This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.
Much of the produce that Americans eat is grown in the Mexican state of Baja California, the site of a multibillion-dollar export agricultural boom that has generated jobs and purportedly reduced poverty and labor migration to the United States. But how has this growth affected those living in Baja? Based on a decade of ethnographic fieldwork, Made in Baja examines the unforeseen consequences for residents in the region of San Quintín. The ramifications include the tripling of the region’s population, mushrooming precarious colonia communities lacking basic infrastructure and services, and turbulent struggles for labor, civic, and political rights. Anthropologist Christian Zlolniski reveals the outcomes of growers structuring the industry around an insatiable demand for fresh fruits and vegetables. He also investigates the ecological damage—"watercide”—and the social side effects of exploiting natural resources for agricultural production. Weaving together stories from both farmworkers and growers, Made in Baja provides an eye-opening look at the dynamic economy developing south of the border.
This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.
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