Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.
A fascinating natural history of an incredibly curious substance. “Preternaturally hardened whale dung” is not the first image that comes to mind when we think of perfume, otherwise a symbol of glamour and allure. But the key ingredient that makes the sophisticated scent linger on the skin is precisely this bizarre digestive by-product—ambergris. Despite being one of the world’s most expensive substances (its value is nearly that of gold and has at times in history been triple it), ambergris is also one of the world’s least known. But with this unusual and highly alluring book, Christopher Kemp promises to change that by uncovering the unique history of ambergris. A rare secretion produced only by sperm whales, which have a fondness for squid but an inability to digest their beaks, ambergris is expelled at sea and floats on ocean currents for years, slowly transforming, before it sometimes washes ashore looking like a nondescript waxy pebble. It can appear almost anywhere but is found so rarely, it might as well appear nowhere. Kemp’s journey begins with an encounter on a New Zealand beach with a giant lump of faux ambergris—determined after much excitement to nothing more exotic than lard—that inspires a comprehensive quest to seek out ambergris and its story. He takes us from the wild, rocky New Zealand coastline to Stewart Island, a remote, windswept island in the southern seas, to Boston and Cape Cod, and back again. Along the way, he tracks down the secretive collectors and traders who populate the clandestine modern-day ambergris trade. Floating Gold is an entertaining and lively history that covers not only these precious gray lumps and those who covet them, but presents a highly informative account of the natural history of whales, squid, ocean ecology, and even a history of the perfume industry. Kemp’s obsessive curiosity is infectious, and eager readers will feel as though they have stumbled upon a precious bounty of this intriguing substance.
This book has information of all New Jersey Civil War Regiment were organized in the state. This is a research base book to find the information about one or more of the New Jersey Regiments all in one place. The information is: who the commanding officers were are the organization (mustering in) of the regiment; what battles the regiment was involved in; the armies the regiment belonged to; total enrolled and break down of causalities; and when and where the regiment was organized and mustered out.
Cicero's Brutus (46 BCE), a tour-de-force of intellectual and political history, was written amidst political crisis: Caesar's defeat of the republican resistance at the battle of Thapsus. This magisterial example of the dialogue genre capaciously documents the intellectual vibrancy of the Roman Republic and its Greco-Roman traditions. This book studies the work from several distinct yet interrelated perspectives: Cicero's account of oratorical history, the confrontation with Caesar, and the exploration of what it means to write a history of an artistic practice. Close readings of this dialogue-including its apparent contradictions and tendentious fabrications-reveal a crucial and crucially productive moment in Greco-Roman thought. Cicero, this book argues, created the first nuanced, sophisticated, and ultimately 'modern' literary history, crafting both a compelling justification of Rome's oratorical traditions and also laying a foundation for literary historiography that abides to this day. This title is also available as Open Access on Cambridge Core.
Most of the poetry in this book was written during a 6-month period in the winter of 2002-2003. These are my collective thoughts from that time period addressing what I felt then in my heart. It comprises thoughts that I wished to share with people in my life but had not, be it because of distance, hurt, shyness, or anger. It was an attempt to express parts of myself that I had not shown to the world.
Although the passing of the Northwest Ordinance in 1787 banned African American slavery in the Upper Mississippi River Valley, making the new territory officially "free," slavery in fact persisted in the region through the end of the Civil War. Slaves accompanied presidential appointees serving as soldiers or federal officials in the Upper Mississippi, worked in federally supported mines, and openly accompanied southern travelers. Entrepreneurs from the East Coast started pro-slavery riverfront communities in Illinois, Wisconsin, Iowa, and Minnesota to woo vacationing slaveholders. Midwestern slaves joined their southern counterparts in suffering family separations, beatings, auctions, and other indignities that accompanied status as chattel. This revealing work explores all facets of the "peculiar institution" in this peculiar location and its impact on the social and political development of the United States.
