Christoph Wagener's Books

Cancer Signaling

From Molecular Biology to Targeted Therapy

By: Christoph Wagener,Carol Stocking,Oliver Müller

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Cancer Signaling

From Molecular Biology to Targeted Therapy

By: Christoph Wagener,Carol Stocking,Oliver Müller

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

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Page Count

446

Publisher

John Wiley & Sons

Published Date

ISBN 10

3527800468

ISBN 13

9783527800469

Cancer Signaling, Enhanced Edition

From Molecular Biology to Targeted Therapy

By: Christoph Wagener,Carol Stocking,Oliver Müller

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Cancer Signaling, Enhanced Edition

From Molecular Biology to Targeted Therapy

By: Christoph Wagener,Carol Stocking,Oliver Müller

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356

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John Wiley & Sons

Published Date

ISBN 10

3527800476

ISBN 13

9783527800476

Final Sale in Berlin

The Destruction of Jewish Commercial Activity, 1930-1945

By: Christoph Kreutzmüller

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Final Sale in Berlin

The Destruction of Jewish Commercial Activity, 1930-1945

By: Christoph Kreutzmüller

Before the Nazis took power, Jewish businesspeople in Berlin thrived alongside their non-Jewish neighbors. But Nazi racism changed that, gradually destroying Jewish businesses before murdering the Jews themselves. Reconstructing the fate of more than 8,000 companies, this book offers the first comprehensive analysis of Jewish economic activity and its obliteration. Rather than just examining the steps taken by the persecutors, it also tells the stories of Jewish strategies in countering the effects of persecution. In doing so, this book exposes a fascinating paradox where Berlin, serving as the administrative heart of the Third Reich, was also the site of a dense network for Jewish self-help and assertion.

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383

Publisher

Berghahn Books

Published Date

ISBN 10

1782388125

ISBN 13

9781782388128

The Organs of J.S. Bach

A Handbook

By: Christoph Wolff,Markus Zepf

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The Organs of J.S. Bach

A Handbook

By: Christoph Wolff,Markus Zepf

The Organs of J. S. Bach is a comprehensive and fascinating guide to the organs encountered by Bach throughout Germany in his roles as organist, concert artist, examiner, teacher, and visitor. Newly revised and updated, the book's entries are listed alphabetically by geographical location, from Arnstadt to Zschortau, providing an easy-to-reference overview. Includes detailed organ-specific information: high-quality color photographs each instrument's history, its connection to Bach, and its disposition as Bach would have known it architectural histories of the churches housing the instruments identification of church organists Lynn Edwards Butler's graceful translation of Christoph Wolff and Markus Zepf's volume incorporates new research and many corrections and updates to the original German edition. Bibliographical references are updated to include English-language sources, and the translation includes an expanded essay by Christoph Wolff on Bach as organist, organ composer, and organ expert. The volume includes maps, a timeline of organ-related events, transcriptions of Bach's organ reports, a guide to examining organs attributed to Saxony's most famous organ builder Gottfried Silbermann, and biographical information on organ builders. Publication of this volume is supported by the American Bach Society.

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243

Publisher

University of Illinois Press

Published Date

ISBN 10

0252093917

ISBN 13

9780252093913

Social Security, Demographics, and Risk

By: Christoph Hendrik Borgmann

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Social Security, Demographics, and Risk

By: Christoph Hendrik Borgmann

This volume addresses the most important issues of the ongoing discussion on designing social security. It provides fundamental results for pay-as-you-go social security, covers the issues of social security during demographic transition and examines the inclusion of risk aspects into the analysis of social security. An empirical case study of Germany yields the surprising result that de facto the German public pension scheme already comprises an implicit demographic factor. This book allows a subtle understanding of how interacting risks are treated within different pension systems and thereby provides a basis for the development of innovative ways of risk sharing.

