another woman by drowning her in her bathtub. As Watts attempted to do the same to twenty-year-old Lori Lister, her roommate made a daring escape, leading to Watts’s arrest. Watts confessed to thirteen murders, but with no direct evidence, he managed to plea bargain his sentence down to sixty years for burglary. Through the untiring efforts of investigators and the mother of one of his victims, Watts was finally convicted of murder and sentenced to life in prison, where he remained the prime suspect in dozens of other slayings. Experts theorized that Watts may have slain more than Ted Bundy, Jeffrey Dahmer, and John Wayne Gacy . . . combined! Bestselling author Corey Mitchell tells the chilling story of how he almost got away with murder. Praise for the writing of Corey Mitchell “Corey Mitchell empathized with crime victims in a unique and personal way. That empathy is evident in every true crime book he wrote.” —Suzy Spencer, New York Times–bestselling author “No one faces evil head on like Corey Mitchell.” —Gregg Olsen, New York Times–bestselling author “Corey Mitchell uncovers yet another level of the insanity behind the world of youth and violence.” —Aphrodite Jones, New York Times–bestselling author
Applying critical sociological theory, this book explores the shortcomings of popular tactics in animal liberation efforts. Building a case for a scientifically-grounded grassroots approach, it is argued that professionalized advocacy that works in the service of theistic, capitalist, patriarchal institutions will find difficulty achieving success.
Argues that the process of biological evolution is not only fully consistent with the existence of a Grand Designer, but is unintelligible in the absence of one. Considers the implausibility of non-theistic evolution, directed evolution, a theological justification for evolution, and the implications of deistic evolution for theology. Paper edition (unseen), $37. Annotation copyright by Book News, Inc., Portland, OR
Corey W. Dyck presents a new account of Kant's criticism of the rational investigation of the soul in the 'Critique of Pure Reason', in light of its 18th-century German context. He reinterprets the aims and results of the Paralogisms, and illuminates Kant's discussion of the soul's substantiality, simplicity, personality, and existence.
Documents the growing fascination with political danger and disaster, reexamines fear's modern interpreters including Hobbes and Tocqueville, and offers an antidote to the culture of fear.
“Success can be elusive, but it can be found, and it’s easier when you know the secrets. This book is a gateway to many of those secrets.” —John Gray, #1 New York Times–bestselling author of Men Are from Mars, Women Are from Venus The Book of Why (and How) is designed to help people discover their passion, purpose, and mission while also leveraging the top habits of the world’s top achievers. Broken down into three sections, The Book of Why (and How) reveals the four WHYs that can dramatically change a person’s life, the shortest path to thriving in a challenging world, and the key to becoming more enlightened in the process. In short, multiple-time TEDx speaker, Corey Poirier, helps readers tap into their purpose so they can thrive in a more enlightened way. The Book of Why (and How) is unique in the way it addresses the importance of uncovering the WHY while also revealing the HOW. Many people struggle with feeling a lack of purpose in their life and work. They also struggle with how to uncover their purpose as well as what to do with it once they do. The Book of Why (and How) tackles this exact challenge while revealing the timeless secrets Corey Poirier has discovered while interviewing more than 5,000 of the world’s top achievers. “Corey has discovered a new vitamin that may just be the most important one yet because of how it feeds your mind. It’s Vitamin P—for purpose, and in The Book of Why (and How), Corey will help you get it so you can optimize your mind and create abundance in your lives.” —JJ Virgin, New York Times–bestselling author of The Virgin Diet
Given their tendency to splinter over tactics and goals, social movements are rarely unified. Following the modern Western animal rights movement over thirty years, Corey Lee Wrennapplies the sociological theory of Bourdieu, Goffman, Weber, and contemporary social movement researchers to examine structural conditions in the animal rights movement, facilitating factionalism in today’s era of professionalized advocacy. Modern social movements are dominated by bureaucratically oriented nonprofits, a special arrangement that creates tension between activists and movement elites who compete for success in a corporate political arena. Piecemeal Protest examines the impact of nonprofitization on factionalism and a movement’s ability to mobilize, resonate, and succeed. Wrenn’sexhaustive analysis of archival movement literature and exclusive interviews with movement leaders illustrate how entities with greater symbolic capital are positioned to monopolize claims-making, disempower competitors, and replicate hegemonic power, eroding democratic access to dialogue and decision-making essential for movement health. Piecemeal Protest examines social movement behavior shaped by capitalist ideologies and state interests. As power concentrates to the disadvantage of marginalized factions in the modern social movement arena, Piecemeal Protest shines light on processes of factionalism and considers how, in the age of nonprofits, intra-movement inequality could stifle social progress.
