“Supply Chain Risk Management is an issue that many companies face and yet few companies know how to deal with it in a systematic and pragmatic manner. While avoiding and reducing supply chain risks are certainly preferable, developing ways to restore and stabilize supply chain operations rapidly after a major disruption is critical for managing global supply chains. Sodhi and Tang present important concepts, frameworks, strategies, and analyses that are essential for managing supply chain risks. Not only does this book suggest some practical ways to work with different partners to manage the risks that are present in a global supply chain, it creates a framework that would enable practitioners to engage researchers to work on this important area.” —Thomas A. Debrowski, Executive Vice President, Worldwide Operations, Mattel, Inc. “When a firm outsources its operations to external suppliers, the firm is vulnerable to major and rare disruptions that can occur at any link in the global supply chain. Because these disruptions rarely occur, few firms take commensurable actions to identify, assess, mitigate and respond to various types of supply chain risks. By introducing frameworks and concepts along with several case studies and a review of academic literature, Sodhi and Tang treat this important subject with practical relevance and academic rigor. This book will bring practitioners and researchers to develop effective and efficient ways to manage supply chain risks.” —Marshall L. Fisher, UPS Professor, Professor of Operations and Information Management and Co-Director of Fishman-Davidson Center for Service and Operations Management, The Wharton School, University of Pennsylvania “This book ties observations in practice to methodologies and research. The rich case examples motivated the approaches and methodologies used to mitigate risks, and in the course of doing so, Sodhi and Tang provided insights on existing and new research opportunities. As a result, this book is highly relevant to both practitioners and academics. Also, the book is also written with management lessons on how risks can be mitigated, and how risks can be contained once disruptions have occurred. As such, it is also a book for management to gain insights and to develop management skills.” —Hau L. Lee, Thoma Professor of Operations, Information and Technology and Director of the Stanford Global Supply Chain Management Forum, Graduate School of Business, Stanford University “As companies have extended their supply chains globally and as the face increasing resource issues, they face a number of new risk challenges. While there are various case studies written about supply chain risks, this book gives a comprehensive treatment of the subject with clarity. The concepts and frameworks developed by Sodhi and Tang in this book would create awareness of this important and yet not well understood subject, and strategies described in this book would stimulate practitioners to develop a holistic approach for identifying, assessing, mitigating, and responding to different types of supply chain risks.” —Nick Wildgoose, Global Supply Chain Proposition Manager, Zurich Insurance
This issue of the Surgical Oncology Clinics of North America is devoted to Practical Radiation Oncology and is Guest Edited by Dr. Christopher Willett. Articles in this issue include: Radiotherapy After Mastectomy; Contemporary Radiotherapy in Head and Neck Cancer; Image Guided Brachytherapy: An Update for Gynecologic Surgeons; Radiation Therapy in the Current Management of Anal and Rectal Cancer; Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes; Contemporary Integration of Radiation Oncology with Surgery as Combined Modality Treatment; Chemoradiation Therapy: Localized Esophageal, Gastric, and Pancreatic Cancer; Stereotactic Body Radiotherapy for the Treatment of Primary and Metastatic Pulmonary Malignancies; Radiotherapy and Radiosurgery for Tumors of the Central Nervous System; Practical Radiation Oncology for Extremity Sarcomas; Radiation Therapy for Prostate Cancer; and Present and Future Innovations in Radiation Oncology.
Some people with psoriasis can also develop psoriatic arthritis, when the immune system attacks the joints as well, causing inflammation. Like psoriasis, psoriatic arthritis symptoms flare and subside, vary from person to person, and even change locations in the same person over time. Psoriatic arthritis can affect any joint in the body, and it may affect just one joint, several joints or multiple joints. For example, it may affect one or both knees. This issue will include articles on Genetic and Epigenetic aspects of psoriatic arthritis, Clinical features and diagnostic considerations in psoriatic arthritis, Natural history, prognosis and socioeconomic aspects of psoriatic arthritis, Etiology and pathogenesis of psoriasis and many more!
