Coleman and Hendry's bestselling text has now been completely revised and updated to take account of the many changes that have occurred over the last decade. The book has now been reformatted into textbook style.
For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. - Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. - Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. - Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. - Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. - Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. - Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. - Includes the latest guidelines on facet injections and safety of contrast agents. - Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Plant research has stood at the forefront of the genomics revolution. One of the first genome projects, the sequencing of the commonly used model organism Arabidopsis, has already yielded important results for the study of a broad array of crops such as corn and soybeans. With crop and food bioengineering only in its infancy, the need to understand the fundamental genetic mechanisms of plants will only become more pressing. A comprehensive guide to this fascinating area of genomics, Plant Genomics and Proteomics presents an integrated, broadly accessible treatment of the complex relationship between the genome, transcriptome, and proteome of plants. This clearly written text introduces the reader to the range of molecular techniques applicable to investigating the unique facets of plant growth, development, and response to the environment. Coverage includes: Functional and structural genomics addressed within the context of current techniques and challenges to come How to utilize DNA and protein sequence data Practical considerations for choosing and employing the most commonly available computer applications A review of applications for biotechnology, including genetic modification and defense against pathogens Bioinformatics tools and Web resources Numerous examples from the latest research throughout Assuming no specialized knowledge of plant biology on the part of its reader, Plant Genomics and Proteomics provides an invaluable resource for students and researchers in biotechnology, plant biology, genomics, and bioinformatics.
When Augustus De Morgan died in 1871, he was described as ‘one of the profoundest mathematicians in the United Kingdom’ and even as ‘the greatest of our mathematicians’. But he was far more than just a mathematician. Because much of his voluminous written output on various subjects was scattered throughout journals and encyclopaedias, the breadth of his interests and contributions has been underappreciated by historians. Now, renewed interest in De Morgan’s life and work has coincided with the digitization of his extensive library, revealing the extent to which he pioneered and influenced the development of not merely mathematics but also logic, astronomy, the history of mathematics, education, and bibliography. This edited collection celebrates De Morgan as a polymath. Drawing together multiple elements of his activity from a range of publications and archives, its contributors re-assess his academic work, his place in his intellectual environment, and his legacy. The result offers new insight into De Morgan himself as well as the wider circles in which he moved, including his family life.
Throughout American history, patterns of political intent and impact have linked the wide range of dance movements performed in public places. Groups diverse in their cultural or political identities, or in both, long ago seized on street dancing, marches, open-air revival meetings, and theaters, as well as in dance halls and nightclubs, as a tool for contesting, constructing, or reinventing the social order. Dancing Revolution presents richly diverse case studies to illuminate these patterns of movement and influence in movement and sound in the history of American public life. Christopher J. Smith spans centuries, geographies, and cultural identities as he delves into a wide range of historical moments. These include the God-intoxicated public demonstrations of Shakers and Ghost Dancers in the First and Second Great Awakenings; creolized antebellum dance in cities from New Orleans to Bristol; the modernism and racial integration that imbued twentieth-century African American popular dance; the revolutionary connotations behind images of dance from Josephine Baker to the Marx Brothers; and public movement's contributions to hip hop, antihegemonic protest, and other contemporary transgressive communities’ physical expressions of dissent and solidarity. Multidisciplinary and wide-ranging, Dancing Revolution examines how Americans turned the rhythms of history into the movement behind the movements.
China in the Post-Utopian Age is an interdisciplinary book about China in the post-utopian age, focusing on the transformations that have occurred during the leaderships of Deng Xiaoping and Jiang Zemin throughout the 1980s and 1990s.
