Committee on the Biological and Biomedical Applications of Stem Cell Research's Books

Stem Cells and the Future of Regenerative Medicine

By: Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research

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Stem Cells and the Future of Regenerative Medicine

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

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112

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National Academies Press

Published Date

ISBN 10

0309170427

ISBN 13

9780309170420

Integrity in Scientific Research

Creating an Environment That Promotes Responsible Conduct

By: National Research Council,Institute of Medicine,Division on Earth and Life Studies,Board on Health Sciences Policy,Committee on Assessing Integrity in Research Environments

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Integrity in Scientific Research

Creating an Environment That Promotes Responsible Conduct

By: National Research Council,Institute of Medicine,Division on Earth and Life Studies,Board on Health Sciences Policy,Committee on Assessing Integrity in Research Environments

Many people say that it is the intellect which makes a great scientist. They are wrong: it is character."-Albert Einstein Integrity in Scientific Research attempts to define and describe those elements that encourage individuals involved with scientific research to act with integrity. Recognizing the inconsistency of human behavior, it stresses the important role that research institutions play in providing an integrity-rich environment, citing the need for institutions to provide staff with training and education, policies and procedures, and tools and support systems. It identifies practices that characterize integrity in such areas as peer review and research on human subjects and weighs the strengths and limitations of self-evaluation efforts by these institutions. In addition, it details an approach to promoting integrity during the education of researchers, including how to develop an effective curriculum. Providing a framework for research and educational institutions, this important book will be essential for anyone concerned about ethics in the scientific community.

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217

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National Academies Press

Published Date

ISBN 10

0309084792

ISBN 13

9780309084796

Opportunities in Biotechnology for Future Army Applications

By: National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications

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Opportunities in Biotechnology for Future Army Applications

By: National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

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118

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National Academies Press

Published Date

ISBN 10

0309170737

ISBN 13

9780309170734

Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on Guidelines for Human Embryonic Stem Cell Research

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Guidelines for Human Embryonic Stem Cell Research

Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research.

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224

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National Academies Press

Published Date

ISBN 10

0309096537

ISBN 13

9780309096539

Bioengineering

seventh report of session 2009-10, report, together with formal minutes, oral and written evidence

By: Great Britain: Parliament: House of Commons: Science and Technology Committee

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Bioengineering

seventh report of session 2009-10, report, together with formal minutes, oral and written evidence

By: Great Britain: Parliament: House of Commons: Science and Technology Committee

This report finds that the UK has an excellent research base but is still failing to maximise its potential by translating research into wealth and health. The road to economic recovery will depend, in part, on exploitation of the UK's research base, which in turn requires efficient translation to generate returns on investments. Some areas of bioengineering, such as stem cells, have clearly benefited from strong Government leadership and support, backed up by generous levels of funding from both the public and private sectors. Others, such as genetically modified (GM) crops, are less well supported and funded. This is curious when GM crops are considered by the Government to be safe and offer potential benefits. GM crops are certainly the poor cousin in the bioengineering family, and we strongly urge the Government to signal its support for GM crops as well as improving the regulatory situation in Europe. Regulation of bioengineering is complex and researchers have found that regulations inhibit research and translation, either because of regulatory complexity (stem cells) or a flawed operation of the regulatory process (GM crops). There are good indications that the UK is learning from past experiences in bioengineering when handling new emerging technologies, such as synthetic biology. The Government and Research Councils have recognised the value of synthetic biology early, and are providing funding. The Committee is also concerned that while research is well funded there is not enough forethought about synthetic biology translation, for example developing DNA synthesis capability, which would provide the UK with an excellent opportunity to get ahead internationally. If this is not addressed, synthetic biology runs the risk of becoming yet another story of the UK failing to capitalise on a strong research base and falling behind internationally.

