Committee on the Mathematical Sciences in Genome and Protein Structure Research's Books

Calculating the Secrets of Life

Contributions of the Mathematical Sciences to Molecular Biology

By: National Research Council,Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on the Mathematical Sciences in Genome and Protein Structure Research

Write a review Read reviews Take a Quiz Solve Book Puzzle

Calculating the Secrets of Life

Contributions of the Mathematical Sciences to Molecular Biology

As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important roleâ€"in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race. In this first-ever survey of the partnership between the two fields, leading experts look at how mathematical research and methods have made possible important discoveries in biology. The volume explores how differential geometry, topology, and differential mechanics have allowed researchers to "wind" and "unwind" DNA's double helix to understand the phenomenon of supercoiling. It explains how mathematical tools are revealing the workings of enzymes and proteins. And it describes how mathematicians are detecting echoes from the origin of life by applying stochastic and statistical theory to the study of DNA sequences. This informative and motivational book will be of interest to researchers, research administrators, and educators and students in mathematics, computer sciences, and biology.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

300

Publisher

National Academies Press

Published Date

ISBN 10

0309048869

ISBN 13

9780309048866

Calculating the Secrets of Life

Contributions of the Mathematical Sciences to Molecular Biology

By: Committee on the Mathematical Sciences in Genome and Protein Structure Research,Commission on Physical Sciences, Mathematics, and Applications,Division on Engineering and Physical Sciences,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Calculating the Secrets of Life

Contributions of the Mathematical Sciences to Molecular Biology

As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important role--in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race. In this first-ever survey of the partnership between the two fields, leading experts look at how mathematical research and methods have made possible important discoveries in biology. The volume explores how differential geometry, topology, and differential mechanics have allowed researchers to "wind" and "unwind" DNA's double helix to understand the phenomenon of supercoiling. It explains how mathematical tools are revealing the workings of enzymes and proteins. And it describes how mathematicians are detecting echoes from the origin of life by applying stochastic and statistical theory to the study of DNA sequences. This informative and motivational book will be of interest to researchers, research administrators, and educators and students in mathematics, computer sciences, and biology.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

263

Publisher

National Academies Press

Published Date

ISBN 10

0309075025

ISBN 13

9780309075022

Mathematics and 21st Century Biology

By: National Research Council,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on Mathematical Sciences Research for DOE's Computational Biology

Write a review Read reviews Take a Quiz Solve Book Puzzle

Mathematics and 21st Century Biology

The exponentially increasing amounts of biological data along with comparable advances in computing power are making possible the construction of quantitative, predictive biological systems models. This development could revolutionize those biology-based fields of science. To assist this transformation, the U.S. Department of Energy asked the National Research Council to recommend mathematical research activities to enable more effective use of the large amounts of existing genomic information and the structural and functional genomic information being created. The resulting study is a broad, scientifically based view of the opportunities lying at the mathematical science and biology interface. The book provides a review of past successes, an examination of opportunities at the various levels of biological systemsâ€" from molecules to ecosystemsâ€"an analysis of cross-cutting themes, and a set of recommendations to advance the mathematics-biology connection that are applicable to all agencies funding research in this area.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

163

Publisher

National Academies Press

Published Date

ISBN 10

0309095840

ISBN 13

9780309095846

Mathematical Challenges from Theoretical/Computational Chemistry

By: National Research Council,Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Mathematical Challenges from Computational Chemistry

Write a review Read reviews Take a Quiz Solve Book Puzzle

Mathematical Challenges from Theoretical/Computational Chemistry

Computational methods are rapidly becoming major tools of theoretical, pharmaceutical, materials, and biological chemists. Accordingly, the mathematical models and numerical analysis that underlie these methods have an increasingly important and direct role to play in the progress of many areas of chemistry. This book explores the research interface between computational chemistry and the mathematical sciences. In language that is aimed at non-specialists, it documents some prominent examples of past successful cross-fertilizations between the fields and explores the mathematical research opportunities in a broad cross-section of chemical research frontiers. It also discusses cultural differences between the two fields and makes recommendations for overcoming those differences and generally promoting this interdisciplinary work.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

143

Publisher

National Academies Press

Published Date

ISBN 10

030917662X

ISBN 13

9780309176620

Evaluating the Taxonomic Status of the Mexican Gray Wolf and the Red Wolf

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Board on Life Sciences,Committee on Assessing the Taxonomic Status of the Red Wolf and the Mexican Gray Wolf

