Numerical Machine Learning is a simple textbook on machine learning that bridges the gap between mathematics theory and practice. The book uses numerical examples with small datasets and simple Python codes to provide a complete walkthrough of the underlying mathematical steps of seven commonly used machine learning algorithms and techniques, including linear regression, regularization, logistic regression, decision trees, gradient boosting, Support Vector Machine, and K-means Clustering. Through a step-by-step exploration of concrete numerical examples, the students (primarily undergraduate and graduate students studying machine learning) can develop a well-rounded understanding of these algorithms, gain an in-depth knowledge of how the mathematics relates to the implementation and performance of the algorithms, and be better equipped to apply them to practical problems. Key features - Provides a concise introduction to numerical concepts in machine learning in simple terms - Explains the 7 basic mathematical techniques used in machine learning problems, with over 60 illustrations and tables - Focuses on numerical examples while using small datasets for easy learning - Includes simple Python codes - Includes bibliographic references for advanced reading The text is essential for college and university-level students who are required to understand the fundamentals of machine learning in their courses.
Public and Environmental Health Law is a successor to Public Health Law and Regulation 2nd edition and offers a critical and up to date assessment of the legislation, cases and policies that impact on public health practice in Australia and New Zealand. As with earlier editions, this book outlines and discusses laws in a range of important areas including environmental health, food safety, communicable disease, obesity, tobacco and alcohol, the human health impacts of pollution control and planning law. Particular focus is given to new directions in public and environmental health law including the risk based approaches reflected in recent legislation and statutory duties to protect public health. New issues are also raised and discussed, including sustainability, the challenges of climate change, preparedness for pandemics and other public health emergencies and health impact assessment. Introductory chapters set public and environmental health law in the context of the wider legal system and discuss issues such as its constitutional structure, international trends and obligations, rights questions including natural justice and the proper exercise of statutory power by officers. The principles of legislation and its interpretation and the laws of evidence, with a particular focus on the use of epidemiological data as evidence, are also examined. Public and Environmental Health Lawis designed for students of environmental health and public health, for environmental health officers, medical officers and others working in the field and for all persons interested in the potential for law and legislation to further the practice of public health. It is written in a way that highlights the potential for law to act strategically, as a tool for improving public health outcomes, is extensively referenced to statutes and cases and is accompanied by a detailed bibliography.
International Management: Managing Cultural Diversity International Management explores the dynamic global environment of business management by examining the political, legal, technological, competitive, and cultural factors that shape corporations worldwide. With its hallmark clear and concise approach, International Management places fundamental management theories in an international context. Students will gain a comprehensive understanding of the practices, cultural skills and sensitivities needed to operate successfully in a wide range of cross-national situations. The second Australian edition of International Management focuses on the expanding economics of Australasia, China, India and their increasing trade amongst themselves, the European Union and the Americas. International Management 2nd edition incorporates up-to-date research, increased coverage of ethics, a wide range of case studies and examines recent trends affecting international business managers in today’s hypercompetitive global environment. International Management is suitable for undergraduate and post graduate students majoring in international business, general management or cross cultural studies.
The main goal of the book is to provide a systematic and didactic approach to the physics and technology of free-electron lasers. Numerous figures are used for illustrating the underlying ideas and concepts and links to other fields of physics are provided. After an introduction to undulator radiation and the low-gain FEL, the one-dimensional theory of the high-gain FEL is developed in a systematic way. Particular emphasis is put on explaining and justifying the various assumptions and approximations that are needed to obtain the differential and integral equations governing the FEL dynamics. Analytical and numerical solutions are presented and important FEL parameters are defined, such as gain length, FEL bandwidth and saturation power. One of the most important features of a high-gain FEL, the formation of microbunches, is studied at length. The increase of gain length due to beam energy spread, space charge forces, and three-dimensional effects such as betatron oscillations and optical diffraction is analyzed. The mechanism of Self-Amplified Spontaneous Emission is described theoretically and illustrated with numerous experimental results. Various methods of FEL seeding by coherent external radiation are introduced, together with experimental results. The world’s first soft X-ray FEL, the user facility FLASH at DESY, is described in some detail to give an impression of the complexity of such an accelerator-based light source. The last chapter is devoted to the new hard X-ray FELs which generate extremely intense radiation in the Angstrøm regime. The appendices contain supplementary material and more involved calculations.
