This book reviews existing sensor technologies that are now being coupled with computational intelligence for the remote monitoring of physical activity and ex vivo biosignatures. In today’s frenetic world, consumers are becoming ever more demanding: they want to control every aspect of their lives and look for options specifically tailored to their individual needs. In many cases, suppliers are catering to these new demands; as a result, clothing, food, social media, fitness and banking services are all being democratised to the individual. Healthcare provision has finally caught up to this trend and is currently being rebooted to offer personalised solutions, while simultaneously creating a more effective, scalable and cost-effective system for all. The desire for personalisation, home monitoring and treatment, and provision of care in remote locations or in emerging and impoverished nations that lack a fixed infrastructure, is leading to the realisation that mobile technology might be the best candidate for achieving these goals. A combination of several technological, healthcare and financial factors are driving this trend to create a new healthcare model that stresses preventative ‘health-care’ rather than ‘sick-care’, and a shift from volume to value. Mobile healthcare (mhealth), which could also be termed the “internet of people”, refers to the integration of sensors and smartphones to gather and interpret clinical data from patients in real-time. Most importantly, with an ageing population suffering multiple morbidities, mhealth could provide healthcare solutions to enhance chronically ill patients’ quality of life.
Based on the highly-regarded Walls Manual of Emergency Airway Management and part of the Manual of Emergency Medicine series envisioned by leading authority in emergency medicine, Dr. Ron M. Walls, Manual of Neurologic Emergencies provides evidence-based, easy-to-read coverage on the diagnosis and management of neurologic emergencies. Through the direction and expertise of editors Drs. Andy S. Jagoda and Christopher A. Lewandowski, this reference is a practical guide to approaching the patient with a neurologic complaint in a systematic way, providing a hands-on framework for clinical decision making and therapeutic interventions.
New chapters, new editors and contributors make Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 5th Edition, the most current and complete reference available in this evolving field. Editors Scott R. Lambert and Christopher J. Lyons, both globally recognized leaders, provide authoritative coverage of all the pediatric ophthalmic conditions you’re likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Expert guidance on the complete spectrum of childhood eye disorders and strabismus, including a unique "practical problems" section designed to help you handle difficult patient situations. More than 1,800 high-quality images and artworks provide visual guidance in diagnosis and management. A practical "how to" perform strabismus surgery chapter with extensive step-by-step artworks for complete visual guidance. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Comprehensive updates of all topics, with nine brand-new chapters covering significant advances in the management of refractive errors in children; binocular vision; conjunctival tumors; optimal approaches to patient-family communication, and a unique chapter on the impact of mobile apps for the pediatric ophthalmologist. State-of-the-art coverage of key areas such as OCT and all of the newest imaging techniques for the eye, orbit and visual pathways; anti-VEGF treatment for retinopathy of prematurity; and minimally invasive strabismus surgery. An expanded video collection with more than 60 narrated instructional clips depicting multiple diagnostic and surgical techniques. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This book has information of all Minnesota Civil War Regiment were organized in the state. This is a research base book to find the information about one or more of the Minnesota Regiments all in one place. The information is: who the commanding officers were are the organization (mustering in) of the regiment; what battles the regiment was involved in; the armies the regiment belonged to; total enrolled and break down of causalities; and when and where the regiment was organized and mustered out.
The fiftieth anniversary of many major milestones in what is commonly called the African-American Civil Rights Movement was celebrated in 2013. Fifty years removed from the Birmingham campaign, the assassination of Medgar Evers, and the March on Washington and it is clear that the sacrifices borne by those generations in that decade were not in vain. Monuments, museums, and exhibitions across the world honor the men and women of the Movement and testify to their immeasurable role in redefining the United States. The second edition of Historical Dictionary of the Civil Rights Movement is a guide to the history of the African-American struggle for equal rights in the United States. The history of this period is covered in a detailed chronology, an introductory essay, and an extensive bibliography. The dictionary section has over 500 cross-referenced entries on important personalities, significant legal cases, local struggles, forgotten heroes, and prominent women in the Movement. This book is an excellent access point for students, researchers, and anyone wanting to know more about the Civil Rights Movement.
