Committee on Acute Exposure Guideline Levels's Books

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 14

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 14

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances (EHSs) can be released accidentally as a result of result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. As part of its efforts to develop acute exposure guideline levels for EHSs, EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) in 1991 requested that the National Research Council (NRC) develop guidelines for establishing such levels. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standard Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001, providing updated procedures, methodologies, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances and the Committee on Acute Exposure Guideline Levels (AEGLs) in developing the AEGL values. Using the 1993 and 2001 NRC guidelines reports, the NAC-consisting of members from EPA, the Department of Defense (DOD), the Department of Energy (DOE), the Department of Transportation (DOT), other federal and state governments, the chemical industry, academia, and other organizations from the private sector-has developed AEGLs for more than 270 EHSs. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology (COT) the Committee on Acute Exposure Guideline Levels, which prepared this report. This report is the fourteenth volume in that series. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 14 summarizes the committee's conclusions and recommendations.

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291

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National Academies Press

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ISBN 10

0309283086

ISBN 13

9780309283083

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 12

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 12

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Using the 1993 and 2001 NRC guidelines reports, the National Advisory Committee - consisting of members from the Environmental Protection Agency, the Department of Defense, the Department of Energy, the Department of Transportation, other federal and state governments, the chemical industry, academia, and other organizations form the private sector has developed Acute Exposure Guideline Levels (AEGL) for more than 270 EHSs. In 1998, the EPA and DOD requested that the NRC independently reviewed the AEGLs developed by the NAC. In response to that request, the NRC organized within its Committee on Toxicology the Committee on Acute Exposure Guideline Levels, which prepared this report, Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 12. This report explains the scientifically valid conclusions that are based on the data reviewed by NAC and consistent with the NRC guideline reports and provides comments and recommendations for how AEGL could be improved.

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334

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National Academies Press

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ISBN 10

0309255015

ISBN 13

9780309255011

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part B

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part B

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001; it provided updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Using both these reports, the NAC-consisting of members from the EPA, the Department of Defense (DOD), the Department of Energy (DOE), the Department of Transportation (DOT), other federal and state governments, the chemical industry, academia, and other organizations from the private sector-developed AEGLs for approximately 270 EHSs. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology the Committee on Acute Exposure Guideline Levels, which prepared this report. This report, Twenty-First Interim Report of the Committee on Acute Exposure Guideline Levels: Part B, summarizes the committee's conclusions and recommendations for improving AEGL documents for several chemicals and chemical classes not mentioned in Twenty-First Interim Report of the Committee on Acute Exposure Guideline Levels: Part A.

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National Academies Press

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ISBN 10

0309263905

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9780309263900

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 4

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 4

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

The Bhopal Disaster of 1984 resulted in the death of around 2,000 residents living near chemical plants and irreversible injuries to more than 20,000 other residents. These numbers can be attributed to the community's lack of awareness concerning the chemicals' existence, dangers and effects, and/or how to react in case of emergency. The disaster emphasized the need for governments to identify hazardous substances and to aid local communities in developing plans for emergency exposures. As a result, the United States government issued the Superfund Amendments and Reauthorization Act (SARA) of 1986; requiring the identification of extremely hazardous substances (EHSs) by the Environmental Protection Agency (EPA). EPA was also tasked with assisting Local Emergency Planning Committees (LEPCs) in conducting health-hazard assessments to develop emergency-response plans for sites where EHSs are produced, stored, transported, or used. The EPA identified nearly 400 EHSs in terms of their immediate danger to life and health (IDLH) as their first step in assisting these LEPCs. In 1991 the EPA went on to request that the National Research Council (NRC) Committee on Toxicology (COT) develop criteria and methods for developing emergency exposure levels for EHSs for the general population. The COT, who had published many reports on emergency exposure guidance levels at the time, designated the task to a subcommittee. The subcommittee focused on Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances. Four years later the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC) was created with a focus on identifying, reviewing, and interpreting relevant toxicologic and other scientific data and developing acute exposure guideline levels (AEGLs) for high-priority, acutely toxic chemicals. In Acute Exposure Guideline Levels for Selected Airborne Chemicals:Volume 4, the NAC outlines acute exposure guideline levels for chlorine, hydrogen chloride, toluene 2,4, hydrogen fluoride, 2,6-diisocyanate, and uranium hexafluoride.

