Brother and sister Seth and Sadie Fine love Shabbat. Join them as they spend Shabbat with their family having a picnic, visiting their farm animals, and enjoying the outdoors. It all adds up to a fine day.
From snow on the ground to making applesauce and latkes to lighting the menorah, this sweet, lyrical story shows the seasonal and traditional ways we know Hanukkah is on its way.
As summer ends and fall settles in, a family prepares to celebrate Rosh Hashanah. It's time to pick apples, make cards, light the candles, and eat brisket to ring in the new year!
It’s nearly spring, which means it’s time to celebrate the cheerful Jewish holiday of Purim. Purim recounts the time when Esther, Queen of Persia, saved the Jews from the evil Haman, who wanted to execute the Jewish people. It’s a time to dress up in costumes, fill the hamantashen, swing the noisemakers, and read the Megillah scroll. Join a family as they celebrate the bravery of Queen Esther and the joy of being together.
As winter ends and spring arrives, one family prepares to celebrate Tu B'Shevat. It's time to feast on fruit, share about conservation, and plant trees! A perfect introduction to the Jewish holiday for readers of all ages.
It's time to clean the house, set out our best dishes, and fill our homes with food and family to celebrate the joyous holiday of Passover! In this sweet story, join one family as they gather with loved ones to share the joy of togetherness and freedom that Passover brings.
In this charming picture book for young children, the magic of Shabbat is celebrated through light. As the sun goes down on a Friday evening and darkness descends, different sources of light welcome in the Sabbath: candles, lanterns, the moon and stars, fireflies, nightlights and then the next morning, the sunrise. Told in gently rhythmic rhyming couplets and beautifully illustrated throughout, this is an enchanting exploration of light and dark, and a journey through the various rituals and delights of Shabbat.
What does your Shabbat look like? Join this little boy and his adorable beagle puppy Ellie for a Shabbat spent in the sun, and learn about traditions and the importance of quality time with family, friends and neighbors. After a very busy day – walking to the synagogue and back, a delicious picnic with Gran and Uncle Dave, playing on the beach with Sarina – one by one, everyone drifts off to sleep… With bright and colorful illustrations by an award-winning illustrator, This is My Shabbat is a heart-warming story, perfect for reading together at bedtime.
Siblings Seth and Sadie Fine love Shabbat. Join them as they spend Shabbat with their family having a picnic, visiting their farm animals, and enjoying the outdoors. It all adds up to a fine day.
The first sights of fall arrive—pumpkins, gourds, and colorful leaves—and that means that Sukkot is almost here. Sukkot is the Jewish holiday celebrating the fall harvest and commemorating the time when the children of Israel spent forty years wandering the desert and living in temporary shelters (rebuilt as a sukkah during Sukkot). Soft illustrations and thoughtful gentle text pair for a charming invitation for children to celebrate the joyful holiday.
Many people look at the world through a scientific lens that seems to forbid religious conviction, but then find themselves drawn by curiosity, if not longing, to the religious worldview. Is this tension inevitable . . . or unnecessary? The famously successful marriage of Charles and Emma Darwin illustrates the problem. Charles and Emma were very close to each other in social background and knowledge of the world, yet they found it difficult to agree on the Question of God. Were their religious beliefs driven apart more by his science or by their society? Were these potentially compatible, or inherently irreconcilable? Charles and Emma Darwin: The Option to Believe searches for answers in the family’s history and individual personalities, as well as in the cultural, social, and intellectual history of that family’s society. The book also looks back on the Darwins’ predicament from the perspective of modern science and theology and suggests it is society, not science, that creates the modern tension between science and religion. There is an intellectual option to believe in God that seemed unavailable to Victorians like Charles Darwin yet is certainly available to us today.
Years ago, Chris Bohjalian and his wife traded their Brooklyn co-op for a century-old Victorian house in Lincoln, Vermont (population 975). Bohjalian, a bestselling novelist, began chronicling life in that gloriously quirky little village with a wide variety of magazine essays and his newspaper column, “Idyll Banter.” These pieces, written over the course of twelve years, are honest, funny, and deeply affecting reflections on the unique idiosyncrasies of small-town life (annual outhouse races) and the universal experiences (our hunger for neighborliness) that unite us all.
Tidligere natur- og dyrefilm fokuserede på dyrekernefamilien og den gode forælder. Under indtryk af genrens skift til tv-mediet er fokus nu rettet mod parring, forskelle mellem hanner og hunner og ofte med en tvivlsom henvisning til samme mønstre hos mennesker.