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Page Count

188

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540266976

ISBN 13

9783540266976

Religion in Liberal Democracy as a Form of Life

Free and Equal

By: Christoph Baumgartner

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Religion in Liberal Democracy as a Form of Life

Free and Equal

By: Christoph Baumgartner

Religion in Liberal Democracy as a Form of Life advances a theory to deal with the challenges connected to the liberal democratic ideal that all people are free to codetermine the future of their society and equally entitled to their religion and beliefs, given the historical bias towards Christianity in politics and culture within many European societies. Religious diversity and social and political participation are in fact fiercely contested issues. Critical scholars from philosophy and cultural theory contest that liberal political theories of freedom of religion can adequately deal with issues connected to an increasingly diversified and secularized religious field in historically Christian societies. Consequently, they claim that politics based on such theories cannot deliver on the promise to ensure conditions that allow all members of society equal religious freedom and political participation. By outlining historical developments, and by closely examining case studies of recent controversies about religious diversity in Germany and the Netherlands, this book identifies shortcomings of the currently predominant liberal account of freedom of religion or belief. Based on this analysis, the author proposes a more complex theory of liberal democracy as a form of life, with religion and religious freedom as components of it. This takes into account that informal norms, social structures, and predominant notions of belonging can function as powerful obstacles to freedom and equality, even if formal legal and political institutions prohibit discrimination based on religion. Construing liberal democracy as a “form of life”—that is, as a set of social practices, attitudes, and their institutional manifestations and material expressions—shifts the focus of critical analysis from the law to informal structures and components. This provides an understanding of the dynamics of (culturalized) religion in society, which has often been missing in political philosophical theories. The theory proposed in this book provides normative criteria for building liberal democracies that are tolerant with respect to religious differences and solidaric in terms of ensuring conditions that allow all members of society to codetermine, as equals, the future of society, irrespective of their religion or beliefs. This book will appeal to scholars of political theory, social and political philosophy, religious studies, sociology, and anthropology.

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Page Count

213

Publisher

Taylor & Francis

Published Date

ISBN 10

1040261574

ISBN 13

9781040261576

Hidden Criticism?

The Methodology and Plausibility of the Search for a Counter-Imperial Subtext in Paul

By: Christoph Heilig

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Hidden Criticism?

The Methodology and Plausibility of the Search for a Counter-Imperial Subtext in Paul

By: Christoph Heilig

Is there a counter-imperial message beneath the surface of the text in Paul? Christoph Heilig analyzes the letters of the apostle and concludes that the hypothesis that we can identify critical "echoes" of the Roman Empire in Paul's letters needs to be modified for it to be maintained.

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Page Count

236

Publisher

Mohr Siebeck

Published Date

ISBN 10

3161537955

ISBN 13

9783161537950

The New Grove Bach Family

By: Christoph Wolff,Walter Emery,Richard Jones,Eugene Helm,Ellwood Derr,Ernest Warburton

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The New Grove Bach Family

By: Christoph Wolff,Walter Emery,Richard Jones,Eugene Helm,Ellwood Derr,Ernest Warburton

Traces the life and discusses the compositions of Johann Sebastian Bach and the other musician members of his family.

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400

Publisher

W. W. Norton & Company

Published Date

ISBN 10

0393303543

ISBN 13

9780393303544

Matthaeus Adversus Christianos

By: Christoph Ochs

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Matthaeus Adversus Christianos

By: Christoph Ochs

In this book, Christoph Ochs presents for the first time an extensive study of the use of the Gospel of Matthew in Jewish polemics. These often overlooked texts advance numerous exegetical arguments against Jesus' divinity, the incarnation, and the Trinity. Seven Jewish polemical key texts comprise the main sources for this inquiry: Qissat Mujadalat al-Usquf (c. 8/9th century) and Sefer Nestor ha-Komer (before 1170), Sefer Milhamot ha-Shem (c. 1170), Sefer Yosef ha-Meqanne (c. 13th century), Nizzahon Vetus (13-14th century), Even Bohan (late 14th century), Kelimmat ha-Goyim (c. 1397), and Hizzuq Emunah (c. 1594). Together with the relevant passages in the original Hebrew and in translation, each text is presented with a historical and exegetical introduction. Contemporary parallels are also discussed, but in less detail. The result is a compendium of arguments against the divinity of Jesus based on the Jewish interpretation of Matthew.