Why do people’s financial and economic preferences vary so widely? ‘Nurture’ variables such as socioeconomic factors partially explain these differences, but scientists have been discovering that ‘nature’ also plays an important role. This is the first book to bring together these scientific insights for a holistic view of the role of human biology in financial decision-making. Geneticists are now examining which genetic markers are associated with financial and economic preferences. Neuroscientists are now determining where in the brain financial decisions are made and how that varies between people. Endocrinologists relate the level of different hormones circulating in the body to financial risk-taking. Researchers are exploring how physiology and environmental conditions influence investment decisions, and how three types of cognitive ability play essential roles in investment success. This exciting and relevant work being done in these academic silos has generally not been transmitted among the scientific areas, or to industry. For the first time, this book integrates all these areas, explaining the myriad ways in which a person’s biology influences their investing decisions. Financial analysts, advisors, market participants, and upper-level undergraduate and postgraduate students of behavioral finance, behavioral economics, and investing will find this book invaluable, enabling a deeper understanding of investors’ decision-making processes. To further ensure this new material is accessible to students, PowerPoint slides are available online for instructors’ use.
Governmental Powers: Cases and Readings in Constitutional Law and American Democracy, written by prominent scholar and professor of constitutional law and political theory, Corey Brettschneider, explores the division, enumeration, and roles of the governmental powers established under the U.S. Constitution and the controversies arising from that system in the context of a changing American society. Like its parent volume, Constitutional Law and American Democracy, this text offers a wealth of highly focused case excerpts and interdisciplinary readings dealing with today s most salient debates. These carefully selected readings and cases focus on high-interest topics, including the nature and justification of judicial review, federalism, and separation of powers, and work together to create a nuanced view of key political and constitutional issues. Grounded in precedent, constitutional theory, and history, this bold work explores urgent issues of current debate and controversy making Governmental Powers fun to read and to teach. The clear, well-reasoned writing frequently challenges and always engages. A dynamic book drawing on a wealth of sources, Governmental Powers: Cases and Readings in Constitutional Law and American Democracy, features: An organization linking the history of the Constitution, constitutional law, and the structure of the federal government to contemporary issues and controversies A wealth of primary sources, including case excerpts, concurring and dissenting opinions, law journal and interdisciplinary articles, and published letters A new chapter on the nature and implications of the Supreme Court s 2012 decision regarding the Patient Protection and Affordable Health Care Act A focused selection of cases conveying a nuanced perspective on the Constitution and the political and constitutional disputes that have shaped its meaning Exposure to legal argumentation through astutely selected and edited readings from noted scholars and theorists Coverage spanning the history and development of constitutional law up to the present day, with ample background for considering the big-picture questions of constitutional doctrine and the Supreme Court s role A stimulating balance of foundational and cutting-edge topical coverage that doesn t sidestep provocative or controversial subject matter Overviews in each chapter introducing the constitutional arguments, chapter readings, and cases Discussion questions promoting comprehension, analysis, and classroom discourse Teachers of constitutional law have long awaited a text like this. Brettschneider blends the most important pertinent statements of political and legal theory with skillful excerpts from the major constitutional cases on governmental powers, civil rights, and civil liberties. Brettschneider s insightful commentaries make the text all the richer. Rogers M. Smith, Christopher H. Browne Distinguished Professor of Political Science, University of Pennsylvania
Opaque Melodies That Would Bug Most People is filled with young, vibrant poems from a wise voice. The poems often wax reflective, filled with the historicity of experience, yet always returning to the now. Thus, Mesler's collection is defined by beautiful immediacy, intimacy, and urgency. Constantly, these poems remind the reader what it means to be human, to be alive and living surrounded by a multitude of beating hearts and breathing lungs. While each poem recounts a snippet of life, together the poems create an earthy blanket that connects readers to a single mind whose voice throughout remains delicate, concrete, and vital, like an old friend. The verse engages the commonplace and the abstract with equal measures thoughtfulness. Each piece builds and builds until, by the end, the reader has experienced a life, and come away refreshed, having experienced hopeful energy.
