Paul Rudolph, one of the twentieth century’s most iconoclastic architects, is best known – and most maligned – for his large “brutalist” buildings, like Yale’s Art and Architecture Building. So it will surprise many to learn that early in his career he developed a series of houses that represent the unrivaled possibilities of a modest American modernism. With their distinctive natural landscapes, local architectural precedents, and exploitation of innovative construction materials, the Florida houses, some eighty projects built between 1946 and 1961, brought modern architectural form into a gracious subtropical world of natural abundance developed to a high pitch of stylistic refinement. Paul Rudolph: The Florida Houses reveals all of Rudolph’s early residential work. With Rudolph’s personal essays and renderings, duotone photographs by Ezra Stoller and Joseph Molitor, and insightful text by Joseph King and Christopher Domin, this compelling new book conveys the lightness, timelessness, strength, materiality, and transcendency of Rudolph’s work.
In The Resurrection of the Messiah, Christopher Bryan combines literary, historical, and theological approaches in a study of the doctrine of the Resurrection. The book is divided into three parts. The first section provides a careful and sympathetic description of first-century Jewish and pagan opinions and beliefs about death and what might follow. This is followed by a presentation of a general account of early Christian claims about the death and resurrection of Jesus of Nazareth. The second part of the book offers a detailed, full-length commentary on and exegesis of the main New Testament texts that speak of Jesus' death and resurrection: 1 Corinthians 15 and the narratives in the four canonical gospels. As a framework for this commentary, Bryan utilizes the pattern of apostolic preaching presented by Paul and then echoed by each of the four evangelists, namely the formula "Christ died, Christ was buried, Christ has been raised, Christ appeared." The final section of the book is spent discussing and evaluating various proposals that have been made by those attempting to explain the data in ways that differ from the traditional Christian explanation. Bryan also considers various theological and ethical implications of accepting the claim "Jesus Christ has been raised from the dead." Throughout his study, Bryan exhibits a willingness to face hard questions as well as an appropriate reverence for a faith that for almost two thousand years has enabled millions of people to lead lives of meaning and grace.
Commentary from Christopher Ash Sets Out a Deeply Christian Study of Psalms 51–100 While reading Psalms, it is common for commentaries to focus on Old Testament meaning, without connecting it deeply to Christ's fulfillment in the New Testament. By studying Scripture this way, believers miss out on the fullness of God's word. The key to experiencing authentically Christian worship is learning a Christ-focused approach to praying and singing the Psalms. In this thorough commentary, Christopher Ash provides a careful treatment of Psalms 51–100, examining each psalm's significance to David and the other psalmists, to Jesus during his earthly ministry, and to the church of Christ in every age. Ash includes introductory quotations, a deep analysis of the text's structure and vocabulary, and a closing reflection and response, along with selected quotations from older readings of the Psalms. Perfect for pastors, Bible teachers, and students, this commentary helps readers sing and pray the Psalms with Christ in view. Exhaustive: Christopher Ash's exegesis explores how the Psalms are quoted and echoed throughout the New Testament Applicable and Heartfelt: Explains how a Christ-centered approach to reading the Psalms influences doctrines of prayer, prophecy, the Trinity, ecclesiology, and more Ideal for Pastors and Serious Students of Scripture: Written for Bible teachers, Sunday school and youth leaders, and small-group leaders
Social Inequality and Social Stratification in US Society uses a historical and conceptual framework to explain social stratification and social inequality. The historical scope gives context to each issue discussed and allows the reader to understand how each topic has evolved over the course of American history. The author uses qualitative data to help explain socioeconomic issues and connect related topics. Each chapter examines major concepts, so readers can see how an individual’s success in stratified settings often relies heavily on their access to valued resources—types of capital which involve finances, schooling, social networking, and cultural competence. Analyzing the impact of capital types throughout the text helps map out the prospects for individuals, families, and also classes to maintain or alter their position in social-stratification systems.
