Stroll into Mantorville, and you get the sense that it is a place where you could comfortably live forever. Ghosts seem to feel the same way, and this excursion into the stories of their activity keeps pace with the feverish bustle buried in the towns heritage. From ruined breweries to opera house mummies, Christopher Larsen takes the measure of one of Minnesotas most historic and haunted places. The tale of his investigations might not rob Mantorville of its charm, but when you walk into a gift shop that was once a funeral parlor, you might be a little more susceptible to a shiver.
Examines the effects of the Spanish mission system on population structure and genetic variability in indigenous communities in northern Florida and southern Georgia during the 16th and 17th centuries This book examines the effects of the Spanish mission system on population structure and genetic variability in indigenous communities living in northern Florida and southern Georgia during the 16th and 17th centuries. Data on tooth size were collected from 26 archaeological samples representing three time periods: Late Precontact (~1200-1500), Early Mission (~1600-1650), and Late Mission (~1650-1700) and were subjected to a series of statistical tests evaluating genetic variability. Predicted changes in phenotypic population variability are related to models of group interaction, population demo-graphy, and genetic admixture as suggested by ethnohistoric and archaeological data. Results suggest considerable differences in diachronic responses to the mission environment for each cultural province. The Apalachee demonstrate a marked increase in variability while the Guale demonstrate a decline in variability. Demographic models of population collapse are therefore inconsistent with predicted changes based on population geneticsl, and the determinants of population structure seem largely local in nature. This book highlights the specificity with which indigenous communities responded to European contact and the resulting transformations in their social worlds.
Focusing on juvenile transfer and disposition evaluations, this volume provides an up-to-date integration of current law, science, and practice with respect to juvenile risk assessment, treatment needs/amenability, and sophistication-maturity. Included are perspectives relating to international practices, use of specialized assessment tools, and a separate chapter on resentencing following US Supreme Court decisions on juveniles sentenced to mandatory life without parole. This text will be a useful and comprehensive reference for forensic psychologists and other mental health professionals engaged in juvenile evaluation, as well as legal professionals, juvenile and criminal justice professionals, and others involved with juvenile assessment, decision-making, and rehabilitation.
Long 'on' the Tooth: Dental Evidence of Diet addresses human dental macroscopic and microscopic wear, as well as dental disease, as indicators of diet. The book focuses primarily on 350 pre-contact humans from North America dating from approximately 5,500 to 600 years ago. These populations had subsistence strategies ranging from terrestrial foraging to intensive maize agriculture. The study makes intra- and intergroup comparisons to elucidate dietary nuances that are largely beyond the reach of other means of dietary reconstruction. Finally, the book discusses the importance of using multiple dietary indicators in unison in order to provide paleodietary insights. Includes state-of-the-art dental microwear texture data Focuses on populations largely overlooked in archaeological and dental anthropology volumes Offers the first dental anthropology book to integrate dental pathology and dental microwear texture analysis
The essential guide to the science behind reading and its practical implications for classroom teaching in primary schools. Teaching children to read is one of the most important tasks in primary education and classroom practice needs to be underpinned by a secure foundation of knowledge. Teachers need to know what reading entails, how children learn to read and how it can be taught effectively. This book is an essential guide for primary teachers that explores the key technical and practical aspects of how children read with strong links to theory and how to translate this into the classroom. Bite-size chapters offer accessible research-informed ideas across all major key topics including phonics, comprehension, teaching children with reading difficulties and strategies for the classroom. Key features include: · Discussions of implications for the classroom · Questions for further professional discussions · Retrieval quizzes · Further reading suggestions · Glossary of key terms Christopher Such is a primary school teacher and the author of the education blog Primary Colour. He can be found on Twitter via @Suchmo83.
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.
A Doody's Core Title 2012 New applications of echocardiography, nuclear magnetic resonance, cardiovascular magnetic resonance, and cardiac computed tomography are rapidly developing and it is imperative that trainees and practitioners alike remain up to date in the latest developments. It is becoming increasingly difficult to remain abreast of these advances in each individual modality and thus it is no longer practical to focus on one at a time. In addition, training guidelines are changing and multimodality training has become the norm. Multimodality Imaging in Cardiovascular Medicine presents a clear and in-depth review of the available technologies and evidence supporting their appropriate clinical applications. Hundreds of outstanding images are included to support and augment the discussions from the leading experts in each modality. For maximum clinical value, rather than organize the content by imaging modality, the book is organized by disease so that the reader can utilize the book in real-time problem solving and decision making in daily clinical practice. Features of Multimodality Imaging in Cardiovascular Medicine Include More than 350 multimodality imaging examples of cardiovascular pathophysiology Corresponding text places the images into context at the interface with patient care State-of-the-art chapters contributed by the leading imaging experts
Reflecting recent major advances in the field, Müller's Imaging of the Chest, 2nd Edition, by Drs. Christopher M. Walker and Jonathan H. Chung, remains your go-to reference for all aspects of chest radiology, including the latest diagnostic modalities and interventional techniques. This exhaustive resource begins with a review of normal anatomy, progressing to expert coverage based first on how patients present in clinical practice, then on diagnosis or diagnostic category. This practical, easy-to-use format helps you effectively select and interpret the best imaging studies for the everyday challenges you face in thoracic imaging. Provides extensive new information on lung cancer screening, detailing the technique required to perform a lung cancer screening CT as well as how to interpret these examinations using ACR Lung-RADS. Contains four all-new chapters: Idiopathic pleuroparenchymal fibroelastosis, Interstitial pneumonia with autoimmune features, Non-infectious complications of lung and stem cell transplantation, and Leukemia. Updates you on recent advances regarding interstitial lung disease diagnosis, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), interstitial pneumonia with autoimmune features (IPAF), pleuroparenchymal fibroelastosis, and much more. Explains the recent CT classification in usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) diagnosis and what features are required to correctly categorize a CT into one of four specific patterns. Covers current topics such as bacterial, viral, fungal, and parasitic infections, and new staging and histologic classifications for various lung neoplasms including lung cancer and mesothelioma. Features more than 3,100 superior, large digital-quality images (many in full color) depicting all of the chest imaging findings you’re likely to see, and helping you distinguish between conditions with similar manifestations. Provides boxes highlighting key points to assist you with report writing, as well as suggestions for treatment and future imaging studies. Features a full-color design throughout, color-coded tables, classic signs boxes, and bulleted lists that highlight key concepts and get you to the information you need quickly.
Demonstrates how to actively persuade guests to participate in achieving sustainable hospitality and introduces a five-step methodology on how to directly and effectively involve them in saving energy and water, reducing food waste and cutting carbon.
Widely regarded as the definitive work on forensic psychotherapy, this major compendium is now published in paperback in one volume. This compendium of forensic psychotherapy brings together the contributions of over sixty authors and covers all aspects- both theoretical and applied- of this currently crystallizing field.
This issue of Hematology/Oncology Clinics is focused on Prostate Cancer and highlights topics such as: Prevention, Early Detection, Biomarkers, Risk stratification, Imaging in Prostate Cancer, Adjuvant hormonal therapy, Management of patient with biochemical relapse, Management of patient with newly metastatic disease, and Bone Health Management.
From snot and phlegm to earwax and eye gunk, there's some pretty gross stuff in that body of yours! But why do you have all that sticky slime inside you? And why does it build up sometimes and make you feel so rotten? Learn all about the nasty stuff in yo
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