Committee on Gulf War and Health: Updated Literature Review of Sarin's Books

Gulf War and Health

Updated Literature Review of Sarin

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Committee on Gulf War and Health: Updated Literature Review of Sarin

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Gulf War and Health

Updated Literature Review of Sarin

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Committee on Gulf War and Health: Updated Literature Review of Sarin

The Gulf War in 1990-1991 was considered a brief and successful military operation, with few injuries or deaths of US troops. The war began in August 1990, and the last US ground troops returned home by June 1991. Although most Gulf War veterans resumed their normal activities, many soon began reporting a variety of nonexplained health problems that they attributed to their participation in the Gulf War, including chronic fatigue, muscle and joint pain, loss of concentration, forgetfulness, headache, and rash. Because of concerns about the veterans' health problems, the Department of Veterans Affairs (VA) requested that the Institute of Medicine (IOM) review the scientific and medical literature on the long-term adverse health effects of agents to which the Gulf War veterans may have been exposed. This report is a broad overview of the toxicology of sarin and cyclosarin. It assesses the biologic plausibility with respect to the compounds in question and health effects.

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132

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National Academies Press

Published Date

ISBN 10

0309092949

ISBN 13

9780309092944

Gulf War and Health

Updated Literature Review of Sarin

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Committee on Gulf War and Health: Updated Literature Review of Sarin

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Gulf War and Health

Updated Literature Review of Sarin

By: Institute of Medicine,Board on Health Promotion and Disease Prevention,Committee on Gulf War and Health: Updated Literature Review of Sarin

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132

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National Academies Press

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ISBN 10

0309092949

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9780309092944

Gulf War and Health

Volume 11: Generational Health Effects of Serving in the Gulf War

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on Gulf War and Health, Volume 11: Generational Health Effects of Serving in the Gulf War

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Gulf War and Health

Volume 11: Generational Health Effects of Serving in the Gulf War

For the United States, the 1991 Persian Gulf War was a brief and successful military operation with few injuries and deaths. However, soon after returning from duty, a large number of veterans began reporting health problems they believed were associated with their service in the Gulf. At the request of Congress, the National Academies of Sciences, Engineering, and Medicine has been conducting an ongoing review of the evidence to determine veterans' long-term health problems and potential causes. Some of the health effects identified by past reports include post-traumatic stress disorders, other mental health disorders, Gulf War illness, respiratory effects, and self-reported sexual dysfunction. Veterans' concerns regarding the impacts of deployment-related exposures on their health have grown to include potential adverse effects on the health of their children and grandchildren. These concerns now increasingly involve female veterans, as more women join the military and are deployed to war zones and areas that pose potential hazards. Gulf War and Health: Volume 11 evaluates the scientific and medical literature on reproductive and developmental effects and health outcomes associated with Gulf War and Post-9/11 exposures, and designates research areas requiring further scientific study on potential health effects in the descendants of veterans of any era.

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519

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National Academies Press

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ISBN 10

030947826X

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9780309478267

Gulf War and Health

Volume 5. Infectious Diseases

By: Abigail E. Mitchell,Laura B. Sivitz,Robert E. Black,Committee on Gulf War and Health: Infectious Diseases

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Gulf War and Health

Volume 5. Infectious Diseases

By: Abigail E. Mitchell,Laura B. Sivitz,Robert E. Black,Committee on Gulf War and Health: Infectious Diseases

Infectious diseases have been a problem for military personnel throughout history. The consequences in previous conflicts have ranged from frequent illnesses disrupting daily activities and readiness to widespread deaths. Preventive measures, early diagnosis, and treatment greatly limit the exposures and acute illnesses of troops today in comparison with those in armies of the past, but infections and consequent acute illnesses still occur.Thousands of US veterans of the Persian Gulf War have reported an array of unexplained illnesses since the war ended in 1991. Many veterans have believed that the illnesses were associated with their military service in southwest Asia during the war. This volume of Gulf War and Health evaluates the scientific literature on chemical, biologic, and physical agents to which military personnel in the gulf were potentially exposed and possible long-term adverse health outcomes.