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309

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National Academies Press

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ISBN 10

0309091470

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9780309091473

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 5

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 5

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

In 1993, the National Research Council's Committee on Toxicology developed criteria and methods for EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) to develop community emergency exposure levels for extremely hazardous substances for the general population. A few years later, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC)â€"composed of members of EPA, DOD, other federal and state agencies, industry, academia, and other organizationsâ€"was established to identify, review, and interpret toxicologic and other scientific data to develop acute exposure guidelines (AEGLs) for high-priority, acutely toxic chemicals. Three levelsâ€"AEGL-1, AEGL-2, and AEGL-3 are developed for each of five exposure periods (10 min, 30 min, 1 hr, 4 hr, and 8 hr) and are distinguished by varying degrees of severity of toxic effects. This current report reviews the NAC reports for their scientific validity, completeness, and consistency with the NRC guideline reports developed in 1993 and 2001. This report is the fifth volume in the series and covers AEGLs for chlorine dioxide, chlorine trifluoride, cyclohexylamine, ethylenediamine, hydrofluoroether-7100, and tetranitromethane. It concludes that the AEGLs developed by NAC are scientifically valid and consistent with the NRC guideline reports. AEGLs are needed for a wide range of planning, response, and prevention applications. These values provide data critical to evacuation decisions and discussions between community leaders and industries as they seek ways to minimize the health impact should the chemical release occur. Some of the finalized AEGLs have been officially adopted by the Department of the Army, FEMA, and the Department of Transportation as the official levels for use by those agencies.

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292

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ISBN 10

0309103584

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9780309103589

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 10

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 10

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances (EHSs)² can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. As part of its efforts to develop acute exposure guideline levels for EHSs, EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) in 1991 requested that the National Research Council (NRC) develop guidelines for establishing such levels. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standard Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001, providing updated procedures, methodologies, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances and the Committee on Acute Exposure Guideline Levels (AEGLs) in developing the AEGL values. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology (COT) the Committee on Acute Exposure Guideline Levels, which prepared this report. Acute Exposure Guideline Levels for Selected Airborne Chemicals is the tenth volume of the series and documents for N,N-dimethylformamide, jet propellant fuels 5 and 8, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

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322

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ISBN 10

0309219876

ISBN 13

9780309219877

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 6

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 6

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

This book is the sixth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and includes AEGLs for chemicals such as ammonia, nickel carbonyl and phosphine, among others. At the request of the Department of Defense, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for 12 new chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies such as accidental or intentional chemical releases in the community, the workplace, transportation, the military, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts.

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320

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ISBN 10

0309112133

ISBN 13

9780309112130

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 13

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 13

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 13 includes AEGLs for boron trifluoride, bromoacetone, chloroacetone, hexafluoroacetone, perchloryl fluoride, piperidine, propargyl alcohol, trimethoxysilane and tetramethoxysilane, and trimethylbenzenes.

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293

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ISBN 10

0309290252

ISBN 13

9780309290258

Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. As a result the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993 and Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances in 2001; providing updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Stemming from this report the NAC has developed AEGLs for at least 270 EHSs. There are currently three AEGLs: AEGL-1, AEGL-2, and AEGL-3. AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population could experience notable discomfort, irritation, or certain asymptomatic nonsensory effects. These effects are not disabling and are transient and reversible once exposure is stopped. AEGL-2 is the airborne concentration (of a substance above which it is predicted that the general population could experience irreversible, long-lasting adverse health effects or an impaired ability to escape. AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population could experience life threatening health effects or death. On April 22-24 2013, the NRC-established Committee on Acute Exposure Guideline Levels 2013 met to review AEGL documents approved by the NAC. The committee members were selected for their expertise in toxicology, medicine, industrial hygiene, biostatistics, and risk assessment. Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels presents a review of AEGLs for various chemicals including acrylonitrile, halogen fluorides, tellurium hexafluoride, and thionyl chloride.

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ISBN 10

0309290600

ISBN 13

9780309290609

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 20

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 20

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 20 reviews and updates the technical support document on acute exposure guideline levels (AEGLs) for selected chloroformates. This update focuses on establishing AEGL-3 values for n-propyl chloroformate and isopropyl chloroformate, but will also consider whether any new data are available that would affect the proposed values for the other 10 chloroformates. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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195

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ISBN 10

0309449154

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9780309449151

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 17

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 17

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 17 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for acrylonitrile, carbon tetrachloride, cyanogen, epichlorohydrin, ethylene chlorohydrin, toluene, trimethylacetyl chloride, hydrogen bromide, and boron tribromide in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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405

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ISBN 10

0309304792

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9780309304795

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 19

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 19

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 19 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for cyanide salts, diketene, methacrylaldehyde, pentaborane, tellurium hexafluoride, and tetrafluoroethylene in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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207

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ISBN 10

0309368979

ISBN 13

9780309368971

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 15 identifies, reviews, and interprets relevant toxicologic and other scientific data for ethyl mercaptan, methyl mercaptan, phenyl mercaptan, tert-octyl mercaptan, lewisite, methyl isothiocyanate, and selected monoisocyanates in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three level--AEGL-1, AEGL-2, and AEGL-3--are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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229

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ISBN 10

0309291232

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9780309291231

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 18

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 18

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 18 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for bromine chloride, carbonyl fluoride, selected halogen fluorides, and oxygen difluoride in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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182

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ISBN 10

0309311926

ISBN 13

9780309311922

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

This book is the ninth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for bromine, ethylene oxide, furan, hydrogen sulfide, propylene oxide, and xylenes.