Examining the interdependent nature of substance, space, and subjectivity, this book constitutes an interdisciplinary analysis of the intoxication indigenous to what has been termed "our narcotic modernity." The first section – Drug/Culture – demonstrates how the body of the addict and the social body of the city are both inscribed by "controlled" substance. Positing addiction as a "pathology (out) of place" that is specific to the (late-)capitalist urban landscape, the second section – Dope/Sick – conducts a critique of the prevailing pathology paradigm of addiction, proposing in its place a theoretical reconceptualization of drug dependence in the terms of "p/re/in-scription." Remapping the successive stages or phases of our narcotic modernity, the third section – Narco/State – delineates three primary eras of narcotic modernity, including the contemporary city of "safe"/"supervised" consumption. Employing an experimental, "intra-textual" format, the fourth section – Brain/Disease – mimics the sense, state or scape of intoxication accompanying each permutation of narcotic modernity in the interchangeable terms of drug, dream and/or disease. Tracing the parallel evolution of "addiction," the (late-)capitalist cityscape, and the pathological project of modernity, the four parts of this book thus together constitute a users’ guide to urban space.
Emphasizing fiber-matrix adhesion and its characterization in composite materials, reports results from applying the most commonly used test methods, such as fragmentation, pull-out, and indentation, to high-performance composites and their constituents. The 13 papers were presented at a symposium i
This book follows the story of the Second French Republic from its idealistic beginnings in February 1848 to its formal replacement in December 1852 by the Second Empire. Based on original archival research, The Second French Republic gives a detailed account of the internal tensions that irrevocably weakened France’s shortest republic. During this short period French political life was buffeted by strong and often contrary forces: universal manhood suffrage, fear of socialism, the President Louis-Napoleon Bonaparte, and the political ambitions of the military high command for the restoration of the monarchy.
Moneyball for the New England Patriots, award-winning sportswriter Christopher Price goes into the inner workings of the legendary football franchise in The Blueprint For years, the New England Patriots were a certifiable joke of a franchise. They were run on the cheap and were once the very example of how not to manage a team. They hired inept coaches--one of whom (Clive Rush) was nearly electrocuted when he grabbed a microphone at his introductory press conference. In 1968 their scouting director, Ed McKeever, suggested they draft a wide receiver . . . before someone in the organization realized the player had been dead for six months. They plucked ex-players out of the stands minutes before kickoff--Bob Gladieux was enjoying a beer at the game when he heard his name called over the P.A. (The Patriots had cut a player earlier that morning and found themselves short. Gladieux, who would go on to spend four years in the league as a running back, made the tackle on the opening kickoff.) And they played in a run-down stadium that was one of the worst venues in professional sports. There were brief moments of success, but on each occasion, front-office infighting would invariably cause the franchise to slide back down to the basement again. But in the first four months of 2000, everything changed. The hiring of head coach Bill Belichick and Vice President of Player Personnel Scott Pioli and the drafting of quarterback Tom Brady turned the fortunes of the franchise around. And their nontraditional approach to acquiring personnel--remembering that it's not about collecting talent, it's about assembling a team--quickly led to three Super Bowl titles in four seasons. It's a feat that, in the salary cap era, with free agency, planned parity and balanced scheduling, is in many ways even more impressive than anything achieved by the past dynasties of Green Bay, Pittsburgh, Dallas, and San Francisco. Along the way, Christopher Price has had a front-row seat for football history, chronicling the rise to power of the NFL's unlikeliest superpower. Price takes the reader inside the franchise to give him a dynamic portrait of a mighty organization at the height of its power. Readers are immersed in the locker room during the strange and tumultuous days of 2001 and 2003, when major personnel moves involving a pair of the most popular players in franchise history--Drew Bledsoe and Lawyer Milloy--threatened to rock their championship foundation to the core. Readers get an up-close look at the team that dominated the league on the way to a record-setting winning streak in 2004. And Price analyzes what went wrong when they fell short in 2005 and 2006, and how they plan to return to Super Bowl form. The Blueprint explores how the Patriots went from the dregs to a dynasty, becoming the gold standard for professional sports franchises everywhere. It will prompt sports fans (and those who study organizations) to acknowledge what many football insiders have believed for a long time: when it comes to building a successful system, the Patriots have the Blueprint.
