This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Secret Darlington explores the lesser-known history of the town of Darlington through a fascinating selection of stories, unusual facts and attractive photographs.
The eighteenth century is often viewed as the heroic age of the British iron industry - a time of triumphant technological progress. In fact, it was an age of thwarted ambition, when the take-up of new technologies proved frustratingly slow. The eighteenth century was more accurately the age of Baltic iron. Swedish and Russian iron surged onto the British market, meeting the demand that British ironmasters could not satisfy. This was of epochal importance: Swedish iron allowed British steel makers and hardware manufacturers to dominate Atlantic markets. In turn, the rhythms of Atlantic commerce resounded through peasant communities in Sweden. Baltic iron in the Atlantic world captures this moment. In doing so it internationalises Swedish history in a radical way and presses an oceanic perspective on the traditionally insular view of the rise of heavy industry in Britain.
Experience 100 key dates that shaped Darlington’s history, highlighted its people’s genius (or silliness) and embraced the unexpected. Featuring an amazing mix of social, criminal and sporting events, this book reveals a past that will fascinate, delight and surprise residents and visitors alike.
Do you support Reading FC? Are you knowledgeable about the long line of memorable players and managers who have shaped the club's history? Have you followed all the highs and lows of Reading FC through the years? If you answered yes to any of the preceding questions, why not find out how much you really know about the Royals with this exciting new quiz book? Researched and compiled to test your memory of the people and places that have shaped the Royals, The Reading Quiz Book is full of fascinating facts. With 250 questions covering all aspects of Reading's glorious past including club honours and records, legendary players, top goalscorers, famous opponents, wins, draws and losses, you can’t fail to learn something new about your favourite team. With a fitting foreword by Roger Winslet, this quiz book is guaranteed to score a hit with Reading fans of all ages and is a must-have guide for anyone interested in finding out more about one of the oldest established teams in English football.
Work Under Capitalism synthesizes recent institutionalist and Marxist ideas about the organization of production, situating production within a social context. Starting with the transaction rather than the individual, it builds upon a coherent theory and applies it to a wide range of experience, from household labour to transformations of health c
Drawing on his experience of research and many stress-busting workshops he has run for teachers, the author of this book explains the nature and source of stress, how to pre-empt stress, a range of direct action and palliative coping strategies and what successful schools do to minimize stress on their staff. It aims to be the key to defeating teacher stress.
First Published in 2002. It is easy to see that we are living in a time of rapid and radical social change. It is much less easy to grasp the fact that such change will inevitably affect the nature of those disciplines that both reflect our society and help to shape it. Yet this is nowhere more apparent than in the central field of what may, in general terms, be called literary studies. ‘New Accents’ is intended as a positive response to the initiative offered by such a situation. Each volume in the series will seek to encourage rather than resist the process of change. To stretch rather than reinforce the boundaries that currently define literature and its academic study.
For a bowler, taking all ten wickets in an innings is the ultimate statistical feat. It is also a very rare one: in nearly 60,000 first-class matches it has been achieved only 81 times. Surprisingly, although books have been written about Hedley Verity’s world record ten for 10 in 1932 and Jim Laker’s all-ten in the 1956 Old Trafford Test, nobody has ever written a book describing every all-ten. Until now. All Ten chronicles each all-ten, from Edmund Hinkly’s at Lord’s in 1848 to Zulfiqar Babar’s at Multan over a century and a half later. All-tens have been taken at many different venues, from famous Test match grounds to outgrounds on which first-class cricket is no longer played. Some were taken by great bowlers such as Colin Blythe and Clarrie Grimmett, some by less well-known ones including Harry Pickett of Essex and Tom Graveney’s brother Ken. Some bowlers were at the beginning of their careers, some were nearing the end. You will read about them all here and their very special feat, and maybe wonder why the bowlers at the other end didn’t strike even once, why many of the greatest bowlers of all-time never took an all-ten, and why all-tens have become much rarer in the last half century.
