The Chemical Biology of Carbon examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways ideal for medicinal chemists, chemical biologists and postgraduate students.
This volume aims to provide an in-depth view of the complete biochemistry of sulfur with an emphasis on aspects not covered elsewhere. Given its role in the formation of proteins and presence in the amino acids methionine and cysteine, sulfur is essential to life. Current literature on the biochemistry of sulfur is vast and widely dispersed, as such this volume is intended as a single-source for everything concerning sulfur biochemistry from metabolic roles of inorganic sulfur, to thiol and thioether chemical biology, to the university of cysteine chemistry in proteomes. Authored by a renowned biochemist and experienced writer and educator, this book is ideal for students and researchers in biochemistry, biology and the life sciences with an interest in sulfur and its role in life.
From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology.
The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy
Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.
An examination of a 1970s Conceptual art project—advertisements for fictional shows by fictional artists in a fictional gallery—that hoodwinked the New York art world. From the summer of 1970 to March 1971, advertisements appeared in four leading art magazines—Artforum, Art in America, Arts Magazine, and ARTnews—for a group show and six solo exhibitions at the Jean Freeman Gallery at 26 West Fifty-Seventh Street, in the heart of Manhattan's gallery district. As gallery goers soon discovered, this address did not exist—the street numbers went from 16 to 20 to 24 to 28—and neither did the art supposedly exhibited there. The ads were promoting fictional shows by fictional artists in a fictional gallery. The scheme, eventually exposed by a New York Times reporter, was concocted by the artist Terry Fugate-Wilcox as both work of art and critique of the art world. In this book, Christopher Howard brings this forgotten Conceptual art project back into view. Howard demonstrates that Fugate-Wilcox's project was an exceptionally clever embodiment of many important aspects of Conceptualism, incisively synthesizing the major aesthetic issues of its time—documentation and dematerialization, serialism and process, text and image, publishing and publicity. He puts the Jean Freeman Gallery in the context of other magazine-based work by Mel Bochner, Judy Chicago, Yoko Ono, and Ed Ruscha, and compares the fictional artists' projects with actual Earthworks by Walter De Maria, Peter Hutchinson, Dennis Oppenheim, and more. Despite the deadpan perfection of the Jean Freeman Gallery project, the art establishment marginalized its creator, and the project itself was virtually erased from art history. Howard corrects these omissions, drawing on deep archival research, personal interviews, and investigation of fine-printed clues to shed new light on a New York art world mystery.
It is the aim of this book to present reviews on a wide range of aspects of bacterial respiratory systems. Because the on-going publication elsewhere of reviews on bacterial respiration, ablanket coverage of the field has not been attempted. Rather, a range of topics have been selected, either because they are of special current interest, they have not been reviewed recently, or they have never been reviewed.
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
At the heart of this book is the problem of war termination. Britain won an almost unbroken string of tactical military victories during an undeclared war against the Republic of Indonesia in the 1960s, yet it proved difficult to translate this into strategic success. Using conflict termination theories, this book argues that British strategy during Confrontation was both exemplary and flawed, both of which need not be mutually exclusive. The British experience in Indonesia represents an illuminating case study of the difficulties associated with strategy and the successful termination of conflicts. The value of this book lies in two areas: as a contribution to the literature on British counter-insurgency operations and as a contribution to the debates on the problems of war termination in the context of strategic thought.
This magnificent volume marks the fiftieth anniversary of this museum and art school housed in buildings designed by world-renowned architects Eliel Saarinen, I.M. Pei, and Richard Meier. Illustrated essays cover the history of the Center and its distinguished architecture. Colorplates and commentary present more than 100 masterpieces of 20th-century art and tribal arts.
Rising income inequality is highlighted as one of the largest challenges facing the United States, affecting civic participation and political representation. Although the wealthy often can and do exert more political influence, this is not always the case. To fix political inequality, it is important to understand exactly how class divisions manifest themselves in political outcomes, and what factors serve to enhance, or depress, inequalities in political voice. Christopher Ellis argues citizens’—and legislators’—views of class politics are driven by lived experience in particular communities. While some experience is formally political, on an informal basis citizens learn a great deal about their position in the broader socioeconomic spectrum and the social norms governing how class intersects with day-to-day life. These factors are important for policymakers, since most legislators do not represent “the public” at large, but specific constituencies. Focusing on U.S. congressional districts as the contextual unit of interest, Ellis argues individuals’ political behavior cannot be separated from their environment, and shows how income’s role in political processes is affected by the contexts in which citizens and legislators interact. Political inequality exists in the aggregate, but it does not exist everywhere. It is, rather, a function of specific arrangements that depress the political influence of the poor. Identifying and understanding these factors is a crucial step in thinking about what reforms might be especially helpful in enhancing equality of political voice.