This is the 2nd edition of Key Questions in Cardiac Surgery, which has become the must-read book for all cardiac surgical practitioners and is part of the revolutionary 'Key Questions' series of cardiothoracic surgical textbooks, including Key Questions in Thoracic Surgery and Key Questions in Congenital Cardiac Surgery. The 1st edition was an international bestselling cardiac surgical textbook, for many years being the most popular cardiac surgical book on amazon, with amazing feedback and reviews. It also received a Highly Commended Award at the British Medical Association (BMA) Medical Book Awards and has been placed on the US Thoracic Surgery Directors Association (TSDA) recommended reading list for American cardiothoracic surgery residents and fellows. Key Questions in Cardiac Surgery provides a systematic overview of the important topics in contemporary adult cardiac surgical practice. The text is evidence-based, incorporating current literature and has been updated from the 1st edition with the most recent American Heart Association and European Society of Cardiology guidelines. This illustrated concise text is a practical and clinically focused book that covers all the key questions in cardiac surgery. Additional chapters on statistics and pulmonary embolism have been included, with the main chapters having been updated describing contemporary surgical techniques and management philosophies. Whilst being an ideal reference for cardiac surgical trainees and residents, especially when undertaking their cardiothoracic surgery board examinations, this book is also of great value to other specialties involved in the care of cardiac surgical patients, including cardiologists, cardiothoracic intensivists, nurses and physiotherapists. Here are just a few of the reviews on the 1st edition: “Although this book is aimed at cardiac surgical trainees and residents, the authors’ refreshing approach of posing questions and answers as a teaching tool makes this a joy to read for someone who has been practising cardiac surgery for over 30 years. It is beautifully presented with exceptionally clear diagrams interposed with photographs, a combination which works well. Overall, this is an exceptionally well produced book which is a delight to read and is likely to run to several more editions.” Professor of Cardiac Surgery, Royal Brompton Hospital, London, UK on behalf of the British Journal of Cardiology “I recommend this book for cardiac surgery trainees, full-fledged surgeons, and also for other medical practitioners wanting a brief and precise overview into our speciality, without having to pick up heavy textbooks and spend precious time searching for information.” Professor of Cardiac Surgery, University Hospital Zurich, Switzerland on behalf of the European Society of Cardiology "The title of this book Key Questions in Cardiac Surgery is appropriate since it covers systematically all questions asked in examinations or during the ward round. It is written in a question-answer format which makes it interesting to read. The illustrations are very good. The diagrams have been made in such a way that they provide a surgeon’s view. This book is based on the guidelines issued by the American Heart Association and European Society of Cardiology, and incorporates facts based on current scientific literature. Each chapter has a list of key scientific references for further reading. We would recommend this book as a companion for all cardiac surgery and cardiology trainees, perfusionists and cardiac anaesthesiologists. Overall, this book provides a practical and new approach to understand adult cardiac surgery." Professor of Cardiac Surgery & Editor-in-Chief on behalf of the Indian Journal of Thoracic and Cardiovascular Surgery "A wonderful book. I have been looking for such a book for a very long time. It gives a global view on all aspects of adult cardiac surgery with emphasis on the important points. It is written in a very smooth and easy way. Its size is perfect so it can be carried everywhere. In my opinion, it is a must-have book if one is preparing for the speciality exam. Junior and senior trainees will also find it helpful during their career." Waterstones review “...it is a definite 'must have' for all cardiac surgery trainees. It not only covers practical issues but also those areas that are favourites of examiners! It will also be of use to those experienced cardiac surgeons who have to take recertification exams (in the US) or for those who are simply looking for questions (and the answers) to throw out on ward rounds!” Amazon review “What a fantastic book that covers all the important topics for everyday practice in cardiac surgery. It answers all the questions asked on a ward round and also the exams, and is perfect to read between cases or whilst on call. The book is written in a concise, structured and easy to read manner. The best part of the book is its colour illustrations, and the text!!! They seem to have been drawn from a surgical perspective and beautifully illustrate the important features when operating. On top of that, the book has hundreds of cardiac investigations images that demonstrate all the different pathologies.” Amazon review “Covering all aspects of cardiothoracic surgery by highlighting the most important details, for sure it can be the guide for every cardiothoracic trainee. Easy to read and understand, perfect illustrations and full of secrets and details that only experienced surgeons would be aware off.” Amazon review “This is an amazing book. It is the only text I came across that puts all the important information in one place without having to dig around the internet or several textbooks. The book is very well written with a simple question and answer style that also lends itself to reading in small segments as well as concentrated revision. It comprehensively covers the basic sciences, cardiac investigations, cardiopulmonary bypass, cardiac surgical diseases and the post-operative management of these patients. It answers all the questions that are asked in the operating room, on rounds or in an oral examination. Unlike other revision texts, this book has an amazing array of colour images, both illustrations and real radiology/cardiology investigations which help to explain the key concepts. Surgical anatomy and technique is clearly demonstrated. The book also has a fantastic collection of all the seminal publications important for contemporary cardiac practice, especially in the coronary artery disease and heart failure chapters. It also includes all the up-to-date American and European guidelines, including the recently published ESC coronary revascularisation recommendations.” Amazon review
Covering the full spectrum of clinical issues and options in anesthesiology, Barash, Cullen, and Stoelting’s Clinical Anesthesia, Ninth Edition, edited by Drs. Bruce F. Cullen, M. Christine Stock, Rafael Ortega, Sam R. Sharar, Natalie F. Holt, Christopher W. Connor, and Naveen Nathan, provides insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This award-winning text delivers state-of-the-art content unparalleled in clarity and depth of coverage that equip you to effectively apply today’s standards of care and make optimal clinical decisions on behalf of your patients.
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.
Federal administrative law is a vast expanse of statutory provisions and case law. This text aims to map these provisions, setting out the case and statute law in a structured and amenable way. Federal Administrative Law commences with discussion of the composition, powers and decision-making processes of the executive government. Then it covers the major remedies available for those who are dissatisfied by a decision of the executive government - reasons for decision, access to information under FOI legislation, judicial review, appeal to the Administrative Appeals Tribunal, review by the Ombudsman, remaking a decision, collateral review and special review. Enright also engages with the perennial conceptual problems of administrative law. Difficulties with separating legislative, executive and judicial power, and in distinguishing between law and fact, are considered insoluble, Enright argues, only because they have not been approached in the right way. Enright argues for going back to basics, emphasising the necessity of asking the right question in the first place. In a similar vein, Enright investigates problems with legitimate expectation in the law of natural justice and argues that difficulties with standing can be treated better by taking a more analytical approach to the interests involved. Federal Administrative Law will serve as a basic text and reference book for those who work in Commonwealth administrative law. It is written in a clear and easy to read style that will make it suitable as a textbook in undergraduate courses.
A career’s worth of portfolio management knowledge in one thorough, efficient guide Portfolio Management is an authoritative guide for those who wish to manage money professionally. This invaluable resource presents effective portfolio management practices supported by their underlying theory, providing the tools and instruction required to meet investor objectives and deliver superior performance. Highlighting a practitioner’s view of portfolio management, this guide offers real-world perspective on investment processes, portfolio decision making, and the business of managing money for real clients. Real world examples and detailed test cases—supported by sophisticated Excel templates and true client situations—illustrate real investment scenarios and provide insight into the factors separating success from failure. The book is an ideal textbook for courses in advanced investments, portfolio management or applied capital markets finance. It is also a useful tool for practitioners who seek hands-on learning of advanced portfolio techniques. Managing other people’s money is a challenging and ever-evolving business. Investment professionals must keep pace with the current market environment to effectively manage their client’s assets while students require a foundation built on the most relevant, up-to-date information and techniques. This invaluable resource allows readers to: Learn and apply advanced multi-period portfolio methods to all major asset classes. Design, test, and implement investment processes. Win and keep client mandates. Grasp the theoretical foundations of major investment tools Teaching and learning aids include: Easy-to-use Excel templates with immediately accessible tools. Accessible PowerPoint slides, sample exam and quiz questions and sample syllabi Video lectures Proliferation of mathematics in economics, growing sophistication of investors, and rising competition in the industry requires advanced training of investment professionals. Portfolio Management provides expert guidance to this increasingly complex field, covering the important advancements in theory and intricacies of practice.
