Christian Behl's Books

Alzheimer’s Disease Research

What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift

By: Christian Behl

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Alzheimer’s Disease Research

What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift

By: Christian Behl

This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.

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661

Publisher

Springer Nature

Published Date

ISBN 10

3031315707

ISBN 13

9783031315701

Estrogen — Mystery Drug for the Brain?

The Neuroprotective Activities of the Female Sex Hormone

By: Christian Behl

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Estrogen — Mystery Drug for the Brain?

The Neuroprotective Activities of the Female Sex Hormone

By: Christian Behl

It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and therefore "from bench to bed”.

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256

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3709161894

ISBN 13

9783709161890

Cell Aging: Molecular Mechanisms and Implications for Disease

By: Christian Behl,Christine Ziegler

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Cell Aging: Molecular Mechanisms and Implications for Disease

By: Christian Behl,Christine Ziegler

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

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113

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Springer Science & Business Media

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ISBN 10

3642451799

ISBN 13

9783642451799

Amar Akbar Anthony

Bollywood, Brotherhood, and the Nation

By: William Elison,Christian Lee Novetzke,Andy Rotman

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Amar Akbar Anthony

Bollywood, Brotherhood, and the Nation

By: William Elison,Christian Lee Novetzke,Andy Rotman

A Bollywood blockbuster when it was released in 1977, Amar Akbar Anthony has become a classic of Hindi cinema and a touchstone of Indian popular culture. Delighting audiences with its songs and madcap adventures, the film follows the heroics of three Bombay brothers separated in childhood from their parents and one another. Beyond the freewheeling comedy and camp, however, is a potent vision of social harmony, as the three protagonists, each raised in a different religion, discover they are true brothers in the end. William Elison, Christian Lee Novetzke, and Andy Rotman offer a sympathetic and layered interpretation of the film’s deeper symbolism, seeing it as a lens for understanding modern India’s experience with secular democracy. Amar Akbar Anthony’s celebration of an India built on pluralism and religious tolerance continues to resonate with audiences today. But it also invites a critique of modernity’s mixed blessings. As the authors show, the film’s sunny exterior only partially conceals darker elements: the shadow of Partition, the crisis of Emergency Rule, and the vexed implications of the metaphor of the family for the nation. The lessons viewers draw from the film depend largely on which brother they recognize as its hero. Is it Amar, the straight-edge Hindu policeman? Is it Akbar, the romantic Muslim singer? Or is it Anthony, the Christian outlaw with a heart of gold? In this book’s innovative and multi-perspectival approach, each brother makes his case for himself (although the last word belongs to their mother).

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345

Publisher

Harvard University Press

Published Date

ISBN 10

0674495993

ISBN 13

9780674495999

The Quotidian Revolution

Vernacularization, Religion, and the Premodern Public Sphere in India

By: Christian Lee Novetzke

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The Quotidian Revolution

Vernacularization, Religion, and the Premodern Public Sphere in India

By: Christian Lee Novetzke

In thirteenth-century Maharashtra, a new vernacular literature emerged to challenge the hegemony of Sanskrit, a language largely restricted to men of high caste. In a vivid and accessible idiom, this new Marathi literature inaugurated a public debate over the ethics of social difference grounded in the idiom of everyday life. The arguments of vernacular intellectuals pushed the question of social inclusion into ever-wider social realms, spearheading the development of a nascent premodern public sphere that valorized the quotidian world in sociopolitical terms. The Quotidian Revolution examines this pivotal moment of vernacularization in Indian literature, religion, and public life by investigating courtly donative Marathi inscriptions alongside the first extant texts of Marathi literature: the Lilacaritra (1278) and the Jñanesvari (1290). Novetzke revisits the influence of Chakradhar (c. 1194), the founder of the Mahanubhav religion, and Jnandev (c. 1271), who became a major figure of the Varkari religion, to observe how these avant-garde and worldly elites pursued a radical intervention into the social questions and ethics of the age. Drawing on political anthropology and contemporary theories of social justice, religion, and the public sphere, The Quotidian Revolution explores the specific circumstances of this new discourse oriented around everyday life and its lasting legacy: widening the space of public debate in a way that presages key aspects of Indian modernity and democracy.

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429

Publisher

Columbia University Press

Published Date

ISBN 10

0231542410

ISBN 13

9780231542418

Solid State Batteries: Materials Design and Optimization

By: Christian Julien,Gholam-Abbas Nazri

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Solid State Batteries: Materials Design and Optimization

By: Christian Julien,Gholam-Abbas Nazri

The field of solid state ionics is multidisciplinary in nature. Chemists, physicists, electrochimists, and engineers all are involved in the research and development of materials, techniques, and theoretical approaches. This science is one of the great triumphs of the second part of the 20th century. For nearly a century, development of materials for solid-state ionic technology has been restricted. During the last two decades there have been remarkable advances: more materials were discovered, modem technologies were used for characterization and optimization of ionic conduction in solids, trial and error approaches were deserted for defined predictions. During the same period fundamental theories for ion conduction in solids appeared. The large explosion of solid-state ionic material science may be considered to be due to two other influences. The first aspect is related to economy and connected with energy production, storage, and utilization. There are basic problems in industrialized countries from the economical, environmental, political, and technological points of view. The possibility of storing a large amount of utilizable energy in a comparatively small volume would make a number of non-conventional intermittent energy sources of practical convenience and cost. The second aspect is related to huge increase in international relationships between researchers and exchanges of results make considerable progress between scientists; one find many institutes joined in common search programs such as the material science networks organized by EEC in the European countries.