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Page Count

240

Publisher

The Stationery Office

Published Date

ISBN 10

0215545265

ISBN 13

9780215545268

Stem Cells and the Future of Regenerative Medicine

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Stem Cells and the Future of Regenerative Medicine

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113

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National Academies Press

Published Date

ISBN 10

0309076307

ISBN 13

9780309076302

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

By: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

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300

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National Academies Press

Published Date

ISBN 10

0309178894

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9780309178891

Using 21st Century Science to Improve Risk-Related Evaluations

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations

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Using 21st Century Science to Improve Risk-Related Evaluations

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

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201

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National Academies Press

Published Date

ISBN 10

0309453518

ISBN 13

9780309453516

Government proposals for the regulation of hybrid and chimera embryos

fifth report of session 2006-07, Vol. 2: Oral and written evidence

By: Great Britain: Parliament: House of Commons: Science and Technology Committee

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Government proposals for the regulation of hybrid and chimera embryos

fifth report of session 2006-07, Vol. 2: Oral and written evidence

By: Great Britain: Parliament: House of Commons: Science and Technology Committee

For Vol. 1, see (ISBN 9780215033512)

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194

Publisher

The Stationery Office

Published Date

ISBN 10

0215033531

ISBN 13

9780215033536

Capturing the Full Power of Biomaterials for Military Medicine

Report of a Workshop

By: National Research Council,Division on Engineering and Physical Sciences,National Materials Advisory Board,Board on Manufacturing and Engineering Design,Committee on Capturing the Full Power of Biomaterials for Military Medical Needs

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Capturing the Full Power of Biomaterials for Military Medicine

Report of a Workshop

Recent results in biomaterials R&D suggest that there are exceptional opportunities for these emerging materials in military medicine. To facilitate this possibility, the National Research Council convened a workshop at the request of the Department of Defense to help create a technology development roadmap to enhance military R&D into biomaterials technology. The workshop focused primarily on identifying useful near- and mid-term applications of biomaterials including wound care, tissue engineering, drug delivery, and physiological sensors and diagnostics. This report presents a summary of the workshop. It provides a review of biomaterials and their importance to military medicine, the roadmap, and a discussion of ways to enable biomaterials development. Several important outcomes of successful capture of potential benefits of these materials are also discussed.

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National Academies Press

Published Date

ISBN 10

0309092833

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9780309092838

Final Report of the National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

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Final Report of the National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

In 2005, the National Academies released the book, Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of comprehensive federal funding, was lacking national standards for research. In order to keep the Guidelines up to date, given the rapid pace of scientific and policy developments in the field of stem cell research, the Human Embryonic Stem Cell Research Advisory Committee was established in 2006 with support from The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute. As it did in 2007 and 2008, the Committee identified issues that warranted revision, and this book addresses those issues in a third and final set of amendments. Specifically, this book sets out an updated version of the National Academies' Guidelines, one that takes into account the new, expanded role of the NIH in overseeing hES cell research. It also identifies those avenues of continuing National Academies' involvement deemed most valuable by the research community and other significant stakeholders.

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National Academies Press

Published Date

ISBN 10

0309156009

ISBN 13

9780309156004

The California Institute for Regenerative Medicine

Science, Governance, and the Pursuit of Cures

By: Institute of Medicine,Board on Health Sciences Policy,Committee on a Review of the California Institute for Regenerative Medicine

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The California Institute for Regenerative Medicine

Science, Governance, and the Pursuit of Cures

By: Institute of Medicine,Board on Health Sciences Policy,Committee on a Review of the California Institute for Regenerative Medicine

The California Institute for Regenerative Medicine (CIRM) was created in 2005 by The California Stem Cell Research and Cures Act (Proposition 71) to distribute $3 billion in state funds for stem cell research. The passage of Proposition 71 by the voters of California occurred at a time when federal funding for research involving human embryonic stem cells was uncertain, given the ethical questions raised by such research. During its initial period of operations, CIRM has successfully and thoughtfully provided more than $1.3 billion in awards to 59 California institutions, consistent with its stated mission. As it transitions to a broadened portfolio of grants to stimulate progress toward its translational goals, the Institute should obtain cohesive, longitudinal, and integrated advice; restructure its grant application review process; and enhance industry epresentation in aspects of its operations. CIRM's unique governance structure, while seful in its initial stages, might diminish its effectiveness moving forward. The California Institute for Regenerative Medicine: Science, Governance, and the Pursuit of Cures recommends specific steps to enhance CIRM's organization and management, as well as its scientific policies and processes, as it transitions to the critical next stages of its research and development program.

