Committee on Rodents's Books

Infectious Diseases of Mice and Rats

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Infectious Diseases of Mice and Rats

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Infectious Diseases of Mice and Rats

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Infectious Diseases of Mice and Rats

This new editionâ€"a must for all researchers who use these lab animalsâ€"provides practical suggestions for breeding, keeping, and identifying pathogen-free laboratory rodents. It contains three informative sections. The first, Principles of Rodent Disease Prevention, summarizes methods for eliminating infectious agents. It offers information on pathogen terminology; pathogen status of rodents; and breeding, transporting, isolating, testing, and diagnosing rodents. The second section, Individual Disease Agents and Their Effects on Research, describes the diagnosis and control of each infectious agent, and the last section, Diagnostic Indexes: Clinical Signs, Pathology, and Research Complications, contains informative tables covering all the diseases listed in the volume, arranged to help in the diagnosis of infected animals.

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Page Count

410

Publisher

National Academies Press

Published Date

ISBN 10

0309063329

ISBN 13

9780309063326

Companion Guide to Infectious Diseases of Mice and Rats

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Infectious Diseases of Mice and Rats

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Companion Guide to Infectious Diseases of Mice and Rats

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Infectious Diseases of Mice and Rats

This companion to Infectious Diseases of Mice and Rats makes practical information on rodent diseases readily accessible to researchers. This volume parallels the three parts of the main volume. Part I, Principles of Rodent Disease Prevention, briefly examines the requirements for maintaining pathogen-free rodents, factors in designing health surveillance programs, and other laboratory management issues. Part II, Disease Agents, is an easy-to-use reference section, listing diagnosis and control methods, the potential for interference with research, and other factors for disease agents ranging from adenoviruses to tapeworms. It covers bacteria, viruses, fungi and common ectoparasites, and endoparasites. Part III, Diagnostic Indexes, presents alphabetical listings of clinical signs, pathology, and research complications and lists infectious agents that might be responsible for each.

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Page Count

106

Publisher

National Academies Press

Published Date

ISBN 10

0309042836

ISBN 13

9780309042833

Microbial Status and Genetic Evaluation of Mice and Rats

Proceedings of the 1999 US/Japan Conference

By: National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research

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Microbial Status and Genetic Evaluation of Mice and Rats

Proceedings of the 1999 US/Japan Conference

By: National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research

US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

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Page Count

167

Publisher

National Academies Press

Published Date

ISBN 10

0309171474

ISBN 13

9780309171472

Microbial and Phenotypic Definition of Rats and Mice

Proceedings of the 1998 US/Japan Conference

By: National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research

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Microbial and Phenotypic Definition of Rats and Mice

Proceedings of the 1998 US/Japan Conference

By: National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research

US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

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Page Count

114

Publisher

National Academies Press

Published Date

ISBN 10

0309065917

ISBN 13

9780309065917

Rodents

By: Committee on Rodents,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

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Rodents

By: Committee on Rodents,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

In the 15 years since the last Institute of Laboratory Animal Resources report on the general management of rodents was published, important advances in biomedical research and increased public awareness have created a new environment for animal research. Modern technology-such as insertion of functional genes from other species into mice or rats, elimination of a single selected gene or function in mice, and the re-creation of elements of the human immune system in mice-has greatly expanded the usefulness of rodents in drug development and as models of human diseases. The technologic requirements of such advanced systems have led to improved understanding and implementation of environmental requirements for the care and use of rodents in research. The intent of this report is to provide current information to laboratory animal scientists (including both animal-care technicians and veterinarians), investigators, research technicians, and administrators on general elements of rodent care and use that should be considered both for optimal design and conduct of research and to meet current standards of care and use.

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Page Count

180

Publisher

National Academies Press

Published Date

ISBN 10

0309585775

ISBN 13

9780309585774

International Animal Research Regulations

Impact on Neuroscience Research: Workshop Summary

By: National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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International Animal Research Regulations

Impact on Neuroscience Research: Workshop Summary

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

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Page Count

102

Publisher

National Academies Press

Published Date

ISBN 10

0309252113

ISBN 13

9780309252119

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Endocrine-Related Low-Dose Toxicity

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Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Endocrine-Related Low-Dose Toxicity

To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.

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Page Count

423

Publisher

National Academies Press

Published Date

ISBN 10

0309458625

ISBN 13

9780309458627

Rodents

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents

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Rodents

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents

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180

Publisher

National Academies Press

Published Date

ISBN 10

0309049369

ISBN 13

9780309049368

Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition

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Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparation--including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

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Page Count

187

Publisher

National Academies Press

Published Date

ISBN 10

0309176859

ISBN 13

9780309176859

Monoclonal Antibody Production

By: National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies

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Monoclonal Antibody Production

By: National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

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National Academies Press

Published Date

ISBN 10

0309173051

ISBN 13

9780309173056

Infant Formula

Evaluating the Safety of New Ingredients

By: Institute of Medicine,Food and Nutrition Board,Committee on the Evaluation of the Addition of Ingredients New to Infant Formula

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Infant Formula

Evaluating the Safety of New Ingredients

By: Institute of Medicine,Food and Nutrition Board,Committee on the Evaluation of the Addition of Ingredients New to Infant Formula

Infant formulas are unique because they are the only source of nutrition for many infants during the first 4 to 6 months of life. They are critical to infant health since they must safely support growth and development during a period when the consequences on inadequate nutrition are most severe. Existing guidelines and regulations for evaluating the safety of conventional food ingredients (e.g., vitamins and minerals) added to infant formulas have worked well in the past; however they are not sufficient to address the diversity of potential new ingredients proposed by manufacturers to develop formulas that mimic the perceived and potential benefits of human milk. This book, prepared at the request of the Food and Drug Administration (FDA) and Health Canada, addresses the regulatory and research issues that are critical in assessing the safety of the addition of new ingredients to infants.

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Page Count

221

Publisher

National Academies Press

Published Date

ISBN 10

0309091500

ISBN 13

9780309091503

Book's by Committee on Rodents

Infectious Diseases of Mice and Rats

Infectious Diseases of Mice and Rats

Companion Guide to Infectious Diseases of Mice and Rats

Companion Guide to Infectious Diseases of Mice and Rats

Microbial Status and Genetic Evaluation of Mice and Rats

Microbial Status and Genetic Evaluation of Mice and Rats

Microbial and Phenotypic Definition of Rats and Mice

Microbial and Phenotypic Definition of Rats and Mice

Rodents

Rodents

International Animal Research Regulations

International Animal Research Regulations

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals

Rodents

Rodents

Nutrient Requirements of Laboratory Animals,

Nutrient Requirements of Laboratory Animals,

Monoclonal Antibody Production

Monoclonal Antibody Production

Infant Formula

Infant Formula

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