Sanitary reform was one of the great debates of the nineteenth century. This reset edition makes available a modern, edited collection of rare documents specifically addressing sanitary reform. An extensive general introduction sets the material in context and extends the debate to provide a contemporary international perspective.
Sanitary reform was one of the great debates of the nineteenth century. This reset edition makes available a modern, edited collection of rare documents specifically addressing sanitary reform. An extensive general introduction sets the material in context and extends the debate to provide a contemporary international perspective.
Sanitary reform was one of the great debates of the nineteenth century. This reset edition makes available a modern, edited collection of rare documents specifically addressing sanitary reform. An extensive general introduction sets the material in context and extends the debate to provide a contemporary international perspective.
Founded in 1900, the National Civic Federation (NCF), a broad-based, nongovernmental social and policy reform organization, emerged throughout the Progressive Era as one of the nation's most powerful policy research and lobbying groups. Amidst the strong demand by rank-and-file Americans for economic and social reform, the NCF proposed that the government begin to assume a more prominent role in managing the nation's economy and providing for the needs of the country's weakest and most vulnerable citizens. The organization constructed broad-based coalitions of business leaders, labor leaders, social scientists, and politicians with diverse backgrounds to fashion model legislation and promote public policy aimed at meeting the demands created by modern capitalism. Cyphers' work challenges the longstanding assumption that organizations like the NCF existed simply to build a relationship between big business and the government for the sole benefit of big business. He argues that the NCF sought the preservation of the fundamental tenets of American liberalism and the redefinition of this liberalism for a modern polity whose life was shaped by industrial and commercial capitalism. It saw the individual states, rather than the federal government, as the ideal mechanism to promote uniform economic and social reform. Cyphers also charts the origins of civic cooperation and the creation of voluntary associations as alternatives to the statist remedies to modern economic and social problems that were championed by America's early 20th-century socialist movement.
Master storyteller and internationally bestselling author Christopher Paolini returns to the World of Eragon in this stunning epic fantasy set a year after the events of the Inheritance Cycle. Join Dragon Rider—and fan favorite—Murtagh and his dragon as they confront a perilous new enemy! “Christopher Paolini is a true rarity.” —The Washington Post The world is no longer safe for the Dragon Rider Murtagh and his dragon, Thorn. An evil king has been toppled, and they are left to face the consequences of the reluctant role they played in his reign of terror. Now they are hated and alone, exiled to the outskirts of society. Throughout the land, hushed voices whisper of brittle ground and a faint scent of brimstone in the air—and Murtagh senses that something wicked lurks in the shadows of Alagaësia. So begins an epic journey into lands both familiar and untraveled, where Murtagh and Thorn must use every weapon in their arsenal, from brains to brawn, to find and outwit a mysterious witch. A witch who is much more than she seems. In this gripping novel starring one of the most popular characters from Christopher Paolini’s blockbuster Inheritance Cycle, a Dragon Rider must discover what he stands for in a world that has abandoned him. Murtagh is the perfect book to enter the World of Eragon for the first time . . . or to joyfully return. Praise for Christopher Paolini: “A spellbinding fantasy writer.” —The Boston Globe “A breathtaking and unheard-of success.” —USA Today “Make[s] literary magic.” —People
A stunning deluxe edition of Christopher Paolini’s instant #1 New York Times bestseller set in the World of Eragon, featuring fan favorite Murtagh and his dragon—with exclusive features and new content: • A long-anticipated scene featuring Eragon and Murtagh • Stunning red decorative stained and stenciled edges • A gorgeous, embellished foil-stamped cover • Never-before-seen full-color maps of Alagaësia and, for the first time, the world beyond • A full-color painting of Mt. Arngor • A letter from Jeod • Two pieces of original black-and-white artwork by Christopher Paolini The world is no longer safe for the Dragon Rider Murtagh and his dragon, Thorn. An evil king has been toppled, and they are left to face the consequences of the reluctant role they played in his reign of terror. Now they are hated and alone, exiled to the outskirts of society. Throughout the land, hushed voices whisper of brittle ground and a faint scent of brimstone in the air—and Murtagh senses that something wicked lurks in the shadows of Alagaësia. So begins an epic journey into lands both familiar and untraveled, where Murtagh and Thorn must use every weapon in their arsenal, from brains to brawn, to find and outwit a mysterious witch. A witch who is much more than she seems. In this gripping novel starring one of the most popular characters from Christopher Paolini’s blockbuster Inheritance Cycle, a Dragon Rider must discover what he stands for in a world that has abandoned him. Murtagh is the perfect book to enter the World of Eragon for the first time . . . or to joyfully return. Praise for Christopher Paolini: “A spellbinding fantasy writer.” —The Boston Globe “A breathtaking and unheard-of success.” —USA Today “The prince of dragons.” —Rolling Stone
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
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