This book provides a comprehensive review of what receptors do in the nervous system, how they do it, the mechanisms by which receptor function is regulated, and the consequences of normal and abnormal receptor function. It contains a series of interrelated chapters describing key neurotransmitter receptors, protein kinases, and protein phosphatases, and details their expression and composition in the development of the central nervous system (CNS).
Millions of alcoholics and addicts recover through spirituality. In The Soul of Recovery: Uncovering the Spiritual Dimension in the Treatment of Addictions, author and journalist Christopher D. Ringwald tells how and why they seek and achieve these transformations. Ranging as far back as the Washingtonian Total Abstinence Society in 1840, Ringwald illuminates the use of spirituality within a wide range of treatment options--from the famous Twelve Step-style programs to those tailored to the needs of addicted women, Native Americans, or homeless teens not ready to quit. Focusing on the results rather than the validity of beliefs espoused by these programs, he demonstrates how addicts recover through practices such as self-examination, meditation, prayer and reliance on a self-defined higher power. But the most compelling evidence of spirituality's importance comes from those directly involved in the process. Ringwald traveled across the country to visit dozens of programs and interview hundreds of addicts, alcoholics, counselors, family members, doctors and scientists. Many share moving stories of suffering, survival, and redemption. A homeless man, a surgeon, a college student, a working mother-each describes the descent into addiction and how spirituality offered a practical, personal means to recovery. Ringwald also examines the controversies surrounding faith-based treatment and the recovery movement, from the conflict between science and spirituality, to skepticism about the "new age" brand of spirituality these programs encourage, to constitutional issues over court-mandated participation in allegedly religious treatment programs. Combining in-depth research with powerful personal accounts, this fascinating exploration of spirituality will provide a fuller understanding of the nature of addiction and how people overcome it.
The shiny rings of the Olympic Games have grown tarnished over the years as doping, corruption and other scandals rise to the surface. Those scandals are the tip of the iceberg, according to author Christopher Shaw, the lead spokesperson for several anti-Games groups. Five Ring Circus details the history of how Vancouver won the bid for the 2010 Games, who was involved, and what the real motives were. It describes the role of corporate media in promoting the Games, the machinations of government and business, and the opposition that emerged. Disturbing questions come to light: Why does the IOC pay no taxes? Who are the real estate developers behind the Vancouver bid? Why are mega projects paid for with tax dollars? What are the true costs of the Games? The Olympic Games, once considered the pinnacle of athleticism and fair play, have become a cesspool of greed, backroom deals and the wholesale trampling of civil liberties. In Vancouver, preparations for the 2010 Games have had a substantial negative impact on the environment and has resulted in the "economic cleansing" of the poor and homeless. This book is a cautionary tale for future Olympic bid cities, and will appeal to those concerned about the effects of globalization on many aspects of life.
This book is about the history, present and future of one the most important policy ideas of the modern era – that there is a single, global dangerous amount of climate change. That dangerous amount of climate change is imagined as two degrees centigrade of global warming above the pre-industrial average. Though the two degree idea is based on the value system of elite policy actors, it is been constructed in public discourses as scientific fact. This false representation of the concept undermines opportunities for positive public engagement with the climate policy debate, yet it is strong public engagement which is a recurring aspiration of climate policy discourses and is considered essential if climate mitigation strategies are to work. Alongside a critical analysis of how the idea of a single dangerous limit has shaped our understanding of what sort of problem climate change is, the book explains how the public have been kept out of that decision making process, the implications of this marginalisation for climate policy and why the dangerous limit idea is undermining our ability to mitigate climate change. The book concludes by exploring possibilities for a deliberation about the future of the two degree limit which allows for public participation in the decision making process. This book illustrates why, at this critical juncture in the climate policy debate, the two degree limit idea has failed to achieve any of the policy goals intended. This is the first book dedicated to questioning the issue of the two degree limit within a social science framework and should be of interest to students and scholars of environmental policy and politics, climate change communication, and science, technology and society studies.
The emerging understanding of age-related neurological disorders suggests that notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders probably arise due to a unique intersection of multiple genetic and toxic factors, combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end-state disease, each is a spectrum disorder, and every individual case is therefore unique. Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how they arise and progress, and, crucially, what might be done to "cure" them. It first introduces the concept of neural dynamics of neurological disease, then examines various diseases and gives examples of the interplay of elements such as neural systems, cell types, and biochemical pathways that can contribute to disease. The concluding chapters point the way to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options. Providing a cross-disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers, and clinicians.