The Creolization of American Culture examines the artworks, letters, sketchbooks, music collection, and biography of the painter William Sidney Mount (1807–1868) as a lens through which to see the multiethnic antebellum world that gave birth to blackface minstrelsy. As a young man living in the multiethnic working-class community of New York's Lower East Side, Mount took part in the black-white musical interchange his paintings depict. An avid musician and tune collector as well as an artist, he was the among the first to depict vernacular fiddlers, banjo players, and dancers precisely and sympathetically. His close observations and meticulous renderings provide rich evidence of performance techniques and class-inflected paths of musical apprenticeship that connected white and black practitioners. Looking closely at the bodies and instruments Mount depicts in his paintings as well as other ephemera, Christopher J. Smith traces the performance practices of African American and Anglo-European music-and-dance traditions while recovering the sounds of that world. Further, Smith uses Mount's depictions of black and white music-making to open up fresh perspectives on cross-ethnic cultural transference in Northern and urban contexts, showing how rivers, waterfronts, and other sites of interracial interaction shaped musical practices by transporting musical culture from the South to the North and back. The "Africanization" of Anglo-Celtic tunes created minstrelsy's musical "creole synthesis," a body of melodic and rhythmic vocabularies, repertoires, tunes, and musical techniques that became the foundation of American popular music. Reading Mount's renderings of black and white musicians against a background of historical sites and practices of cross-racial interaction, Smith offers a sophisticated interrogation and reinterpretation of minstrelsy, significantly broadening historical views of black-white musical exchange.
Infectious Diseases of the Fetus and Newborn Infant, written and edited by Drs. Remington, Klein, Wilson, Nizet, and Maldonado, remains the definitive source of information in this field. The 7th edition of this authoritative reference provides the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants. Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization of the fetus/mother. Nationally and internationally recognized in immunology and infectious diseases, new associate editors Nizet and Maldonado bring new insight and fresh perspective to the book. Get the latest information on maternal infections when they are pertinent to the infant or developing fetus, including disease transmission through breastfeeding Diagnose, prevent, and treat neonatal infectious diseases with expert guidance from the world's leading authorities and evidence-based recommendations. Incorporate the latest findings about infections found in utero, during delivery, and in the neonatal period. Find the critical answers you need quickly and easily thanks to a consistent, highly user-friendly format Get fresh perspectives from two new associate editors—Drs. Yvonne Maldonado, head of the Pediatric Infectious Disease program at Stanford, and Victor Nizet, Professor of Pediatrics & Pharmacy at University of California, San Diego and UCSD School of Medicine. Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother. Overcome the clinical challenges in developing countries where access to proper medical care is limited. Apply the latest recommendations for H1N1 virus and vaccines. Identify and treat infections with the latest evidence-based information on fighting life-threatening diseases in the fetus and newborn infants.
Get the core knowledge in pain medicine you need from one of the most trusted resources in the field. The new fourth edition guides you through every aspect of pain medicine with concise descriptions of evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. From commonly seen pain syndromes, including headaches, trunk pain, orofacial pain, back pain, and extremity pain...through specific pain management challenges such as postoperative pain, pain due to cancer, phantom pain, and pain in the management of AIDS patients...this popular text will equip you with the know-how you need to effectively manage even your most challenging cases. A practical, multidisciplinary approach to pain management makes key concepts and techniques easier to apply to everyday practice. Expert contributors provide the latest knowledge on all aspects of pain management, from general principles through to specific management techniques. Detailed discussions of the latest concepts and treatment plans help you provide the best possible outcomes for all your patients. Extensively updated chapters acquaint you with the most current trends and techniques in pain management. A new section on complications helps you avoid and manage potential pitfalls. A new editorial team ensures that you are getting the freshest, most clinically relevant information available today. New, full-color art clarifies key concepts and techniques.
Gathering leading thinkers in social and clinical psychology, public health, medicine, and sociology, Interpersonal Relationships and Health considers theoretical and empirical issues relevant to understanding the social and clinical psychological mechanisms linking close relationship processes with mental and physical health outcomes. The volume arises out of a recent explosion of interest, across multiple academic and research fields, in the ways that interpersonal relationships affect health and well-being. This volume pulls together a range of scholars who focus on different aspects of relationships and health in order to encourage both collaboration and cross-disciplinary initiatives. This is the first edited volume to pull together noted experts across myriad disciplines whose research is at the intersection of human relationships and health. Topics addressed include key biological processes that influence and, in turn, are influenced by close relationships. Interpersonal Relationships and Health presents research that demonstrates the connections between interpersonal relationships, mental and physical health outcomes, and biophysical markers that figure prominently in the fields of psychoneuroimmunology, endocrinology, and cardiology. In addition, it highlights recent work on marital, family, and social relationships and their interplay with health and well-being. Chapters also address sexual health among young and older adults, as well as clinical intervention efforts that focus on the role of relational factors in influencing health. Each chapter highlights extant theoretical and empirical findings and suggests future avenues for research in this burgeoning area.