This book was the brainchild of Dr. Angelo C. Rose. After fifty years of practicing holistic care, he wanted to leave his patients with a resource they could use as a guide in the natural healing of the more common health problems people typically face. This book provides a wealth of information and includes dietary guidelines, specific healing protocols, remedies, and valuable resources for myriad conditions. The book is designed to be used as a reference for people of all ages, even for those just looking to increase their knowledge of nutrition and diet.
This second edition integrates many new findings into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists.
Theory of Macroeconomic Policy reviews the theoretical foundations of macroeconomic, fiscal, and monetary, policy. It offers a panoramic view of macroeconomic theory, covering a wide range of topics that are not customarily dealt with in macroeconomics texts, as well as more standard material. Advanced theory is bridged with more elementary or intermediate material, and established models are reviewed alongside current research directions. There is an extensive review of empirical evidence on virtually every topic, supplemented by narrative accounts for various episodes. The policy implications of the various theories are emphasised throughout. The chapters are largely self-contained so that different courses can focus at different places. A 'Guidance for Further Study' Section and extensive bibliography give plenty of ideas for all levels of independent study, from Undergraduate Projects to MSc Dissertations to PhD Theses. Theory of Macroeconomic Policy presents a balance between: breadth as well as depth; analytical treatment and intuition; theory and evidence; vintage theories and current directions; theory and policy; (established) theory and debate. Theory of Macroeconomic Policy is an affirmation that there is a well-developed body of theory that is invaluable for an in-depth understanding of the macro-economy and policy; equally, there is much scope for critical discussion and debate.
Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: “where there is life, there is phosphorus”. Phosphorus chemical biology underlies most of life’s reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of ATP every day, required to run almost all metabolic and mechanical events in cells. Authored by a renowned biochemist, The Chemical Biology of Phosphorus provides an in-depth, unifying chemical approach to the logic and reactivity of inorganic phosphate and its three major derivatives (anhydrides, mono- and diesters) throughout biology to examine why life depends on phosphorus. Covering the breadth of phosphorus chemistry in biology, this book is ideal for biochemistry students, postgraduates and researchers interested in the chemical logic of phosphate metabolites, energy generation, biopolymer accumulation and phosphoproteomics.
A new perspective on policy responsiveness in American government. Scholars of American politics have long been skeptical of ordinary citizens’ capacity to influence, let alone control, their governments. Drawing on over eight decades of state-level evidence on public opinion, elections, and policymaking, Devin Caughey and Christopher Warshaw pose a powerful challenge to this pessimistic view. Their research reveals that although American democracy cannot be taken for granted, state policymaking is far more responsive to citizens’ demands than skeptics claim. Although governments respond sluggishly in the short term, over the long term, electoral incentives induce state parties and politicians—and ultimately policymaking—to adapt to voters’ preferences The authors take an empirical and theoretical approach that allows them to assess democracy as a dynamic process. Their evidence across states and over time gives them new leverage to assess relevant outcomes and trends, including the evolution of mass partisanship, mass ideology, and the relationship between partisanship and ideology since the mid-twentieth century; the nationalization of state-level politics; the mechanisms through which voters hold incumbents accountable; the performance of moderate candidates relative to extreme candidates; and the quality of state-level democracy today relative to state-level democracy in other periods.