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448

Publisher

Mohr Siebeck

Published Date

ISBN 10

3161526155

ISBN 13

9783161526152

Literacy Acquisition in School in the Context of Migration and Multilingualism

A binational survey

By: Inken Sürig,Yazgül Şimşek,Christoph Schroeder,Anja Boness

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Literacy Acquisition in School in the Context of Migration and Multilingualism

A binational survey

By: Inken Sürig,Yazgül Şimşek,Christoph Schroeder,Anja Boness

This book presents the outcomes of a multi-methodical investigation of the processes of literacy acquisition. The focus is on mono- and bilingual first- and seventh-graders in schools in socially underprivileged areas of two major cities in Turkey and Germany. By means of extensive analyses of lesson videos, linguistic tests, interviews and ethnographic research, social, cultural, linguistic, pedagogic and didactic differences on the international, national, local and individual level are aligned with the momentary problem of exercising a school lesson and acquiring literacy on a daily basis. The results contradict to some degree that cultural and linguistic differences actually make a huge difference in the organisation and process of literacy acquisition. With the interdisciplinary background of the book, it addresses academics concerned with migration sociology, migration linguistics, classroom research, and bilingual education. In a broader perspective, the book contributes to the pedagogically and politically significant question how social and cultural characteristics of specific groups are stereotyped and partly unjustly combined in order to reach symbolic solutions for actual problems.

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311

Publisher

John Benjamins Publishing Company

Published Date

ISBN 10

9027267030

ISBN 13

9789027267030

Europe in the Long Twentieth Century

A Transnational History

By: Christoph Cornelissen

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Europe in the Long Twentieth Century

A Transnational History

By: Christoph Cornelissen

Thanks to their economic and military strength, the European empires had achieved global supremacy by 1900, with large parts of the world under their dominance in the wake of colonial expansion. This situation fuelled ideas of Europe's permanent, almost natural global superiority, especially among the middle classes. However, as early as the First World War, such claims came under increasing pressure. This volume explains the role played by modern nationalism and anti-imperial movements, the competition between different political orders, changes in the economy and society, and the great ideas and utopias. Their interplay gave rise to enormously destructive forces in Europe. From the Boer and Balkan wars before 1914 to the Yugoslav wars of the 1990s and the Ukraine war since 2022, they have produced a continuum of violence. At the same time, the great promise of political participation and social security is one of the constants of Europe's history in the long twentieth century. Against this backdrop, modern societies emerged whose values had moved far away from the older models. Perceptions of the role of the sexes, families, and generations changed fundamentally. In addition, the major internal European migrations, together with the global immigration that became increasingly significant after 1945, ensured that the ethnic profile of European societies changed considerably. Europe in the Long Twentieth Century shows how, on the one hand, these different factors led to a Europeanisation of living and working conditions and, at the same time, how the political and economic integration of the countries of Europe progressed. On the other hand, it demonstrates how Europe's role in the global context changed fundamentally. As much as the geopolitical provincialisation of Europe continued unabated, Europeans were constantly searching for new ways to assert themselves throughout the long twentieth century. The search continues.

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Page Count

486

Publisher

Oxford University Press

Published Date

ISBN 10

0192699237

ISBN 13

9780192699237

Separate Accounting Or Unitary Apportionment?

The Fairy Tale of Arm's Length Pricing and General Equilibrium Analysis of Multinational Enterprise Behavior Under the Formulary Taxation Alternative

By: Christoph Sommer

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Separate Accounting Or Unitary Apportionment?

The Fairy Tale of Arm's Length Pricing and General Equilibrium Analysis of Multinational Enterprise Behavior Under the Formulary Taxation Alternative

