With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
Haematology Lecture Notes is an accessible and concise best-selling study guide, outlining the physiology, pathology and treatment of the most common blood disorders. Extensively revised and updated to reflect the considerable advances in the understanding of the molecular biology and pathogenesis of haematological disorders, it provides the core knowledge required by all medical students and junior doctors. Key features include: New material on coagulation and transfusion Expanded coverage of haematopoiesis A complete update of all malignant haematology content A brand new companion website at www.lecturenoteseries.com/haematology featuring interactive MCQs with feedback on each answer selected, chapter summaries and revision notes in PowerPoint and PDF formats, and all the figures from the book in PowerPoint format Whether approaching haematology for the first time, or looking for a refresher, Haematology Lecture Notes will enable students and junior doctors to develop an understanding of both the basic science and clinical aspects of this specialty.
A docu-style investigation of our fascination with the gun, from the perspective of the hip-hop generation. The 2003 shooting death of Toronto community-centre worker Kempton Howard put the spotlight on hip hop’s fixation with guns. Media and police soon blamed rap music and its tales of gang life on bullet-ridden US streets for the rising use of firearms in Canadian crime. Were these songs artful accounts of a terrible truth, or a self-fulfilling prophecy? Rodrigo Bascunan and Christian Pearce have interviewed many of the major players in the hip-hop world. As publishers of an award-winning magazine of urban culture, they’d watched rap music become a scapegoat for society’s much older and widely spread fascination with guns. What follows is their international adventure to deconstruct modern gun culture in all its manifestations. Bascunan and Pearce seek out hip-hop artists, illegal gun runners, firearms aficionados and manufacturers, museum curators, academics, politicians, video-game creators, activists, victims of gun violence and the family and friends left behind. Somewhere between Fast Food Nation, No Logo and a Michael Moore documentary, featuring sly sidebar material and original artwork, Enter the Babylon System is part outrageous journalistic pursuit and part passionate cri de coeur for sanity in the face of a society’s obsession.
Various kinds of informal and extra-legal settlements—commonly called shantytowns, favelas, or barrios—are the prevailing type of urban land use in much of the developing world. United Nations estimates suggest that there are close to 900 million people living in squatter communities worldwide, with the number expected to increase in the coming decades. Informal Urbanization in Latin America investigates prevailing strategies for addressing informal settlements, which started to shift away from large-scale slum clearance to on-site upgrading in Latin America over the last 40 years, by improving public spaces, infrastructure and facilities. The cases in this book range from one micro intervention (the Villa Tranquila Project in Buenos Aires) to three large-scale government-run projects: the celebrated Favela Bairro Program in Rio de Janeiro, the social housing program in São Paulo and the famous Proyectos Urbanos Integrales Approach in Medellín. The cases show a collaborative and sensitive transformation of landscape and public space, and provide designers and planners with the tools to develop better strategies that can mitigate the volatility that the residents of non-formal neighborhoods are exposed to. The book is a must-read for all who are interested or working in the global urbanization as well as social equity.
This paper investigates the effects of the adoption of inflation targeting (IT) on the choice of exchange rate regime in emerging markets (EMs), conditional on certain macroeconomic conditions. Using a large sample of EMs and after controlling for the selection bias associated with the adoption of IT, we find that IT countries on average have a relatively more flexible exchange rate regime than other EMs. However, the flexibility of the exchange rate regime shows strong heterogeneity among IT countries depending on their degree of openness and exposure to FX risks. Moreover, we find that the marginal effect of IT adoption on the exchange rate flexibility increases with the duration of the IT regime in place, and with the propensity scores to adopt it.