Before the French Revolution, tens of thousands of foreigners served in France’s army. They included troops from not only all parts of Europe but also places as far away as Madagascar, West Africa, and New York City. Beginning in 1789, the French revolutionaries, driven by a new political ideology that placed "the nation" at the center of sovereignty, began aggressively purging the army of men they did not consider French, even if those troops supported the new regime. Such efforts proved much more difficult than the revolutionaries anticipated, however, owing to both their need for soldiers as France waged war against much of the rest of Europe and the difficulty of defining nationality cleanly at the dawn of the modern era. Napoleon later faced the same conundrums as he vacillated between policies favoring and rejecting foreigners from his army. It was not until the Bourbon Restoration, when the modern French Foreign Legion appeared, that the French state established an enduring policy on the place of foreigners within its armed forces. By telling the story of France’s noncitizen soldiers—who included men born abroad as well as Jews and blacks whose citizenship rights were subject to contestation—Christopher Tozzi sheds new light on the roots of revolutionary France’s inability to integrate its national community despite the inclusionary promise of French republicanism. Drawing on a range of original, unpublished archival sources, Tozzi also highlights the linguistic, religious, cultural, and racial differences that France’s experiments with noncitizen soldiers introduced to eighteenth- and nineteenth-century French society. Winner of the Walker Cowen Memorial Prize for an Outstanding Work of Scholarship in Eighteenth-Century Studies
* Marshalls the arguments for affirmative action* Offers strategies for actionWhy is affirmative action under attack? What were the policy’s original purposes, and have they been achieved? What are the arguments being arrayed against it? And–for all stakeholders concerned about equity and diversity on campus–what’s the way forward, politically, legally, and practically?The authors explore the historical context, the philosophical and legal foundations of affirmative action, present contemporary attitudes to the issue on and off campus, and uncover the tactics and arguments of its opponents. They conclude by offering strategies to counter the erosion of affirmative action, change the basis of the discourse, and coordinate institutional support to foster inclusive college environments and multi-ethnic campus communities.This book analyzes the ideological and legal construction of colorblind legislation that has led to the de facto exclusion of people of color from institutions of higher education. It addresses the role of the courts in affecting affirmative action in higher education as a workplace and place of study. It documents the under-representation of collegians of color and presents research on student opinion on race-based policies at two- and four-year institutions. It details the pervasiveness of the affirmative action debate across educational sectors and the status of race among myriad factors considered in college admissions. Finally, it considers affirmative action as a pipeline issue and in the light of educational policy.
Until the recent political shift pushed workers back into the media spotlight, the mainstream media had largely ignored this significant part of American society in favor of the moneyed "upscale" consumer for more than four decades. Christopher R. Martin now reveals why and how the media lost sight of the American working class and the effects of it doing so. The damning indictment of the mainstream media that flows through No Longer Newsworthy is a wakeup call about the critical role of the media in telling news stories about labor unions, workers, and working-class readers. As Martin charts the decline of labor reporting from the late 1960s onwards, he reveals the shift in news coverage as the mainstream media abandoned labor in favor of consumer and business interests. When newspapers, especially, wrote off working-class readers as useless for their business model, the American worker became invisible. In No Longer Newsworthy, Martin covers this shift in focus, the loss of political voice for the working class, and the emergence of a more conservative media in the form of Christian television, talk radio, Fox News, and conservative websites. Now, with our fractured society and news media, Martin offers the mainstream media recommendations for how to push back against right-wing media and once again embrace the working class as critical to its audience and its democratic function.
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Take an eclectic, evidence-based approach to orthopaedic manual therapy. From theory through practical application of soft tissue and joint mobilization techniques—this comprehensive resource delivers the depth and breadth of coverage you need to optimize patient outcomes through informed clinical decision-making as part of a comprehensive intervention regimen.