Change Management is a crucial process for gaining the competitive advantage that is the goal of many organisations. Leaders and change agents are often faced with conflicting challenges of motivating and understanding increasingly diverse workforces, accounting to stakeholders and planning for the future in a chaotic environment. Organisation Change: Development and Transformation, 7e takes both an organisational development and transformational approach to change, to reflect the environment of change faced by organisations today. With the field of organisational change continuing to evolve, especially in an international context, future directions of change management are also discussed. To emphasise the relationship between theory to practice, this text provides 10 local and international case studies, practitioner vignettes and a suite of online cases supported by a case matrix.
The term latex covers emulsion polymers, polymer dispersions and polymer colloids. This review report provides a general overview of the emulsion polymerisation processes and explains how the resulting latices are used in industrial applications. The classes of emulsion polymers are surveyed and the commercial technologies and potential future uses discussed. An additional indexed section containing several hundred abstracts from the Polymer Library gives useful references for further reading.
This volume aims to provide an in-depth view of the complete biochemistry of sulfur with an emphasis on aspects not covered elsewhere. Given its role in the formation of proteins and presence in the amino acids methionine and cysteine, sulfur is essential to life. Current literature on the biochemistry of sulfur is vast and widely dispersed, as such this volume is intended as a single-source for everything concerning sulfur biochemistry from metabolic roles of inorganic sulfur, to thiol and thioether chemical biology, to the university of cysteine chemistry in proteomes. Authored by a renowned biochemist and experienced writer and educator, this book is ideal for students and researchers in biochemistry, biology and the life sciences with an interest in sulfur and its role in life.
This book constitutes the refereed proceedings of the Third International Conference on Integration of AI and OR Techniques in Constraint Programming for Combinatorial Optimization Problems, CPAIOR 2006, held in Cork, Ireland in May/June 2006. The 20 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 67 submissions. The papers address methodological and foundational issues from AI, OR, and algorithmics and present applications to the solution of combinatorial optimization problems in various fields via constraint programming.
Cancer Screening and Genetics is reviewed extensively in this important Surgical Clinics of North America issue. Articles include: Cancer Genetics and Implications for Clinical Management; Epigenetics and Cancer; Screening and Early Detection of Cancer: Successes and Failures; Screening for Lung Cancer; Screening for Breast Cancer; Viral Hepatitis and Hepatocellular Cancer: How Should Patients Be Screened?; Screening for Pancreatic Cancer: Where Do We Stand?; Hereditary Colorectal Cancer: Genetics and Screening; Personalized Approach to Gastrointestinal Cancers; Screening for Colorectal Cancer; Screening for Prostate Cancer: Why the Controversy?; Gastric Cancer: East versus West—Is screening and early detection the difference?; and more!
Based on a DfES funded study of 300 teachers in 100 primary and secondary schools in England, the authors identify different patterns of influence and effect between groups of teachers, which provide powerful evidence of the complexities of teachers' work, lives, identity and commitment, in relation to their sense of agency, well-being, resilience and pupil attitudes and attainment. This, in turn, provides a clear message for teachers, teachers' associations, school leaders and policy makers internationally, in understanding and supporting the need to build and sustain school and classroom effectiveness.