Why were sonnet sequences popular in Renaissance England? In this study, Christopher Warley suggests that sonneteers created a vocabulary to describe, and to invent, new forms of social distinction before an explicit language of social class existed. The tensions inherent in the genre - between lyric and narrative, between sonnet and sequence - offered writers a means of reconceptualizing the relation between individuals and society, a way to try to come to grips with the broad social transformations taking place at the end of the sixteenth century. By stressing the struggle over social classification, the book revises studies that have tied the influence of sonnet sequences to either courtly love or to Renaissance individualism. Drawing on Marxist aesthetic theory, it offers detailed examinations of sequences by Lok, Sidney, Spenser, Shakespeare and Milton. It will be valuable to readers interested in Renaissance and genre studies, and post-Marxist theories of class.
Star of the previous year's basketball team, Jerry can't do anything right in the new season, but refuses to believe his new friend who, claiming to be a warlock, predicts Jerry's play won't improve until he changes his slovenly habits.
Coming to terms with the rhetorical arts of antiquity necessarily illuminates our own ideas of public discourse and the habits of speech to which they have led. Tacitus wrote the Dialogus at a time (ca. 100 CE) when intense scrutiny of the history, the definitions, and the immediate relevance of public speech were all being challenged and refashioned by a host of vibrant intellects and ambitious practitioners. This book challenges the notion that Tacitus sought to explain the decline of oratory under the Principate. Rather, from examination of the dynamics of argument in the dialogue and the underlying literary traditions there emerges a sophisticated consideration of eloquentia in the Roman Empire. Tacitus emulates Cicero's legacy and challenges his position at the top of Rome's oratorical canon. He further shows that eloquentia is a means by which to compete with the power of the Principate.
A vampire-flipped Dracula in which mortality means life…and life means death. Vampires Jonathan Harker, Lucy Westenra, and Mina Murray live in underground London, trying to keep the undead city safe from the rumored mortals above who seek to give them life, only to kill them. But when the authorities refuse to believe mortals, let alone the mysterious Count Dracula, are anything more than myth, they are on their own to keep their city eternally dead. New York Times best-selling writers Christopher Golden and Tim Lebbon team up with award-winning horror and fantasy artist Peter Bergting for this revamped twist on Dracula!
Key topics and basic laboratory training for beginning students This versatile laboratory manual is designed to support introductory undergraduate courses in forensic anthropology. Usable for both in-person and online classes and suitable to accompany any textbook or for use on its own as a text–lab manual hybrid, it provides basic training for beginner students in relevant methods of biological profile estimation and trauma assessment for use in medico-legal death investigations. Structured in a standard format for classes and existing texts, this manual offers a unique emphasis on lab exercises that align with general studies requirements and basic science competency. Each chapter begins with learning goals and an introductory section that outlines the topics to be covered. The discussion then leads students through the material, including periodic learning checks built into the structure of the chapter, followed by end-of-chapter exercises. Through clear explanations of fundamental principles, the complete medico-legal context is covered with respect to forensic anthropology. Basic information on bone biology, human osteology, and rules of evidence are also presented. Alongside its substantive text discussion of key topics, this manual’s exercises can be used in in-person laboratory classes while its learning checks can be completed by online students without access to skeletal material or casts. This book offers the necessary content to teach forensic anthropology regardless of the experience or location of students or the resources of specific colleges and universities.
The Transatlantic Collapse of Urban Renewal examines how postwar thinkers from both sides of the Atlantic considered urban landscapes radically changed by the political and physical realities of sprawl, urban decay, and urban renewal. With a sweep that encompasses New York, London, Berlin, Philadelphia, and Toronto, among others, Christopher Klemek traces changing responses to the challenging issues that most affected the lives of the world’s cities. In the postwar decades, the principles of modernist planning came to be challenged—in the grassroots revolts against the building of freeways through urban neighborhoods, for instance, or by academic critiques of slum clearance policy agendas—and then began to collapse entirely. Over the 1960s, several alternative views of city life emerged among neighborhood activists, New Left social scientists, and neoconservative critics. Ultimately, while a pessimistic view of urban crisis may have won out in the United States and Great Britain, Klemek demonstrates that other countries more successfully harmonized urban renewal and its alternatives. Thismuch anticipated book provides one of the first truly international perspectives on issues central to historians and planners alike, making it essential reading for anyone engaged with either field.