Extracorporeal circulation has become firmly established as an invaluable and routine adjunct to cardiac and vascular surgery. Since its introduction in 1953, the technique has evolved rapidly with advancing technology leading to improvements in and simplification of the equipment involved. Developments in the understanding and application of basic science have also had a huge impact as our understanding of the complex anatomy, biochemistry, pharmacology and pathophysiology of the heart continues to grow. It is these advances in both technology and science that form the basis of this fourth edition of Techniques in Extracorporeal Cirulation. The book continues to provide a comprehensive overview of the field, covering both established techniques for those new to the field of extracorporeal circulation, and current and future developments. It attempts to answer some of the innumerable practical problems associated with the routine use of artificial circulation and oxygenation, and hopes to stimulate thought and debate among its readers regarding more complex or controversial issues. Topics new to the fourth edition include robotic surgery and off-pump surgery, while other chapters have been thoroughly revised and updated to take into account developments and changes in the field. With its multidisciplinary approach, the book will remain an essential reference for all health care professionals working in the cardiac surgical operating room, in particular cardiothoracic surgeons, anaesthetists and perfusionists.
This book presents an overview of Shiga toxin-producing E. coli (STEC), with in-depth coverage of key areas such as recent Shiga toxin-related poisonings in Europe and the US, the structure, production, and mechanism of action of Shiga toxin, and current methods of detection. The globalization of food production has introduced new risk factors and intensified existing hazards, complicating the assurance of food safety. Foodborne illness outbreaks, such as those related to STEC, are becoming more common and more dangerous. The threat that these bacterial toxins pose to the food supply is magnified by the frequent occurrence and severity of Shiga toxin-caused disease. As a result, STEC and their toxins remain a primary concern in food safety. This review serves as a key resource for scientists in the field and public health and regulatory officials charged with maintaining food safety. This book also looks to the future of treatment of Shiga toxin-associated disease, specifically the translation of lab bench science into clinical therapeutic strategies.
Take an eclectic, evidence-based approach to orthopaedic manual therapy. From theory through practical application of soft tissue and joint mobilization techniques—this comprehensive resource delivers the depth and breadth of coverage you need to optimize patient outcomes through informed clinical decision-making as part of a comprehensive intervention regimen.
This volume in the Contemporary Military, Strategic, and Security Issues series presents a concise introduction to the evolution, key concepts, discourse, and future options for improved strategic communication in today's U.S. government. Strategic Communication: Origins, Concepts, and Current Debates is a groundbreaking study, the first book explicitly focused on strategic communication as it is currently used and discussed in the U.S. government. Written specifically for those who are new to strategic communication, this incisive book clarifies the definitional debate, explores the history of the term and its practice, and embraces a broad, practical definition. But that is only the beginning. Moving to the realities of the issue, author Christopher Paul reviews dozens of government reports on strategic communication and public diplomacy released since 2000, examining specific proposals related to improving strategic communication in the U.S. government and explaining the disagreements. Most important, he offers consensus and clarity for the way ahead, discussing how disparate elements of the government can be coordinated to master—and win—the "war of ideas" through fully integrated and synchronized communications and actions.
Essentials of Computational Chemistry provides a balanced introduction to this dynamic subject. Suitable for both experimentalists and theorists, a wide range of samples and applications are included drawn from all key areas. The book carefully leads the reader thorough the necessary equations providing information explanations and reasoning where necessary and firmly placing each equation in context.