Christopher Collins introduces an exciting new field of research traversing evolutionary biology, anthropology, archaeology, cognitive psychology, linguistics, neuroscience, and literary study. Paleopoetics maps the selective processes that originally shaped the human genus millions of years ago and prepared the human brain to play, imagine, empathize, and engage in fictive thought as mediated by language. A manifestation of the Òcognitive turnÓ in the humanities, Paleopoetics calls for a broader, more integrated interpretation of the reading experience, one that restores our connection to the ancient methods of thought production still resonating within us. Speaking with authority on the scientific aspects of cognitive poetics, Collins proposes reading literature using cognitive skills that predate language and writing. These include the brainÕs capacity to perceive the visible world, store its images, and retrieve them later to form simulated mental events. Long before humans could share stories through speech, they perceived, remembered, and imagined their own inner narratives. Drawing on a wide range of evidence, Collins builds an evolutionary bridge between humansÕ development of sensorimotor skills and their achievement of linguistic cognition, bringing current scientific perspective to such issues as the structure of narrative, the distinction between metaphor and metonymy, the relation of rhetoric to poetics, the relevance of performance theory to reading, the difference between orality and writing, and the nature of play and imagination.
Since the time of Turing, computer scientists have dreamed of building artificial general intelligence (AGI) - a system that can think, learn and act as humans do. Over recent years, the remarkable pace of progress in machine learning research has reawakened discussions about AGI. But what would a generally intelligent agent be able to do? What algorithms, architectures, or cognitive functions would it need? To answer these questions, we turn to the study of natural intelligence. Humans (and many other animals) have evolved precisely the sorts of generality of function that AI researchers see as the defining hallmark of intelligence. The fields of cognitive science and neuroscience have provided us with a language for describing the ingredients of natural intelligence in terms of computational mechanisms and cognitive functions and studied their implementation in neural circuits. Natural General Intelligence describes the algorithms and architectures that are driving progress in AI research in this language, by comparing current AI systems and biological brains side by side. In doing so, it addresses deep conceptual issues concerning how perceptual, memory and control systems work, and discusses the language in which we think and the structure of our knowledge. It also grapples with longstanding controversies about the nature of intelligence, and whether AI researchers should look to biology for inspiration. Ultimately, Summerfield aims to provide a bridge between the theories of those who study biological brains and the practice of those who are seeking to build artificial brains.
This IBM® RedpaperTM publication is a comprehensive guide covering the IBM Power 750 and Power 755 servers supporting AIX®, IBM i, and Linux® operating systems. The goal of this paper is to introduce the major innovative Power 750 and 755 offerings and their prominent functions, including: The POWER7TM processor available at frequencies of 3.0 GHz, 3.3 GHz, and 3.55 GHz The specialized POWER7 Level 3 cache that provides greater bandwidth, capacity, and reliability The 1 Gb or 10 Gb Integrated Virtual Ethernet adapter, included with each server configuration, and providing native hardware virtualization PowerVMTM virtualization including PowerVM Live Partition Mobility and PowerVM Active MemoryTM Sharing. Active Memory Expansion that provides more usable memory than what is physically installed on the system EnergyScaleTM technology that provides features such as power trending, power-saving, capping of power, and thermal measurement. Professionals who want to acquire a better understanding of IBM Power SystemsTM products should read this Redpaper. This Redpaper expands the current set of IBM Power Systems documentation by providing a desktop reference that offers a detailed technical description of the 750 and 755 systems. This paper does not replace the latest marketing materials and configuration tools. It is intended as an additional source of information that, together with existing sources, may be used to enhance your knowledge of IBM server solutions.
This IBM® RedpaperTM publication is a comprehensive guide covering the IBM Power 770 and Power 780 servers supporting IBM AIX®, IBM i, and Linux® operating systems. The goal of this paper is to introduce the major innovative Power 770 and 780 offerings and their prominent functions, including: Unique modular server packaging The specialized IBM POWER7TM Level 3 cache that provides greater bandwidth, capacity, and reliability The 1 Gb or 10 Gb Integrated Virtual Ethernet adapter that brings native hardware virtualization up to 64 logical ports on this server IBM PowerVMTM virtualization including PowerVM Live Partition Mobility and PowerVM Active MemoryTM Sharing Active Memory Expansion that provides more usable memory than what is physically installed on the system IBM EnergyScaleTM technology that provides features such as power trending, power-saving, capping of power, and thermal measurement Enterprise-ready reliability, serviceability, and availability Professionals who want to acquire a better understanding of IBM Power SystemsTM products should read this paper. This paper expands the current set of IBM Power Systems documentation by providing a desktop reference that offers a detailed technical description of the 770 and 780 systems. This paper does not replace the latest marketing materials and configuration tools. It is intended as an additional source of information that, together with existing sources, may be used to enhance your knowledge of IBM server solutions.