In consultation with Dr. Charles Lightdale, Dr. DiMaio has assembled a list of articles devoted to endoscopy in hepatology with the most current and clinically relevant content. Dr. DiMaio invited top experts from well-known institutions to contribute reviews on the following topics: EUS in the evaluation of unexplained biliary dilation and liver function test abnormalities; EUS-guided liver biopsy; Advances in endoscopic imaging of the biliary tree; Expert evaluation of indeterminate biliary strictures; Stenting for benign and malignant biliary strictures; Endoscopic management of biliary issues in the liver transplant patient; Endoscopic management of complex biliary stone disease; EUS-guided biliary drainage; ERCP and EUS-guided drainage of the gallbladder; EUS-guided interventions for the measurement and treatment of portal hypertension; Endoscopic management of portal hypertension-related bleeding; EUS for diagnosis and staging of liver tumors; ERCP-guided ablation for cholangiocarcinoma; and EUS-guided ablation of liver tumors. Readers will come away with the most current clinical information they need to improve outcomes in patients with liver disease.
This volume explores social work as a series of encounters - between clients and social workers, their colleagues and other professionals, and more widely between citizens and the state.
Christianity and Confucianism: Culture, Faith and Politics, sets comparative textual analysis against the backcloth of 2000 years of cultural, political, and religious interaction between China and the West. As the world responds to China's rise and China positions herself for global engagement, this major new study reawakens and revises an ancient conversation. As a generous introduction to biblical Christianity and the Confucian Classics, Christianity and Confucianism tells a remarkable story of mutual formation and cultural indebtedness. East and West are shown to have shaped the mind, heart, culture, philosophy and politics of the other - and far more, perhaps, than either knows or would want to admit. Christopher Hancock has provided a rich and stimulating resource for scholars and students, diplomats and social scientists, devotees of culture and those who pursue wisdom and peace today.
Prepare for success on the Examination of Special Competence in Critical Care Echocardiography (CCEeXAM)! Critical Care Echocardiography Review is a first-of-its-kind, review textbook containing over 1,200 questions and answers. Helmed by Drs. Marvin G. Chang, Abraham Sonny, David Dudzinski, Christopher R. Tainter, Ryan J. Horvath, Sheri M. Berg, Edward A. Bittner as well as a team of associated editors and authors from institutions across the nation , this highly visual resource covers every aspect of the use of ultrasound for clinical diagnosis and management in the critical care setting, providing a thorough, effective review and helping you identify areas of mastery and those needing further study.
Informed authors from across Canada examine recession-related policy fields, including the Canadian banking system, new industrial policy pressures such as the automotive industry bailout, policies in science, technology, and innovation, and suggestions about how to resist the United States' "buy America" trade policies. The chapters in this volume also consider Canada's national, regional, and political divisiveness, the impact of the dynamic Obama Administration on Canadian domestic affairs, and governance during a time of minority government.