By: Christoph Sommer

One field where the implications of the omnipresent globalization and hereby initiated new forms of cross-border business activity are exceptionally profound is the income taxation of multinational enterprises. The contemporary worldwide norm, which was adopted in the 1930s, is the separate accounting method. Despite its longevity as the preferred means for the taxation of multinational enterprises, the erosion of tax revenues from alleged transfer price manipulations by firms has goaded public discussion on whether or not the separate accounting method is still a satisfactory solution to the problem of international income taxation. Particularly the European Commission's study "Company Taxation in the Internal Market" and its suggestion to replace separate accounting with unitary apportionment in the European Union has strongly accelerated the debate about the future of group taxation. In the present treatise, both abovementioned taxation concepts are elucidated as well as qualitatively and quantitatively reviewed against the background of the economic rationale for the multinational enterprise, the way it generates income and the management of its internal affairs. The highlight of this treatise is the general equilibrium model of firm behavior under unitary apportionment, which is, as will be seen, in several important respects more powerful than the usual partial equilibrium treatment of the formulary approach. The presented model, therefore, provides considerable insights regarding the tax incidence and induced real-economic distortions under unitary apportionment. Above all, this model will allow policy-makers and tax authorities to make reasonable estimates concerning potential alterations in tax revenues collected if separate accounting was replaced by unitary apportionment in the future.

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Page Count

290

Publisher

BoD – Books on Demand

Published Date

ISBN 10

3844100148

ISBN 13

9783844100143

CASTLE BY THE RIVER

The Life and Death of Karl Friedrich Schinkel, Painter and Master Builder

By: Christoph Werner

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CASTLE BY THE RIVER

The Life and Death of Karl Friedrich Schinkel, Painter and Master Builder

By: Christoph Werner

Always the canvas recoils when he tries to apply the brush. How can hope be made apparent if he doesn't succeed in putting the white dove into the painting? Brentano's smile was so friendly when he, Schinkel, had made a sketch in his notebook of Brentano's impromptu story even while it was being told. And now, in oil, almost ready on the easel, he can't reach the painting with his brush ... In his feverish dreams, Schinkel struggles to complete his painting "Castle By The River"; on his sick bed, he relives his fulfilled life marked by an overwhelming sense of duty and the tragedy of the architect and artist who became a servant of his king.

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131

Publisher

tredition

Published Date

ISBN 10

334704276X

ISBN 13

9783347042766

Numerical Computation 1

Methods, Software, and Analysis

By: Christoph W. Ueberhuber

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Numerical Computation 1

Methods, Software, and Analysis

By: Christoph W. Ueberhuber

This book deals with various aspects of scientific numerical computing. No at tempt was made to be complete or encyclopedic. The successful solution of a numerical problem has many facets and consequently involves different fields of computer science. Computer numerics- as opposed to computer algebra- is thus based on applied mathematics, numerical analysis and numerical computation as well as on certain areas of computer science such as computer architecture and operating systems. Applied Mathemalies I I I Numerical Analysis Analysis, Algebra I I Numerical Computation Symbolic Computation I Operating Systems Computer Hardware Each chapter begins with sample situations taken from specific fields of appli cation. Abstract and general formulations of mathematical problems are then presented. Following this abstract level, a general discussion about principles and methods for the numerical solution of mathematical problems is presented. Relevant algorithms are developed and their efficiency and the accuracy of their results is assessed. It is then explained as to how they can be obtained in the form of numerical software. The reader is presented with various ways of applying the general methods and principles to particular classes of problems and approaches to extracting practically useful solutions with appropriately chosen numerical software are developed. Potential difficulties and obstacles are examined, and ways of avoiding them are discussed. The volume and diversity of all the available numerical software is tremendous.

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494

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642591183

ISBN 13

9783642591181

Mathematical Chemistry and Chemoinformatics

Structure Generation, Elucidation and Quantitative Structure-Property Relationships

By: Adalbert Kerber,Reinhard Laue,Markus Meringer,Christoph Rücker,Emma Schymanski

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Mathematical Chemistry and Chemoinformatics

Structure Generation, Elucidation and Quantitative Structure-Property Relationships

By: Adalbert Kerber,Reinhard Laue,Markus Meringer,Christoph Rücker,Emma Schymanski

More than 20 years of experience in molecular structure generation, from conceptualization through to applications Innovative, interdisciplinary text demonstrating example queries with software packages such as MOLGEN-online Detailed explanations on establishing QSPRs and QSARs as well as structure elucidation using mass spectrometry and structure generation. Aims and Scope This work provides an introduction to mathematical modeling of molecules and the resulting applications (structure generation, structure elucidation, QSAR/QSPR etc.). Most chemists have experimented with some software that represents molecules in an electronic form, and such models and applications are of increasing interest in diverse and growing fields such as drug discovery, environmental science and metabolomics. Furthermore, structure generation remains the only way to systematically create molecules that are not (yet) present in a database. This book starts with the mathematical theory behind representing molecules, explaining chemical concepts in mathematical terms and providing exercises that can be completed online. The later chapters cover applications of the theory, with detailed explanations on QSPR and QSAR investigations and finally structure elucidation combining mass spectrometry and structure generation. This book is aimed in particular at the users of structure generation methods and corresponding techniques, but also for those interested in teaching and learning mathematical chemistry, and for software designers in chemoinformatics.