By tracing the history of depression in primary care over the past half century in the US and UK, this book opens a pathway for future improvements in the treatment of depressed patients. The authors argue for a public health perspective that will place more emphasis on the roles of society and culture in causing depression and will help close the gap between primary care practice and psychiatric knowledge.
This book examines an important figure of Hindu mythology and literature who until now has been almost entirely ignored by scholars of Indian religion: Pradyumna, the son of the Hindu god Krsna. Pradyumna: Lover, Magician and Scion of the Avatara assembles the most important narratives of this character, offering a long-view analysis of his evolving mythology over the period 300-1300 CE.
Quantitative Research Methods in Translation and Interpreting Studies encompasses all stages of the research process that include quantitative research methods, from conceptualization to reporting. In five parts, the authors cover: • sampling techniques, measurement, and survey design; • how to describe data; • how to analyze differences; • how to analyze relationships; • how to interpret results. Each part includes references to additional resources and extensive examples from published empirical work. A quick reference table for specific tests is also included in the appendix. This user-friendly guide is the essential primer on quantitative methods for all students and researchers in translation and interpreting studies. Accompanying materials are available online, including step-by-step walkthroughs of how analysis was conducted, and extra sample data sets for instruction and self study: https://www.routledge.com/9781138124967. Further resources for Translation and Interpreting Studies are available on the Routledge Translation Studies Portal: http://cw.routledge.com/textbooks/translationstudies.
Alabamians in Blue offers an in-depth scholarly examination of Alabama’s black and white Union soldiers and their contributions to the eventual success of the Union army in the western theater. Christopher M. Rein contends that the state’s anti-Confederate residents tendered an important service to the North, primarily by collecting intelligence and protecting logistical infrastructure. He highlights an underappreciated period of biracial cooperation, underwritten by massive support from the federal government. Providing a broad synthesis, Rein’s study demonstrates that southern dissenters were not passive victims but rather active participants in their own liberation. Ecological factors, including agricultural collapse under levies from both armies, may have provided the initial impetus for Union enlistment. Federal pillaging inflicted further heavy destruction on plantation agriculture. The breakdown in basic subsistence that ensued pushed Alabama’s freedmen and Unionists into federal camps in garrison cities in search of relief and the opportunity for revenge. Once in uniform, Alabama’s Union soldiers served alongside northern regiments and frustrated Confederate General Nathan Bedford Forrest’s attempts to interrupt the Union supply efforts in the 1864 Atlanta campaign, which led to the collapse of Confederate arms in the western theater and the eventual Union victory. Rein describes a “hybrid warfare” of simultaneous conventional and guerilla battles, where each significantly influenced the other. He concludes that the conventional conflict both prompted and eventually ended the internecine warfare that largely marked the state’s experience of the war. A comprehensive analysis of military, social, and environmental history, Alabamians in Blue uncovers a past of biracial cooperation in the American South, and in Alabama in particular, that postwar adherents to the “Myth of the Lost Cause” have successfully suppressed until now.
This work provides methods to measure and analyze features of atrial electrograms - especially complex fractionated atrial electrograms (CFAEs) - mathematically. Automated classification of CFAEs into clinical meaningful classes is applied and the newly gained electrogram information is visualized on patient specific 3D models of the atria. Clinical applications of the presented methods showed that quantitative measures of CFAEs reveal beneficial information about the underlying arrhythmia.