This text - primarily aimed at students of the fundamentals for process safety - presents the fundamentals of process safety in such a form those students, who typically lack such prior knowledge and experience, will fully understand and absorb the subject. The knowledge is presented in a coherent, integrated, academic framework, which is founded in fundamental science, especially in the disciplines of physics and chemistry. The text should help students find the subject more amenable to systematic study and more clearly related to other subjects covered in their curriculum. The information has been used in the teaching of a Process Safety module to undergraduate students of chemical engineering at the University of Bradford.
Play Ball!" Trenton Baseball fans waited a long time to hear this cry ring out in their hometown. And in 1994, minor-league baseball stormed into Trenton with the arrival of the Trenton Thunder and the construction of beautiful Mercer County Waterfront Park stadium. In this fascinating chronicle of the first three seasons of the Double-A Thunder franchise, Trenton Times sportswriter Christopher T. Edwards provides an insider's up-close-and-personal view of the people and events that have made the Thunder one of the most populare minor-league teams in the country.
For most people in the United States, going almost anywhere begins with reaching for the car keys. This is true, Christopher Wells argues, because the United States is Car Country—a nation dominated by landscapes that are difficult, inconvenient, and often unsafe to navigate by those who are not sitting behind the wheel of a car. The prevalence of car-dependent landscapes seems perfectly natural to us today, but it is, in fact, a relatively new historical development. In Car Country, Wells rejects the idea that the nation's automotive status quo can be explained as a simple byproduct of an ardent love affair with the automobile. Instead, he takes readers on a tour of the evolving American landscape, charting the ways that transportation policies and land-use practices have combined to reshape nearly every element of the built environment around the easy movement of automobiles. Wells untangles the complicated relationships between automobiles and the environment, allowing readers to see the everyday world in a completely new way. The result is a history that is essential for understanding American transportation and land-use issues today. Watch the book trailer: http://www.youtube.com/watch?v=48LTKOxxrXQ
Since its premiere in 1868, Wagner’s Die Meistersinger von Nürnberg has defied repeated upheavals in the cultural-political landscape of German statehood to retain its unofficial status as the German national opera. The work’s significance as a touchstone of national culture survived even such troubling episodes as its public endorsement in 1933 as ‘the most German of all German operas’ by Joseph Goebbels or the rendition in previous years by audiences at Bayreuth of both national and Nazi-party anthems at the work’s culmination. This chequered reception history and apparent propensity for reinterpretation or reclamation has long fuelled debates over the socio-political meanings of Wagner’s musical narrative. On the question of Beckmesser, for instance, heated arguments have surrounded the existence of antisemitic stereotypes in the work as well as their possible indication of a racial-political dimension to Sachs’s restoration of Nuremberg society. Through a combination of musical-textual analysis with critical theory, this book interrogates the ideological underpinnings of Die Meistersinger’s narrative. In four interconnected studies of the characters of Walther, Sachs, Beckmesser, and Eva, the book traces a critical potential within the opera’s construction of provincial and national identities and problematizes existing discourse around its depiction of race and gender.
Forming connections between human performance and design Engineering Psychology and Human Performance, 4e examines human-machine interaction. The book is organized directly from the psychological perspective of human information processing. The chapters generally correspond to the flow of information as it is processed by a human being--from the senses, through the brain, to action--rather than from the perspective of system components or engineering design concepts. This book is ideal for a psychology student, engineering student, or actual practitioner in engineering psychology, human performance, and human factors Learning Goals Upon completing this book, readers should be able to: * Identify how human ability contributes to the design of technology. * Understand the connections within human information processing and human performance. * Challenge the way they think about technology's influence on human performance. * show how theoretical advances have been, or might be, applied to improving human-machine interaction
This text provides a clear exposition of genetic principles and problems with comprehensive, up-to-date references. Specialists who have collaborated closely with industry give an inside authentic view of the genetics and breeding of industrial microorganisms such as yeasts, filamentous fungi, actinomycetes, pseudomonads, and other bacteria of major industrial significance. This book will be especially valuable to many professionals in the field of microbial genetics.
This book has information of all Pennsylvania Civil War Regiment (including the United States Colored Troops that were organized in the state). This is a research base book to find the information about one or more of the Pennsylvania Regiments and specific U.S. Colored Troops all in one place. The information is: who the commanding officers were are the organization (mustering in) of the regiment; what battles the regiment was involved in; the armies the regiment belonged to; total enrolled and break down of causalities; and when and where the regiment was organized and mustered out. This is the second book wrote by Christopher Cox. The title of the first is, History of Michigan Civil War Regiments: Artillery, Cavalry, Engineers, Infantry, and Sharpshooters.