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462

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ISBN 10

030915944X

ISBN 13

9780309159449

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 3

By: National Research Council,Division on Engineering and Physical Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 3

By: National Research Council,Division on Engineering and Physical Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

This report reviews documents on acute exposure guideline levels (AEGLs) for nerve agents GA (tabun), GB (sarin), GD (soman), GD, and VX, sulfur mustard, diborane, and methyl isocyanate. The documents were developed by the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Chemicals (NAC). The subcommittee concludes that the AEGLs developed in those documents are scientifically valid conclusions based on data reviewed by NAC and are consistent with the NRC reports on developing acute exposure guideline levels.

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516

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National Academies Press

Published Date

ISBN 10

0309168163

ISBN 13

9780309168168

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 8

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 8

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

This book is the eighth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for acrolein, carbon monoxide, 1,2-dichloroethene, ethylenimine, fluorine, hydrazine, peracetic acid, propylenimine, and sulfur dioxide for scientific accuracy, completeness, and consistency with the NRC guideline reports.

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464

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National Academies Press

Published Date

ISBN 10

0309145155

ISBN 13

9780309145152

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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463

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National Academies Press

Published Date

ISBN 10

0309162661

ISBN 13

9780309162661

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,National Academies Press,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. "Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 18" identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for bromine chloride, carbonyl fluoride, selected halogen fluorides, and oxygen difluoride in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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160

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National Academy Press

Published Date

ISBN 10

0309311896

ISBN 13

9780309311892

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 11

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 11

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. This volume in the series includes AEGLs for bis-chloromethyl ether, chloromethyl methyl ether, chlorosilanes, nitrogen oxides, and vinyl chloride.

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356

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National Academies Press

Published Date

ISBN 10

0309254817

ISBN 13

9780309254816

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Subcommittee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Division on Earth and Life Studies,National Research Council

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

In the Bhopal disaster of 1984, approximately 2,000 residents living near a chemical plant were killed and 20,000 more suffered irreversible damage to their eyes and lungs following the accidental release of methyl isocyanate. This tragedy served to focus international attention on the need for governments to identify hazardous substances and assist local communities in planning how to deal with emergency exposures. Since 1986, the U.S. Environmental Protection Agency has been tasked with identifying extremely hazardous substances and, in cooperation with the Federal Emergency Management Agency and the Department of Transportation, assist local emergency response planners. The National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances was established in 1995 to develop acute exposure guideline levels (AEGLs) for high priority toxic chemicals that could be released into the air from accidents at chemical plants, storage sites, or during transportation. This book reviews toxicity documents on five chemicals--chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride--for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.

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194

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National Academies Press

Published Date

ISBN 10

0309073995

ISBN 13

9780309073998

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 9

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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462

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National Academies Press

Published Date

ISBN 10

030915944X

ISBN 13

9780309159449

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 20

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

Volume 20

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195

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National Academies Press

Published Date

ISBN 10

0309449154

ISBN 13

9780309449151

Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

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Acute Exposure Guideline Levels for Selected Airborne Chemicals

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

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229

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National Academies Press

Published Date

ISBN 10

0309291232

ISBN 13

9780309291231

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

By: National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

By: National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.

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Page Count

225

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National Academies Press

Published Date

ISBN 10

030907553X

ISBN 13

9780309075534

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part B

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Part B

By: National Research Council,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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ISBN 10

0309263905

ISBN 13

9780309263900

Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

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Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels

In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. As a result the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993 and Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances in 2001; providing updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Stemming from this report the NAC has developed AEGLs for at least 270 EHSs. There are currently three AEGLs: AEGL-1, AEGL-2, and AEGL-3. AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population could experience notable discomfort, irritation, or certain asymptomatic nonsensory effects. These effects are not disabling and are transient and reversible once exposure is stopped. AEGL-2 is the airborne concentration (of a substance above which it is predicted that the general population could experience irreversible, long-lasting adverse health effects or an impaired ability to escape. AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population could experience life threatening health effects or death. On April 22-24 2013, the NRC-established Committee on Acute Exposure Guideline Levels 2013 met to review AEGL documents approved by the NAC. The committee members were selected for their expertise in toxicology, medicine, industrial hygiene, biostatistics, and risk assessment. Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels presents a review of AEGLs for various chemicals including acrylonitrile, halogen fluorides, tellurium hexafluoride, and thionyl chloride.