Mushrooms have been used as medicine for thousands of years and their value in boosting immunity, improving memory, and even fighting cancer is being recognized and documented in scientific research. Christopher Hobbs, a mycologist and herbalist at the forefront of contemporary research, profiles the most powerful medicinal mushrooms and explains the nutritional and medicinal compounds in each one. Detailed instructions cover how to select, store, and prepare each variety for use. Whether readers are growing or foraging their own mushrooms, or sourcing them from a local provider, this essential handbook will guide them in making health-boosting medicine. This publication conforms to the EPUB Accessibility specification at WCAG 2.0 Level AA.
Services Marketing: People, Technology, Strategy is the ninth edition of the globally leading textbook for Services Marketing by Jochen Wirtz and Christopher Lovelock, extensively updated to feature the latest academic research, industry trends, and technology, social media, and case examples.This book takes on a strong managerial approach presented through a coherent and progressive pedagogical framework rooted in solid academic research. It features cases and examples from all over the world and is suitable for students who want to gain a wider managerial view.Supplementary Material Resources:Resources are available to instructors who adopt this textbook for their courses. These include: (1) Instructor's Manual, (2) Case Teaching Notes, (3) PowerPoint deck, and (4) Test Bank. Please contact sales@wspc.com.Key Features:
Creating and Restoring Wetlands: From Theory to Practice, Second Edition describes the challenges and opportunities relating to the restoration of freshwater and estuarine wetlands in natural, agricultural, and urban environments in the coming century. This second edition is structured by clearly defined chapters based on specific wetland types (e.g. Peatlands, Mangroves) and with a consistent and coherent organization for ease of discoverability. The table of contents is divided into four main subjects: Foundations, Restoration of Freshwater Wetlands, Restoration of Estuarine Wetlands, and From Theory to Practice, each with multiple chapters. Part 1, Foundations, contains chapters describing definitions of wetlands, ecological theory used to guide restoration, and considerations on where to implement restoration on the landscape. In Parts 2 and 3, restoration of specific freshwater (marshes, forests, peatlands) and estuarine (tidal marshes, mangroves) wetlands are described. Part 4, From Theory to Practice, contains chapters describing performance standards to gauge success of projects and case studies describing small-scale and large-scale restoration projects of various freshwater and estuarine wetlands. Each chapter contains clearly labeled sections which assist the reader to quickly and easily key in on the subject matter that they are seeking. The approach of Creating and Restoring Wetlands is unique in that, in each chapter, it links ecological theory important to ecosystem restoration with practical techniques to undertake and implement successful wetland restoration projects, including recommendations for performance standards to gauge success as well as realistic expectations and timescales for achieving success. Each chapter ends with a summary table describing keys to ensure success for a given wetland ecosystem. - Each chapter ends with a summary table describing keys to ensure success for a given wetland ecosystem - Written by a single author, providing a consistent structure that is coherent, cohesive and well referenced - Contains case studies of small- and large-scale restoration activities ensuring relevance to individuals and organizations
From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology.
Despite decades of developments in immunization and drug therapy, tuberculosis remains among the leading causes of human mortality, and no country has successfully eradicated the disease. Reenvisioning tuberculosis from the perspective of population biology, this book examines why the disease is so persistent and what must be done to fight it. Treating tuberculosis and its human hosts as dynamic, interacting populations, Christopher Dye seeks new answers to key questions by drawing on demography, ecology, epidemiology, evolution, and population genetics. Dye uses simple mathematical models to investigate how cases and deaths could be reduced, and how interventions could lead to TB elimination. Dye's analysis reveals a striking gap between the actual and potential impact of current interventions, especially drug treatment, and he suggests placing more emphasis on early case detection and the treatment of active or incipient tuberculosis. He argues that the response to disappointingly slow rates of disease decline is not to abandon long-established principles of chemotherapy, but to implement them with greater vigor. Summarizing epidemiological insights from population biology, Dye stresses the need to take a more inclusive view of the factors that affect disease, including characteristics of the pathogen, individuals and populations, health care systems, and physical and social environments. In broadening the horizons of TB research, The Population Biology of Tuberculosis demonstrates what must be done to prevent, control, and defeat this global threat in the twenty-first century.