Autism is not a single disease but a syndrome of different diseases. In this completely reworked and updated third edition, two world authorities, Christopher Gillberg and Mary Coleman, address the difficulties this presents for clinical diagnosis with diagnostic aids and clear guidelines for medical evaluation. Epidemiology, neuropsychological studies and behavior complexes, such as self-injury, are reviewed in detail, and the authors give a detailed explanation of what is known about the molecular biology and genetics of autism. Epilepsy and electrophysiological studies are also covered, as well as biochemistry, endocrinology, immunology, brain imaging and neuropathology. The available medical therapies are reviewed, along with an update on what is known about other interventions, such as psychoeducational and behavioral modification procedures. The book concludes with an integration of current knowledge from diverse fields. This is an essential text for clinicians and will also be of interest to parents of autistic children.
One of the North’s greatest generals—the Rock of Chickamauga Most Southerners in the U.S. Army resigned their commissions to join the Confederacy in 1861. But at least one son of a distinguished, slaveholding Virginia family remained loyal to the Union. George H. Thomas fought for the North and secured key victories at Chickamauga and Nashville. Thomas’s wartime experiences transformed him from a slaveholder to a defender of civil rights. Remembered as the “Rock of Chickamauga,” Thomas became one of the most prominent Union generals and was even considered for overall command of the Union Army in Virginia. Yet he has been eclipsed by such names as Grant, Sherman, and Sheridan. Offering vivid accounts of combat, Einolf depicts the fighting from Thomas’s perspective to allow a unique look at the real experience of decision making on the battlefield. He examines the general’s recurring confrontations with the Union high command to make a strong case for Thomas’s integrity and competence, even as he exposes Thomas’s shortcomings and poor decisions. The result is a more balanced, nuanced picture than has previously been available. Probing Thomas’s personal character, Einolf reveals how a son of the South could oppose the views of friends and family. George Thomas: Virginian for the Union offers a fresh appraisal of an important career and lends new insight into the inner conflicts of the Civil War.
DIVSince the dawn of the millennium, no football team has enjoyed greater success than the New England Patriots, with 12 straight winning seasons, 10 playoff appearances, 5 Super Bowl trips, and 3 championship titles. Under coach Bill Belichick, the Patriots and quarterback Tom Brady have been a dominant force on the gridiron, a veritable dynasty in an era of NFL parity. But the history of this team, beginning long before the arrival of Belichick and Brady, includes more than 50 years of memorable games, all-star characters, and plenty of winning and losing moments./divDIV/divDIVRevised and updated to include the most recent NFL seasons, New England Patriots: The Complete Illustrated History immerses fans in the history of this beloved franchise through fascinating stories and hundreds of images. Award-winning sportswriter Christopher Price explores every era of Patriots football and introduces—or reintroduces—readers to all the team’s legendary players: from Gino Cappelletti and Babe Parelli in the early years to John Hannah and Mike Haynes in the 1970s; the surprise Super Bowl squad of Steve Grogan, Stanley Morgan, and Andre Tippett; the 1990s resurgence under coach Bill Parcells with Pro Bowlers Bruce Armstrong and Ben Coates; and up through the recent heroes like Wes Welker, Troy Brown, Mike Vrabel, Tedy Bruschi, Ty Law, and Brady./divDIV/divDIVFeaturing tons of glorious photos of these and many other Patriot icons, images of memorabilia spanning the team’s entire history, and an appendix of individual stats and team records, New England Patriots: The Complete Illustrated History is the ultimate celebration of an incomparable football franchise./div
Released in conjunction with the franchise’s 50th anniversary, this fully illustrated history of the New England Patriots celebrates the team from its origins in 1960 through its dynastic success in the new millenium. The book highlights the great players, coaches, teams, and moments that have made the Patriots one of the most successful franchises in NFL history. With chapters organized by era and articles profiling the top players and characters, New England Patriots: The Complete Illustrated History explores every aspect of Patriots history and traditions. Includes stats and some 200 photos.
There are four types of capital: economic, human, cultural, and social. The distribution of capital in home and school settings affects the types of educational outcomes and the quality of lifelong opportunities that individuals are able to enjoy. Resource availability and accessibility influence the success levels at which teaching and learning is experienced. Capital possession or acquisition impacts the ability to navigate the academic pipeline and to recognize the appropriate tools by which to do so. Minimal attempts have been taken to address different perspectives related to economic, human, cultural, and social capital. This book identifies the various tenets of capital as having shared similarities and/or differences, as well as reveals how the distribution of capital impacts educational settings. More specifically, this book reveals that given the increases in the parental education or the cultural capital of African Americans, no significant changes have occurred in the number of years that African-American children attend schools. This finding remains consistent in terms of the sort of cultural capital that they are able to gain. In sum, the research concludes that cultural capital does assume a significant role in the transfer of advantages that stem from middle- and upper-level socioeconomic backgrounds.