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ISBN 10

0309290600

ISBN 13

9780309290609

Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,National Research Council

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Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels

By: Committee on Acute Exposure Guideline Levels,Committee on Toxicology,National Research Council

The present report is the committee's 19th interim report. It summarizes the committee's conclusions and recommendations for improving NAC's AEGL documents for the following chemicals and chemical classes: acrylonitrile, benzonitrile, boron tribromide, BZ (3-quinuclidinyl benzilate), chloroarsenicals, chloroformates, bis-chloromethylether, chloromethylether, chlorosilanes (26 selected compounds), cyanogen, ethyl mercaptan, hexafluoroacetone, lewisites, mercury vapor, nitric acid, nitric oxide, nitrogen dioxide, nitrogen tetroxide, oleum, phenyl mercaptan, propargyl alcohol, selenium hexafluoride, silane, sulfer trioxide, sulfuric acid, tear gas, tert-octyl mercaptan, tetramethoxy silane, thionyl chloride, trimethoxysilane, trimethylbenzenes (1,2,4-; 1,2,5-;and 1,3,5-TMB), and vinyl chloride.

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218

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National Academies Press

Published Date

ISBN 10

0309187621

ISBN 13

9780309187626

Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

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Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Acute Exposure Guideline Levels

Extremely hazardous substances (EHSs), as defined in the Superfund Amendments and Reauthorization Act of 1986, can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars or trucks used in transporting these substances, or intentionally through terrorist activities. It is also feasible that these substance can be released by improper storage and/or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental and intentional releases. This report provides technical guidance on establishing community Acute Exposure Guideline Levels (AEGLs) for certain hazardous chemicals. It reviews the scientific validity of AEGLs developed by the national Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances, identifies research priorities, and identifies guidance issues that may require modification or further development based on the toxicological database for the chemicals reviewed. This twelfth interim report offers recommendations for improving AEGLs for the following 15 chemicals: toluene, xylenes, ammonia, bromine, aniline, methyl ethyl ketone, hydrazine, iron pentacarbonyl, phosphine, chlorine, trifluoride, ethyleneimine, propyleneimine, allyl alcohol, ethylene oxide, and nickel carbonyl.

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ISBN 10

0309095883

ISBN 13

9780309095884

Research Priorities for Airborne Particulate Matter

IV. Continuing Research Progress

By: Committee on Research Priorities for Airborne Particulate Matter,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

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Research Priorities for Airborne Particulate Matter

IV. Continuing Research Progress

By: Committee on Research Priorities for Airborne Particulate Matter,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council

In 1997, the U.S. Environmental Protection Agency (EPA) established regulatory standards to address health risks posed by inhaling tiny particles from smoke, vehicle exhaust, and other sources. At the same time, Congress and the EPA began a multimillion dollar research effort to better understand the sources of these airborne particles, the levels of exposure to people, and the ways that these particles cause disease. To provide independent guidance to the EPA, Congress asked the National Research Council to study the relevant issues. The result was a series of four reports on the particulate-matter research program. The first two books offered a conceptual framework for a national research program, identified the 10 most critical research needs, and described the recommended timing and estimated costs of such research. The third volume began the task of assessing initial progress made in implementing the research program. This, the fourth and final volume, gauged research progress made over a 5-year period on each of the 10 research topics. The National Research Council concludes that particulate matter research has led to a better understanding of the health effects caused by tiny airborne particles. However, the EPA, in concert with other agencies, should continue research to reduce further uncertainties and inform long-term decisions.

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380

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National Academies Press

Published Date

ISBN 10

0309091993

ISBN 13

9780309091992

Evaluating Research Efficiency in the U.S. Environmental Protection Agency

By: Committee on Science, Engineering, and Public Policy (U.S.). Committee on Evaluating the Efficiency of Research and Development Programs at the U.S. Environmental Protection Agency,Committee on Science, Engineering, and Public Policy (U.S.),National Research Council (U.S.). Board on Environmental Studies and Toxicology

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Evaluating Research Efficiency in the U.S. Environmental Protection Agency

Introduction: The government performance and results act, the program assessment rating tool, and the Environmental Protection Agency -- Efficiency metrics used by the Environmental Protection Agency and other federal research and development programs -- Are the efficiency metrics used by the federal research and development programs sufficient and outcome-based? -- A model for evaluating research and development programs -- Findings, principles, and recommendations -- Appendices -- Boxes, figures and tables.

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156

Published Date

ISBN 10

0309116848

ISBN 13

9780309116848

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