What can a theologian do with Deleuze? While using philosophy as a resource for theology is nothing new, Gilles Deleuze (1925-1995) presents a kind of limit-case for such a theological appropriation of philosophy: a thoroughly "modern" philosophy that would seem to be fundamentally hostile to Christian theology-a philosophy of atheistic immanence with an essentially chaotic vision of the world. Nonetheless, Deleuze's philosophy can generate many potential intersections with theology opening onto a field of configurations: a fractious middle between radical Deleuzian theologies that would think through theology and reinterpret it from the perspective of some version of Deleuzian philosophy and other theologies that would seek to learn from and respond to Deleuze from the perspective of confessional theology-to take from the encounter with Deleuze an opportunity to clarify and reform an orthodox Christian self-understanding.
The text offers a comprehensive and unique perspective on disaster risk associated with natural hazards. It covers a wide range of topics, reflecting the most recent debates but also older and pioneering discussions in the academic field of disaster studies as well as in the policy and practical areas of disaster risk reduction (DRR). This book will be of particular interest to undergraduate students studying geography and environmental studies/science. It will also be of relevance to students/professionals from a wide range of social and physical science disciplines, including public health and public policy, sociology, anthropology, political science and geology.
International Human Resource Management is a critically engaging and student friendly textbook for International HRM modules at all levels, including the CIPD Level 7 Advanced International HRM module. Providing wide international coverage and incorporating a global strategy perspective, it offers a particular focus on cross-cultural, comparative and strategic HRM issues, with a strong emphasis on culture and its impact on organizational behaviour and HRM. This fully updated 4th edition of International Human Resource Management includes extended coverage of cross-cultural management, a broader scope of countries and key topics such as global talent management, global leadership, global knowledge management, and differing national contexts. Filled with geographically diverse examples and case studies, and covering topics from culture and reward systems to managing expatriate assignment and diversity in international forms of working, it is an ideal textbook for all students of international HRM as well as HRM specialists and practicing managers. Online supporting resources include an instructor's manual, lecture slides and additional case studies.
Coleman and Hendry's bestselling text has now been completely revised and updated to take account of the many changes that have occurred over the last decade. The book has now been reformatted into textbook style.
How did the ancient Greeks and Romans envision the end of the world? What is the long-term future of the human race? Will the world always remain as it is or will it undergo a catastrophic change? What role do the gods, human morality, and the forces of nature play in bringing about the end of the world? In Apocalypse and Golden Age, Christopher Star reveals the answers that Greek and Roman authors gave to these questions. The first large-scale investigation of the various scenarios for the end of the world in classical texts, this book demonstrates that key thinkers often viewed their world as shaped by catastrophe. Star focuses on how this theme was explored over the centuries in the works of poets, such as Hesiod, Vergil, Ovid, and Lucan, and by philosophers, including the Presocratics, Plato, Epicurus, Lucretius, Cicero, and Seneca. With possibilities ranging from periodic terrestrial catastrophes to the total dissolution of the world, these scenarios address the ultimate limits that define human life and institutions, and place humanity in the long perspective of cosmic and natural history. These texts also explore various options for the rebirth of society after world catastrophe, such as a return of the Golden Age or the redevelopment of culture and political institutions. Greek and Roman visions of the end, Star argues, are not calls to renounce this world and prepare for a future kingdom. Rather, they are set within larger investigations that examine and seek to improve personal and political life in the present. Contextualizing classical thought about the apocalypse with biblical studies, Star shows that the seeds of our contemporary anxieties about globalization, politics, and technology were sown during the Roman period. Even the prevalent link between an earthly leader and the beginning of the end times can be traced back to Greek and Roman rulers, the emperor Nero in particular. Apocalypse and Golden Age enriches our understanding of apocalyptic thought.