This book describes the mechanisms that allow aquatic photosynthetic organisms to contribute about half of the global primary productivity; in order to mitigate climate change by sequestering carbon dioxide and producing oxygen, they transform the original anoxic atmosphere of the Earth over geological time. Aquatic photosynthesis is performed by a wide diversity of organisms, predominantly involving cyanobacteria, and algae derived from the “red-lineage”, unlike terrestrial primary productivity, which is restricted to “green-lineage” plants. Blue Planet, Red and Green Photosynthesis describes how, in order to maximize productivity, aquatic primary producers have evolved a series of structures and mechanisms that increase the limiting supply of carbon dioxide to the enzyme, Rubisco, which is responsible for carbon dioxide fixation. This book covers the molecular mechanisms involved in aquatic carbon uptake and the global consequences as humankind alters the blue planet.
Thoroughly revised to reflect new advances in the field, Savage & Aronson’s Comprehensive Textbook of Perioperative and Critical Care Echocardiography, Third Edition, remains the definitive text and reference on transesophageal echocardiography (TEE). Edited by Drs. Alina Nicoara, Robert M. Savage, Nikolaos J. Skubas, Stanton K. Shernan, and Christopher A. Troianos, this authoritative reference covers material relevant for daily clinical practice in operating rooms and procedural areas, preparation for certification examinations, use of echocardiography in the critical care setting, and advanced applications relevant to current certification and practice guidelines.
Authored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.
Diagnose tumors with confidence with Diagnostic Histopathology of Tumors, 4th Edition. Dr. Christopher Fletcher's renowned reference provides the advanced, expert guidance you need to evaluate and interpret even the most challenging histopathology specimens more quickly and accurately. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Diagnose efficiently and effectively using diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Employ immunohistochemistry, molecular and genetic diagnostic tests, and other modern techniques as well as the best morphologic diagnostic methods to effectively identify each tumor or tumor-like entity. Utilize new, clinically important molecular genetic data and updated classification schemes to help guide treatment and targeted therapy. Apply the latest techniques and diagnostic criteria with completely rewritten chapters on Small and Large Intestines, Heart, Larynx and Trachea, Ear, and Peritoneum. Find critical information quickly thanks to more tables and bulleted lists throughout.
Extracorporeal circulation has become firmly established as an invaluable and routine adjunct to cardiac and vascular surgery. Since its introduction in 1953, the technique has evolved rapidly with advancing technology leading to improvements in and simplification of the equipment involved. Developments in the understanding and application of basic
Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher's Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out. - Discusses the latest developments in immunohistochemistry, molecular genetics, targeted therapy/personalized medicine, and prognostic/predictive markers to assist in the diagnosis of the complete range of neoplastic entities. - Includes coverage of newly described variants and new histologic entities. - Covers all modern diagnostic techniques while retaining a strong emphasis on morphologic diagnosis, which remains the cornerstone of diagnosis for most lesions. - Features thousands of high-quality photographs, photomicrographs, and artwork throughout. - Incorporates the latest TNM and WHO classification and staging systems. - Contains diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. - Shares the knowledge and expertise of internationally renowned experts in tumor pathology, including Dr. Christopher Fletcher, as well as numerous global authorities in the field.
New chapters, new editors and contributors make Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 5th Edition, the most current and complete reference available in this evolving field. Editors Scott R. Lambert and Christopher J. Lyons, both globally recognized leaders, provide authoritative coverage of all the pediatric ophthalmic conditions you’re likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Expert guidance on the complete spectrum of childhood eye disorders and strabismus, including a unique "practical problems" section designed to help you handle difficult patient situations. More than 1,800 high-quality images and artworks provide visual guidance in diagnosis and management. A practical "how to" perform strabismus surgery chapter with extensive step-by-step artworks for complete visual guidance. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Comprehensive updates of all topics, with nine brand-new chapters covering significant advances in the management of refractive errors in children; binocular vision; conjunctival tumors; optimal approaches to patient-family communication, and a unique chapter on the impact of mobile apps for the pediatric ophthalmologist. State-of-the-art coverage of key areas such as OCT and all of the newest imaging techniques for the eye, orbit and visual pathways; anti-VEGF treatment for retinopathy of prematurity; and minimally invasive strabismus surgery. An expanded video collection with more than 60 narrated instructional clips depicting multiple diagnostic and surgical techniques. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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