Greater southern Africa has a wealth of mammal species, almost 400 – all of which are covered in this fully updated, comprehensive field guide. Now expanded to include species found in Angola, Zambia and Malawi, it has also been extensively revised to include: • the most recent research and taxonomy • revised distribution maps and many new images • colour-coded grouping of families • spoor and size icons • skull photographs, grouped for easy comparison • detailed descriptions of each species, offering insight into key identification characters, typical behaviour, preferred habitat, food choice, reproduction and longevity.
International Relations" is the multi-disciplinary and heterogeneous study which goes to the heart of relations between states and international organisations embracing international politics, economics, political economy, diplomatic and international history. It seeks to explain the mainsprings of global politics, which is a prime field for historians and especially for political scientists and IR theory, and provides the essential intellectual underpinning of the discipline. This book features over 250 alphabetical entries covering the most important and the latest cutting-edge theory from anarchy to world systems theory. Entries include scholars, writers, concepts, principal debates, argumentation, theories, leading schools of thought, states, international bodies, conflicts and war, treaties and alliances. The coverage is global and comprehensive with substantial cross-referencing, and the extensive index serves as a major reference tool enabling readers to pick up additional important subjects from the main alphabetical entries.Clear and concise writing cuts through even the most opaque theoretical subjects and the result is an essential reference guide for students of International Relations, politics and history and will guide both specialists and general readers through the fast-changing complexities of global politics.
Critically examining current journalistic practices using both theoretical and applied approaches, this book addresses the interplay between the right to free expression (and what that means to a free press) and the right to privacy. Privacy, and the criticism that journalists unreasonably and regularly invade it in order to get a “good story”, is the most significant ethical dilemma for journalists, alongside accurately reporting the truth. Where is the line between fair exposure in the public interest and interesting the public? This book explains what privacy is, why we need it and why we go to some lengths to protect it. The law, the regulators, the key court cases and regulator complaints are covered, as well as issues raised by new technological developments. The book also briefly examines regulators in Ireland as well as privacy and free expression elsewhere in Europe and in North America, considering the contrary cultures of the two continents. This insightful exploration of privacy and journalism combines theory and practice to provide a valuable resource for both Media and Journalism students and working journalists.
The Unlocking the Law series makes the law accessible. Each chapter contains activities such as quick quizzes and self-test questions, key facts charts to consolidate your knowledge and diagrams to aid learning. Cases, judgments and primary source quotations are prominently displayed. Summaries help you understand each chapter, there is a glossary of legal terminology. New features include problem questions with guidance on answering, as well as essay questions and answer plans, plus cases and materials exercises. All titles in the series follow the same formula and include the same features so students can move easily from one subject to another.
Contract law is an essential element of all law degrees. Unlocking Contract Law will ensure that you grasp the main concepts with ease, providing you with an indispensable foundation in contract law. This third edition is fully up-to-date with the latest changes in the law and includes discussion of the Consumer Protection from Unfair Trading Regulations, as well as all the major new cases. The Unlocking the Law series is designed specifically to make the law accessible. Each chapter opens with aims and objectives and contains activities such as quick quizzes and self-test questions, key facts charts, diagrams to aid learning and numerous headings and sub-headings to make the subject manageable. New features include summaries to check your understanding of each chapter, a glossary of legal terminology, essay questions with answer plans and exam questions with guidance on answering. All titles in the series follow the same formula and include the same features so students can move easily from one subject to another. The series covers all the core subjects required by the Bar Council and the Law Society for entry onto professional qualifications as well as popular option units. Resources supporting this book are available online at www.unlockingthelaw.co.uk. These include: multiple choice questions key questions and answers revision mp3s available for free download interactive glossary and flashcards
This book gives the fullest account so far of the origins, success and public impact of Walter Greenwood’s Love on the Dole in all three of its versions: novel (1933), play (1935) and film (1941).