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Page Count

521

Publisher

Walter de Gruyter

Published Date

ISBN 10

3110254077

ISBN 13

9783110254075

The Europeanisation of National Administrations

Patterns of Institutional Change and Persistence

By: Christoph Knill

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The Europeanisation of National Administrations

Patterns of Institutional Change and Persistence

By: Christoph Knill

A comparative assessment of the factors influencing administrative adjustment to European policy.

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Page Count

276

Publisher

Cambridge University Press

Published Date

ISBN 10

0521000920

ISBN 13

9780521000925

Culture and Education

By: Birgitta Qvarsell, Christoph Wulf

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Culture and Education

By: Birgitta Qvarsell, Christoph Wulf

Although the educational system still fulfills the task of anchoring young generations within the national cultures that make up Europe, the progressive loss of significance of national states, which is connected to the process of unification and globalization, is creating new challenges to the various European cultures and to the education systems embodied in their people. Cultures are sustained and transformed through the manner in which they communicate with the younger generation; it is at this level that they constitute their particular power and dynamic.

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Page Count

244

Publisher

Waxmann Verlag

ISBN 10

3830962274

ISBN 13

9783830962274

Luke's Portrait of Gentiles Prior to Their Coming to Faith

By: Christoph W. Stenschke

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Luke's Portrait of Gentiles Prior to Their Coming to Faith

By: Christoph W. Stenschke

Christoph W. Stenschke examines Luke's portrait of the Gentiles' state prior to their coming to Christian faith. Following the history of research, he commences with Luke's direct references to the Gentiles prior to faith and then draws conclusions concerning their state from the Gentile encounter with Jesus and Christian salvation. This includes Luke's notes on the condition of Gentiles and on their appropriation of salvation. Finally conclusions from Luke's portrayal of Gentile Christians are drawn.With his approach Christoph W. Stenschke challenges some previous contributions to Lukan anthropology. He argues that the main study in the field (J.-W. Taeger, Der Mensch und sein Heil) does not sufficiently consider all the evidence. By concentrating on the Gentiles in Luke-Act (including Samaritans and God-fearers) the author's thesis covers all the relevant material. Contrary to Taeger, who suggests that Gentiles do not need 'salvation' as much as 'correction', he discovers that Luke portrays Gentiles prior to faith in a condition requiring God's saving intervention. Thorough correction has to accompany and follow this salvation. Though allowing for distinct Lukan emphases, this portrait is not essentially at odds with that of other NT authors.These results further show that the Areopagus speech needs to and can be satisfactorily interpreted in its context and in conjunction with similar statements. The author further argues that Luke's narrative sections and the characterization they present should no longer be neglected in favour of the speeches. Luke's portrayal of Gentiles prior to faith also bears on his understanding of sin and provides additional justification for the Gentile mission. Christoph W. Stenschke challenges proposals of Luke's alleged anti-Judaism and provides some hitherto little-noticed correctives.

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Page Count

488

Publisher

Mohr Siebeck

Published Date

ISBN 10

3161471393

ISBN 13

9783161471391

Briefwechsel unter Einschluss des Briefwechsels von Luise Adelgunde Victorie Gottsched: 1734-1735

By: Johann Christoph Gottsched

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Briefwechsel unter Einschluss des Briefwechsels von Luise Adelgunde Victorie Gottsched: 1734-1735

By: Johann Christoph Gottsched

Johann Christoph Gottsched (1700-1766) is considered to be one of the greatest scholars of the Early German Enlightenment. His extensive correspondence is being presented here in a standard edition: 25 volumes, approx. 6.000 letters to and from Gottsched, are being published with a critical apparatus and an academic commentary.

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