Approaching carbohydrate chemistry for the first time can be daunting as basic information is often buried in texts intended for advanced practitioners in the field. This brief primer attempts to bridge that gap. Chapter 1 introduces the basics of carbohydrate structure. Chapter 2 introduces the various roles carbohydrates play in biology. Chapter 3 discusses the glycosylation reaction used to assemble oligosaccharides along with a survey of commonly used glycosyl donors. Chapter 4 discusses commonly used protecting groups. Chapter 5 covers advances in automating the carbohydrate synthesis. Chapter 6 introduces the role of enzymes in the synthesis of homogeneous carbohydrates and glycoproteins. The authors hope this primer will introduce the uninitiated to the challenges and beauty of carbohydrate synthesis and inspire them to bring a new perspective and new advances to the field. Only by doing so will we, as a community of synthetic chemists, be able to tame one of the last and arguably most complex areas of chemical space to create new advances in human health.
The Papers of Henry Clay span the crucial first half of the nineteenth century in American history. Few men in his time were so intimately concerned with the formation of national policy, and few influenced so profoundly the growth of American political institutions. The year 1837 found Henry Clay hard at work in a successful effort to organize and strengthen the new Whig party. In his attempt to provide for it an ideological core, he emphasized restoration of the Bank of the United States, distribution of the treasury surplus to the states, continued adherence to his Compromise Tariff Act of 1833, and federal funding of internal improvements. The achievement of these goals, Clay reasoned, would mitigate the severe impact of the Depression of 1837 and sweep the Whigs into the White House in 1840. Soon after the election of 1836, Clay began running again for the presidency. By 1838 it was clear to him that he would have to come to grips politically with the long-muted slavery question. This he did in February 1839 in a Senate speech that was so proslavery, anti-abolitionist, and racially extremist that it cost him the Whig presidential nomination at the Harrisburg convention in December 1839. William Henry Harrison was nominated in his stead and won handily. But one month after his inauguration Harrison died and Vice President John Tyler, a states' rights Democrat turned Whig, was elevated to the presidency. Senator Clay emerged from his disappointment at Harrisburg as the acknowledged leader of the Whig party and further unified it in a wide-ranging assault on the Tyler administration's refusal to support Whig principles. By the end of 1843 Tyler had been broken, the Whig party was Clay's to lead, and the Kentuckian was again in the presidential lists. Confident that 1844 would surely be his year, Clay unfortunately failed to see the formation and growth of the black cloud that was Texas annexation. Publication of this book was assisted by a grant from the National Historical Publications and Records Commission.
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