In 1914, the Associated Newspapers sent correspondent Herbert Corey to Europe on the day Great Britain declared war on Germany. During the Great War that followed, Corey reported from France, Britain, and Germany, visiting the German lines on both the western and eastern fronts. He also reported from Greece, Italy, Switzerland, Holland, Belgium, and Serbia. When the Armistice was signed in November 1918, Corey defied the rules of the American Expeditionary Forces and crossed into Germany. He covered the Paris Peace Conference the following year. No other foreign correspondent matched the longevity of his reporting during World War I. Until recently, however, his unpublished memoir lay largely unnoticed among his papers in the Library of Congress. With publication of Herbert Corey’s Great War, coeditors Peter Finn and John Maxwell Hamilton reestablish Corey’s name in the annals of American war reporting. As a correspondent, he defies easy comparison. He approximates Ernie Pyle in his sympathetic interest in the American foot soldier, but he also told stories about troops on the other side and about noncombatants. He is especially illuminating on the obstacles reporters faced in conveying the story of the Great War to Americans. As his memoir makes clear, Corey didn’t believe he was in Europe to serve the Allies. He viewed himself as an outsider, one who was deeply ambivalent about the entry of the United States into the war. His idiosyncratic, opinionated, and very American voice makes for compelling reading.
From many to few -- Beyond Uncle Tom -- Race doesn't matter -- Black power through conservative principles -- Like crabs in a barrel -- Whither the Republican Party.
This book examines how rhetorically effective uses of silence and materiality mediate feminist activism and discusses the implications of these dynamics for pedagogy. Specifically, the text establishes a theoretical foundation for what the author terms “psychosocial composing,” or “the metaphorical composing and revising of individual participants and society, and the contribution of written and visual texts as an input and output of the relationships between individuals and social culture.” This idea is examined through primary research on the Clothesline Project, an international event that invites people who have experienced gender violence (directly or indirectly) to decorate tee shirts that get hung on clotheslines in public places. Through looking at values and roles of silence in global cultures and the use of material arts in activist efforts, the author argues for the unique value of silence and materiality in individual and collective spaces. The manuscript includes discussion questions and sample teaching materials. Overall, making connections among composition and rhetoric, psychology, sociology, politics, women’s studies, art and design, pedagogy, and history, this book further demonstrates the potential interdisciplinary approaches to rhetoric and communication.
The God Hypothesis seeks to reverse the profound misunderstanding that science has disproved the existence of God. Drawing on the fairy tale of Goldilocks and The Three Bears, Michael A. Corey believes that the "just right" conditions that created life on earth provide overwhelming evidence of an Intelligent Designer at work.
Are the sophists merely another group of villains in Plato's dialogues, no different than amoral rhetoricians such as Thrasymachus, Callicles, and Polus? Building on a wave of recent interest in the Greek sophists, The Sophists in Plato's Dialogues argues that, contrary to the conventional wisdom, there exist important affinities between Socrates and the sophists he engages in conversation. Both focused squarely on aretē (virtue or excellence). Both employed rhetorical techniques of refutation, revisionary myth construction, esotericism, and irony. Both engaged in similar ways of minimizing the potential friction that sometimes arises between intellectuals and the city. Perhaps the most important affinity between Socrates and the sophists, David D. Corey argues, was their mutual recognition of a basic epistemological insight—that appearances (phainomena) both physical and intellectual were vexingly unstable. Such things as justice, beauty, piety, and nobility are susceptible to radical change depending upon the angle from which they are viewed. Socrates uses the sophists and sometimes plays the role of sophist himself in order to awaken interlocutors and readers from their dogmatic slumber. This in turn generates wonder (thaumas), which, according to Socrates, is nothing other than the beginning of philosophy.