Sustainability and the Rights of Nature: An Introduction is a much-needed guide that addresses the exciting and significant paradigm shift to the Rights of Nature, as it is occurring both in the United States and internationally in the fields of environmental law and environmental sustainability. This shift advocates building a relationship of integrity and reciprocity with the planet by placing Nature in the forefront of our rights-based legal systems. The authors discuss means of achieving this by laying out Nature’s Laws of Reciprocity and providing a roadmap of the strategies and directions needed to create a Rights of Nature-oriented legal system that will shape and maintain human activities in an environmentally sustainable manner. This work is enriched with an array of unique and relevant points of reference such as the feudal notions of obligation, principles of traditional indigenous cultivation, the Pope Francis Encyclical on the environment, and the new Rights of Nature-based legal systems of Ecuador and Bolivia that can serve as prototypes for the United States and other countries around the world to help ensure a future of environmental sustainability for all living systems.
The significance of the Corinthians Football Club, founded in 1882, has been widely acknowledged by historians of football and by sports historians generally. As a ’super club’ comprising the best amateur talent available they were an important formative influence on football in Britain from the 1880s to the 1930s. As a touring club - they first travelled to South Africa in 1897 and made regular forays into Europe and also to Canada, the United States and Brazil - they were the self-proclaimed standard bearers for gentlemanly values in sport. Indeed for many years they were most famous football club in the world, drawing huge crowds and helping to ensure that the version of football emanating from the English public schools and universities in the mid-nineteenth century became a global game. Though their playing strength and influence waned after the First World War, they remained a significant force through to 1939, upholding ’true blue’ amateurism at a time when football was increasingly associated with professionalism and seen as a branch of commercial entertainment. Whilst much has been written about the Corinthians, mainly by club insiders, this is the first complete scholarly history to cover their activities both in England and in other parts of the world. It critically reassesses the club’s role in the development of football and fills a gap in existing literature on the relationship between the progress of the game in England and globally. Most crucially, the book re-examines the sporting ideology of gentlemanly amateurism within the context of late-nineteenth century and early-twentieth century society.
At the beginning of the Roaring Twenties the NFL was just a footnote within the landscape of American sports. The early pro game was played on dirt fields by vagabond athletes who would beat up or punch out their opponent for fifty dollars a game. But one team was different than the rest: the Oorang Indians. Comprised entirely of Native Americans and led by star athlete Jim Thorpe, the Oorang Indians were an instant hit in almost every city they visited. In Walter Lingo, Jim Thorpe, and the Oorang Indians: How a Dog Kennel Owner Created the NFL's Most Famous Traveling Team, NFL historian Chris Willis tells the story of this unique and fascinating part of professional football history. In 1922 Walter Lingo, a dog kennel owner from tiny La Rue, Ohio, joined forces with Jim Thorpe, the country’s greatest athlete, to create the Oorang Indians. Willis recounts how Lingo used the football team, the star attraction of player-coach Thorpe, and the all Native-American squad to help advertise his kennel and sell dogs, putting the small town of La Rue on the map. With the complete cooperation of the Lingo family and unlimited access to family photos and archives, Walter Lingo, Jim Thorpe, and the Oorang Indians provides an up-close and behind-the-scenes view into the making of this little-known team. It is a remarkable story that will be enjoyed by football fans and historians alike.