Write a review Read reviews Take a Quiz Solve Book Puzzle

Evaluating the Taxonomic Status of the Mexican Gray Wolf and the Red Wolf

Scientists strive to develop clear rules for naming and grouping living organisms. But taxonomy, the scientific study of biological classification and evolution, is often highly debated. Members of a species, the fundamental unit of taxonomy and evolution, share a common evolutionary history and a common evolutionary path to the future. Yet, it can be difficult to determine whether the evolutionary history or future of a population is sufficiently distinct to designate it as a unique species. A species is not a fixed entity â€" the relationship among the members of the same species is only a snapshot of a moment in time. Different populations of the same species can be in different stages in the process of species formation or dissolution. In some cases hybridization and introgression can create enormous challenges in interpreting data on genetic distinctions between groups. Hybridization is far more common in the evolutionary history of many species than previously recognized. As a result, the precise taxonomic status of an organism may be highly debated. This is the current case with the Mexican gray wolf (Canis lupus baileyi) and the red wolf (Canis rufus), and this report assesses the taxonomic status for each.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

105

Publisher

National Academies Press

Published Date

ISBN 10

0309488273

ISBN 13

9780309488273

Catalyzing Inquiry at the Interface of Computing and Biology

By: National Research Council,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Committee on Frontiers at the Interface of Computing and Biology

Write a review Read reviews Take a Quiz Solve Book Puzzle

Catalyzing Inquiry at the Interface of Computing and Biology

By: National Research Council,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Committee on Frontiers at the Interface of Computing and Biology

Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

469

Publisher

National Academies Press

Published Date

ISBN 10

030909612X

ISBN 13

9780309096126

Review of the Department of Energy's Genomics: GTL Program

By: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Review of the Department of Energy's Genomics: GTL Program

Write a review Read reviews Take a Quiz Solve Book Puzzle

Review of the Department of Energy's Genomics: GTL Program

By: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Review of the Department of Energy's Genomics: GTL Program

The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

102

Publisher

National Academies Press

Published Date

ISBN 10

0309180716

ISBN 13

9780309180719

The Mathematical Sciences in 2025

By: National Research Council,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on the Mathematical Sciences in 2025

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Mathematical Sciences in 2025

By: National Research Council,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on the Mathematical Sciences in 2025

The mathematical sciences are part of nearly all aspects of everyday life-the discipline has underpinned such beneficial modern capabilities as Internet search, medical imaging, computer animation, numerical weather predictions, and all types of digital communications. The Mathematical Sciences in 2025 examines the current state of the mathematical sciences and explores the changes needed for the discipline to be in a strong position and able to maximize its contribution to the nation in 2025. It finds the vitality of the discipline excellent and that it contributes in expanding ways to most areas of science and engineering, as well as to the nation as a whole, and recommends that training for future generations of mathematical scientists should be re-assessed in light of the increasingly cross-disciplinary nature of the mathematical sciences. In addition, because of the valuable interplay between ideas and people from all parts of the mathematical sciences, the report emphasizes that universities and the government need to continue to invest in the full spectrum of the mathematical sciences in order for the whole enterprise to continue to flourish long-term.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

223

Publisher

National Academies Press

Published Date

ISBN 10

0309284570

ISBN 13

9780309284578

Refining the Concept of Scientific Inference When Working with Big Data

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on Applied and Theoretical Statistics

Write a review Read reviews Take a Quiz Solve Book Puzzle

Refining the Concept of Scientific Inference When Working with Big Data

Proceedings of a Workshop

The concept of utilizing big data to enable scientific discovery has generated tremendous excitement and investment from both private and public sectors over the past decade, and expectations continue to grow. Using big data analytics to identify complex patterns hidden inside volumes of data that have never been combined could accelerate the rate of scientific discovery and lead to the development of beneficial technologies and products. However, producing actionable scientific knowledge from such large, complex data sets requires statistical models that produce reliable inferences (NRC, 2013). Without careful consideration of the suitability of both available data and the statistical models applied, analysis of big data may result in misleading correlations and false discoveries, which can potentially undermine confidence in scientific research if the results are not reproducible. In June 2016 the National Academies of Sciences, Engineering, and Medicine convened a workshop to examine critical challenges and opportunities in performing scientific inference reliably when working with big data. Participants explored new methodologic developments that hold significant promise and potential research program areas for the future. This publication summarizes the presentations and discussions from the workshop.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

115

Publisher

National Academies Press

Published Date

ISBN 10

0309454441

ISBN 13

9780309454445

Gene Drives on the Horizon

Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct

Write a review Read reviews Take a Quiz Solve Book Puzzle

Gene Drives on the Horizon

Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

231

Publisher

National Academies Press

Published Date

ISBN 10

0309437903

ISBN 13

9780309437905

The Potential Impact of High-End Capability Computing on Four Illustrative Fields of Science and Engineering