If you're a movie or television fan - how many of these questions can you answer? What was the last picture show in The Last Picture Show? Where was the stagecoach headed in Stagecoach? What was the name of the dinosaur bone in Bringing Up Baby? What did Gomer Pyle do before he entered the Marines? Who played Gentle Ben? Like The Book of Answers, this book answers hundreds of questions in one of the New York Public LIbrary Telephone Reference Service's most popular areas - film and television. It covers the biggest stars, breakthrough productions, famous on-and-off-screen incidents, and film and TV history and trivia. Movies and TV: The New York Public Library Book of Answers is both informative and entertaining - a treasure trove of fascinating movie and TV facts, a perfect companion to The Book of Answers, and a real treat for movie and TV fans.
* Unique woodcut illustrations decorate both volumes * Trail map to follow story locations in each volume * For both hikers and armchair adventurers of the PCT Exploring the people, places, and history of the Pacific Crest Trail as it ranges 2,600 miles from Mexico to Canada, THE PACIFIC CREST TRAILSIDE READER EBOOK brings together short excerpts from classic works of regional writing with boot-tested stories from the trail. The heart of this anthology is these real trail tales, stories taken from PCT hikers: trailside humor and traditions, "trail angels" and "trail magic," encounters with wildlife and wild weather, stories of being lost and found, rescues, and unusual incidents. Revealing a larger context are historical accounts of events such as Moses Schallenberger's winter on Donner Pass and pioneer efforts like the old Naches Road that ended up creating access to today's trails; Native American myths and legends such as that of Lost Lake near Mount Hood; and selections from highly-regarded environmental writers who have captured the region in print, including Mary Austin in The Land of Little Rain ; John Muir in The Mountains of California; and Barry Lopez in Crossing Open Ground. Readers will also enjoy a few more surprising contributions from the likes of Mark Twain and Ursula Le Guin. For this digital edition of the PCT READER, we combined our two print volumes into a single, robust ebook that features stories from both the CALIFORNIA and OREGON & WASHINGTON volumes. Because the two-volume set is a compilation of old and new essays, however, the editors were not able to obtain digital publication rights for some of the previously published material. So while this combination ebook includes all the newly commissioned stories, as well as many other pieces for which the editors did have digital access, there are approximately four contributions from each of the printed books that do not appear here.
Learn the fundamentals of clean, effective Python coding and build the practical skills to tackle your own software development or data science projects Key FeaturesBuild key Python skills with engaging development tasks and challenging activitiesImplement useful algorithms and write programs to solve real-world problemsApply Python in realistic data science projects and create simple machine learning modelsBook Description Have you always wanted to learn Python, but never quite known how to start? More applications than we realize are being developed using Python because it is easy to learn, read, and write. You can now start learning the language quickly and effectively with the help of this interactive tutorial. The Python Workshop starts by showing you how to correctly apply Python syntax to write simple programs, and how to use appropriate Python structures to store and retrieve data. You'll see how to handle files, deal with errors, and use classes and methods to write concise, reusable, and efficient code. As you advance, you'll understand how to use the standard library, debug code to troubleshoot problems, and write unit tests to validate application behavior. You'll gain insights into using the pandas and NumPy libraries for analyzing data, and the graphical libraries of Matplotlib and Seaborn to create impactful data visualizations. By focusing on entry-level data science, you'll build your practical Python skills in a way that mirrors real-world development. Finally, you'll discover the key steps in building and using simple machine learning algorithms. By the end of this Python book, you'll have the knowledge, skills and confidence to creatively tackle your own ambitious projects with Python. What you will learnWrite clean and well-commented code that is easy to maintainAutomate essential day-to-day tasks with Python scriptsDebug logical errors and handle exceptions in your programsExplore data science fundamentals and create engaging visualizationsGet started with predictive machine learningKeep your development process bug-free with automated testingWho this book is for This book is designed for anyone who is new to the Python programming language. Whether you're an aspiring software engineer or data scientist, or are just curious about learning how to code with Python, this book is for you. No prior programming experience is required.