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248

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中国法制出版社

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ISBN 10

0309101069

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9780309101066

Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations

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Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations

More than 3.7 million U.S. service members have participated in operations taking place in the Southwest Asia Theater of Military Operations since 1990. These operations include the 1990-1991 Persian Gulf War, a post-war stabilization period spanning 1992 through September 2001, and the campaigns undertaken in the wake of the September 11, 2001, attacks. Deployment to Iraq, Kuwait, Saudi Arabia, Bahrain, Gulf of Aden, Gulf of Oman, Oman, Qatar, the United Arab Emirates, and Afghanistan exposed service members to a number of airborne hazards, including oil-well fire smoke, emissions from open burn pits, dust and sand suspended in the air, and exhaust from diesel vehicles. The effects of these were compounded by stressors like excessive heat and noise that are inevitable attributes of service in a combat environment. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations reviews the scientific evidence regarding respiratory health outcomes in veterans of the Southwest Asia conflicts and identifies research that could feasibly be conducted to address outstanding questions and generate answers, newly emerging technologies that could aid in these efforts, and organizations that the Veterans Administration might partner with to accomplish this work.

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271

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National Academies Press

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ISBN 10

0309679109

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9780309679107

Review of Report and Approach to Evaluating Long-Term Health Effects in Army Test Subjects

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review Report on Long-Term Health Effects on Army Test Subjects

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Review of Report and Approach to Evaluating Long-Term Health Effects in Army Test Subjects

Between 1942 and 1975, the U.S. Army conducted tests on human subjects to study the effects of a variety of agents, including chemical warfare agents, biological agents, medications, vaccines, and other substances. The tests investigated the immediate or short-term health effects from acute exposure to understand vulnerabilities to attack. Whether the exposures could have resulted in long-term health consequences to the test subjects has been assessed periodically, and the Army is required to notify subjects of information relating to potential health effects associated with exposure to the test agents. Most recently, a 2016 court injunction directed the Army to provide test subjects with new information about potential long-term health effects associated with their exposures, and to provide medical care if an injury or illness could be attributed to their participation in an Army chemical or biological testing program. In support of the first requirement, the Army contracted a report, Assessment of Potential Long-Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances: Literature Review and Analysis (the Report), to determine whether new information published since 2006 should be provided to the veterans. At the request of the Army, the National Academies of Sciences, Engineering, and Medicine formed an ad hoc committee that was tasked with conducting an independent review of the Report. The committee assessed whether the Report appropriately identified potential long-term health effects that could have resulted from test exposures using an adequate weight-of-evidence approach. The general approach for evaluating agent- and outcome-specific associations as outlined in the Army Memorandum was also reviewed. An interim report of its overarching findings and their supporting evidence was prepared in February 2018. This final report provides additional detail about the basis of the committee's findings and recommendations. No new findings or recommendations have been added to this report.

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National Academies Press

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ISBN 10

0309474183

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9780309474184

Improving the Presumptive Disability Decision-Making Process for Veterans

By: Institute of Medicine,Board on Military and Veterans Health,Committee on Evaluation of the Presumptive Disability Decision-Making Process for Veterans

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Improving the Presumptive Disability Decision-Making Process for Veterans

By: Institute of Medicine,Board on Military and Veterans Health,Committee on Evaluation of the Presumptive Disability Decision-Making Process for Veterans

The United States has long recognized and honored the service and sacrifices of its military and veterans. Veterans who have been injured by their service (whether their injury appears during service or afterwards) are owed appropriate health care and disability compensation. For some medical conditions that develop after military service, the scientific information needed to connect the health conditions to the circumstances of service may be incomplete. When information is incomplete, Congress or the Department of Veterans Affairs (VA) may need to make a "presumption" of service connection so that a group of veterans can be appropriately compensated. The missing information may be about the specific exposures of the veterans, or there may be incomplete scientific evidence as to whether an exposure during service causes the health condition of concern. For example, when the exposures of military personnel in Vietnam to Agent Orange could not be clearly documented, a presumption was established that all those who set foot on Vietnam soil were exposed to Agent Orange. The Institute of Medicine (IOM) Committee was charged with reviewing and describing how presumptions have been made in the past and, if needed, to make recommendations for an improved scientific framework that could be used in the future for determining if a presumption should be made. The Committee was asked to consider and describe the processes of all participants in the current presumptive disability decision-making process for veterans. The Committee was not asked to offer an opinion about past presumptive decisions or to suggest specific future presumptions. The Committee heard from a range of groups that figure into this decision-making process, including past and present staffers from Congress, the VA, the IOM, veterans service organizations, and individual veterans. The Department of Defense (DoD) briefed the Committee about its current activities and plans to better track the exposures and health conditions of military personnel. The Committee further documented the current process by developing case studies around exposures and health conditions for which presumptions had been made. Improving the Presumptive Disability Decision-Making Process for Veterans explains recommendations made by the committee general methods by which scientists, as well as government and other organizations, evaluate scientific evidence in order to determine if a specific exposure causes a health condition.