Organisms are said to be drug-resistant when drugs meant to neutralise them have reduced effect. When an organism is resistant to more than one drug, it is said to be multi-drug resistant. The most prominent example of this is antibiotic resistance. Drug resistance is also found in some tumour cells, which makes it more difficult to use chemotherapy to attack tumours made of those cells. When a drug such as an antibiotic is administered, those which have a genetic resistance to the drug will survive and reproduce, and the new population will be drug-resistant. This book provides in depth research on multi-drug resistance and its impact on neuorology. This includes studies on GS-X Pump/Multidrug Resistance Proteins, Quantitation of O6 -- Methylguanine, Therapeutic Responses to Chemotherapy, Profiles in Cancer, Neurodegenerative Diseases and Multiple Sclerosis.
Tribal Warfare thoroughly investigates a central element of the hit reality television show Survivor that the existing literature on reality television has overlooked: class politics. Christopher J. Wright combines textual analysis and survey research to demonstrate that Survivor operates and resonates as a political allegory. Using the work of Fredric Jameson, this book reveals how Survivor frames its 'characters' as 'haves' and 'have-nots.' For those new to Jameson, Wright breaks down the theorist's complex notion of the political unconscious into easily understandable language. Furthermore, using the results of a survey of Survivor viewers, Tribal Warfare demonstrates that viewers divide along gender, racial, age, and—most significantly—class-related lines in their consumption of, and reaction to, the program. The first book to explore the premise of 'Survivor as society,' this unique work serves as both an engaging analysis of a popular television program and a highly readable primer for those new to critical theory.
One of the North’s greatest generals—the Rock of Chickamauga Most Southerners in the U.S. Army resigned their commissions to join the Confederacy in 1861. But at least one son of a distinguished, slaveholding Virginia family remained loyal to the Union. George H. Thomas fought for the North and secured key victories at Chickamauga and Nashville. Thomas’s wartime experiences transformed him from a slaveholder to a defender of civil rights. Remembered as the “Rock of Chickamauga,” Thomas became one of the most prominent Union generals and was even considered for overall command of the Union Army in Virginia. Yet he has been eclipsed by such names as Grant, Sherman, and Sheridan. Offering vivid accounts of combat, Einolf depicts the fighting from Thomas’s perspective to allow a unique look at the real experience of decision making on the battlefield. He examines the general’s recurring confrontations with the Union high command to make a strong case for Thomas’s integrity and competence, even as he exposes Thomas’s shortcomings and poor decisions. The result is a more balanced, nuanced picture than has previously been available. Probing Thomas’s personal character, Einolf reveals how a son of the South could oppose the views of friends and family. George Thomas: Virginian for the Union offers a fresh appraisal of an important career and lends new insight into the inner conflicts of the Civil War.
For more than half a century, Chris-Craft reigned supreme in the world of motorboating. This market dominance was due in no small part to the design and construction techniques employed in the company’s studios and on its factory floors. Building Chris-Craft examines the company’s design and production heritage, looking at Chris-Craft’s considerable accomplishments in the context of key competitors and industrial trends in general. High-quality archival images take readers inside the factories, design studios, and lofts of Chris-Craft factories in Algonac, Holland; Cadillac, Michigan; Salisbury, Maryland; Chattanooga, Tennessee; and Caruthersville, Missouri.
Clinical Radiology of the Horse is the best-selling, practical guide to all areas of equine radiography and radiology written by an experienced group of clinicians with a broad range of backgrounds. Offers an atlas of normal and clinical images, as well as a comprehensive guide to techniques, equipment, positioning, and interpretation for general veterinary practitioners and specialists in imaging and orthopaedics Updates to this fourth edition fully reflect the move to digital imaging with many new figures in the book and major revisions to the chapters on the head, thorax, and abdomen Contains expanded coverage of the foot, pastern, and fetlock (now in separate chapters) Includes a password-protected website with all the images from the book as well as over 200 additional images with examples of more subtle lesions, more fractures, correct technique and positioning versus incorrect, immature horses, progression of disease, and pathological images
The book, illustrated with case examples, identifies and makes explicit the often diverse values of those involved in healthcare commissioning, whether as commissioners, providers or users of services. It provides a skills base and other support processes for working with differences in values held by those engaged in making decisions.