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177

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National Academies Press

Published Date

ISBN 10

0309265932

ISBN 13

9780309265935

Human Tissue and Embryos (Draft) Bill

Vol. 2: Evidence

By: Great Britain: Parliament: Joint Committee on the Human Tissue and Embryos (Draft) Bill

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Human Tissue and Embryos (Draft) Bill

Vol. 2: Evidence

By: Great Britain: Parliament: Joint Committee on the Human Tissue and Embryos (Draft) Bill

The draft Bill was published in May 2007 as Command paper Cm 7087 (ISBN 9780101708722). Vol. 1 of this report is also available (ISBN 9780104011348)

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500

Publisher

The Stationery Office

Published Date

ISBN 10

0104011432

ISBN 13

9780104011430

2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

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2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

In 2005, the National Academies released the report Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of comprehensive federal funding, was lacking national standards for research. In order to keep the Guidelines up to date, given the rapid pace of scientific developments in the field of stem cell research, the Human Embryonic Stem Cell Research Advisory Committee was established in 2006 with support from The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute. As it did in 2007, the Committee identified issues that warranted revision, and this book addresses those issues in a second set of amendments. Most importantly, this book addresses new scientific developments in reprogramming of somatic cells to pluripotency by adding a new section and revising other relevant sections of the Guidelines.

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National Academies Press

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ISBN 10

030918567X

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9780309185677

2007 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

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2007 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

By: National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee

In 2005, the National Academies released the report Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of comprehensive federal funding, was lacking national standards for research. In order to keep the Guidelines up to date, given the rapid pace of scientific developments in the field of stem cell research, the Human Embryonic Stem Cell Research Advisory Committee was established in 2006 with support from The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute. This letter report is the committee's first set of amendments to the Guidelines and clarifies earlier recommendations and conclusions, including the criteria for determining which stem cell lines it is acceptable to use. Future deliberations of the committee will address items for which additional information gathering and more extensive debate and discussion will be necessary.

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National Academies Press

Published Date

ISBN 10

0309105595

ISBN 13

9780309105590

Guidelines for Human Embryonic Stem Cell Research

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Guidelines for Human Embryonic Stem Cell Research

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224

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National Academies Press

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ISBN 10

0309096537

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9780309096539

Book's by Committee on the Biological and Biomedical Applications of Stem Cell Research

Stem Cells and the Future of Regenerative Medicine

Stem Cells and the Future of Regenerative Medicine

Integrity in Scientific Research

Integrity in Scientific Research

Opportunities in Biotechnology for Future Army Applications

Opportunities in Biotechnology for Future Army Applications

Guidelines for Human Embryonic Stem Cell Research

Guidelines for Human Embryonic Stem Cell Research

Bioengineering

Bioengineering

Stem Cells and the Future of Regenerative Medicine

Stem Cells and the Future of Regenerative Medicine

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Using 21st Century Science to Improve Risk-Related Evaluations

Using 21st Century Science to Improve Risk-Related Evaluations

Government proposals for the regulation of hybrid and chimera embryos

Government proposals for the regulation of hybrid and chimera embryos

Capturing the Full Power of Biomaterials for Military Medicine

Capturing the Full Power of Biomaterials for Military Medicine

Final Report of the National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

Final Report of the National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

The California Institute for Regenerative Medicine

The California Institute for Regenerative Medicine

Human Tissue and Embryos (Draft) Bill

Human Tissue and Embryos (Draft) Bill

2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

2007 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

2007 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

Guidelines for Human Embryonic Stem Cell Research

Guidelines for Human Embryonic Stem Cell Research

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