A bold new account of European imperialism told through the history of water In the nineteenth and twentieth centuries, a handful of powerful European states controlled more than a third of the land surface of the planet. These sprawling empires encompassed not only rainforests, deserts, and savannahs but also some of the world’s most magnificent rivers, lakes, marshes, and seas. Liquid Empire tells the story of how the waters of the colonial world shaped the history of imperialism, and how this imperial past still haunts us today. Spanning the major European empires of the period, Corey Ross describes how new ideas, technologies, and institutions transformed human engagements with water and how the natural world was reshaped in the process. Water was a realm of imperial power whose control and distribution were closely bound up with colonial hierarchies and inequalities—but this vital natural resource could never be fully tamed. Ross vividly portrays the efforts of officials, engineers, fisherfolk, and farmers to exploit water, and highlights its crucial role in the making and unmaking of the colonial order. Revealing how the legacies of empire have persisted long after colonialism ebbed away, Liquid Empire provides needed historical perspective on the crises engulfing the world’s waters, particularly in the Global South, where billions of people are faced with mounting water shortages, rising flood risks, and the relentless depletion of sea life.
How have powerful Americans convinced their fellow citizens to support policies beneficial only to the wealthy? Why have so many given up on public education, safe food and safe streets, living wages – even on democracy itself? Kill it to Save it lays bare the hypocrisy of US political discourse by documenting the story of capitalism’s triumph over democracy. As the Progressive Left tries to understand how President Trump came to power, Corey Dolgon documents his historical, political and cultural road map. Dolgon argues that American citizens now accept policies that destroy the public sector and promote political stories that feel right “in the gut”, regardless of science or facts. Covering the post-Vietnam era to present day, Dolgon dismantles US common sense cultural discourse and explains why the endless crisis in US policy will continue until American citizens recognize what has been lost, and in whose interest.
Forensic mental health assessment (FMHA) has grown into a specialization informed by research and professional guidelines. This series presents up-to-date information on the most important and frequently conducted forms of FMHA. The 20 topical volumes address best approaches to practice for particular types of evaluation in the criminal, civil and juvenile/family areas. Each volume contains a thorough discussion of the relevant legal and psychological concepts, followed by a step-by-step description of the assessment process from preparing for the evaluation to writing the report and testifying in court. Volumes include the following helpful features: - Boxes that zero in on important information for use in evaluations - Tips for best practice and cautions against common pitfalls - Highlighting of relevant case law and statutes - Separate list of assessment tools for easy reference - Helpful glossary of key terms for the particular topic In making recommendations for best practice, authors consider empirical support, legal relevance, and consistency with ethical and professional standards. These volumes offer invaluable guidance for anyone involved in conducting or using forensic evaluations. A majority of police departments across the country conduct psychological evaluations of their police applicants and many also conduct periodic evaluations of incumbent police officers. With a small percentage of psychologists conducting these evaluations, and an even smaller number who have passed through board certification in forensic psychology or police and public safety psychology, there is a pressing need for education and training resources for practitioners seeking to develop competency in this area of practice. Evaluations of Police Suitability and Fitness for Duty, fills a gap in the literature, and explains the legal, procedural, ethical, and clinical foundations for these types of evaluations untethered to any single assessment instrument. Throughout the text, authors David M. Corey and Mark Zelig distinguish between enforceable, standards-based requirements and aspirational best practices. The book starts with a review of the most prominent federal laws and regulations, professional practice guidelines, and ethical standards pertinent to these evaluations. From there, applied chapters provide detailed procedural guidance, including advice for obtaining informed consent, providing disclosure to the involved parties, conducting clinical and collateral interviews, selecting written assessment instruments, integrating assessment findings to reach determinations of suitability and fitness, and preparing written reports and testimony for various audiences and uses.