Human Physiology in Extreme Environments, Second Edition, offers evidence on how human biology and physiology is affected by extreme environments, also highlighting technological innovations that allow us to adapt and regulate environments. Covering a broad range of extreme environments, including high altitude, underwater, tropical climates, desert climates, arctic climates and space travel, the book also includes case studies that can be used to illustrate practical application. Graduate students, medical students and researchers will find this to be an interesting, informative and useful resource for human physiology, environmental physiology and medical studies. - Includes coverage of current global challenges and their consequences on human physiology and performance - Presents human physiological challenges in extreme environments - Provides an excellent source of information on paleontological and anthropological aspects - Offers practical medical and scientific uses of current concepts
Nestled by rows of luscious grapevines, wineries evoke images of fine living few other places can rival. The spirit of each winery is as distinctive as the wines it produces. With a multitude of unique design touches, each one creates a sense of place, and a charming invitation to slow down and savor a way of life deeply rooted in growing cycles and the seasons. This lavishly illustrated compendium showcases the new wave of winery buildings. This school of design takes its lead from architect Herzog de Meuron's 1997 design for Dominus Winery, setting a trend away from the rustic and embracing the sleekest contemporary ethos. Since then leading wineries have commissioned chic tasting rooms and spectacular facilities by architectural luminaries such as Santiago Calatrava, Rafael Moneo, Zaha Hadid, Frank O. Gehry and Norman Foster. ? A unique gift for the wine connoisseur and design devotee alike ? A compelling look at all the design elements that make up the world's most beautiful wineries
Everything engineers need to know about mechanical vibration and shock...in one authoritative reference work! This fully updated and revised 3rd edition addresses the entire field of mechanical vibration and shock as one of the most important types of load and stress applied to structures, machines and components in the real world. Examples include everything from the regular and predictable loads applied to turbines, motors or helicopters by the spinning of their constituent parts to the ability of buildings to withstand damage from wind loads or explosions, and the need for cars to maintain structural integrity in the event of a crash. There are detailed examinations of underlying theory, models developed for specific applications, performance of materials under test conditions and in real-world settings, and case studies and discussions of how the relationships between these affect design for actual products. Invaluable to engineers specializing in mechanical, aeronautical, civil, electrical and transportation engineering, this reference work, in five volumes is a crucial resource for the solution of shock and vibration problems. The relative and absolute response of a mechanical system with a single degree of freedom is considered for an arbitrary excitation, and its transfer function is defined in various forms. The characteristics of sinusoidal vibration are examined in the context both of the real world and of laboratory tests, and for both transient and steady state response of the one-degree-of-freedom system. Viscous damping and then non-linear damping are considered. The various types of swept sine perturbations and their properties are described and, for the one-degree-of-freedom system, the consequence of an inappropriate choice of sweep rate are considered. From the latter, rules governing the choice of suitable sweep rates are then developed.
The modelling tools for soils and rocks require more and more specific parameters not always available from the standard or usual survey campaigns, this generally for reasons of delay or costs. The use of correlations to solve the gap between available parameters and the required ones is a common practice. Many of them exist but are spread throughout numerous papers or books. The aim of this formulary is to provide a large synthesis of the existing correlations accumulated by the authors during more than 40 years academic and consulting careers.
Are companies, churches, and states genuine agents? Or are they just collections of individual agents that give a misleading impression of unity? This question is important, since the answer dictates how we should go about explaining the behaviour of these entities and whether we should treat them as responsible and accountable in the manner of individuals. Group Agency offers a new approach to that question and is relevant, therefore, in a range of fields from philosophy to law, politics, and the social sciences. Christian List and Philip Pettit take the line that there really are group or corporate agents, over and above the individual agents who compose them, and that a proper social science and a proper approach to law, morality, and politics have to take account of this fact. Unlike some earlier defences of group agency, their account is entirely unmysterious in character and, despite not being technically difficult, is grounded in cutting-edge work in social choice theory, economics, and philosophy.
Though many archival digital objects were not "born digital," film archives are now becoming important resources for digital scholarship as a consequence of digitization. Moreover, with advancements in digital research methods involving video annotation, visual analysis, and GIS affecting the way we look at archival films' material, stylistic histories and circulation, new research practices are more important than ever. Visualizing Film History is an accessible introduction to archive-based digital scholarship in film and media studies and beyond. With a combined focus on the history of film historiography, archiving, and recent digital scholarship-covering a period from the "first wave" of film archiving in the early 1900s to recent data art-this book proposes ways to work critically with digitized archives and research methods. Christian Olesen encourages a shift towards new critical practices in the field with an in-depth assessment of and critical approach to doing film historiography with the latest digital tools and digitized archives. Olesen argues that if students, scholars and archivists are to fully realize the potential of emerging digital tools and methodologies, they must critically consider the roles that data analysis, visualization, interfaces and procedural human-machinery interactions play in producing knowledge in current film historical research. If we fail to do so, we risk losing our ability to critically navigate and renew contemporary research practices and evaluate the results of digital scholarship"--
In response to the catastrophic destruction of Syria’s ancient city of Palmyra, a UNESCO world heritage site, a group of major international scholars gathered to focus on the art, archaeology, and history of the beleaguered site and present their latest findings. Their papers, given at a symposium at The Metropolitan Museum of Art in May 2016, have been collected in this fascinating and important publication. They are accompanied by a moving tribute by Waleed Khaled al-Asa‘ad to his father, Khaled al-Asa‘ad, the Syrian archaeologist and head of antiquities for the ancient city of Palmyra who was brutally murdered in 2015 while defending the site. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 14.0px Verdana} Palmyra: Mirage in the Desert, published simultaneously in English and Arabic, is the latest volume in the Metropolitan Museum symposium series. It is a major contribution to the knowledge and understanding of this multicultural desert—located at the crossroads of the ancient world—that will help preserve the memory of this extraordinary place for generations to come.
