Committee on Hazardous Biological Substances in the Laboratory,National Research Council's Books

Biosafety in the Laboratory

Prudent Practices for Handling and Disposal of Infectious Materials

By: Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Hazardous Biological Substances in the Laboratory,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Biosafety in the Laboratory

Prudent Practices for Handling and Disposal of Infectious Materials

Biosafety in the Laboratory is a concise set of practical guidelines for handling and disposing of biohazardous material. The consensus of top experts in laboratory safety, this volume provides the information needed for immediate improvement of safety practices. It discusses high- and low-risk biological agents (including the highest-risk materials handled in labs today), presents the "seven basic rules of biosafety," addresses special issues such as the shipping of dangerous materials, covers waste disposal in detail, offers a checklist for administering laboratory safetyâ€"and more.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

237

Publisher

National Academies Press

Published Date

ISBN 10

0309039754

ISBN 13

9780309039758

Prudent Practices in the Laboratory

Handling and Disposal of Chemicals

By: National Research Council,Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Prudent Practices for Handling, Storage, and Disposal of Chemicals in Laboratories

Write a review Read reviews Take a Quiz Solve Book Puzzle

Prudent Practices in the Laboratory

Handling and Disposal of Chemicals

This volume updates and combines two National Academy Press bestsellers--Prudent Practices for Handling Hazardous Chemicals in Laboratories and Prudent Practices for Disposal of Chemicals from Laboratories--which have served for more than a decade as leading sources of chemical safety guidelines for the laboratory. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices for Safety in Laboratories provides step-by-step planning procedures for handling, storage, and disposal of chemicals. The volume explores the current culture of laboratory safety and provides an updated guide to federal regulations. Organized around a recommended workflow protocol for experiments, the book offers prudent practices designed to promote safety and it includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices for Safety in Laboratories is essential reading for people working with laboratory chemicals: research chemists, technicians, safety officers, chemistry educators, and students.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

450

Publisher

National Academies Press

Published Date

ISBN 10

0309052297

ISBN 13

9780309052290

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

By: National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

Write a review Read reviews Take a Quiz Solve Book Puzzle

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

By: National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

225

Publisher

National Academies Press

Published Date

ISBN 10

030907553X

ISBN 13

9780309075534

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 15 identifies, reviews, and interprets relevant toxicologic and other scientific data for ethyl mercaptan, methyl mercaptan, phenyl mercaptan, tert-octyl mercaptan, lewisite, methyl isothiocyanate, and selected monoisocyanates in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three level--AEGL-1, AEGL-2, and AEGL-3--are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

229

Publisher

National Academies Press

Published Date

ISBN 10

0309291232

ISBN 13

9780309291231

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part A

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Write a review Read reviews Take a Quiz Solve Book Puzzle

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part A

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fire, or accidents involving railroad cars or trucks transporting EHSs, or they can be released intentionally through terrorist activities. These substances can also be released by improper storage or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental or intentional releases. As part of its efforts to develop acute exposure guideline levels for EHSs, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) in 1991 requested that the National Research Council (NRC) develop guidelines for establishing such levels. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001. It provided updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) in considering acute adverse health effects to develop AEGL values. Using both these reports, the NAC-consisting of members from the EPA, the Department of Defense (DOD), the Department of Energy (DOE), the Department of Transportation (DOT), other federal and state governments, the chemical industry, academia, and other organizations from the private sector-developed AEGLS for approximately 270 EHSs. Twenty-First Interim Report of the Committee on Acute Exposure Guideline Levels: Part A summarizes the committee's conclusions and recommendations for improving AEGL documents for several chemicals and chemical classes.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

National Academies Press

Published Date

ISBN 10

0309263859

ISBN 13

9780309263856

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 17

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Write a review Read reviews Take a Quiz Solve Book Puzzle

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 17

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 17 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for acrylonitrile, carbon tetrachloride, cyanogen, epichlorohydrin, ethylene chlorohydrin, toluene, trimethylacetyl chloride, hydrogen bromide, and boron tribromide in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

405

Publisher

National Academies Press

Published Date

ISBN 10

0309304792

ISBN 13

9780309304795

Ranking Hazardous-Waste Sites for Remedial Action

By: National Research Council,Division on Earth and Life Studies,Commission on Geosciences, Environment and Resources,Committee on Remedial Action Priorities for Hazardous Waste Sites

Write a review Read reviews Take a Quiz Solve Book Puzzle

Ranking Hazardous-Waste Sites for Remedial Action

By: National Research Council,Division on Earth and Life Studies,Commission on Geosciences, Environment and Resources,Committee on Remedial Action Priorities for Hazardous Waste Sites

The United States may not be able to make all hazardous-waste sites as clean as possible. Therefore, priorities must be set for the timing of waste site remediations. This book assesses several of the government's methods of ranking sites for remediation and compares the performance of three such models using input data developed from the same set of waste sites. Because inconsistent methods may be neither effective nor prudent, the book recommends that the government consider developing a unified national approach to setting priorities to replace the current multiple approaches.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

