This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.
The surgeon who desires an atlas of techniques covering operations on the colon and rectum almost surely prefers a concise volume rather than an encyclopedic compilation of the innumerable procedures that have been described in the literature. This book includes the operations that have proved to be useful and have survived the test of time. They now are in general use in the Massachusetts General Hospital. Space limitations have necessitated exclusion of detailed illustrations of a number of infrequently performed procedures, such as pelvic exenter ation for cancer of the rectum. In such instances bibliographic references have been provided for ready reference. The bibliography emphasizes recent contributions because they are easily available to the reader. Critical comments by the authors concerning certain technical pro cedures may be due to personal bias and certainly do not imply that the alternative methods are undesirable. Furthermore, the brevity of discus sion of anatomy, physiology, and pathology and the neglect of details of medical therapy of numerous colorectal diseases must be attributed to the fact that this volume is directed primarily toward the practicing surgeon. Thanks are due to the artists Mrs. Edith Tagrin and Mr. Robert Galla, and to Miss Evelyn Hall for help in the preparation of the manuscript. Claude E. Welch, M.D. Leslie W. Ottinger, M.D. John P. Welch, M.D. .
This innovative textbook teaches the basics of drug information, literature evaluation, and biostatistics, and relates these topics to evidence-based pharmaceutical care. Readers will learn what to look for in studies, how to critique them, and how to apply them in clinical pharmacy practice. A major focus is critical appraisal of evidence derived from different types of studies—cases, cohorts, surveys, randomized controlled clinical trials, pharmacoeconomic studies, and systematic reviews. Concluding chapters discuss clinical decision-making using evidence from studies.
Genetics of Fitness and Physical Performance is the first comprehensive reference on the role of the genes in influencing individual variation in fitness and performance. This essential compendium reviews the past 25 years of accumulated evidence on the genetic basis of health- and performance-related fitness phenotypes. Focusing on the interests of sport scientists, the authors provide insight into the significance of this research on nearly every aspect of the study of human physical activity. The book presents the biological basis of heredity and explains the concepts and methods of genetic epidemiology and molecular biology that are necessary to understand this specialized field. With the rapid advances in molecular biology and the paradigms of human genetics, exercise scientists face a dynamic and vibrant new field. This book offers readers new opportunities to better understand atherosclerosis, noninsulin dependent diabetes, obesity, and hypertension by searching for single gene effects and identifying susceptibility genes. The authors review the evidence on the role of the genes for human traits as it pertains to the exercise science field. And they explore the scientific, practical, and ethical issues that confront exercise scientists as progress is made in this field. Genetics of Fitness and Physical Performance is vital reading for scholars in the field of exercise and sport science to understand how recent discoveries in genetics might shape their future research.
Successfully combining cross-cultural management and business research methods, this team of international authors provide much-needed coverage of the implications that should be considered when undertaking research across different cultures. Through the implementation of methodological pluralism, the book investigates the various cultural influences that affect business theories and practices across the world, particularly the specific management styles, behavioural standards and consumer attitudes that exist in developing nations. Examples and theoretical understanding as well as vignettes, diagrams and figures are used to illustrate these key considerations, including: Language and the role of the dominant culture Design and implementation Methodological issues Strategies for improving its relevance within international business. Ideal for students, researchers and practitioners looking to do business research in an international or cross-cultural context.
Maintaining a balance between depth and breadth, the Sixth Edition of Principles of Polymer Systems continues to present an integrated approach to polymer science and engineering. A classic text in the field, the new edition offers a comprehensive exploration of polymers at a level geared toward upper-level undergraduates and beginning graduate students. Revisions to the sixth edition include: A more detailed discussion of crystallization kinetics, strain-induced crystallization, block copolymers, liquid crystal polymers, and gels New, powerful radical polymerization methods Additional polymerization process flow sheets and discussion of the polymerization of polystyrene and poly(vinyl chloride) New discussions on the elongational viscosity of polymers and coarse-grained bead-spring molecular and tube models Updated information on models and experimental results of rubber elasticity Expanded sections on fracture of glassy and semicrystalline polymers New sections on fracture of elastomers, diffusion in polymers, and membrane formation New coverage of polymers from renewable resources New section on X-ray methods and dielectric relaxation All chapters have been updated and out-of-date material removed. The text contains more theoretical background for some of the fundamental concepts pertaining to polymer structure and behavior, while also providing an up-to-date discussion of the latest developments in polymerization systems. Example problems in the text help students through step-by-step solutions and nearly 300 end-of-chapter problems, many new to this edition, reinforce the concepts presented.
In nineteenth-century America, the belief that blacks and whites could not live in social harmony and political equality in the same country led to a movement to relocate African Americans to Liberia, a West African colony established by the United States government and the American Colonization Society in 1822. In The Price of Liberty, Claude Clegg accounts for 2,030 North Carolina blacks who left the state and took up residence in Liberia between 1825 and 1893. By examining both the American and African sides of this experience, Clegg produces a textured account of an important chapter in the historical evolution of the Atlantic world. For almost a century, Liberian emigration connected African Americans to the broader cultures, commerce, communication networks, and epidemiological patterns of the Afro-Atlantic region. But for many individuals, dreams of a Pan-African utopia in Liberia were tempered by complicated relationships with the Africans, whom they dispossessed of land. Liberia soon became a politically unstable mix of newcomers, indigenous peoples, and "recaptured" Africans from westbound slave ships. Ultimately, Clegg argues, in the process of forging the world's second black-ruled republic, the emigrants constructed a settler society marred by many of the same exclusionary, oppressive characteristics common to modern colonial regimes.
Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students. - Presents dedicated chapters on tendons and myotendinous junction which are anatomical components frequently ignored in the study of muscles - Includes descriptions of diabetic foot myopathies featured by magnetic resonance imaging (MRI) - Provides illustrations of myopathies and tendinopathies with state-of-the-art MRI images and MR imaging protocols for myopathies - Covers anatomical and biomechanic descriptions of all intrinsic and extrinsic muscles
This volume of the Encyclopaedia offers a systematic introduction and a comprehensive survey of the theory of complex spaces. It covers topics like semi-normal complex spaces, cohomology, the Levi problem, q-convexity and q-concavity. It is the first survey of this kind. The authors are internationally known outstanding experts who developed substantial parts of the field. The book contains seven chapters and an introduction written by Remmert, describing the history of the subject. The book will be very useful to graduate students and researchers in complex analysis, algebraic geometry and differential geometry. Another group of readers will consist of mathematical physicists who apply results from these fields.
The arrival of photographer Claude C 'Pop' Laval in Fresno in 1911, marked the beginning of a commercial photography career that would span fifty-five years. During this time he took pictures of the region. This title features his photographs that give the people of Fresno and the Valley an opportunity to view their historic community.
The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity. - Presents a clear differentiation of Charcot neuroarthropathy with other conditions such as osteoarthritis, gout, psoriasis, rheumatoid arthritis, the Madura foot, and others - Provides a state-of-art catalogue of all radiological features of Charcot neuroarthropathy with MRI - Describes the pre-and post-surgical procedures used for the management of Charcot neuroarthropathy and their socioeconomic impacts - Includes MRI color images of soft tissue damages for ease of understanding
The role of lipids in nutrition science has evolved considerably in the past decade with new concepts following new discoveries. Lipids: Nutrition and Health reviews the role of dietary lipids in maintaining health, bringing the latest knowledge from a myriad of sources into one convenient resource. Taking a combined approach that integrates lipid
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