From the trashy to the epic, from the classics to today's blockbusters, this cinefile’s guidebook reviews nearly 1,000 of the biggest, baddest, and brightest from every age and genre of cinematic science fiction! Once upon a time, science fiction was only in the future. It was the stuff of drive-ins and cheap double-bills. Then, with the ever-increasing rush of new, society-altering technologies, science fiction pushed its way to the present, and it busted out of the genre ghetto of science fiction and barged its way into the mainstream. What used to be mere fantasy (trips to the moon? Wristwatch radios? Supercomputers capable of learning?) are now everyday reality. Whether nostalgic for the future or fast-forwarding to the present, The Sci-Fi Movie Guide: The Universe of Film from Alien to Zardoz covers the broad and widening range of science-fiction movies. You’ll find more than just Star Wars, Star Trek, and Transformers, with reviews on many overlooked and under-appreciated gems and genres, such as ... Monsters! Pacific Rim, Godzilla, The Thing, Creature from the Black Lagoon Superheroes: Thor, Iron Man, X-Men, The Amazing Spider-man, Superman Dystopias: THX 1138, 1984, The Hunger Games Avant-garde masterpieces: Solaris, 2001, Brazil, The Man Who Fell to Earth Time travel: 12 Monkeys, The Time Machine, Time Bandits, Back to the Future Post-apocalyptic action: The Road Warrior, I Am Legend, Terminator Salvation Comedy: Dark Star, Mars Attacks!, Dr. Strangelove, The Adventures of Buckaroo Banzai Across the Eighth Dimension, Mystery Science Theater 3000 Aliens! The Day the Earth Stood Still, Close Encounters of the Third Kind, Contact, Invasion of the Body Snatchers, Signs Mad scientists! Frankenstein, The Invisible Man, The Abominable Dr. Phibes Shoot-em-ups: Aliens, Universal Soldier, Starship Troopers What the...?: Battlefield Earth, Prayer of the Rollerboys, Repo: The Genetic Opera, Tank Girl, The 10th Victim Animation: WALL-E, Akira, Ghost in the Shell Small budgets, big ideas: Donnie Darko, Primer, Sound of My Voice, Computer Chess Neglected greats: Things to Come, Children of Men Epics: Metropolis, Blade Runner, Cloud Atlas and many, many more categories and movies!! In addition to the nearly one thousand science fiction film reviews, this guide includes fascinating and fun Top-10 lists and sidebars that are designed to lead fans to similar titles they might not have known about. The Sci-Fi Movie Guide: The Universe of Film from Alien to Zardoz will help ensure that you will never again have to worry about what to watch next. Useful both as a handy resource or a fun romp through the film world of science fiction. It also includes a helpful bibliography and an extensive index, adding to its usefulness.
I think this is an excellent book–I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style." –BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." –American Journal of Human Biology, March 2009 With the sequencing of the human genome and the mapping of millions of single nucleotide polymorphisms, epidemiology has moved into the molecular domain. Scientists can now use molecular markers to track disease-associated genes in populations, enabling them to study complex chronic diseases that might result from the weak interactions of many genes with the environment. Use of these laboratory generated biomarker data and an understanding of disease mechanisms are increasingly important in elucidating disease aetiology. Molecular Epidemiology of Disease crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research. Covers categories of biomarkers of exposure, susceptibility and disease Includes chapters on novel technologies: genomics, transcriptomics, proteomics and metabonomics, which are increasingly finding application in population studies Emphasizes new statistical and bioinformatics approaches necessitated by the large data sets generated using these new methodologies Demonstrates the potential applications of laboratory techniques in tackling epidemiological problems while considering their limitations, including the sources of uncertainty and inaccuracy Discusses issues such as reliability (compared to traditional epidemiological methods) and the timing of exposure Explores practical elements of conducting population studies, including biological repositories and ethics Molecular Epidemiology of Disease provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. It also provides a useful tool for courses on molecular epidemiology, using many examples from population studies to illustrate key concepts and principles.
