Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines's Books

Adverse Effects of Pertussis and Rubella Vaccines

By: Institute of Medicine,Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines

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Adverse Effects of Pertussis and Rubella Vaccines

By: Institute of Medicine,Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines

Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura. The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.

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Page Count

382

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National Academies Press

Published Date

ISBN 10

0309044995

ISBN 13

9780309044998

Adverse Effects of Pertussis and Rubella Vaccines

By: Institute of Medicine,Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines

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Adverse Effects of Pertussis and Rubella Vaccines

By: Institute of Medicine,Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines

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382

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National Academies Press

Published Date

ISBN 10

0309103681

ISBN 13

9780309103688

Adverse Effects of Vaccines

Evidence and Causality

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines

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Adverse Effects of Vaccines

Evidence and Causality

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

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894

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National Academies Press

Published Date

ISBN 10

0309214351

ISBN 13

9780309214353

Adverse Events Associated with Childhood Vaccines

Evidence Bearing on Causality

By: Institute of Medicine,Vaccine Safety Committee

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Adverse Events Associated with Childhood Vaccines

Evidence Bearing on Causality

By: Institute of Medicine,Vaccine Safety Committee

Childhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization. This volume provides the most thorough literature review available about links between common childhood vaccinesâ€"tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b, and hepatitis Bâ€"and specific types of disorders or death. The authors discuss approaches to evidence and causality and examine the consequencesâ€"neurologic and immunologic disorders and deathâ€"linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders. This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents.

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481

Publisher

National Academies Press

Published Date

ISBN 10

0309048958

ISBN 13

9780309048958

Adverse Effects of Vaccines

Evidence and Causality

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines

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Adverse Effects of Vaccines

Evidence and Causality

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines

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Page Count

894

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National Academies Press

Published Date

ISBN 10

0309214351

ISBN 13

9780309214353

Adverse Events Associated with Childhood Vaccines

Evidence Bearing on Causality

By: Institute of Medicine,Vaccine Safety Committee

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Adverse Events Associated with Childhood Vaccines

Evidence Bearing on Causality

By: Institute of Medicine,Vaccine Safety Committee

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481

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National Academies Press

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ISBN 10

0309048958

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9780309048958

Immunization Safety Review

Measles-Mumps-Rubella Vaccine and Autism

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee

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Immunization Safety Review

Measles-Mumps-Rubella Vaccine and Autism

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee

Immunization is widely regarded as one of the most effective and beneficial tools for protecting the public's health. In the United States, immunization programs have resulted in the eradication of smallpox, the elimination of polio, and the control and near elimination of once-common, often debilitating and potentially life-threatening diseases, including measles, mumps, rubella, diphtheria, pertussis, tetanus, and Haemophilus influenza type b. Along with the benefits of widespread immunization, however, have come concerns about the safety of vaccines. No vaccine is perfectly safe or effective, and vaccines may lead to serious adverse effects in some instances. Furthermore, if a serious illness is observed after vaccination, it is often unclear whether that sequence is coincidental or causal, and it can be difficult to determine the true nature of the relationship, if any, between the vaccination and the illness. Ironically, the successes of vaccine coverage in the United States have made it more difficult for the public to weigh the benefits and complications of vaccines because the now-controlled diseases and their often-serious risks are no longer familiar. However, because vaccines are so widely used-and because state laws require that children be vaccinated before entering daycare and school, in part to protect others-it is essential that safety concerns be fully and carefully studied. Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism, the first of a series from the Institute of Medicine (IOM) Immunization Safety Review Committee, presents an assessment of the evidence regarding a hypothesized causal association between the measles-mumps-rubella (MMR) vaccine and autism, an assessment of the broader significance for society of the issues surrounding the MMR-autism hypothesis, and the committee's conclusions and recommendations based on those assessments.

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102

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National Academies Press

Published Date

ISBN 10

0309074479

ISBN 13

9780309074476

Immunization Safety Review

Vaccinations and Sudden Unexpected Death in Infancy

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee

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Immunization Safety Review

Vaccinations and Sudden Unexpected Death in Infancy

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee

With current recommendations calling for infants to receive multiple doses of vaccines during their first year of life and with sudden infant death syndrome (SIDS) the most frequent cause of death during the postneonatal period, it is important to respond to concerns that vaccination might play a role in sudden unexpected infant death. The committee reviewed epidemiologic evidence focusing on three outcomes: SIDS, all SUDI (sudden unexpected death in infancy), and neonatal death (infant death, whether sudden or not, during the first 4 weeks of life). Based on this review, the committee concluded that the evidence favors rejection of a causal relationship between some vaccines and SIDS; and that the evidence is inadequate to accept or reject a causal relationship between other vaccines and SIDS, SUDI, or neonatal death. The evidence regarding biological mechanisms is essentially theoretical, reflecting in large measure the lack of knowledge concerning the pathogenesis of SIDS.

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Page Count

118

Publisher

National Academies Press

Published Date

ISBN 10

0309088860

ISBN 13

9780309088862

Book's by Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines

Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Pertussis and Rubella Vaccines

Adverse Effects of Vaccines

Adverse Effects of Vaccines

Adverse Events Associated with Childhood Vaccines

Adverse Events Associated with Childhood Vaccines

Adverse Effects of Vaccines

Adverse Effects of Vaccines

Adverse Events Associated with Childhood Vaccines

Adverse Events Associated with Childhood Vaccines

Immunization Safety Review

Immunization Safety Review

Immunization Safety Review

Immunization Safety Review

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