313

Publisher

National Academies Press

Published Date

ISBN 10

0309050928

ISBN 13

9780309050920

Environmental Management Technology-Development Program at the Department of Energy

1995 Review

By: Committee on Environmental Management Technologies,Commission on Geosciences, Environment and Resources,Division on Earth and Life Studies,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Environmental Management Technology-Development Program at the Department of Energy

1995 Review

By: Committee on Environmental Management Technologies,Commission on Geosciences, Environment and Resources,Division on Earth and Life Studies,National Research Council

This book provides the National Academy of Sciences' 1995 review of the technology development program for the remediation of the Department of Energy's weapons complex facilities. It makes scientific, technical, and programmatic recommendations to strengthen technology development within DOE and ensure that it meet its goals of cost effectiveness, safety, and decreased risk. The recommendations address DOE's five focus areas: landfill stabilization; contaminant plume containment and remediation; facility transitioning, decommissioning, and final disposition; mixed waste characterization treatment; and high-level waste in tanks. The book also addresses technologies in areas that cross cut the above focus area programs, namely characterization monitoring and sensor technologies, efficient separations and processing, robotics, and waste disposal.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

146

Publisher

National Academies Press

Published Date

ISBN 10

0309589088

ISBN 13

9780309589086

Scientific Review of the Proposed Risk Assessment Bulletin from the Office of Management and Budget

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the OMB Risk Assessment Bulletin

Write a review Read reviews Take a Quiz Solve Book Puzzle

Scientific Review of the Proposed Risk Assessment Bulletin from the Office of Management and Budget

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the OMB Risk Assessment Bulletin

Risk assessments are often used by the federal government to estimate the risk the public may face from such things as exposure to a chemical or the potential failure of an engineered structure, and they underlie many regulatory decisions. Last January, the White House Office of Management and Budget (OMB) issued a draft bulletin for all federal agencies, which included a new definition of risk assessment and proposed standards aimed at improving federal risk assessments. This National Research Council report, written at the request of OMB, evaluates the draft bulletin and supports its overall goals of improving the quality of risk assessments. However, the report concludes that the draft bulletin is "fundamentally flawed" from a scientific and technical standpoint and should be withdrawn. Problems include an overly broad definition of risk assessment in conflict with long-established concepts and practices, and an overly narrow definition of adverse health effects-one that considers only clinically apparent effects to be adverse, ignoring other biological changes that could lead to health effects. The report also criticizes the draft bulletin for focusing mainly on human health risk assessments while neglecting assessments of technology and engineered structures.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

302

Publisher

National Academies Press

Published Date

ISBN 10

0309104777

ISBN 13

9780309104777

Occupational Health and Safety in the Care and Use of Research Animals

By: Committee on Occupational Safety and Health in Research Animal Facilities,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Occupational Health and Safety in the Care and Use of Research Animals

By: Committee on Occupational Safety and Health in Research Animal Facilities,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

167

Publisher

National Academies Press

Published Date

ISBN 10

0309520398

ISBN 13

9780309520393

Biosafety in the Laboratory

Prudent Practices for Handling and Disposal of Infectious Materials

By: Committee on Hazardous Biological Substances in the Laboratory,National Research Council,Commission on Physical Sciences, Mathematics, and Applications,Division on Engineering and Physical Sciences

Write a review Read reviews Take a Quiz Solve Book Puzzle

Biosafety in the Laboratory

Prudent Practices for Handling and Disposal of Infectious Materials

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

216

Publisher

National Academies Press

Published Date

ISBN 10

0309090245

ISBN 13

9780309090247

Review of Biotreatment, Water Recovery, and Brine Reduction Systems for the Pueblo Chemical Agent Destruction Pilot Plant

By: National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Review of Biotreatment, Water Recovery, and Brine Reduction Systems for the Pueblo Chemical Agent Destruction Pilot Plant

Write a review Read reviews Take a Quiz Solve Book Puzzle

Review of Biotreatment, Water Recovery, and Brine Reduction Systems for the Pueblo Chemical Agent Destruction Pilot Plant

The Pueblo Chemical Depot (PCD) in Colorado is one of two sites that features U.S. stockpile of chemical weapons that need to be destroyed. The PCD features about 2,600 tons of mustard-including agent. The PCD also features a pilot plant, the Pueblo Chemical Agent Destruction Pilot Plant (PCAPP), which has been set up to destroy the agent and munition bodies using novel processes. The chemical neutralization or hydrolysis of the mustard agent produces a Schedule 2 compound called thiodiglycol (TDG) that must be destroyed. The PCAPP uses a combined water recovery system (WRS) and brine reduction system (BRS) to destroy TDG and make the water used in the chemical neutralization well water again. Since the PCAPP is using a novel process, the program executive officer for the Assembled Chemical Weapons Alternatives (ACWA) program asked the National Research Council (NRC) to initiate a study to review the PCAPP WRS-BRS that was already installed at PCAPP. 5 months into the study in October, 2012, the NRC was asked to also review the Biotreatment area (BTA). The Committee on Review of Biotreatment, Water Recovery, and Brine Reduction Systems for the Pueblo Chemical Agent Destruction Pilot Plant was thus tasked with evaluating the operability, life-expectancy, working quality, results of Biotreatment studies carried out prior to 1999 and 1999-2004, and the current design, systemization approached, and planned operation conditions for the Biotreatment process. Review of Biotreatment, Water Recovery, and Brine Reduction Systems for the Pueblo Chemical Agent Destruction Pilot Plant is the result of the committee's investigation. The report includes diagrams of the Biotreatment area, the BRS, and WRS; a table of materials of construction, the various recommendations made by the committee; and more.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