DNA evidence is widely used in the modern justice system. Statistical methodology plays a key role in ensuring that this evidence is collected, interpreted, analysed and presented correctly. This book is a guide to assessing DNA evidence and presenting that evidence in a courtroom setting. It offers practical guidance to forensic scientists with little dependence on mathematical ability, and provides the scientist with the understanding they require to apply the methods in their work. Since the publication of the first edition of this book in 2005 there have been many incremental changes, and one dramatic change which is the emergence of low template DNA (LTDNA) profiles. This second edition is edited and expanded to cover the basics of LTDNA technology. The author's own open-source R code likeLTD is described and used for worked examples in the book. Commercial and free software are also covered.
The World Social Forum quickly became the largest political gathering in human history and continues to offer a direct challenge to the extreme inequities of corporate-led globalisation. It has expanded its presence and continues to be an exciting experiment in global and participatory democracy. The book's contributors have participated in World Social Forums around the globe. Recounting dozens of dramatic firsthand experiences, they draw on their knowledge of global politics to introduce the process, its foundations and relevance to ongoing transnational efforts toward democracy. This second edition of Global Democracy shows how the Forums have developed since their inception in 2001 and how they are now connected with other global movements including Occupy, the Arab Spring and beyond.
Agathokles of Syracuse ruled large areas of Sicily and southern Italy between 317 and 289 BC. In this book, Christopher de Lisle argues that Agathokles was an important player in the Mediterranean world at a key moment in its history. Agathokles' career has important implications for our definition of the Hellenistic world and its relationship to both the western Mediterranean and earlier Greek history. However, he has tended not to feature in studies of the Hellenistic world or of ancient Sicily. In ancient discourse about him, in the coins he issued, in his interactions with the world around him, and in the way he ruled, Agathokles is simultaneously heir to a long tradition and actively engaged in his contemporary world. The failure to place Agathokles in both of these contexts up till now has contributed to the development of an excessively deep separation between the western and eastern Mediterranean and between the Classical and Hellenistic periods. This work - the first book-length study of Agathokles in English in over a century - places him in the context of both the earlier history of Sicily, and the developments in the eastern Mediterranean that mark the start of the Hellenistic era. The volume includes a narrative of his career, studies of his coinage and his representation in literary sources, and a series of explorations of important themes and regions.
Includes over 30 maps and Illustrations The Staff Ride Handbook for the Vicksburg Campaign, December 1862-July 1863, provides a systematic approach to the analysis of this key Civil War campaign. Part I describes the organization of the Union and Confederate Armies, detailing their weapons, tactics, and logistical, engineer, communications, and medical support. It also includes a description of the U.S. Navy elements that featured so prominently in the campaign. Part II consists of a campaign overview that establishes the context for the individual actions to be studied in the field. Part III consists of a suggested itinerary of sites to visit in order to obtain a concrete view of the campaign in its several phases. For each site, or “stand,” there is a set of travel directions, a discussion of the action that occurred there, and vignettes by participants in the campaign that further explain the action and which also allow the student to sense the human “face of battle.” Part IV provides practical information on conducting a Staff Ride in the Vicksburg area, including sources of assistance and logistical considerations. Appendix A outlines the order of battle for the significant actions in the campaign. Appendix B provides biographical sketches of key participants. Appendix C provides an overview of Medal of Honor conferral in the campaign. An annotated bibliography suggests sources for preliminary study.
The rise of environmentalism has been one of the more remarkable developments in the politics of western societies in recent decades. However, as environmental awareness has become more generalized, the forms of expression of environmental concern have changed. Established environmental movement organizations have become embedded in policy networks, but, in some countries, there has been a resurgence of environmental radicalism. New groups, adopting innovative tactics, have mounted spectacular and disruptive protests. These developments pose interesting questions for social scientists and policy-makers. Has the institutionalization of established environmental organizations demobilized their supporters and reduced them to a passive, credit-card waving 'conscience' constituency? Has direct participation in environmental protest become the specialized activity of smaller numbers of people? Has there been a decline in the total volume of environmental protest, or is it merely that the forms of protest have changed? Have the protest repertoires of established groups moderated over time, or have they been stimulated by the emergence of more radical groups to adopt more challenging tactics? Has environmental protest become more confrontational? Do protests employ different repertoires of action according to the issues at stake? How does the incidence of protest vary over time and from one country to another? Is there evidence of a Europeanization of either the issues or the forms of environmental protest? These are some of the questions this volume addresses. Based upon an analysis of the protest events reported in one quality newspaper in each of eight countries during the ten years 1988 to 1997, this is the first systematically comparative study of environmental protest in a representative cross-section of EU member states. It breaks entirely new ground in the study of environmental politics in Europe and is a major contribution to the study of protest events.