“...the most comprehensive adventure sport physiology book I am aware of; therefore, I recommend it wholeheartedly.” The Sport and Exercise Scientist, March 2009 This book provides students and professionals with a well-written, accessible introduction to the science underlying a variety of adventure sports. Written specifically for this increasingly popular field of study, the text has been divided into two parts: the first provides the foundations for adventure physiology, the second the specific physiological and environmental demands of a range of adventure sports including kayaking, canoeing, sailing, windsurfing, climbing, mountaineering and skiing. Written by two adventure sports performers with extensive teaching and coaching experience, this book will prove invaluable to students taking courses in adventure and outdoor education and professional instructors involved in such activities. In addition, students of sport and exercise science and physical education will find this an excellent introduction to the physiological response to exercise. Clearly explains the basic physiological principles and applies them to a variety of land and water-based sports. In full colour throughout, the book includes numerous illustrations, together with key points and chapter summaries to reinforce learning. Contains original pieces from elite and high-level athletes describing the physiological demands of their particular sport in a real-world context. These include London sports personality of the year Anna Hemmings, respected climbers Dave Macleod and Neil Gresham, and Olympic medallists Tim Brabants and Ben Ainslie. Dedicated web site contains an original sample training programme and a set of adventure sport specific exercises.
Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis. Based on this, a variety of food applications with medical claims are being generated by food manufacturers worldwide in order to expand the market potential of products creating interesting linkages with other market segments, such as cosmetics and pharmaceuticals. However, in addition to the health benefits, active principles of such components often remain unexplored. This book focusses on the specific interactions between food ingredients and the immune system along the entire immune defense response. Starting from the immune barrier, through the innate and adaptive immune response, to active limitation and termination, all major mechanisms of the immune response are addressed and different biochemical, cellular and genetic interactions of components of our diet are discussed. The book presents a wealth of disease patterns for which nutritional factors are relevant and thereby provides indications for potential intervention strategies. In addition, associated food-technological aspects are discussed. Being the first of its kind, this book provides an overview of the variety of functional food components and their influence on immunological responses. Written in an accessible style, it addresses researchers, health professionals and students with different scientific backgrounds.
MOLECULAR ENZYMOLOGY, BECAUSE OF ITS CHEMICAL AND MATHEMATICAL content, is often regarded as a formidable and forbidding topic by undergraduates on a biology or biochemistry course, As a result of teaching enzymology to undergraduates for a number of years, we recognize the areas which appear to cause the most common difficulties in conceptual understanding. We feel that a book treating those areas by means of a logical approach carefully developed from basic principles fills a gap in the multiplicity of enzymology texts currently available. In writing this book we h;:lVe had in mind the needs of Honours Biochemistry students, in particular those who may take a special interest in enzymology. The text covers the main bulk of the material required in the second and third years of such courses. In addition, those taking courses in Biological Chemistry may well find the book to be of central interest. The book begins with a description of the fundamentals of catalysis, illustrating these with simple chemical reactions which may be supposed to serve as models of catalytic processes. Protein structure is discussed in terms of the fundamental forces which determine the shape and dynamic behaviour of protein molecules. The approach emphasizes those features thought to be most intimately involved in the catalytic function of enzyme molecules, and is illustrated with specific examples.
Theories of the Policy Process provides a forum for the experts in the most established and widely used theoretical frameworks in policy process research to present the basic propositions, empirical evidence, latest updates, and the promising future research opportunities of each framework. This well-regarded volume covers such enduring classics as Multiple Streams (Zahariadis et al.), Punctuated Equilibrium (Jones et al.), Advocacy Coalition Framework (Jenkins-Smith et al.), Institutional Analysis and Development Framework (Schlager and Cox), and Policy Diffusion (Berry and Berry), as well as two newer theories—Policy Feedback (Mettler and SoRelle) and Narrative Policy Framework (McBeth et al.). The fourth edition now includes a discussion of global and comparative perspectives in each theoretical chapter and a brand-new chapter that explores how these theories have been adapted for, and employed in, non-American and non-Western contexts. An expanded introduction and revised conclusion fully examines and contextualizes the history, trajectories and functions of public policy research. Since its first publication in 1999, Theories of the Policy Process has been, and remains, the quintessential gateway to the field of policy process research for students, scholars and practitioners.
In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.
Intended for students in the visual arts and for others with an interest in art, but with no prior knowledge of physics, this book presents the science behind what and how we see. The approach emphasises phenomena rather than mathematical theories and the joy of discovery rather than the drudgery of derivations. The text includes numerous problems, and suggestions for simple experiments, and also considers such questions as why the sky is blue, how mirrors and prisms affect the colour of light, how compact disks work, and what visual illusions can tell us about the nature of perception. It goes on to discuss such topics as the optics of the eye and camera, the different sources of light, photography and holography, colour in printing and painting, as well as computer imaging and processing.
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