A riveting inside look at an elite unit within the Pentagon—the Defense Innovation Unit, also known as Unit X—whose mission is to bring Silicon Valley’s cutting-edge technology to America’s military: from the two men who launched the unit. A vast and largely unseen transformation of how war is fought as profound as the invention of gunpowder or advent of the nuclear age is occurring. Flying cars that can land like helicopters, artificial intelligence-powered drones that can fly into buildings and map their interiors, microsatellites that can see through clouds and monitor rogue missile sites—all these and more are becoming part of America’s DIU-fast-tracked arsenal. Until recently, the Pentagon was known for its uncomfortable relationship with Silicon Valley and for slow-moving processes that acted as a brake on innovation. Unit X was specifically designed as a bridge to Valley technologists that would accelerate bringing state of the art software and hardware to the battle space. Given authority to cut through red tape and function almost as a venture capital firm, Shah, Kirchhoff, and others in the Unit who came after were tasked particularly with meeting immediate military needs with technology from Valley startups rather than from so-called “primes”—behemoth companies like Lockheed, Raytheon, and Boeing. Taking us inside AI labs, drone workshops, and battle command centers—and, also, overseas to Ukraine’s frontlines—Shah and Kirchhoff paint a fascinating picture of what it takes to stay dominant in a fast-changing and often precarious geopolitical landscape. In an era when America’s chief rival, China, has ordered that all commercial firms within its borders make their research and technology available for military exploitation, strengthening the relationship between Washington and Silicon Valley was always advisable. Today, it is an urgent necessity.
Conveniently structured into five sections, The Routledge Research Companion to Outsourcing Security offers an overview of the different ways in which states have come to rely on private contractors to support interventions. Part One puts into context the evolution of outsourcing in Western states that are actively involved in expeditionary operations as well as the rise of the commercial security sector in Afghanistan. To explain the various theoretical frameworks that students can use to study security/military outsourcing, Part Two outlines the theories behind security outsourcing. Part Three examines the law and ethics surrounding the outsourcing of security by focusing on how states might monitor contractor behaviour, hold them to account and prosecute them where their behaviour warrants such action. The drivers, politics and consequences of outsourcing foreign policy are covered in Part Four, which is divided into two sections: section one is concerned with armed contractors (providing the provision of private security with the main driver being a capability gap on the part of the military/law enforcement agencies), and section two looks at military contractors (supporting military operations right back to antiquity, less controversial politically and often technologically driven). The final Part takes into consideration emerging perspectives, exploring areas such as gender, feminist methodology, maritime security and the impact of private security on the military profession. This book will be of much interest to students of military and security studies, foreign policy and International Relations.
Why our belief in government by the people is unrealistic—and what we can do about it Democracy for Realists assails the romantic folk-theory at the heart of contemporary thinking about democratic politics and government, and offers a provocative alternative view grounded in the actual human nature of democratic citizens. Christopher Achen and Larry Bartels deploy a wealth of social-scientific evidence, including ingenious original analyses of topics ranging from abortion politics and budget deficits to the Great Depression and shark attacks, to show that the familiar ideal of thoughtful citizens steering the ship of state from the voting booth is fundamentally misguided. They demonstrate that voters—even those who are well informed and politically engaged—mostly choose parties and candidates on the basis of social identities and partisan loyalties, not political issues. They also show that voters adjust their policy views and even their perceptions of basic matters of fact to match those loyalties. When parties are roughly evenly matched, elections often turn on irrelevant or misleading considerations such as economic spurts or downturns beyond the incumbents' control; the outcomes are essentially random. Thus, voters do not control the course of public policy, even indirectly. Achen and Bartels argue that democratic theory needs to be founded on identity groups and political parties, not on the preferences of individual voters. Now with new analysis of the 2016 elections, Democracy for Realists provides a powerful challenge to conventional thinking, pointing the way toward a fundamentally different understanding of the realities and potential of democratic government.