National Academies Press

Published Date

ISBN 10

030926393X

ISBN 13

9780309263931

Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: Subcommittee on Laboratory Animal Nutrition,Committee on Animal Nutrition,Board on Agriculture,Institute for Laboratory Animal Research,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: Subcommittee on Laboratory Animal Nutrition,Committee on Animal Nutrition,Board on Agriculture,Institute for Laboratory Animal Research,National Research Council

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparation--including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

188

Publisher

National Academies Press

Published Date

ISBN 10

0309588499

ISBN 13

9780309588492

Rodents

By: Committee on Rodents,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

Write a review Read reviews Take a Quiz Solve Book Puzzle

Rodents

By: Committee on Rodents,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

In the 15 years since the last Institute of Laboratory Animal Resources report on the general management of rodents was published, important advances in biomedical research and increased public awareness have created a new environment for animal research. Modern technology-such as insertion of functional genes from other species into mice or rats, elimination of a single selected gene or function in mice, and the re-creation of elements of the human immune system in mice-has greatly expanded the usefulness of rodents in drug development and as models of human diseases. The technologic requirements of such advanced systems have led to improved understanding and implementation of environmental requirements for the care and use of rodents in research. The intent of this report is to provide current information to laboratory animal scientists (including both animal-care technicians and veterinarians), investigators, research technicians, and administrators on general elements of rodent care and use that should be considered both for optimal design and conduct of research and to meet current standards of care and use.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

180

Publisher

National Academies Press

Published Date

ISBN 10

0309585775

ISBN 13

9780309585774

Rodents

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents

Write a review Read reviews Take a Quiz Solve Book Puzzle

Rodents

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

180

Publisher

National Academies Press

Published Date

ISBN 10

0309049369

ISBN 13

9780309049368

Systems and Technologies for the Treatment of Non-Stockpile Chemical Warfare Materiel

By: National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Review and Evaluation of the Army Non-Stockpile Chemical Materiel Disposal Program

Write a review Read reviews Take a Quiz Solve Book Puzzle

Systems and Technologies for the Treatment of Non-Stockpile Chemical Warfare Materiel

The main approach adopted by the U.S. Army for destruction of all declared chemical weapon materiel (CWM) is incineration. There has been considerable public opposition to this approach, however, and the Army is developing a mix of fixed site and mobile treatment technologies to dispose of non-stockpile CWM. To assist in this effort, the Army requested NRC to review and evaluate these technologies, and to assess its plans for obtaining regulatory approval for and to involve the public in decisions about the application of those technologies. This book presents an assessment of non-stockpile treatment options and the application of these systems to the non-stockpile inventory, of regulatory and permitting issues, and of the role of the public.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

124

Publisher

National Academies Press

Published Date

ISBN 10

0309084520

ISBN 13

9780309084529

Evaluation of Alternative Technologies for Disposal of Liquid Wastes from the Explosive Destruction System

Write a review Read reviews Take a Quiz Solve Book Puzzle

Evaluation of Alternative Technologies for Disposal of Liquid Wastes from the Explosive Destruction System

Chemical warfare materiel (CWM) encompasses diverse items that were used during 60 years of efforts by the United States to develop a capability for conducting chemical warfare. Non-Stockpile CWM (NSCWM) is materiel not included in the current U.S. inventory of chemical munitions and includes buried materiel, recovered materiel, components of binary chemical weapons, former production facilities, and miscellaneous materiel. Because NSCWM is stored or buried at many locations, the Army is developing transportable treatment systems that can be moved from site to site as needed. Originally, the Army planned to develop three transportable treatment systems for nonstockpile chemical materiel: the rapid response system (RRS), the munitions management device (MMD), and the explosive destruction system (EDS). This report supplements an earlier report that evaluated eight alternative technologies for destruction of the liquid waste streams from two of the U.S. Army's transportable treatment systems for nonstockpile chemical materiel: the RRS and the MMD. This report evaluates the same technologies for the destruction of liquid waste streams produced by the EDS and discusses the regulatory approval issues and obstacles for the combined use of the EDS and the alternative technologies that treat the EDS secondary waste streams. Although it focuses on the destruction of EDS neutralent, it also takes into consideration the ability of posttreatment technologies to process the more dilute water rinses that are used in the EDS following treatment with a reagent.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

National Academies Press

Published Date

ISBN 10

0309082692

ISBN 13

9780309082693

Book's by Committee on Hazardous Biological Substances in the Laboratory,National Research Council

Username

Password

Password again

Birthday

Email