When the first edition of Pediatric Psychopharmacology published in 2002, it filled a void in child and adolescent psychiatry and quickly establishing itself as the definitive text-reference in pediatric psychopharmacology. While numerous short, clinically focused paperbacks have been published since then, no competitors with the scholarly breadth, depth, and luster of this volume have emerged. In the second edition, Christopher Kratochvil, MD, a highly respected expert in pediatric psychopharmacology, joins the outstanding editorial team led by Dr. Martin and Dr. Scahill. In the new edition, the editors streamline the flow of information to reflect the growth in scientific data since the first edition appeared. The overall structure of the book remains the same, with major sections on underlying biology; somatic interventions; assessment and treatment; and special considerations.
In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme in
WETLANDS The definitive guide to wetlands for students and professionals alike Wetlands rank among the most productive but also the most vulnerable ecosystems. They break down toxins and help maintain aquatic ecosystems, provide both permanent and temporary homes for key species, and contribute enormously to biodiversity and global ecological health. In recent years the importance of wetlands has been increasingly well understood, and their management and restoration has become a particular focus of environmental research. Wetlands provides a thorough and comprehensive overview of wetlands, updated to reflect the latest research findings and methodological approaches, as it has done for more than a generation. The new edition has been optimized for classroom use, breaking down the topic into four parts: introduction to wetlands, the wetland environment, wetland ecosystems, and wetland management. Readers of the sixth edition of Wetlands will also find: A detailed discussion of the role of wetlands in improving water quality, protection from storm damage, and other ecosystem services The latest approaches and examples of wetland creation and restoration A thorough discussion of the impacts of climate change on wetlands, and how to mitigate them Wetlands is essential reading for students and professionals in ecology, environmental engineering, and water resource management.
For 40 years, Fischer’s Mastery of Surgery has provided expert, highly illustrated coverage of the procedures that general surgeons and trainees need to know. The fully revised eighth edition, under the editorial leadership of Drs. E. Christopher Ellison, Gilbert R. Upchurch Jr., Philip A. Efron, Steven D. Wexner, Nancy D. Perrier, V. Suzanne Klimberg, John H. Stewart IV, Valerie W. Rusch, Jon C. Gould, Susan Galandiuk, Timothy M. Pawlik, William C. Chapman, Benjamin K. Poulose, Peter K. Henke, Alicia M. Mohr, Saleem Islam, Anne M.R. Agur, Carol Scott-Conner, and David Renton continues the tradition of excellence with two full-color volumes that include the essentials of diagnosis, anatomy, and pre-operative planning while maintaining a focus on clear, step-by-step depictions and descriptions of procedures.
The Autisms, written by Mary Coleman and Christopher Gillberg, demonstrates that autism, like mental retardation, is a clinical presentation of numerous different diseases, many with genomic underpinnings. In this ground-breaking work, the authors explain in great detail how to clinically diagnose infants, children, adolescents and adults with autistic behavioral features and their psychiatric and neurological work-ups. This new edition contains several chapters on the associated problems of autism, such as intellectual disability, epilepsy, tics, eating disorders and sleep problems, as well as a chapter on epidemiology that documents the historical increase in autism diagnoses. Several chapters summarize the latest data on neuroanatomy, biochemistry and neuropsychology, while three neurogenomics chapters show evidence suggesting that autism occurs due to genetic errors which cause interruption or misdirection of critical neurodevelopmental circuits in the fetal brain. Completely up-to-date, The Autisms is relevant and necessary reading for researchers and clinicians in neuroscience, neurology, pediatrics, psychiatry, and psychology.
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