Quiet Powers of the Possible offers an excellent introduction to contemporary French phenomenology through a series of interviews with its most prominent figures. Guided by rigorous questions that push into the most important aspects of the latest phenomenological research, the book gives readers a comprehensive sense of each thinker’s intellectual history, motivations, and philosophical commitments. The book introduces readers to debates that have not previously been accessible to the English-speaking world, such as the growing interest in the phenomenological concept of life in its affective and even vital dimensions, the emerging dialogue with the analytic philosophy of mind and language, and reassessments of the so-called theological turn. The diversity of approaches collected here has its origin in a deeper debate about the conceptual and historical foundations of phenomenology itself. In this way the book offers the most accessible and wide-ranging introduction to French phenomenology to have appeared in the English-speaking world to date.
With the rapid advances in computing and Internet technologies, an integrated and collaborative environment, which is based on the complementary functions of concurrent engineering and Internet-based collaborative engineering, is imperative for companies to facilitate and expedite the product realization processes. Topics such as concurrent and collaborative engineering, feature-based design and manufacturing, evolutionary computational techniques such as Tabu Search, Simulated Annealing, Genetic Algorithms features, intelligent and computer-aided process planning are important strategies and enabling technologies for developing an integrative environment, facilitating modern product design and development. This book covers the state-of-the-art research and development status of these strategies and technologies. Implementation strategies and case studies are provided with an emphasis on technical details to help readers understand the underlying algorithms and infrastructures. Contents: Manufacturing Feature Recognition Technology - State-of-the-Art; A Hybrid Method for Interacting Manufacturing Feature Recognition; Integration of Design-by-Feature and Manufacturing Feature Recognition; Intelligent Optimization of Process Planning; Collaborative Computer-Aided Design - State-of-the-Art; Development of Web-Based Process Planning Optimization System; Distributed and Collaborative Design-by-Feature System. Key Features Provides comprehensive surveys in the integrative and collaborative product development Updates the most recent R & D work of the last decade in the relevant areas Contains highly analytical approaches and methodologies Comprehensively covers implementation strategies and case studies Detailed discussions and comparisons of various approaches, algorithms and techniques Readership: Mechanical and manufacturing engineering graduate students, researchers in the field of concurrent engineering, collaborative engineering and intelligent engineering. Engineers in charge of utilization, development of concurrent and collaborative software tools.
Fixtures are an essential part of manufacturing production. This book covers computer-aided fixture design, fixture clamping synthesis and optimisation, workpiece-fixture interaction, intelligent fixture designed to integrate with processing equipment or machine tools so as to improve productivity and product quality, Internet-enabled fixture design and modular fixture database management. These are the emerging issues central to the development of computer-integrated manufacturing. Covering the established knowledge of fixture design automation and the niche areas of fixture system integration and Internet-enabled design, the book would be a prevalent reference for academics, manufacturing & industrial engineers, and a valuable text for engineering graduate students.
This book liberates evolution from misrepresentative scientific myths to find a more nuanced vision of life that shows how advantages persist, trust is beneficial, and the diversity of species emerges.
The badgers of Wytham Woods (Oxford, UK) have been studied continuously and intensively by David Macdonald for almost 50 years (25 of them with his former student and co-author Chris Newman), generating a wealth of data pertaining to every facet of their ecology and evolution. Through a mix of accessible, highly readable prose and cutting-edge science, the authors weave a riveting scientific story of the lives of these intriguing creatures, highlighting the insights offered to science more broadly through badgers as a model system. They provide a paradigm - from population down to molecule - for a deeper understanding of mammalian behaviour, ecology, epidemiology, evolutionary biology, and conservation. The real value of this long-term study is particularly apparent with current and globally relevant challenges such as climate change, disease epidemics, and senescence. This unique dataset enables us to examine these issues in a context that only a half-century experiment can reveal. The Badgers of Wytham Woods will appeal to a broad audience of professional academics (especially carnivore and mammalian biologists), researchers and students at all levels, governmental and non-governmental wildlife bodies, and to the natural historian fascinated by wild animals and the remarkable processes of nature they exemplify.
This book provides readers with the tools and methods with which to create effective tabletop games. It covers the design and development process thoroughly, guiding readers through the necessary mechanics, messages, and motivations of games that must be understood in order to build successful tabletop games, including serious educational games for teaching or training. Through a range of learning activities and methodologies, readers will develop an understanding of games and an appreciation for the creating and testing of game play whilst critically exploring the relationship between games, motivation, and learning. It includes chapters on design methodology, narrative, accessibility, playtesting, and more. This book will be of great interest to students of game design and serious game design courses. It will also appeal to designers, educators, and hobbyists interested in designing and developing their own tabletop games, educational or otherwise.