From the trashy to the epic, from the classics to today's blockbusters, this cinefile’s guidebook reviews nearly 1,000 of the biggest, baddest, and brightest from every age and genre of cinematic science fiction! Once upon a time, science fiction was only in the future. It was the stuff of drive-ins and cheap double-bills. Then, with the ever-increasing rush of new, society-altering technologies, science fiction pushed its way to the present, and it busted out of the genre ghetto of science fiction and barged its way into the mainstream. What used to be mere fantasy (trips to the moon? Wristwatch radios? Supercomputers capable of learning?) are now everyday reality. Whether nostalgic for the future or fast-forwarding to the present, The Sci-Fi Movie Guide: The Universe of Film from Alien to Zardoz covers the broad and widening range of science-fiction movies. You’ll find more than just Star Wars, Star Trek, and Transformers, with reviews on many overlooked and under-appreciated gems and genres, such as ... Monsters! Pacific Rim, Godzilla, The Thing, Creature from the Black Lagoon Superheroes: Thor, Iron Man, X-Men, The Amazing Spider-man, Superman Dystopias: THX 1138, 1984, The Hunger Games Avant-garde masterpieces: Solaris, 2001, Brazil, The Man Who Fell to Earth Time travel: 12 Monkeys, The Time Machine, Time Bandits, Back to the Future Post-apocalyptic action: The Road Warrior, I Am Legend, Terminator Salvation Comedy: Dark Star, Mars Attacks!, Dr. Strangelove, The Adventures of Buckaroo Banzai Across the Eighth Dimension, Mystery Science Theater 3000 Aliens! The Day the Earth Stood Still, Close Encounters of the Third Kind, Contact, Invasion of the Body Snatchers, Signs Mad scientists! Frankenstein, The Invisible Man, The Abominable Dr. Phibes Shoot-em-ups: Aliens, Universal Soldier, Starship Troopers What the...?: Battlefield Earth, Prayer of the Rollerboys, Repo: The Genetic Opera, Tank Girl, The 10th Victim Animation: WALL-E, Akira, Ghost in the Shell Small budgets, big ideas: Donnie Darko, Primer, Sound of My Voice, Computer Chess Neglected greats: Things to Come, Children of Men Epics: Metropolis, Blade Runner, Cloud Atlas and many, many more categories and movies!! In addition to the nearly one thousand science fiction film reviews, this guide includes fascinating and fun Top-10 lists and sidebars that are designed to lead fans to similar titles they might not have known about. The Sci-Fi Movie Guide: The Universe of Film from Alien to Zardoz will help ensure that you will never again have to worry about what to watch next. Useful both as a handy resource or a fun romp through the film world of science fiction. It also includes a helpful bibliography and an extensive index, adding to its usefulness.
First Published in 1997. In special education we are, at last, in a good position to offer pupils a broad and balanced curriculum which is relevant to their needs and which is based on the same range of provision enjoyed by all pupils. Such a curriculum can only be planned as a cohesive whole; compartmentalizing aspects of the whole curriculum risks seeing one part as having more merit or worth than another. The whole curriculum in ail schools will vary, depending on local needs and opportunities. In special education it is important that we embrace that whole curriculum, using its diversity and opportunity to plan for breadth, balance and relevance. This book makes a significant contribution to the developments in planning for access to the whole curriculum.
Otorhinolaryngology- Head & Neck Surgery is the latest edition of this comprehensive two-volume guide to all the sub-specialties of otorhinolaryngology, including brand new chapters and the most recent developments in the field. New topics in this edition include laryngopharyngeal reflux, trauma and stenosis of the larynx, and laryngeal cancer, bringing the text firmly up to date. Illustrated in full colour across 2000 pages, this vast two-volume set is an ideal source of reference for otorhinolaryngoloy practitioners and residents.
With first-hand accounts and colour artwork, this title describes the planes and pilots of the famous 4th Fighter Group 'Fourth but First' that became the highest-scoring unit of the mighty 8th Air Force in World War 2. Formed around a nucleus of pilots already seasoned by their experience as volunteers in the RAF's Eagle Squadrons, the 4th Fighter Group was established in England in October 1942. Initially flying Spitfires, the Debden Eagles went on to fly the P-47 and P-51, becoming, in July 1943, the first Eighth Air Force fighter group to penetrate German air space. The group's record of 583 air and 469 ground victories was unmatched in the Eighth Air Force, and the group produced a cast of characters that included legendary aces Don Blakeslee, Pierce McKennon, “Kid” Hofer, Duane Beeson, Steve Pisanos and Howard Hively. Involved in the D-Day landings, Operation Market Garden, the Battle of the Bulge and the crossing of the Rhine, the group's achievements came at a high price, with a 42 percent casualty rate. Packed with pilots' experiences, detailed aircraft profiles and full combat histories, this book is an intriguing insight into the best-known American fighter unit in World War II.