This book constitutes the refereed proceedings of the 10th International Symposium on Recent Advances in Intrusion Detection, RAID 2007, held in Gold Coast, Australia in September 2007. The 17 revised full papers presented were carefully reviewed and selected from 101 submissions. The papers are organized in topical sections on anomaly detection, attacks, system evaluation and threat assessment, malware collection and analysis, anomaly- and specification-based detection, and network intrusion detection.
Advanced Planning Systems (APS) are a key enabler of the supply chain management. However, APS are highly complex and difficult to comprehend. This book provides students with valuable insights into the capabilities of state-of-the-art APS and bridges the gap between theory (model building and solution algorithms), software implementation, and adaptation to a specific business case. Our business case – named Frutado – provides a unifying framework for illustrating the different planning tasks that arise in a company – from demand planning to the distribution of goods – that are addressed by APS. In addition, the book guides through interactive learning units which have been created and recorded for each module of SAP ́s APS. Learning units can be downloaded free of charge ready to be displayed in a web browser. Together, the textbook and the learning units provide the required skills to better understand the concepts, models, and algorithms underlying today ́s APS.
Strengthening of Concrete Structures Using Fiber Reinforced Polymers (FRP): Design, Construction and Practical Applications presents a best practice guide on the structural design and strengthening of bridge structures using advanced Fiber Reinforced Polymer (FRP) composites. The book briefly covers the basic concepts of FRP materials and composite mechanics, while focusing on practical design and construction issues, including inspection and quality control, paying special attention to the differences in various design codes (US, Japan, and Europe) and recommendations. At present, several design guides from the US, Japan, and Europe are available. These guidelines are often inconsistent and do not cover all necessary design and inspection issues to the same degree of detail. This book provides a critical review and comparison of these guidelines, and then puts forward best practice recommendations, filling a significant gap in the literature, and serving as an important resource for engineers, architects, academics, and students interested in FRP materials and their structural applications. Written from a practitioner's point-of-view, it is a valuable design book for structural engineers all over the world. - Includes a large quantity of design examples and structural software to facilitate learning and help readers perform routine design - Provides recommendations for best practices in design and construction for the strengthening of bridge structures using advanced fiber-reinforced polymer (FRP) composites - Presents comprehensive guidelines on design, inspection, and quality control, including laboratory and field testing information
This book discusses the functional ink systems of graphene and related two-dimensional (2D) layered materials in the context of their formulation and potential for various applications, including in electronics, optoelectronics, energy, sensing, and composites using conventional graphics and 3D printing technologies. The authors explore the economic landscape of 2D materials and introduce readers to fundamental properties and production technologies. They also discuss major graphics printing technologies and conventional commercial printing processes that can be used for printing 2D material inks, as well as their specific strengths and weaknesses as manufacturing platforms. Special attention is also paid to scalable production methods for ink formulation, making this an ideal book for students and researchers in academia or industry, who work with functional graphene and other 2D material ink systems and their applications. Explains the state-of-the-art 2D material production technologies that can be manufactured at the industrial scale for functional ink formulation; Provides starting formulation examples of 2D material, functional inks for specific printing methods and their characterization techniques; Reviews existing demonstrations of applications related to printed 2D materials and provides possible future development directions while highlighting current knowledge gaps; Gives a snapshot and forecast of the commercial market for printed GRMs based on the current state of technologies and existing patents.
Services Marketing: People, Technology, Strategy is the eighth edition of the globally leading textbook for Services Marketing by Jochen Wirtz and Christopher Lovelock, extensively updated to feature the latest academic research, industry trends, and technology, social media and case examples.This textbook takes on a strong managerial approach presented through a coherent and progressive pedagogical framework rooted in solid academic research. Featuring cases and examples from all over the world, Services Marketing: People, Technology, Strategy is suitable for students who want to gain a wider managerial view of Services Marketing.
Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher's Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out. - Discusses the latest developments in immunohistochemistry, molecular genetics, targeted therapy/personalized medicine, and prognostic/predictive markers to assist in the diagnosis of the complete range of neoplastic entities. - Includes coverage of newly described variants and new histologic entities. - Covers all modern diagnostic techniques while retaining a strong emphasis on morphologic diagnosis, which remains the cornerstone of diagnosis for most lesions. - Features thousands of high-quality photographs, photomicrographs, and artwork throughout. - Incorporates the latest TNM and WHO classification and staging systems. - Contains diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. - Shares the knowledge and expertise of internationally renowned experts in tumor pathology, including Dr. Christopher Fletcher, as well as numerous global authorities in the field.
Comprehensive and practice-oriented, the fully updated 3rd Edition of this easy-to-use text covers the full range of obstetric and gynecologic pathology, including information on treatment and patient management. Written largely by the pathology and clinical faculty at Harvard's Brigham and Women's Hospital, it covers the most up-to-date information available in the field, including molecular genetics and diagnostics. Drs. Christopher P. Crum and Marisa R. Nucci are joined by new editors Scott R. Granter, Brooke E. Howitt, Mana M. Parast, and Theonia K. Boyd, to provide complete, beautifully illustrated coverage of both neoplastic and non-neoplastic disorders of the female genital system, ideal for improving pathological diagnosis. - Provides distinct diagnostic/differential diagnostic criteria for any potential obstetric/gynecologic specimen encountered in practice. - Features more than 2,250 full-color images, key points at the end of each chapter, and an appendix with commonly used ICD-10 codes - Covers topics not often found in gynecologic pathology textbooks, such as vulvodynia, and diseases of the anus. - Approaches topics from a practice-oriented point of view, beginning with clinical presentation and progressing through histopathology, differential diagnosis, and treatment for each disorder. - Emphasizes new practice issues and their biologic basis including approaches to vulvar, cervical and endometrial precursors as well as the underpinnings of cervical, endometrial and ovarian cancer. - A comprehensive look at mesenchymal neoplasia, including not only lower genital tract and uterus but also the retroperitoneum. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Diagnose tumors with confidence with Diagnostic Histopathology of Tumors, 4th Edition. Dr. Christopher Fletcher's renowned reference provides the advanced, expert guidance you need to evaluate and interpret even the most challenging histopathology specimens more quickly and accurately. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Diagnose efficiently and effectively using diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Employ immunohistochemistry, molecular and genetic diagnostic tests, and other modern techniques as well as the best morphologic diagnostic methods to effectively identify each tumor or tumor-like entity. Utilize new, clinically important molecular genetic data and updated classification schemes to help guide treatment and targeted therapy. Apply the latest techniques and diagnostic criteria with completely rewritten chapters on Small and Large Intestines, Heart, Larynx and Trachea, Ear, and Peritoneum. Find critical information quickly thanks to more tables and bulleted lists throughout.
Benign Prostatic Hyperplasia presents all the treatments available - medical, surgical and therapeutic - for this important condition. Written by a renowned group from the Committee of the European Urology Foundation, this concise guide to BPH will be compulsory reading for all urologists and family physicians.
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.
Through a case-based approach, this book illustrates the best practices for all facets of breast cancer imaging - from screening of asymptomatic patients to cancer staging, identifying metastases, and assessing efficacy of treatment - in a succinct, practical source. Contributing authors from a wide range of subspecialties provide well-rounded guidance to meet the needs of today's multidisciplinary work environment. Presents multidisciplinary discussions on the advantages and/or limitations of all available modalities. Includes advice from leading experts on cross-sectional imaging, breast imaging, and PET/CT, with input from radiation oncology, medical oncology, and breast surgery, to span the complete spectrum of care from screening to diagnosis to treatment, reflecting today's team approach to patient care. Covers all imaging modalities to help you correlate disease presentations on mammography, CT, MR, US, and PET images. Offers a very practical, clinical, concise approach to the subject in a case-based format. Provides over 1,000 high-resolution images of disease appearance for comparison with the findings you encounter in your practice.
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