The Académie Royale de Peinture et de Sculpture (French Academy of Painting and Sculpture)—perhaps the single most influential art institution in history—governed the arts in France for more than 150 years, from its founding in 1648 until its abolition in 1793. Christian Michel's sweeping study presents an authoritative, in-depth analysis of the Académie’s history and legacy. The Académie Royale assembled nearly all of the important French artists working at the time, maintained a virtual monopoly on teaching and exhibitions, enjoyed a priority in obtaining royal commissions, and deeply influenced the artistic landscape in France. Yet the institution remains little understood today: all commentary on it, during its existence and since its abolition, is based on prejudices, both favorable and critical, that have shaped the way the institution has been appraised. This book takes a different approach. Rather than judging the Académie Royale, Michel unravels existing critical discourse to consider the nuances and complexities of the academy’s history, reexamining its goals, the shifting power dynamics both within the institution and in the larger political landscape, and its relationship with other French academies and guilds.
... less about film than about the psychology of the viewing experience." --American Film Employing Freudian psychoanalysis, Christian Metz explores the nature of cinematic spectatorship and looks at the operations of meaning in the film text.
The "European Yearbook" promotes the scientific study of nineteen European supranational organisations and the Organisation for Economic Co-operation and Development (OECD). Each volume contains a detailed survey of the history, structure and yearly activities of each organisation and an up-to-date chart providing a clear overview of the member states of each organisation. In addition, a number of articles on topics of general interest are included in each volume. A general index by subject and name, and a cumulative index of all the articles which have appeared in the "Yearbook," are included in every volume and provide direct access to the "Yearbook"'s subject matter. Each volume contains a comprehensive bibliography covering the year's relevant publications. This is an indispensable work of reference for anyone dealing with the European institutions.
The influence of satiation before and after a pasta meal was studied through the evaluation of aroma release and chewing activity during the consumption of a flavored model cheese. Aroma release during cheese consumption was found to be higher after satiation than before. The difference can be explained by an increase in the duration of the chewing sequence and an increase in the chewing muscular work after satiation. However, the pulmonary flow was not affected by satiation.
This book is the first investigation of the relationship between Palmyra and its surrounding territory from the Roman to the early Islamic period since the 1930s. It discusses the agricultural potential of the hinterland, its role in the food supply of the city, and the interaction with the nomadic networks on the Syrian dry steppe.
By exploring the intense interaction between painting and printmaking between art theory and unbridled artistic ambition, Printing the Grand Manner breaks new ground in its analysis of both the reproductive prints and Le Brun's original compositions. --Book Jacket.
Les 3 batteries du "Coaching Global":Equilibrer son alimentation pour qu'elle devienne source d'énergie.Pratiquer un sport pour évacuer le stress et améliorer sa condition physique.Communiquer de façon assertive, pour défendre son point de vue et ses idées tout en respectant son interlocuteur et en veillant à ce qu'il ne se sente jamais "agressé".Faire preuve d'empathie pour être un "conseil" plutôt qu'un "juge".S'entourer de gens positifs qui contribueront à alimenter et à recharger nos "batteries", et tenir à l'écart les situations ou les personnes qui ont tendance à faire passer notre "curseur énergie" dans la "zone rouge".Voici quelques sujets et bien d'autres, que vous découvrirez ou redécouvrirez dans ce livre, véritable« boîte à outils » du Coaching Global.
Vienna's once exalted status as the showpiece of an empire is reflected in the elegance and monumentality of its architecture. But behind and beyond the stately fa'ades, design innovations are transforming interiors and resulting in exciting new residential and commercial buildings being constructed at the city's edges. This user-friendly little guide profiles some of the most notable projects built during the last few years and includes color photographs and a site map.
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