Humans¾there's no understanding them, And no dealing with them either. Or even their planet. Pity the poor aliens, whose shape-changing ability should let them take over the planet Earth before the humans even know they're there-if it weren't for all that omnipresent pollution. Or consider another set of invaders, from a planet where the weather is always mild and the changing of the seasons is hardly noticeable. They land in force and their weapons are more powerful than those of the primitive humans-but they've never before had to deal with below-zero temperatures, flash floods or tornados-not to mention volcanoes. Then there were the aliens who noticed how belligerent humans were, and gave them the "gift" of TV-like devices which would show anything anywhere on Earth, which was sure to lead to war. Imagine how surprised the aliens were when the humans took the gadgets apart, improved them, and started spying on everything the aliens were up to, all over the galaxy. Humans don't make sense, they don't fight fair, and they're making aliens throughout interstellar space think seriously about pulling up stakes and moving to another galaxy! At the publisher's request, this title is sold without DRM (Digital Rights Management).
There’s nothing quite as controversial in American sports as college football’s national championship, making it common fodder for talk around the water cooler as well as loftier debates among professional journalists in the sports pages. Walsh takes a comprehensive view of over a century of controversy, breaking teams down into one of three categories: perennial powers, contenders, and former greats. He then reviews the ten most controversial championships, suggests candidates for the best overall football program, and concludes with some thoughts on the future of the BCS. A comprehensive appendix lists national champions since 1869; AP and USA Today/UPI final polls; final BCS standings; first-team All-Americans; and College Football Hall of Fame inductees.
It's the exciting sequel to Messiah CompleX! Cyclops has complete faith that his son, Cable, will do everything he can to protect the so-called mutant messiah - who he believes will save mutantkind. But he also knows what havoc former X-Man Lucas Bishop has wreaked in the nightmarish future. So now he's sent his black ops team, the X-Force, on a risky, time-traveling mission to save Cable and the child, completely unaware that there's something else waiting for them in the future. Something not even Bishop was counting on... Collects X-Force/Cable: Messiah War, X-Force (2008) #14-16, Cable (2008) #13-15.
Moisture dynamics in brick, stone and concrete has a controlling influence on the durability and performance of the built environment. Water Transport in Brick, Stone and Concrete provides a unified description of transport processes involving saturated and unsaturated flow in porous inorganic materials and structures. It sets out fundamental physics and materials science, mathematical description and experimental measurement as a basis for engineering design and construction practice. Now in its third edition, the book combines a systematic presentation of the scientific and technical principles with new analyses of topics such as sorption isotherms, temperature dependence of sorptivity, time-dependent properties of cement-based materials, layered materials, air-trapping and driving rain. It serves as an authoritative reference for research workers, practising engineers and students of civil, building, architectural and materials engineering. Much of the fundamental work is relevant to engineers in soil science and geotechnics, as well as oilfield, chemical and process engineering.
Ideas Have Consequences _ for Adventure! Hard-SF master and renowned John W. Campbell Analog regular Christopher Anvil astounds with mind-bending ideas and their often deadly (and darkly humorous) consequences. Morton Hommel, erstwhile Director of Banner Drug and Vitamin Laboratories, applies the science of pharmacology and the art of sweet reason to a world on the verge of a technological nervous breakdown. These "Hommels" are Anvil at his speculative best¾ all edited by modern-day SF master, Eric Flint! At the publisher's request, this title is sold without DRM (Digital Rights Management).
One of the world's leading social critics and educational theorists, Henry A. Giroux has contributed significantly to critical pedagogy, cultural studies, youth studies, social theory, and cultural politics. This new book offers a carefully selected cross-section of Giroux's many scholarly and popular writings, which bridge the theoretical and practical, integrate multiple academic disciplines, and fuse scholarly rigor with social relevance. The essays underscore the continuities and transformations in Giroux's thought, just as they offer invaluable approaches to understanding a range of social problems. Giroux's work suggests that a more humane and democratic world is possible and provides critical tools that can assist concerned citizens in bringing it into being.
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