The author reads the Book of Revelation as a text firmly situated in the world of imperial Roman Asia Minor, where it was written. He argues that Revelation is a Christian version of that world, complete with its own gladiatorial combats and other public spectacles.
Commentary from Christopher Ash Sets Out a Deeply Christian Study of Psalms 101–150 While reading Psalms, it is common for commentaries to focus on Old Testament meaning, without connecting it deeply to Christ's fulfillment in the New Testament. By studying Scripture this way, believers miss out on the fullness of God's word. The key to experiencing authentically Christian worship is learning a Christ-focused approach to praying and singing the Psalms. In this thorough commentary, Christopher Ash provides a careful treatment of Psalms 101–150, examining each psalm's significance to David and the other psalmists, to Jesus during his earthly ministry, and to the church of Christ in every age. Ash includes introductory quotations, a deep analysis of the text's structure and vocabulary, and a closing reflection and response, along with selected quotations from older readings of the Psalms. Perfect for pastors, Bible teachers, and students, this commentary helps readers sing and pray the Psalms with Christ in view. Exhaustive: Christopher Ash's exegesis explores how the Psalms are quoted and echoed throughout the New Testament Applicable and Heartfelt: Explains how a Christ-centered approach to reading the Psalms influences doctrines of prayer, prophecy, the Trinity, ecclesiology, and more Ideal for Pastors and Serious Students of Scripture: Written for Bible teachers, Sunday school and youth leaders, and small-group leaders
The Oxford Handbook of Mesoamerican Archaeology provides a current and comprehensive guide to the recent and on-going archaeology of Mesoamerica. Though the emphasis is on prehispanic societies, this Handbook also includes coverage of important new work by archaeologists on the Colonial and Republican periods. Unique among recent works, the text brings together in a single volume article-length regional syntheses and topical overviews written by active scholars in the field of Mesoamerican archaeology. The first section of the Handbook provides an overview of recent history and trends of Mesoamerica and articles on national archaeology programs and practice in Central America and Mexico written by archaeologists from these countries. These are followed by regional syntheses organized by time period, beginning with early hunter-gatherer societies and the first farmers of Mesoamerica and concluding with a discussion of the Spanish Conquest and frontiers and peripheries of Mesoamerica. Topical and comparative articles comprise the remainder of Handbook. They cover important dimensions of prehispanic societies--from ecology, economy, and environment to social and political relations--and discuss significant methodological contributions, such as geo-chemical source studies, as well as new theories and diverse theoretical perspectives. The Handbook concludes with a section on the archaeology of the Spanish conquest and the Colonial and Republican periods to connect the prehispanic, proto-historic, and historic periods. This volume will be a must-read for students and professional archaeologists, as well as other scholars including historians, art historians, geographers, and ethnographers with an interest in Mesoamerica.
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.
This book presents an overview of Shiga toxin-producing E. coli (STEC), with in-depth coverage of key areas such as recent Shiga toxin-related poisonings in Europe and the US, the structure, production, and mechanism of action of Shiga toxin, and current methods of detection. The globalization of food production has introduced new risk factors and intensified existing hazards, complicating the assurance of food safety. Foodborne illness outbreaks, such as those related to STEC, are becoming more common and more dangerous. The threat that these bacterial toxins pose to the food supply is magnified by the frequent occurrence and severity of Shiga toxin-caused disease. As a result, STEC and their toxins remain a primary concern in food safety. This review serves as a key resource for scientists in the field and public health and regulatory officials charged with maintaining food safety. This book also looks to the future of treatment of Shiga toxin-associated disease, specifically the translation of lab bench science into clinical therapeutic strategies.
