The inability of science to discern truth properly and its politicization go hand in hand. The "Irreproducibility Crisis" builds on this history of concern over the threats to scientific integrity, but it is also a departure. In this case, we are calling out a particular class of errors in contemporary science. Those errors are sometimes connected to the politicization of the sciences and scientific misconduct, but sometimes not. The reforms we call for would make for better science in the sense of limiting needless errors, but those reforms would also narrow the opportunities for sloppy political advocacy and damaging government edicts. This report deals with an epistemic problem, which is most visible in the large numbers of articles in reputable peer-reviewed journals in the sciences that have turned out to be invalid or highly questionable. Findings from experimental work or observational studies turn out, time and again, to be irreproducible. The high rates of irreproducibility are an ongoing scandal that rightly has upset a large portion of the scientific community.