Like many parents and children, Jacqueline Kennedy Onassis and JFK Jr. shared an intense, tender, and often tempestuous bond. It was, quite simply, the most important relationship in John's life. With riveting insight, Andersen reveals how mother and son influenced, challenged, and supported each other through good times and bad, unveiling startling new details about a family we thought we already knew: John's reaction to his mother's bout with suicidal depression and growing dependence on prescription drugs; the surreal and ultimately catastrophic impact of the Onassis years; the premonitions that terrified Jackie about John's fate; Jackie's success at keeping John away from his hellraising cousins, and his complicated relationship with the rest of the clan; the power she wielded over his affairs with Madonna, Sarah Jessica Parker, Daryl Hannah, and others; how John privately handled the scandalous revelations about his parents' marriage; the secrets about John's own turbulent marriage and his senseless death. Bittersweet, provocative, thoughtful and inspiring, this is the often heartbreaking tale of two lives tested by history and tragedy.--From publisher description.
Despite its image as an epicenter of progressive social policy, New York City continues to have one of the nation's most segregated school systems. Tracing the quest for integration in education from the mid-1950s to the present, The Battle Nearer to Home follows the tireless efforts by educational activists to dismantle the deep racial and socioeconomic inequalities that segregation reinforces. The fight for integration has shifted significantly over time, not least in terms of the way "integration" is conceived, from transfers of students and redrawing school attendance zones, to more recent demands of community control of segregated schools. In all cases, the Board eventually pulled the plug in the face of resistance from more powerful stakeholders, and, starting in the 1970s, integration receded as a possible solution to educational inequality. In excavating the history of New York City school integration politics, in the halls of power and on the ground, Christopher Bonastia unearths the enduring white resistance to integration and the severe costs paid by Black and Latino students. This last decade has seen activists renew the fight for integration, but the war is still far from won.
How do you decide what stories an audience should hear? How do you make your theatre stand out in a crowded and intensely competitive marketplace? How do you make your building a home for artistic risk and innovation, while ensuring the books are balanced? It is the artistic director's job to answer all these questions, and many more. Yet, despite the central role that these people play in the modern theatre industry, very little has been written about what they do or how they do it. In The Art of the Artistic Director, Christopher Haydon (former artistic director of the Gate Theatre, 'London's most relentlessly ambitious theatre' – Time Out) compiles a fascinating set of interviews that get to the heart of what it is to occupy this unique role. He speaks to twenty of the most prominent and successful artistic directors in the US and UK, including: Oskar Eustis (Public Theater, New York), Diane Paulus (American Repertory Theater, Boston), Rufus Norris (National Theatre, London) and Vicky Featherstone (Royal Court Theatre, London), uncovering the essential skills and abilities that go into making an accomplished artistic director. The only book of its kind available, The Art of the Artistic Director includes a foreword by Michael Grandage, former artistic director of the Sheffield Crucible and the Donmar Warehouse in London.
Thinking of a jaunt to England? Let Arthur Bryant and John May, London’s oldest police detectives, show you the oddities behind the city’s façades in this tongue-in-cheek travel guide. “The best fun is running all over the city with these amiable partners.”—The New York Times Book Review, on Bryant & May: The Lonely Hour It’s getting late. I want to share my knowledge of London with you, if I can remember any of it. So says Arthur Bryant. He and John May are the nation’s oldest serving detectives. Who better to reveal its secrets? Why does this rainy, cold, gray city capture so many imaginations? Could its very unreliability hold the key to its longevity? The detectives are joined by their boss, Raymond Land, and some of their most disreputable friends, each an argumentative and unreliable expert in their own dodgy field. Each character gives us a short tour of odd buildings, odder characters, lost venues, forgotten disasters, confusing routes, dubious gossip, illicit pleasures, and hidden pubs. They make all sorts of connections—and show us why it’s almost impossible to separate fact from fiction in London.
Infectious Diseases of the Fetus and Newborn Infant, written and edited by Drs. Remington, Klein, Wilson, Nizet, and Maldonado, remains the definitive source of information in this field. The 8th edition of this authoritative reference provides the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants. Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization of the fetus/mother. Nationally and internationally recognized in immunology and infectious diseases, new associate editors Nizet and Maldonado bring new insight and fresh perspective to the book. Form a definitive diagnosis and create the best treatment plans possible using evidence-based recommendations and expert guidance from world authorities. Locate key content easily and identify clinical conditions quickly thanks to a consistent, highly user-friendly format now featuring a full-color design with hundreds of illustrations, and fresh perspectives from six new authoritative chapter lead authors. Explore what's changing in key areas such as: - emerging problems and concepts in maternal, fetal, and neonatal infectious diseases - anticipation and recognition of infections occurring in utero, during delivery, and in the neonatal period Stay on the cutting edge of your field with new and improved chapters including: obstetric factors associated with infections of the fetus and newborn infant; human milk; borella infections; tuberculosis; bordetella pertussis and other bordetella sp infections; herpes simplex; toxoplasmosis; pneumocystis and other less common fungal infections; and healthcare-associated infections in the nursery Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother. Overcome clinical challenges in developing countries where access to proper medical care is limited. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
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