Organisms are said to be drug-resistant when drugs meant to neutralise them have reduced effect. When an organism is resistant to more than one drug, it is said to be multi-drug resistant. The most prominent example of this is antibiotic resistance. Drug resistance is also found in some tumour cells, which makes it more difficult to use chemotherapy to attack tumours made of those cells. When a drug such as an antibiotic is administered, those which have a genetic resistance to the drug will survive and reproduce, and the new population will be drug-resistant. This book provides in depth research on multi-drug resistance and its impact on neuorology. This includes studies on GS-X Pump/Multidrug Resistance Proteins, Quantitation of O6 -- Methylguanine, Therapeutic Responses to Chemotherapy, Profiles in Cancer, Neurodegenerative Diseases and Multiple Sclerosis.
This book includes every Supreme Court case relevant to gender and sexual equality from the Court's beginnings in 1787 to the end of the 1999/2000 term. It is a primary document reference book, organized topically in eight chapter civic and social rights and duties; educational policies and instructions; employment and careers; sexual privacy and procreative rights; morality and sexual ethics; family; gender and sexual orientation; and other issues. Every case is included either as a full (edited) version of the majority or per curiam opinion, extensive excerpts of the opinion, or a detailed description of the case. In one book, a researcher can see how American legal history, in its entirety, played out. Back matter includes a table of cases and an extensive bibliography of books and legal periodicals.
Chief Justice John Marshall argued that a constitution "requires that only its great outlines should be marked [and] its important objects designated." Ours is "intended to endure for ages to come, and consequently, to be adapted to the various crises of human affairs." In recent years, Marshall's great truths have been challenged by proponents of originalism and strict construction. Such legal thinkers as Supreme Court Justice Antonin Scalia argue that the Constitution must be construed and applied as it was when the Framers wrote it. In Keeping Faith with the Constitution, three legal authorities make the case for Marshall's vision. They describe their approach as "constitutional fidelity"--not to how the Framers would have applied the Constitution, but to the text and principles of the Constitution itself. The original understanding of the text is one source of interpretation, but not the only one; to preserve the meaning and authority of the document, to keep it vital, applications of the Constitution must be shaped by precedent, historical experience, practical consequence, and societal change. The authors range across the history of constitutional interpretation to show how this approach has been the source of our greatest advances, from Brown v. Board of Education to the New Deal, from the Miranda decision to the expansion of women's rights. They delve into the complexities of voting rights, the malapportionment of legislative districts, speech freedoms, civil liberties and the War on Terror, and the evolution of checks and balances. The Constitution's framers could never have imagined DNA, global warming, or even women's equality. Yet these and many more realities shape our lives and outlook. Our Constitution will remain vital into our changing future, the authors write, if judges remain true to this rich tradition of adaptation and fidelity.
The US Supreme Court is an institution that operates almost totally behind closed doors. This book opens those doors by providing a comprehensive look at the justices, procedures, cases, and issues over the institution’s more than 200-year history. The Court is a legal institution born from a highly politicized process. Modern justices time their departures to coincide with favorable administrations and the confirmation process has become a highly-charged political spectacle played out on television and in the national press. Throughout its history, the Court has been at the center of the most important issues facing the nation: federalism, separation of powers, war, slavery, civil rights, and civil liberties. Through it all, the Court has generally, though not always, reflected the broad views of the American people as the justices decide the most vexing issues of the day. The Historical Dictionary of the U.S. Supreme Court covers its history through a chronology, an introductory essay, appendixes, and an extensive bibliography. The dictionary section has over 700 cross-referenced entries on every justice, major case, issue, and process that comprises the Court’s work. This book is an excellent access point for students, researchers, and anyone wanting to know more about the Supreme Court.
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