Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.
The brilliantly expressive clay models created by Gian Lorenzo Bernini (1598-1680) as "sketches" for his works in marble offer extraordinary insights into his creative imagination. Although long admired, the terracotta models have never been the subject of such detailed examination. This publication presents a wealth of new discoveries (including evidence of the artist's fingerprints imprinted on the clay), resolving lingering issues of attribution while giving readers a vivid sense of how the artist and his assistants fulfilled a steady stream of monumental commissions. Essays describe Bernini's education as a modeler; his approach to preparatory drawings; his use of assistants; and the response to his models by 17th-century collectors. Extensive research by conservators and art historians explores the different types of models created in Bernini's workshop. Richly illustrated, Bernini transforms our understanding of the sculptor and his distinctive and fascinating working methods."--Publisher's website.
This book traces the life of Cholesky (1875-1918), and gives his family history. After an introduction to topography, an English translation of an unpublished paper by him where he explained his method for linear systems is given, studied and replaced in its historical context. His other works, including two books, are also described as well as his involvement in teaching at a superior school by correspondence. The story of this school and its founder, Léon Eyrolles, are addressed. Then, an important unpublished book of Cholesky on graphical calculation is analyzed in detail and compared to similar contemporary publications. The biography of Ernest Benoit, who wrote the first paper where Cholesky ́s method is explained, is provided. Various documents, highlighting the life and the personality of Cholesky, end the book.
Many times destroyed, many times rebuilt, Rome never completely disappeared. The famous symbols of the Eternal City - the Colosseum, the Pantheon and Trajan's Column - have survived twenty centuries of pillage and invasions. Treasure hunters and scholars, archaeologists and artists, popes and poets adored, occupied and plundered them - and restored and embellished them as well. This is the story of how Rome's magnificence has endured it all.
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