The concept of surplus captures the politics of production and also conveys the active material means by which people develop the strategies to navigate everyday life. Surplus: The Politics of Production and the Strategies of Everyday Life examines how surpluses affected ancient economies, governments, and households in civilizations across Mesoamerica, the Southwest United States, the Andes, Northern Europe, West Africa, Mesopotamia, and eastern Asia.A hallmark of archaeological research on sociopolitical complexity, surplus is central to theories of political inequality and institutional finance. This book investigates surplus as a macro-scalar process on which states or other complex political formations depend and considers how past people—differentially positioned based on age, class, gender, ethnicity, role, and goal—produced, modified, and mobilized their social and physical worlds.Placing the concept of surplus at the forefront of archaeological discussions on production, consumption, power, strategy, and change, this volume reaches beyond conventional ways of thinking about top-down or bottom-up models and offers a comparative framework to examine surplus, generating new questions and methodologies to elucidate the social and political economies of the past.
Depression, now recognized as a significant source of disability across the globe, is something many of us will be familiar with. This book explores the way people have discussed depression and examines how scientific understanding has led to ways to better appreciate and treat the condition. Through evaluations of contemporary research and literature, this book examines how depression has been depicted throughout history and presents an up-to-date account of how a diagnosis is made. Offering a narrative steeped in cognitive neuropsychology and emotion regulation, chapters explore the different theories behind current explanations of why depression develops and how this understanding drives the different ways to treat and manage the condition. It presents a holistic approach that considers depression in the context of physical health and how it impacts across the lifespan. This book is an essential read for practising and trainee clinical psychologists, but its accessible and readable style will appeal to a broader audience of those looking to further understand depression.
This title was first published in 2002: Why are rates of suicidal behaviour in Chinese adolescents so high? What factors in school, community, family and interpersonal relationships cause this tragedy? Using key new research from leading researchers and social workers with first hand knowledge of these problems in Hong Kong, this enthralling study examines those most at risk and signposts the most effective interventions in therapy and strategic prevention programmes. The result is a highly original and readable account which will be compulsive reading for social workers and academics around the world.
Up to date and comprehensive, the New Edition of Fletcher's renowned Diagnostic Histopathology of Tumors provides you with today's best knowledge on the pathologic diagnosis of human tumors. This 3rd edition incorporates all of the latest ancillary diagnostic and prognostic techniques so you can effectively evaluate and confidently interpret suspected tumor specimens. Plus, more than 50 internationally recognized authorities and over 3,100 full-color illustrations provide you with an up-to-date account of tumor morphology, the application of modern diagnostic techniques (including molecular genetics), and key aspects of differential diagnosis. Features over 3,000 high-quality full-color illustrations, providing visual guidance to each tumor or tumor-like entity. Presents correlations of gross appearances to microscopic findings for virtually every tumor type. Includes detailed discussions of differential diagnosis. Provides full coverage of all the latest classification schemes. Incorporates the latest advances in molecular biology and immunohistochemistry throughout. Presents an increased focus on everyday diagnostic problems you are likely to encounter. Features extensively rewritten gynecology and hematology chapters. Uses additional diagnostic flow charts and summary tables for easy retrieval of information. Includes more differential diagnosis tables for better recognition and evaluation of similar looking entities.
Good communication between parents and doctors is the cornerstone of getting good care for the child. Doctors are increasingly pressed for time and appointment visits are shorter than ever. Unfortunately, when time is short, what often suffers is explaining to parents what to expect and why. There is another reason explaining often takes a back seat in parent-physician encounters—they are increasingly encounters between strangers. These days many children rarely see the same doctor twice, and more doctor visits happen in emergency departments and walk-in clinics, places where the doctors and families are strangers to each other. In these conditions parents need to learn how to make the most of their brief time with the doctor. This book will help them do that. This book is not a description of a laundry list of pediatric diseases. There are already plenty of those on bookstore shelves. Rather, it uses specific, familiar examples—things like ear infections, asthma attacks, broken bones, and appendicitis—to explain what is happening inside a child's body as it heals. But the book goes beyond that. It does not simply explain; it demonstrates, using vivid narrative techniques so readers can better visualize the processes being described.