The relentless loss of biodiversity is among the greatest problems facing the world today. The third edition of this established textbook provides an updated and comprehensive overview of the essential background, concepts, and tools required to understand how genetics can be used to conservespecies, reduce threat of extinction, and manage species of ecological or commercial importance. This edition is thoroughly revised to reflect the major contribution of genomics to conservation of populations and species. It includes two new chapters: "Genetic Monitoring" and a final "ConservationGenetics in Practice" chapter that addresses the role of science and policy in conservation genetics.New genomic techniques and statistical analyses are crucial tools for the conservation geneticist. This accessible and authoritative textbook provides an essential toolkit grounded in population genetics theory, coupled with basic and applied research examples from plants, animals, and microbes. Thebook examines genetic and phenotypic variation in natural populations, the principles and mechanisms of evolutionary change, evolutionary response to anthropogenic change, and applications in conservation and management.Conservation and the Genomics of Populations helps demystify genetics and genomics for conservation practitioners and early career scientists, so that population genetic theory and new genomic data can help raise the bar in conserving biodiversity in the most critical 20 year period in the historyof life on Earth. It is aimed at a global market of applied population geneticists, conservation practitioners, and natural resource managers working for wildlife and habitat management agencies. It will be of particular relevance and use to upper undergraduate and graduate students taking coursesin conservation biology, conservation genetics, and wildlife management.
The second edition of Anaesthesia for the Elderly Patient offers a fully up-to-date, comprehensive introduction to the major clinical issues facing anaesthetists working with elderly patients.
This study explores maternity in the 'disciplines' of early modern England. Placing the reproductive female body centre-stage in Shakespeare's theatre, Laoutaris ranges beyond the domestic sphere in order to recuperate the wider intellectual, epistemological, and archaeological significance of maternity to the Renaissance imagination. Focusing on 'anatomy' in Hamlet, 'natural history' in The Tempest, 'demonology' in Macbeth, and 'heraldry' in Antony and Cleopatra, this book reveals the ways in which the maternal body was figured in, and in turn contributed towards the re-conceptualisation of, bodies of knowledge. Laoutaris argues that Shakespeare resists a monolithic concept of motherhood, presenting instead a range of contested 'maternities' which challenge the distinctive 'ways of knowing' these early disciplines worked to impose on the order of created nature.
Vital reading' - THE TIMES 'Brilliantly unillusioned thinking... It could hardly be more necessary in these all-too-moralistic times' - James Marriott, THE TIMES Morals have held empires together, kept soldiers marching under fire, fed the hungry, passed laws, built walls, welcomed immigrants, destroyed careers and governed our sex lives. But what if morality's all meaningless rubbish, a malfunctioning relic of our evolutionary past? This is the provocative argument that Chris Paley makes. This isn't an attack on one set of moral codes or one way of thinking about ethics: it's a call for abolishing the whole caboodle. He uses evolutionary psychology to show how and why morality emerged: they enabled our forebears to survive and prosper in tribal groups. Today, our morals constrain us, bias us, and push us in the wrong direction. The biggest challenges our species faces, whether global warming, nuclear proliferation or the rise of the robots, are pan-human. These challenges are beyond what our moral minds were designed to cope with. You can't build smartphones with stone-age axes, and you can't solve modern humanity's problems with tools that are designed to create primitive, competitive groups. From Chris Paley, author of the 'extraordinary', 'startling' and 'thought-provoking' Unthink, comes Beyond Bad, which shows morals hinder us from achieving what we want to achieve. Beyond Bad is the book that 'does for morals what Dawkins did for God'.
The Oulipo (Ouvroir de littérature potentielle, or Workshop for Potential Literature) is a literary think tank that brings together writers and mathematicians. Since 1960, its worldwide influence has refreshed ways of making and thinking about literature. How to Do Things with Forms assesses the work of the group, explores where it came from, and envisages its future. Redefining the Oulipo’s key concept of the constraint in a clear and rigorous way, Chris Andrews weighs the roles of craft and imitation in the group’s practice. He highlights the importance of translation for the Oulipo’s writers, explaining how their new forms convey meanings and how these famously playful authors are also moved by serious concerns. Offering fresh interpretations of emblematic Oulipian works such as Georges Perec’s Life: A User’s Manual, Andrews also examines lesser-known texts by Jacques Roubaud, Anne F. Garréta, and Michelle Grangaud. How to Do Things with Forms addresses questions of interest to anyone involved in the making of literature, illuminating how writers decide when to stop revising, the risks and benefits of a project mentality in creative writing, and ways of holding a reader’s interest for as long as possible.