By: National Research Council,Division on Earth and Life Studies,Division on Engineering and Physical Sciences,Committee on the Potential Impact of High-End Computing on Illustrative Fields of Science and Engineering

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Potential Impact of High-End Capability Computing on Four Illustrative Fields of Science and Engineering

Many federal funding requests for more advanced computer resources assume implicitly that greater computing power creates opportunities for advancement in science and engineering. This has often been a good assumption. Given stringent pressures on the federal budget, the White House Office of Management and Budget (OMB) and Office of Science and Technology Policy (OSTP) are seeking an improved approach to the formulation and review of requests from the agencies for new computing funds. This book examines, for four illustrative fields of science and engineering, how one can start with an understanding of their major challenges and discern how progress against those challenges depends on high-end capability computing (HECC). The four fields covered are: atmospheric science astrophysics chemical separations evolutionary biology This book finds that all four of these fields are critically dependent on HECC, but in different ways. The book characterizes the components that combine to enable new advances in computational science and engineering and identifies aspects that apply to multiple fields.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

158

Publisher

National Academies Press

Published Date

ISBN 10

0309134439

ISBN 13

9780309134439

Bits of Power

Issues in Global Access to Scientific Data

By: Committee on Issues in the Transborder Flow of Scientific Data,Commission on Physical Sciences, Mathematics, and Applications,Division on Engineering and Physical Sciences,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Bits of Power

Issues in Global Access to Scientific Data

Since Galileo corresponded with Kepler, the community of scientists has become increasingly international. A DNA sequence is as significant to a researcher in Novosibirsk as it is to one in Pasadena. And with the advent of electronic communications technology, these experts can share information within minutes. What are the consequences when more bits of scientific data cross more national borders and do it more swiftly than ever before? Bits of Power assesses the state of international exchange of data in the natural sciences, identifying strengths, weaknesses, and challenges. The committee makes recommendations about access to scientific data derived from public funding. The volume examines: Trends in the electronic transfer and management of scientific data. Pressure toward commercialization of scientific data, including the economic aspects of government dissemination of the data. The implications of proposed changes to intellectual property laws and the role of scientists in shaping legislative and legal solutions. Improving access to scientific data by and from the developing world. Bits of Power explores how these issues have been addressed in the European Community and includes examples of successful data transfer activities in the natural sciences. The book will be of interest to scientists and scientific data managers, as well as intellectual property rights attorneys, legislators, government agencies, and international organizations concerned about the electronic flow of scientific data.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

250

Publisher

National Academies Press

Published Date

ISBN 10

0309523567

ISBN 13

9780309523561

Condensed-Matter and Materials Physics

The Science of the World Around Us

By: National Research Council,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on CMMP 2010

Write a review Read reviews Take a Quiz Solve Book Puzzle

Condensed-Matter and Materials Physics

The Science of the World Around Us

By: National Research Council,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on CMMP 2010

The development of transistors, the integrated circuit, liquid-crystal displays, and even DVD players can be traced back to fundamental research pioneered in the field of condensed-matter and materials physics (CMPP). The United States has been a leader in the field, but that status is now in jeopardy. Condensed-Matter and Materials Physics, part of the Physics 2010 decadal survey project, assesses the present state of the field in the United States, examines possible directions for the 21st century, offers a set of scientific challenges for American researchers to tackle, and makes recommendations for effective spending of federal funds. This book maintains that the field of CMPP is certain to be principle to both scientific and economic advances over the next decade and the lack of an achievable plan would leave the United States behind. This book's discussion of the intellectual and technological challenges of the coming decade centers around six grand challenges concerning energy demand, the physics of life, information technology, nanotechnology, complex phenomena, and behavior far from equilibrium. Policy makers, university administrators, industry research and development executives dependent upon developments in CMPP, and scientists working in the field will find this book of interest.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

285

Publisher

National Academies Press

Published Date

ISBN 10

0309109698

ISBN 13

9780309109697

Opportunities in Biology

By: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Biology,Committee on Research Opportunities in Biology

Write a review Read reviews Take a Quiz Solve Book Puzzle

Opportunities in Biology

By: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Biology,Committee on Research Opportunities in Biology

Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€"recombinant DNA, scanning tunneling microscopes, and moreâ€"are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€"for funding, effective information systems, and other supportâ€"of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

471

Publisher

National Academies

Published Date

ISBN 10

0309039274

ISBN 13

9780309039277

The Role of Theory in Advancing 21st-Century Biology

Catalyzing Transformative Research

By: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Defining and Advancing the Conceptual Basis of Biological Sciences in the 21st Century

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Role of Theory in Advancing 21st-Century Biology

Catalyzing Transformative Research

By: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Defining and Advancing the Conceptual Basis of Biological Sciences in the 21st Century