Part of the popular and well-regarded Clinical Anesthesia family of titles, and founded by Drs. Paul G. Barash, Bruce F. Cullen, and Robert K. Stoelting, Clinical Anesthesia Fundamentals, Second Edition, is a concise, highly visual resource covering the core concepts in anesthesiology. The editorial board comprised of Drs. Bruce F. Cullen, M. Christine Stock, Rafael Ortega, Sam R. Sharar, Natalie F. Holt, Christopher W. Connor, and Naveen Nathan, and their team of expert contributors clearly and simply present the information you need on key aspects of anesthesia for every specialty area and key organ systems. From physiology and pharmacology to anatomy and system-based anesthesia, it uses full-color graphics, easy-to-read tables, and clear, concise text to convey the essential principles of the field.
Get comprehensive, practical coverage of both surgical and non-surgical treatment approaches from the world's most trusted authorities in spine surgery and care. Rothman-Simeone and Herkowitz's The Spine, 7th Edition, edited by Drs. Steven R. Garfin, Frank J. Eismont, Gordon R. Bell, Jeffrey S. Fischgrund, and Christopher M. Bono, presents state-of-the-art techniques helping you apply today's newest developments in your practice. - Highlights critical information through the use of pearls, pitfalls, and key points throughout the text, as well as more than 2,300 full-color photographs and illustrations. - Offers a newly revised, streamlined format that makes it easier than ever to find the information you need. - Contains new chapters on the clinical relevance of finite element modeling and SI joint surgery. - Includes an expanded section on minimally invasive spine surgery, including recent developments and future directions. - Provides the latest evidence-based research from high-quality studies, including new randomized controlled trials for lumbar stenosis, surgery, fusion, and injections. - Presents the knowledge and expertise of new international contributors, as well as new editorial leadership from Dr. Steven Garfin. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Benjamin Franklin Cheatham was a Nashville native and a descendant of the city's founder, James Robertson. Born in 1820, he achieved fame through his military service in the Mexican War and, especially, the Civil War. After the war Cheatham farmed, ran for Congress, and, at the time of his death in 1866, was postmaster of Nashville. Cheatham was one of Nashville's most popular sons, and his funeral, which drew some thirty thousand people, was reportedly the largest ever held in the city.
The 2007–9 financial crisis threatened economic disaster on a scale not seen since the Great Depression, but rapid state action prevented the widely feared devastation. The German response was considerably more generous to banks than the American or British bailouts. Drawing on interviews and primary sources in government, private firms, and media, Mitchell explains how the structure of national financial systems and interbank relationships produced extensive private rescues and pressure on different states. Mitchell explores the different responses and results in Germany, the UK and the US using a combination of detailed case study analyses of the three countries' responses to the crisis and a quantitative analysis of patterns of state responses to financial crises. This book will be essential reading for scholars and advanced students of political economy, comparative politics, economic sociology, economics, and public policy.
Late in 1755, an army of British regulars and Massachusetts volunteers completed one of the cruelest, most successful military campaigns in North American history, capturing and deporting seven thousand French-speaking Catholic Acadians from the province of Nova Scotia, and chasing an equal number into the wilderness of eastern Canada. Thousands of Acadians endured three decades of forced migrations and failed settlements that shuttled them to the coasts of South America, the plantations of the Caribbean, the frigid islands of the South Atlantic, the swamps of Louisiana, and the countryside of central France. The Acadian Diaspora tells their extraordinary story in full for the first time, illuminating a long-forgotten world of imperial desperation, experimental colonies, and naked brutality. Using documents culled from archives in France, Great Britain, Canada, and the United States, Christopher Hodson reconstructs the lives of Acadian exiles as they traversed oceans and continents, pushed along by empires eager to populate new frontiers with inexpensive, pliable white farmers. Hodson's compelling narrative situates the Acadian diaspora within the dramatic geopolitical changes triggered by the Seven Years' War. Faced with redrawn boundaries and staggering national debts, imperial architects across Europe used the Acadians to realize radical plans: tropical settlements without slaves, expeditions to the unknown southern continent, and, perhaps strangest of all, agricultural colonies within old regime France itself. In response, Acadians embraced their status as human commodities, using intimidation and even violence to tailor their communities to the superheated Atlantic market for cheap, mobile labor. Through vivid, intimate stories of Acadian exiles and the diverse, transnational cast of characters that surrounded them, The Acadian Diaspora presents the eighteenth-century Atlantic world from a new angle, challenging old assumptions about uprooted peoples and the very nature of early modern empire.