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577

Publisher

Springer Science & Business Media

Published Date

ISBN 10

146152704X

ISBN 13

9781461527046

Network Programmability and Automation

By: Matt Oswalt,Christian Adell,Scott S. Lowe,Jason Edelman

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Network Programmability and Automation

By: Matt Oswalt,Christian Adell,Scott S. Lowe,Jason Edelman

Network engineers are finding it harder than ever to rely solely on manual processes to get their jobs done. New protocols, technologies, delivery models, and the need for businesses to become more agile and flexible have made network automation essential. The updated second edition of this practical guide shows network engineers how to use a range of technologies and tools, including Linux, Python, APIs, and Git, to automate systems through code. This edition also includes brand new topics such as network development environments, cloud, programming with Go, and a reference network automation architecture. Network Programmability and Automation will help you automate tasks involved in configuring, managing, and operating network equipment, topologies, services, and connectivity. Through the course of the book, you'll learn the basic skills and tools you need to make this critical transition. You'll learn: Programming skills with Python and Go: data types, conditionals, loops, functions, and more How to work with Linux-based systems, the foundation for modern networking and cloud platforms Data formats and models: JSON, XML, YAML, and YANG Jinja templating for creating network device configurations The role of application programming interfaces (APIs) in network automation Source control with Git to manage code changes during the automation process Cloud-native technologies like Docker and Kubernetes How to automate network devices and services using Ansible, Salt, and Terraform Tools and technologies for developing and continuously integrating network automation

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828

Publisher

"O'Reilly Media, Inc."

Published Date

ISBN 10

1098110803

ISBN 13

9781098110802

The Endocannabinoid System in Local and Systemic Inflammation

By: Melanie E. M. Kelly,Christian Lehmann,Juan Zhou

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The Endocannabinoid System in Local and Systemic Inflammation

By: Melanie E. M. Kelly,Christian Lehmann,Juan Zhou

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

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209

Publisher

Biota Publishing

Published Date

ISBN 10

1615047492

ISBN 13

9781615047499

Religion and Public Memory

A Cultural History of Saint Namdev in India

By: Christian Lee Novetzke

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Religion and Public Memory

A Cultural History of Saint Namdev in India

By: Christian Lee Novetzke

Namdev is a central figure in the cultural history of India, especially within the field of bhakti, a devotional practice that has created publics of memory for over eight centuries. Born in the Marathi-speaking region of the Deccan in the late thirteenth century, Namdev is remembered as a simple, low-caste Hindu tailor whose innovative performances of devotional songs spread his fame widely. He is central to many religious traditions within Hinduism, as well as to Sikhism, and he is a key early literary figure in Maharashtra, northern India, and Punjab. In the modern period, Namdev appears throughout the public spheres of Marathi and Hindi and in India at large, where his identity fluctuates between regional associations and a quiet, pan-Indian, nationalist-secularist profile that champions the poor, oppressed, marginalized, and low caste. Christian Lee Novetzke considers the way social memory coheres around the figure of Namdev from the sixteenth century to the present, examining the practices that situate Namdev's memory in multiple historical publics. Focusing primarily on Maharashtra and drawing on ethnographies of devotional performance, archival materials, scholarly historiography, and popular media, especially film, Novetzke vividly illustrates how religious communities in India preserve their pasts and, in turn, create their own historical narratives.

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334

Publisher

Columbia University Press

Published Date

ISBN 10

0231512562

ISBN 13

9780231512565

Global Sedimentology of the Ocean

An Interplay between Geodynamics and Paleoenvironment

By: Christian M. Robert

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Global Sedimentology of the Ocean

An Interplay between Geodynamics and Paleoenvironment

By: Christian M. Robert

A great deal of information has been gained during the past 20 years about the deep ocean. This book synthesizes new information in marine sedimentology, applying concepts to case studies, and integrating the information in a context of plate tectonics, global circulation, and sedimentary processes. The potential of sediment series as archives of past environments is highlighted.* complete update of synthetic information in marine sedimentology.* association of information on the origin and transport of sediment particles, the evolution of sediment series and their role as archives of past environments.

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498

Publisher

Elsevier

Published Date

ISBN 10

008093093X

ISBN 13

9780080930930

Cell Aging: Molecular Mechanisms and Implications for Disease

By: Christian Behl,Christine Ziegler

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Cell Aging: Molecular Mechanisms and Implications for Disease

By: Christian Behl,Christine Ziegler

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113

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Springer Science & Business Media

Published Date

ISBN 10

3642451799

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9783642451799

Estrogen — Mystery Drug for the Brain?

The Neuroprotective Activities of the Female Sex Hormone

By: Christian Behl

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Estrogen — Mystery Drug for the Brain?

The Neuroprotective Activities of the Female Sex Hormone

By: Christian Behl

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256

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Springer Science & Business Media

Published Date

ISBN 10

3709161894

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9783709161890

Book's by Christian Behl

Alzheimer’s Disease Research

Alzheimer’s Disease Research

Estrogen — Mystery Drug for the Brain?

Estrogen — Mystery Drug for the Brain?

Cell Aging: Molecular Mechanisms and Implications for Disease

Cell Aging: Molecular Mechanisms and Implications for Disease

Amar Akbar Anthony

Amar Akbar Anthony

The Quotidian Revolution

The Quotidian Revolution

Solid State Batteries: Materials Design and Optimization

Solid State Batteries: Materials Design and Optimization

Network Programmability and Automation

Network Programmability and Automation

The Endocannabinoid System in Local and Systemic Inflammation

The Endocannabinoid System in Local and Systemic Inflammation

Religion and Public Memory

Religion and Public Memory

Global Sedimentology of the Ocean

Global Sedimentology of the Ocean

Cell Aging: Molecular Mechanisms and Implications for Disease

Cell Aging: Molecular Mechanisms and Implications for Disease

Estrogen — Mystery Drug for the Brain?

Estrogen — Mystery Drug for the Brain?

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