An accessible introduction to the life and work of the inventive Welsh poet. Dylan Thomas—author of some of the century’s greatest poetry, stories, and film scripts as well as one of the greatest radio features ever broadcast, Under Milk Wood—is often characterized as self-indulgent. This concise and up-to-date biography challenges this depiction with a fresh portrait of the artist as a consummate professional. John Goodby and Chris Wigginton locate the source of Thomas’s daring and inventive style in the poet’s Anglo-Welsh origins as well as his historical, cultural, and social contexts: the Great Depression and 1930s literary London, surrealism, World War II, and Cold War popular culture. The result is a revealing and fresh introduction to the life and work of this important Welsh writer.
Social criticism at its scorching-hot best."--Barbara Ehrenreich "Think H.L. Mencken crossed with Jon Stewart."--The Phoenix In Rich People Things, Chris Lehmann lays bare the various dogmas and delusions that prop up plutocratic rule in the post-meltdown age. It's a humorous and harrowing tale of warped populism, phony reform, and blind deference to the nation's financial elite. As the author explains, American class privilege is very much like the idea of sex in a Catholic school--it's not supposed to exist in the first place, but once it presents itself in your mind's eye, you realize that it's everywhere. A concise and easy-to-use guide, Rich People Things catalogs the fortifications that shelter the opulent from the resentments of the hoi polloi. From ideological stanchions such as the Free Market through the castellation of media including The New York Times and Wired magazine, to gatekeepers such as David Brooks, Steve Forbes, and Alan Greenspan, Lehmann covers the vast array of comforting and comprehensive protections that allow the über-privileged to maintain their iron grip on almost half of America's wealth. With chapters on Malcolm Gladwell, the Supreme Court, the memoir, and more, no one is spared from Lehmann's pointed prose. Chris Lehmann is employed, ever precariously, as an editor for Yahoo! News, Bookforum, and The Baffler, while dissecting the excesses of his social betters for his column Rich People Things at TheAwl.com. He lives in Washington, DC, with his wife Ana Marie Cox and a quartet of excellent pets.
The emergence of symbolic culture is generally linked with the development of the hunger-gatherer adaptation based on a sexual division of labor. This original and ingenious book presents a new theory of how this symbolic domain originated. Integrating perspectives of evolutionary biography and social anthropology within a Marxist framework, Chris Knight rejects the common assumption that human culture was a modified extension of primate behavior and argues instead that it was the product of an immense social, sexual, and political revolution initiated by women. Culture became established, says Knight, when evolving human females began to assert collective control over their own sexuality, refusing sex to all males except those who came to them with provisions. Women usually timed their ban on sexual relations with their periods of infertility while they were menstruating, and to the extent that their solidarity drew women together, these periods tended to occur in synchrony. The result was that every month with the onset of menstruation, sexual relations were ruptured in a collective, ritualistic way as the prelude to each successful hunting expedition. This ritual act was the means through which women motivated men not only to hunt but also to concentrate energies on bringing back the meat. Knight shows how this hypothesis sheds light on the roots of such cultural traditions as totemic rituals, incest and menstrual taboos, blood-sacrifice, and hunters’ atonement rites. Providing detailed ethnographic documentation, he also explains how Native American, Australian Aboriginal, and other magico-religious myths can be read as derivatives of the same symbolic logic.
The incredible story of the primitive railways, known as tramroads, built in order to link the iconic ironworks around Blaenavon - now a UNESCO world heritage site.
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