Although its importance is not always recognized, theory is an integral part of all biological research. Biologists' theoretical and conceptual frameworks inform every step of their research, affecting what experiments they do, what techniques and technologies they develop and use, and how they interpret their data. By examining how theory can help biologists answer questions like "What are the engineering principles of life?" or "How do cells really work?" the report shows how theory synthesizes biological knowledge from the molecular level to the level of whole ecosystems. The book concludes that theory is already an inextricable thread running throughout the practice of biology; but that explicitly giving theory equal status with other components of biological research could help catalyze transformative research that will lead to creative, dynamic, and innovative advances in our understanding of life.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

209

Publisher

National Academies Press

Published Date

ISBN 10

0309112494

ISBN 13

9780309112499

Cities and Their Vital Systems

Infrastructure Past, Present, and Future

By: Advisory Committee on Technology and Society

Write a review Read reviews Take a Quiz Solve Book Puzzle

Cities and Their Vital Systems

Infrastructure Past, Present, and Future

By: Advisory Committee on Technology and Society

Cities and Their Vital Systems asks basic questions about the longevity, utility, and nature of urban infrastructures; analyzes how they grow, interact, and change; and asks how, when, and at what cost they should be replaced. Among the topics discussed are problems arising from increasing air travel and airport congestion; the adequacy of water supplies and waste treatment; the impact of new technologies on construction; urban real estate values; and the field of "telematics," the combination of computers and telecommunications that makes money machines and national newspapers possible.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

1298

Publisher

National Academies Press

Published Date

ISBN 10

0309037867

ISBN 13

9780309037860

Mathematics and 21st Century Biology

Write a review Read reviews Take a Quiz Solve Book Puzzle

Mathematics and 21st Century Biology

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

162

Publisher

National Academies Press

Published Date

ISBN 10

0309165067

ISBN 13

9780309165068

Mathematics and 21st Century Biology

Write a review Read reviews Take a Quiz Solve Book Puzzle

Mathematics and 21st Century Biology

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

163

Publisher

National Academies Press

Published Date

ISBN 10

0309095840

ISBN 13

9780309095846

Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey

Workshop Summary

By: National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Steering Committee for the Workshop on Guidelines for Returning Individual Results from Genome Research Using Population-Based Banked Specimens

Write a review Read reviews Take a Quiz Solve Book Puzzle

Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey

Workshop Summary

Population surveys traditionally collect information from respondents about their circumstances, behaviors, attitudes, and other characteristics. In recent years, many surveys have been collecting not only questionnaire answers, but also biologic specimens such as blood samples, saliva, and buccal swabs, from which a respondent's DNA can be ascertained along with other biomarkers (e.g., the level of a certain protein in the blood). The National Health and Nutrition Examination Survey (NHANES), sponsored by the National Center for Health Statistics (NCHS), has been collecting and storing genetic specimens since 1991, and other surveys, such as the Health and Retirement Study (HRS) funded by the National Institute on Aging, have followed suit. In order to give their informed consent to participate in a survey, respondents need to know the disposition and use of their data. Will their data be used for one research project and then destroyed, or will they be archived for secondary use? Sponsors of repeated cross-sectional surveys, such as NHANES, and of longitudinal surveys that follow panels of individuals over time, such as HRS, generally want to retain data for a wide range of secondary uses, many of which are not explicitly foreseen at the time of data collection. They typically inform respondents that their data will be stored in a secure manner and may be provided to researchers with suitable protections against individual identification. The addition of biologic specimens to a survey adds complications for storing, protecting, and providing access to such data and measurements made from them. There are also questions of whether, when, and for which biologic measurements the results should be reported back to individual respondents. Recently, the cost of full genomic sequencing has plummeted, and research findings are beginning to accumulate that bear up under replication and that potentially have clinical implications for a respondent. For example, knowing that one possesses a certain gene or gene sequence might suggest that one should seek a certain kind of treatment or genetic counseling or inform one's blood relatives. Biomedical research studies, in which participants are asked to donate tissues for genetic studies and are usually told that they will not be contacted with any results, are increasingly confronting the issue of when and which DNA results to return to participants. Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey is the summary of a workshop convened in February 2013 by the Committee on National Statistics in the Division of Behavioral and Social Sciences and Education of the National Research Council. This report considers how population surveys, in particular NHANES, should implement the reporting of results from genomic research using stored specimens and address informed consent for future data collection as well as for the use of banked specimens covered by prior informed consent agreements. The report will be of interest to survey organizations that include or contemplate including the collection of biologic specimens in population surveys for storing for genetic research. The issues involved are important for advancing social, behavioral, and biomedical knowledge while appropriately respecting and protecting individual survey respondents.

Average ratings

N/A