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813

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National Academies Press

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ISBN 10

0309164397

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9780309164399

Amyotrophic Lateral Sclerosis in Veterans

Review of the Scientific Literature

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans

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Amyotrophic Lateral Sclerosis in Veterans

Review of the Scientific Literature

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans

Amyotrophic lateral sclerosis (ALS) our Lou Gehrig's disease is a fatal, mostly non-familial disease that affects the nervous system of humans by causing the degeneration of nerve cells in the brain and spinal cord. The degeneration halts communication between the nervous system and voluntary muscles in the body. This leads to muscle paralysis and eventually the muscles that aid in breathing are affect; causing respiration to fail. The disease, which affects 20,000-30,000 men and women in the United States at any given time, has no effective treatment; most people with ALS die from respiratory failure within 5 years of the onset of symptoms. Recent epidemiologic studies report an association between the development of ALS and prior service in the U.S. military. The studies evaluated either veterans of the 1991 Persian Gulf War or veterans who served in the military in the period 1910-1982. Due to these findings, the Department of Veterans Affairs (VA) asked the National Academies to conduct an assessment of the potential relationship between military service and the later development of ALS. The project was assigned to the Institute of Medicine (IOM), which appointed a committee and gave it the task of evaluating the scientific literature on ALS in veterans. The committee began its work by identifying medical and scientific literature on ALS. PubMed, a database created and managed by the National Library of Medicine. Amyotrophic Lateral Sclerosis in Veterans; Review of the Scientific Literature presents the findings of this committee. The committee reviewed, evaluated, and summarized the scientific literature on ALS in veterans, composed primarily of peer-reviewed, published literature. This report includes the recommendations of the committee.

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National Academies Press

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ISBN 10

0309102545

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9780309102544

Assessing Health Outcomes Among Veterans of Project SHAD (Shipboard Hazard and Defense)

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on the Health of Select Populations,Committee on Shipboard Hazard and Defense II (SHAD II)

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Assessing Health Outcomes Among Veterans of Project SHAD (Shipboard Hazard and Defense)

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on the Health of Select Populations,Committee on Shipboard Hazard and Defense II (SHAD II)

Between 1963 and 1969, the U.S. military carried out a series of tests, termed Project SHAD (Shipboard Hazard and Defense), to evaluate the vulnerabilities of U.S. Navy ships to chemical and biological warfare agents. These tests involved use of active chemical and biological agents, stimulants, tracers, and decontaminants. Approximately 5,900 military personnel, primarily from the Navy and Marine Corps, are reported to have been included in Project SHAD testing. In the 1990s some veterans who participated in the SHAD tests expressed concerns to the Department of Veterans Affairs (VA) that they were experiencing health problems that might be the result of exposures in the testing. These concerns led to a 2002 request from VA to the Institute of Medicine (IOM) to carry out an epidemiological study of the health of SHAD veterans and a comparison population of veterans who had served on similar ships or in similar units during the same time period. In response to continuing concerns, Congress in 2010 requested an additional IOM study. This second study expands on the previous IOM work by making use of additional years of follow up and some analysis of diagnostic data from Medicare and the VA health care system.

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197

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National Academies Press

Published Date

ISBN 10

0309380715

ISBN 13

9780309380713

Returning Home from Iraq and Afghanistan

Preliminary Assessment of Readjustment Needs of Veterans, Service Members, and Their Families

By: Institute of Medicine,Board on the Health of Select Populations,Committee on the Initial Assessment of Readjustment Needs of Military Personnel, Veterans, and Their Families

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Returning Home from Iraq and Afghanistan

Preliminary Assessment of Readjustment Needs of Veterans, Service Members, and Their Families

By: Institute of Medicine,Board on the Health of Select Populations,Committee on the Initial Assessment of Readjustment Needs of Military Personnel, Veterans, and Their Families

Nearly 1.9 million U.S. troops have been deployed to Afghanistan and Iraq since October 2001. Many service members and veterans face serious challenges in readjusting to normal life after returning home. This initial book presents findings on the most critical challenges, and lays out the blueprint for the second phase of the study to determine how best to meet the needs of returning troops and their families.