Winner of the William Foote Whyte and Kathleen King Whyte Book Prize from the Rutgers Institute for the Study of Employee Ownership and Profit Sharing Employee ownership creates stronger companies, helps workers build wealth, and fosters a fairer, more stable society. In this book, two leading experts show how it works-and how it can be greatly expanded. Why are wages stagnant and wealth inequality increasing? One factor has inexplicably been left out: who owns the companies that drive the economy. Ownership gives people a claim to the fruits of free enterprise. Employee ownership gives workers-the people who have a stake in the company-a fair chance to benefit from their labors. In three simple parts, Corey Rosen and John Case create a powerful argument for why employee ownership is the answer to capitalism's crisis and how to implement it: 1. What's wrong with what we have-The authors explain why companies usually end up being sold off to investors and the often-horrific consequences that result for workers, communities, and the environment. 2. How can we change things?-This section shows how overlooking ownership limits attempts to reform capitalism and why employee ownership is a realistic and practical way to save capitalism from its own excesses. 3. Reinventing capitalism for the 21st century-This section describes how employee ownership has been done, is being done, and can be expanded and gives examples of companies of all sizes and sectors.
Dear Friend, This book teaches you the hidden secrets of self-reliance so you can reach your full potential and accomplish your grandest goals and dreams. It will help you to discover your true purpose and calling in life. How to get any job or career you want. How you can get the upper hand in any personal or professional negotiation. The ultimate time management strategy that will help you maximize the use of your time, enable you to focus on your core competencies and reach your goals in the quickest most efficient way possible. It will teach you success and problem solving mindsets and skillsets that will enable you to overcome any obstacle, challenge or setback. The secrets to health, vitality and unlimited energy that keeps you free from common colds, flu and illnesses so you can enjoy your life with exceptional mental clarity, focus and efficiency
Given the excellent historical context in which Corey frames his case and the rational manner in which he closes off the loopholes, the stage is set for paradigm shift in the secular area. I highly recommend this book.'-Hugh Ross, Astronomer
This introductory textbook examines diminishing terrestrial and aquatic habitats in the tropics, covering a broad range of topics including the fate of the coral reefs; the impact of agriculture, urbanization, and logging on habitat depletion; and the effects of fire on plants and animal survival. Includes case studies and interviews with prominent conservation scientists to help situate key concepts in a real world context Covers a broad range of topics including: the fate of the coral reefs; the impact of agriculture, urbanization, and logging on habitat depletion; and the effects of fire on plants and animal survival Highlights conservation successes in the region, and emphasizes the need to integrate social issues, such as human hunger, into a tangible conservation plan Documents the current state of the field as it looks for ways to predict future outcomes and lessen human impact “Sodhi et al. have done a masterful job of compiling a great deal of literature from around the tropical realm, and they have laid out the book in a fruitful and straightforward manner...I plan to use it as a reference and as supplemental reading for several courses and I would encourage others to do the same.” Ecology, 90(4), 2009, pp. 1144–1145
Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.
Jeff Corey (1914–2002) made a name for himself in the 1940s as a character actor in films like Superman and the Mole Men (1951), Joan of Arc (1948), and The Killers (1946). Everything changed in 1951, when he was summoned before the House Un-American Activities Committee. Corey refused to name names and was promptly blacklisted, which forced him to walk away from a vibrant livelihood as an actor and embark on a career as one of the industry's most revered acting instructors. In Improvising Out Loud: My Life Teaching Hollywood How to Act, Corey recounts his extraordinary story. Among the actors who would soon fill his classes were James Dean, Kirk Douglas, Jane Fonda, Rob Reiner, Jack Nicholson, and Leonard Nimoy. In 1962, when the blacklist ended, Corey was one of the industry's first trailblazers to seamlessly reboot his acting career and secure roles in some of the classic films of the era, including Butch Cassidy and the Sundance Kid (1969), True Grit (1969), and Little Big Man (1970), in which he starred as the infamous Wild Bill Hickok. Throughout his life, Corey sought to capture the human heart: in conflict, in terror, in love, and in all of its small triumphs. His memoir, which he wrote with his daughter Emily Corey, provides a unique and personal perspective on the man whose teaching inspired some of Hollywood's biggest names to star in the roles that made them famous.