This new companion to Hochberg et al.'s Rheumatology masterwork focuses on the momentous recent advances in our understanding of the genetics and immunology of psoriatic and reactive arthritis, and their implications for diagnosis and management. Leading international authorities explore new concepts in genetic and pathogenic mechanisms and early diagnosis; provide comprehensive, well-illustrated coverage of clinical features; evaluate the very latest therapeutic options, including biologics; and discuss clinical outcome measures. Examines the very latest pathogenic mechanisms and diagnostic criteria, providing the necessary tools for early diagnosis and monitoring of disease progression. Offers comprehensive coverage of the clinical manifestations of psoriatic and reactive arthritis, including a 'mini atlas' of color plates.Examines the pros and cons of the available therapeutic options, including the very latest biological as well as traditional therapies.Includes practical discussions of clinical outcome measures, delivering ongoing tools for assessment of function, disease activity, and quality of life.
This proceedings volume presents the very latest developments in non-astronomical adaptive optics. This international workshop, the sixth in a biennial series, was the largest ever held and boasted significant involvement by industry. Adaptive optics is on the verge of being used in many products; indeed, at this meeting, the use of adaptive optics in DVD players was disclosed for the first time. Sample Chapter(s). Liquid Crystal Lenses For Correction Of Presbyopia (586 KB). Contents: Wavefront Correctors and Control: Liquid Crystal Lenses for Correction of Presbyopia (G Li & N Peyghambarian); Woofer-Tweeter Adaptive Optics (T Farrell & C Dainty); Wavefront Sensors: A Fundamental Limit for Wavefront Sensing (C Paterson); Direct Diffractive Image Simulation (A P Maryasov et al.); Adaptive Optics in Vision Science: A Study of Field Aberrations in the Human Eye (A V Goncharov et al.); Characterization of an AO-OCT System (J W Evans et al.); Adaptive Optics in Optical Storage and Microscopy: Commercialization of the Adaptive Scanning Optical Microscope (ASOM) (B Potsaid et al.); Towards Four Dimensional Particle Tracking for Biological Applications (H I Campbell et al.); Adaptive Optics in Lasers: New Results in High Power Lasers Beam Correction (A Kudryashov et al.); Adaptive Optics Control of Solid-State Lasers (W Lubeigt et al.); Adaptive Optics in Communication and Atmospheric Compensation: Fourier Image Sharpness Sensor for Laser Communications (K N Walker & R K Tyson); Adaptive Optics System for a Small Telescope (G Vdovin et al.); and other papers. Readership: Industry- and university-level researchers in optics and laser physics.
Extracorporeal circulation has become firmly established as an invaluable and routine adjunct to cardiac and vascular surgery. Since its introduction in 1953, the technique has evolved rapidly with advancing technology leading to improvements in and simplification of the equipment involved. Developments in the understanding and application of basic science have also had a huge impact as our understanding of the complex anatomy, biochemistry, pharmacology and pathophysiology of the heart continues to grow. It is these advances in both technology and science that form the basis of this fourth edition of Techniques in Extracorporeal Cirulation. The book continues to provide a comprehensive overview of the field, covering both established techniques for those new to the field of extracorporeal circulation, and current and future developments. It attempts to answer some of the innumerable practical problems associated with the routine use of artificial circulation and oxygenation, and hopes to stimulate thought and debate among its readers regarding more complex or controversial issues. Topics new to the fourth edition include robotic surgery and off-pump surgery, while other chapters have been thoroughly revised and updated to take into account developments and changes in the field. With its multidisciplinary approach, the book will remain an essential reference for all health care professionals working in the cardiac surgical operating room, in particular cardiothoracic surgeons, anaesthetists and perfusionists.
This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes pertinent quality control considerations, as well as the optimum presentation of results. In addition to the comprehensive 'basic' semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. Throughout the handbook the interpretation of laboratory results in the clinical context is highlighted, and safe laboratory practice is emphasized. It is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.
This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
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