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192

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National Academies Press

Published Date

ISBN 10

0309147638

ISBN 13

9780309147637

Gulf War and Health

Volume 1: Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines

By: Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on Health Effects Associated with Exposures During the Gulf War

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Gulf War and Health

Volume 1: Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines

By: Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on Health Effects Associated with Exposures During the Gulf War

The men and women who served in the Gulf War theater were potentially exposed to a wide range of biological and chemical agents. Gulf War and Health: Volume 1 assesses the scientific literature concerning the association between these agents and the adverse health effects currently experienced by a large number of veterans.

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426

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National Academies Press

Published Date

ISBN 10

030907178X

ISBN 13

9780309071789

Gulf War and Health

Updated Literature Review of Depleted Uranium

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Gulf War and Health: Updated Literature Review of Depleted Uranium

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Gulf War and Health

Updated Literature Review of Depleted Uranium

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Gulf War and Health: Updated Literature Review of Depleted Uranium

The 1991 Persian Gulf War was considered a brief and successful military operation with few injuries and deaths. A large number of returning veterans, however, soon began reporting health problems that they believed to be associated with their service in the gulf. Under a Congressional mandate, the Institute of Medicine (IOM) is reviewing a wide array of biologic, chemical, and physical agents to determine if exposure to these agents may be responsible for the veterans' health problems. In a 2000 report, Gulf War and Health, Volume 1: Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines, the IOM concluded that there was not enough evidence to draw conclusions as to whether long-term health problems are associated with exposure to depleted uranium, a component of some military munitions and armor. In response to veterans' ongoing concerns and recent publications in the literature, IOM updated its 2000 report. In this most recent report, Gulf War and Health: Updated Literature Review of Depleted Uranium, the committee concluded that there is still not enough evidence to determine whether exposure to depleted uranium is associated with long-term health problems. The report was sponsored by the U.S. Department of Veterans Affairs.

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284

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National Academies Press

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ISBN 10

0309119197

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9780309119191

Gulf War and Health

Volume 4: Health Effects of Serving in the Gulf War

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Gulf War and Health: A Review of the Medical Literature Relative to the Gulf War Veterans' Health

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Gulf War and Health

Volume 4: Health Effects of Serving in the Gulf War

By: Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Gulf War and Health: A Review of the Medical Literature Relative to the Gulf War Veterans' Health

In 1998, in response to the growing concerns that many returning Gulf War veterans began reporting numerous health problems that they believed to be associated with their service in the Persian Gulf, Congress passed two laws which directed the Secretary of Veterans Affairs to enter into a contract with the National Academy of Sciences. They were tasked to review and evaluate the scientific and medical literature regarding associations between illness and exposure to toxic agents, environmental or wartime hazards, and preventive medicines or vaccines associated with Gulf War service. In addition, the Institute of Medicine of the National Academy of Sciences provided conclusions to these studies that were considered when making decisions about compensation to veterans. Gulf War and Health Volume 4: Health Effects of Serving in the Gulf War summarizes in one place the current status of health effects in veterans deployed to the Persian Gulf irrespective of exposure information. This book reviews, evaluates, and summarizes both peer-reviewed scientific and medical literature addressing the health status of Gulf War veterans.

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292

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National Academies Press

Published Date

ISBN 10

0309164567

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9780309164566

Gulf War and Health

Volume 10: Update of Health Effects of Serving in the Gulf War, 2016

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on the Health of Select Populations,Committee on Gulf War and Health, Volume 10: Update of Health Effects of Serving in the Gulf War

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Gulf War and Health

Volume 10: Update of Health Effects of Serving in the Gulf War, 2016

For the United States, the 1991 Persian Gulf War was a brief and successful military operation with few injuries and deaths. However, soon after returning from duty, a large number of veterans began reporting health problems they believed were associated with their service in the Gulf. At the request of Congress, the Institute of Medicine (IOM) has been conducting an ongoing review of the evidence to determine veterans' long-term health problems and potential causes. The fourth volume in the series, released in 2006, summarizes the long-term health problems seen in Gulf War veterans. In 2010, the IOM released an update that focuses on existing health problems and identifies possible new ones, considering evidence collected since the initial summary. Gulf War and Health: Volume 10 is an update of the scientific and medical literature on the health effects associated with deployment to the Gulf War that were identified in Volumes 4 and 8. This report reviews and evaluates the associations between illness and exposure to toxic agents, environmental or wartime hazards, or preventive measures and vaccines associated with Gulf War service, and provides recommendations for future research efforts on Gulf War veterans.

