Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: * Essential thrombocythemia (ET) - characterized by increased platelet count * Polycythemia vera (PV) - characterized by excessive production of red blood cells * Primary myelofibrosis - a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.
Myelofibrosis is a myeloproliferative neoplasm that has markedly heterogeneous features. The clinical phenotype can range from initial indolent presentation, which may be stable for many years, through to marked cytopenias, debilitating constitutional symptoms, massive splenomegaly and an inherent risk of leukemic transformation. Despite many advances regarding molecular classification, prognostication models and rapeutic options over the last few decades, allogeneic stem cell transplantation remains the only curative option, yet is suitable only for a minority of patients. ‘Fast Facts: Myelofibrosis’ is written for health professionals by two leading experts in the field, and provides up-to-date guidance on its accurate diagnosis, risk stratification and management. It also provides key insights into the molecular biology underpinning the disease. This concise handbook is an indispensable read for anyone wanting to get up to speed with best practice in the diagnosis and care of people with myelofibrosis. Table of Contents: • Presentation, classification and epidemiology • Molecular biology and pathogenesis • Clinical assessment and diagnosis • Prognostic models • Treatment approaches • Allogeneic stem cell transplantation • Management of blast-phase myelofibrosis • Therapies in development
Edwin Judge's description of early Christian communities as 'scholastic communities' provides the starting point of a search for a sociological description of the Christian communities portrayed in 1 Corinthians, 1 and 2 Timothy and Titus. An original methodology uses a multi-layered exegetical approach to study every occurrence of the vocabulary of 'teaching' in the letters. The focus is on the activity of teaching (e.g., participants, method, manner, purpose, result, etc). The vocabulary represents ten semantic groupings, which shed further light on the place and practice of education in the communities ( core-teaching, speaking, traditioning, announcing, revealing, worshipping, commanding, correcting, remembering / imitation, and false teaching ). Claire S. Smith supports and develops Judge's 1960 description, advancing on it by showing that the communities are better described as 'learning communities' with horizontal (human-human) and vertical (divine-human) dimensions.
This book weaves a social, economic and cultural history of Australia with rare first-hand accounts of the lived experience of change related to farming and agriculture. It provides a rich sociology of how living on the land has changed throughout Australia’s history. The book investigates the complex effects of the state on everyday life, using an historical agricultural case study of place to explore long-running sociohistorical processes of change examined through both a macro and micro sociological lens. This provides a multi-faceted perspective from which to examine economic, social and cultural transformations in each of these contexts and change is examined through multiple sites of expression: public policy and the role of the state; colonial processes of dispossession; social and cultural systems of value; economic change and its consequences; farming practices and lived experience; neoliberalism and globalisation and their social impacts; community decline and trends toward corporate and foreign land ownership. Each of these transformations impact upon lived experience and everyday life and this book provides grounded insight into exactly this relationship and process.
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