Ecology and Power in the Age of Empire provides the first wide-ranging environmental history of the heyday of European imperialism, from the late nineteenth century to the end of the colonial era. It focuses on the ecological dimensions of the explosive growth of tropical commodity production, global trade, and modern resource management-transformations that still visibly shape our world today-and how they were related to broader social, cultural, and political developments in Europe's colonies. Covering the overseas empires of all the major European powers, Corey Ross argues that tropical environments were not merely a stage on which conquest and subjugation took place, but were an essential part of the colonial project, profoundly shaping the imperial enterprise even as they were shaped by it. The story he tells is not only about the complexities of human experience, but also about people's relationship with the ecosystems in which they were themselves embedded: the soil, water, plants, and animals that were likewise a part of Europe's empire. Although it shows that imperial conquest rarely represented a sudden bout of ecological devastation, it nonetheless demonstrates that modern imperialism marked a decisive and largely negative milestone for the natural environment. By relating the expansion of modern empire, global trade, and mass consumption to the momentous ecological shifts that they entailed, this book provides a historical perspective on the vital nexus of social, political, and environmental issues that we face in the twenty-first-century world.
A cleareyed, accessible, and informative primer: vital reading for all Americans." —Kirkus Reviews, starred review Can the president launch a nuclear attack without congressional approval? Is it ever a crime to criticize the president? Can states legally resist a president’s executive order? In today’s fraught political climate, it often seems as if we must become constitutional law scholars just to understand the news from Washington, let alone make a responsible decision at the polls. The Oath and the Office is the book we need, right now and into the future, whether we are voting for or running to become president of the United States. Constitutional law scholar and political science professor Corey Brettschneider guides us through the Constitution and explains the powers—and limits—that it places on the presidency. From the document itself and from American history’s most famous court cases, we learn why certain powers were granted to the presidency, how the Bill of Rights limits those powers, and what “we the people” can do to influence the nation’s highest public office—including, if need be, removing the person in it. In these brief yet deeply researched chapters, we meet founding fathers such as James Madison and Alexander Hamilton, as well as key figures from historic cases such as Brown v. Board of Education and Korematsu v. United States. Brettschneider breathes new life into the articles and amendments that we once read about in high school civics class, but that have real impact on our lives today. The Oath and the Office offers a compact, comprehensive tour of the Constitution, and empowers all readers, voters, and future presidents with the knowledge and confidence to read and understand one of our nation’s most important founding documents.
We have been living and working in the information society for decades, yet still we struggle to understand and keep up in the face of its constant flux and vast scope. In this unique interdisciplinary text, three scholars at the forefront of this dynamic field provide a clear conceptual framework and interpretation of the global information society. They explain the three pillars of the information society—technology, knowledge, and mobility—and the global information society as a whole, both as an interconnected web and a regionally distinct phenomenon. Offering a nuanced understanding of this complex subject, this book will enable students to navigate and thrive in the dynamic and evolving world of information and communication technology.
The Natural History of Creation is the third and final installment in M.A. Corey's natural theology series. This remarkable trilogy has worked in tandem with the findings of modern science to help spearhead the rebirth of the once-dead natural theology movement. In this detailed, yet easy to read work, the author focuses on the religious account of creation found in Genesis One and comes to the astonishing conclusion that there is indeed much scientific truth to be found in this ancient work. Many other writers have also noticed the breathtaking parallels that exist between modern evolutionism and the creation account given in the Bible, but nowhere will the reader find a more thorough description of them than in The Natural History of Creation. - Back cover.
This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions.
In 1987, Anthrax unleashed a heavy metal & pop culture touchstone with the release of their historic Among the Living album! Now Anthrax & Z2 invite you to explore the album like never before with this original anthology graphic novel! Each song on the album is given an original story by an amazing creative team, along with extra content and the introduction of the new NOTMAN designed by Greg Nicetero (Walking Dead)! Come on this dark journey into the ‘87 underground in America with these esteemed creators...
Our Own Felicity is about purpose, which banishes boredom and brings hope and joy. The West has twice lost it, but can recover. Discussions will generate comprehension and motivation. www.committeeforcorrespondence.net.
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