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293

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National Academies Press

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ISBN 10

0309380448

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9780309380447

Gulf War and Health

Volume 8: Update of Health Effects of Serving in the Gulf War

By: Institute of Medicine,Board on the Health of Select Populations,Committee on Gulf War and Health: Health Effects of Serving in the Gulf War, Update 2009

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Gulf War and Health

Volume 8: Update of Health Effects of Serving in the Gulf War

By: Institute of Medicine,Board on the Health of Select Populations,Committee on Gulf War and Health: Health Effects of Serving in the Gulf War, Update 2009

For the United States, the 1991 Persian Gulf War was a brief and successful military operation with few injuries and deaths. However, soon after returning from duty, a large number of veterans began reporting health problems they believed were associated with their service in the Gulf. At the request of Congress, the IOM is conducting an ongoing review of the evidence to determine veterans' long-term health problems and what might be causing those problems. The fourth volume in the series, released in 2006, summarizes the long-term health problems seen in Gulf War veterans. In 2008, the IOM began an update to look at existing health problems and identify possible new ones, considering evidence collected since the initial summary. In this report, the IOM determines that Gulf War service causes post-traumatic stress disorder (PTSD) and that service is associated with multisymptom illness; gastrointestinal disorders such as irritable bowel syndrome; alcohol and other substance abuse; and anxiety disorders and other psychiatric disorders. To ensure that our veterans receive the best possible care, now and in the future, the government should continue to monitor their health and conduct research to identify the best treatments to assist Gulf War veterans still suffering from persistent, unexplained illnesses.

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319

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National Academies Press

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ISBN 10

030915765X

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9780309157650

Review of Report and Approach to Evaluating Long-Term Health Effects in Army Test Subjects

Interim Report

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Review of Report and Approach to Evaluating Long-Term Health Effects in Army Test Subjects

Interim Report

Between 1942 and 1975, the U.S. Army conducted tests with human subjects to study the effects of a variety of agents, including chemical warfare and biological agents. The potential long-term health effects on the test subjects from their exposures have been evaluated periodically, most recently in a report titled Assessment of Potential Long-Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances: Literature Review and Analysis (the Report), which was prepared by a contractor to assist the Army with making determinations about providing medical care to former test subjects. In response to a request by the Army, the National Academies of Sciences, Engineering, and Medicine formed a committee that was tasked with examining whether the Report appropriately identified potential long-term health effects from exposure to the test agents and whether an adequate weight-of-evidence approach was used to characterize the strength of the associations between the agents and their potential health effects. The committee was made aware at its first meeting on November 30, 2017, that the Army had already begun to receive applications for medical care and that some determinations may need to be made before the committee's evaluation of the Report was completed. Because of this urgency, the Army developed a process by which applications for medical care will be reviewed, and as a result, the committee was given the additional task of reviewing the Army's Memorandum that describes the approach that will be used by the Army to evaluate agent- and outcome-specific associations. This interim report was prepared to facilitate the Army's deliberations. A review of the Report is presented first, followed by a review of the Memorandum.

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ISBN 10

0309472091

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9780309472098

Health Consequences of Service During the Persian Gulf War

Recommendations for Research and Information Systems

By: Institute of Medicine,Medical Follow-up Agency,Committee to Review the Health Consequences of Service During the Persian Gulf War

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Health Consequences of Service During the Persian Gulf War

Recommendations for Research and Information Systems

By: Institute of Medicine,Medical Follow-up Agency,Committee to Review the Health Consequences of Service During the Persian Gulf War

In January 1995 the Institute of Medicine released a preliminary report containing initial findings and recommendations on the federal government's response to reports by some veterans and their families that they were suffering from illnesses related to military service in the Persian Gulf War. The committee was asked to review the government's means of collecting and maintaining information for assessing the health consequences of military service and to recommend improvements and epidemiological studies if warranted. This new volume reflects an additional year of study by the committee and the full results of its three-year effort.

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206

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National Academies Press

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ISBN 10

0309055369

ISBN 13

9780309055369

Book's by Committee on Gulf War and Health: Updated Literature Review of Sarin

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