Christine Slingsby's Books

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

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Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a 'clamp' or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

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Page Count

328

Publisher

World Scientific

Published Date

ISBN 10

9814749346

ISBN 13

9789814749343

Jamaica Ladies

Female Slaveholders and the Creation of Britain's Atlantic Empire

By: Christine Walker

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Jamaica Ladies

Female Slaveholders and the Creation of Britain's Atlantic Empire

By: Christine Walker

Jamaica Ladies is the first systematic study of the free and freed women of European, Euro-African, and African descent who perpetuated chattel slavery and reaped its profits in the British Empire. Their actions helped transform Jamaica into the wealthiest slaveholding colony in the Anglo-Atlantic world. Starting in the 1670s, a surprisingly large and diverse group of women helped secure English control of Jamaica and, crucially, aided its developing and expanding slave labor regime by acquiring enslaved men, women, and children to protect their own tenuous claims to status and independence. Female colonists employed slaveholding as a means of advancing themselves socially and financially on the island. By owning others, they wielded forms of legal, social, economic, and cultural authority not available to them in Britain. In addition, slaveholding allowed free women of African descent, who were not far removed from slavery themselves, to cultivate, perform, and cement their free status. Alongside their male counterparts, women bought, sold, stole, and punished the people they claimed as property and vociferously defended their rights to do so. As slavery's beneficiaries, these women worked to stabilize and propel this brutal labor regime from its inception.

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Page Count

334

Publisher

UNC Press Books

Published Date

ISBN 10

1469655276

ISBN 13

9781469655277

Inventing the Industrial Revolution

The English Patent System, 1660-1800

By: Christine MacLeod

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Inventing the Industrial Revolution

The English Patent System, 1660-1800

By: Christine MacLeod

This book examines the development of the English patent system and its relationship with technical change during the period between 1660 and 1800, when the patent system evolved from an instrument of royal patronage into one of commercial competition among the inventors and manufacturers of the Industrial Revolution. It analyses the legal and political framework within which patenting took place and gives an account of the motivations and fortunes of patentees, who obtained patents for a variety of purposes beyond the simple protection of an invention. It includes the first in-depth attempt to gauge the reliability of the patent statistics as a measure of inventive activity and technical change in the early part of the Industrial Revolution, and suggests that the distribution of patents is a better guide to the advance of capitalism than to the centres of inventive activity. It also queries the common assumption that the chief goal of inventors was to save labour, and examines contemporary criticism of the patent system in the light of the changing conceptualisation of invention among natural scientists and political economists.

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Page Count

320

Publisher

Cambridge University Press

Published Date

ISBN 10

0521893992

ISBN 13

9780521893992

Charity and the Great Hunger in Ireland

The Kindness of Strangers

By: Christine Kinealy

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Charity and the Great Hunger in Ireland

The Kindness of Strangers

By: Christine Kinealy

The Great Irish Famine was one of the most devastating humanitarian disasters of the nineteenth century. In a period of only five years, Ireland lost approximately 25% of its population through a combination of death and emigration. How could such a tragedy have occurred at the heart of the vast, and resource-rich, British Empire? Charity and the Great Hunger in Ireland explores this question by focusing on a particular, and lesser-known, aspect of the Famine: that being the extent to which people throughout the world mobilized to provide money, food and clothing to assist the starving Irish. This book considers how, helped by developments in transport and communications, newspapers throughout the world reported on the suffering in Ireland, prompting funds to be raised globally on an unprecedented scale. Donations came from as far away as Australia, China, India and South America and contributors emerged from across the various religious, ethnic, social and gender divides. Charity and the Great Hunger in Ireland traces the story of this international aid effort and uses it to reveal previously unconsidered elements in the history of the Famine in Ireland.

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Page Count

424

Publisher

A&C Black

Published Date

ISBN 10

144111758X

ISBN 13

9781441117588

Glorious Ribbons

By: Christine Kingdom

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Glorious Ribbons

By: Christine Kingdom

Weave it. Pleat it. Fold it. Then try embroidery and appliqueacute;-all with ribbon. Bows, baskets, roses, garlands, and 50 other projects provide hours of crafting pleasure and fill the home with affordable accents and exquisitely personal touches.

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Page Count

132

Publisher

Krause Publications

Published Date

ISBN 10

0801984858

ISBN 13

9780801984853

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

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Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

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Page Count

328

Publisher

World Scientific

Published Date

ISBN 10

9814749346

ISBN 13

9789814749343

Structure and Action of Molecular Chaperones

Machines that Assist Protein Folding in the Cell

By: Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard

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Structure and Action of Molecular Chaperones

Machines that Assist Protein Folding in the Cell

By: Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition -- binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly -- the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

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Page Count

319

Publisher

World Scientific Publishing Company

Published Date

ISBN 10

981474932X

ISBN 13

9789814749329

Even There

By: Mary Christine Shields

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Even There

By: Mary Christine Shields

Even There is a book of short stories inspired by the love of God. It is meant to bring the reader glimpses of courage and faith as it relates to instances of God's amazing care in the everyday moments of our lives. It is hoped that we all look for defining happenings like this in our own lives. It is said that if we don't look for something, we will never find it, or as Jesus told us, "Seek and ye shall find.

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Publisher

Covenant Books, Inc.

Published Date

ISBN 13

9798886449853

Book's by Christine Slingsby

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Jamaica Ladies

Jamaica Ladies

Inventing the Industrial Revolution

Inventing the Industrial Revolution

Charity and the Great Hunger in Ireland

Charity and the Great Hunger in Ireland

Glorious Ribbons

Glorious Ribbons

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure and Action of Molecular Chaperones

Structure and Action of Molecular Chaperones

Even There

Even There

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