Stand-Alone Commentary Set from Christopher Ash Sets Out a Deeply Christian Study of the Psalms While reading Psalms, it is common for commentaries to focus on Old Testament meaning, without connecting it deeply to Christ's fulfillment in the New Testament. By studying Scripture this way, believers miss out on the fullness of God's word. The key to experiencing authentically Christian worship is learning a Christ-focused approach to praying and singing the Psalms. In this in-depth, 4-volume commentary, Christopher Ash provides a thorough treatment of all 150 Psalms, examining each psalm's significance to David and the other psalmists, to Jesus during his earthly ministry, and to the church of Christ in every age. The first volume in the set is a detailed handbook that explains how to interpret the Psalms with Christ at the center. The remaining 3 volumes cover each psalm in depth, with introductory quotations, a deep analysis of the text's structure and vocabulary, and a closing reflection and response. Ash also includes selected quotations from older readings of the Psalms, including patristic, medieval, Reformation, and post-Reformation scholars. Perfect for pastors, Bible teachers, and students, this commentary set helps readers sing and pray the Psalms with Christ in view. Stand-Alone Commentary: Ash's research also builds on other commentaries for a comprehensive, thorough resource on the Psalms Exhaustive: Christopher Ash's exegesis includes all 150 Psalms and their superscriptions, and explores how the Psalms are quoted and echoed throughout the New Testament Applicable and Heartfelt: Explains how a Christ-centered approach to reading the Psalms influences doctrines of prayer, prophecy, the Trinity, ecclesiology, and more Ideal for Pastors and Serious Students of Scripture: Written for Bible teachers, Sunday school and youth leaders, and small-group leaders
John A. McClernand was a career politician, and those ambitions and qualities continued during his Civil War service. A member of the Illinois General Assembly and a U.S. Representative for 10 years, McClernard was connected to other prominent figures of the time such as Abraham Lincoln and Stephen Douglas. However, he is best known for his rivalry with Gen. Ulysses S. Grant, and this biography balances McClernard's political career with his military leadership and his place in the Union command structure.
Democratic elections are designed to create unequal outcomes: for some to win, others have to lose. This book examines the consequences of this inequality for the legitimacy of democratic political institutions and systems. Using survey data collected in democracies around the globe, the authors argue that losing generates ambivalent attitudes towards political authorities. Because the efficacy and ultimately the survival of democratic regimes can be seriously threatened if thelosers do not consent to their loss, the central themes of this book focus on losing: how losers respond to their loss and how institutions shape losing. While there tends to be a gap in support for the political system between winners and losers, it is not ubiquitous. The book paints a picture oflosers' consent that portrays losers as political actors whose experience and whose incentives to accept defeat are shaped both by who they are as individuals as well as the political environment in which loss is given meaning.Given that the winner-loser gap in legitimacy is a persistent feature of democratic politics, the findings presented in this book contain crucial implications for our understanding of the functioning and stability of democracies.
Brought by leaders in the field, Martin Christopher, Remko van Hoek and Carlos Mena, Leading Procurement Strategy will equip the reader with the skills, knowledge and tools needed to articulate an effective procurement strategy and embrace a transformational role to lead procurement teams. Ultimately, it will show the reader how procurement can become an influential function that delivers sustainable competitive advantage. Leading Procurement Strategy is a must-read for all senior procurement executives wishing to further enhance their skill set, master the latest developments in procurement strategy, and really come into their own as procurement leaders. By tackling the major issues that senior procurement practitioners encounter, this book equips readers with the skills to apply powerful and practical tools for managing procurement and supply. Leading Procurement Strategy provides the latest thinking in procurement and supply management within the broad perspective of different industries. The book is supported by an extensive range of real-world case studies drawn from the author's experiences, including Tesco, IKEA, Toyota, Coca-cola, and Apple. It includes forewords by David Noble, Group CEO of CIPS, and Peter Kraljic, Director Emeritus, McKinsey and Company.
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