The outdoor music festival market has developed and commercialised significantly since the mid-1990s, and is now a mainstream part of the British summertime leisure experience. The overall number of outdoor music festivals staged in the UK doubled between 2005 and 2011 to reach a peak of over 500 events. UK Music (2016) estimates that the sector attracts over 3.7 million attendances each year, and that music tourism as a whole sustains nearly 40,000 full-time jobs. Music Festivals in the UK is the first extended investigation into this commercialised rock and pop festival sector, and examines events of all sizes: from mega-events such as Glastonbury Festival, V Festival and the Reading and Leeds Festivals to ‘boutique’ events with maximum attendances as small as 250. In the past, research into festivals has typically focused either on their carnivalesque heritage or on developing managerial tools for the field of Events Management. Anderton moves beyond such perspectives to propose new ways of understanding and theorising the cultural, social and geographic importance of outdoor music festivals. He argues that changes in the sector since the mid-1990s, such as professionalisation, corporatisation, mediatisation, regulatory control, and sponsorship/branding, should not necessarily be regarded as a process of transgressive 'alternative culture’ being co-opted by commercial concerns; instead, such changes represent a reconfiguration of the sector in line with changes in society, and a broadening of the forms and meanings that may be associated with outdoor music events.
An investigation into what happens in creative practice when the materials of art and research behave and perform in ways beyond the creators' intentions. In Alien Agency, Chris Salter tells three stories of art in the making. Salter examines three works in which the materials of art—the “stuff of the world”—behave and perform in ways beyond the creator's intent, becoming unknown, surprising, alien. Studying these works—all three deeply embroiled in and enabled by science and technology—allows him to focus on practice through the experiential and affective elements of creation. Drawing on extensive ethnographic observation and on his own experience as an artist, Salter investigates how researcher-creators organize the conditions for these experimental, performative assemblages—assemblages that sidestep dichotomies between subjects and objects, human and nonhuman, mind and body, knowing and experiencing. Salter reports on the sound artists Bruce Odland and Sam Auinger (O+A) and their efforts to capture and then project unnoticed urban sounds; tracks the multi-year project TEMA (Tissue Engineered Muscle Actuators) at the art research lab SymbioticA and its construction of a hybrid “semi-living” machine from specially grown mouse muscle cells; and describes a research-creation project (which he himself initiated) that uses light, vibration, sound, smell, and other sensory stimuli to enable audiences to experience other cultures' “ways of sensing.” Combining theory, diary, history, and ethnography, Salter also explores a broader question: How do new things emerge into the world and what do they do?
New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of s
This is a book of reading on religion and culture in Africa comprising ten papers by experts in religion and cultural matters and an introductory note by the editor himself. Covered in the volume are papers covering: the impact of secularisation and urbanisation on a most cherished socio-cultural practice of the extended family system of the Isoko people in Nigeria; the traditional medical practices in Urhobo with particular focus on the use of local herbs to treat ailments; the socioreligious as well as the political significance of Obiri (family hall) in Ikwerreland; the rationale behind the use of the concept ‘Dunamis’ in the Gospel According to Staint Mark. Although his paper does not focus on African (traditional) religion, its inclusion here is based purely on the theological significance of the concept of ‘Dunamis’; the extent to which evil spirits and mysterious forces have influenced the religion and culture of the Urhobo people of Nigeria; the significance of festivals in the traditional African society; John Wesley’s innovations in Christendom and their implications for Africa; the recent unprecedented upsurge in the assumed use of religious powers to cast out evil spirits as well as for prayer healing among Muslims in Nigeria; the culture of alienation, anxiety and violence, drawing inspiration from the Fall Story of Genesis 3; and the widowhood practices of some areas in Nigeria.
From the bestselling author of The Flight Attendant comes a thought-provoking story about gender, love, and new relationships. When Allison Banks develops a crush on Dana Stevens, she knows that he will give her what she needs most: attention, gentleness, kindness, passion. Her daughter, Carly, enthusiastically witnesses the change in her mother. But then a few months into their relationship, Dana tells Allison his secret: he has always been certain that he is a woman born into the wrong skin, and soon he will transition. Allison, overwhelmed by the depth of her passion, finds herself unable to leave Dana. By deciding to stay, she finds she must confront questions most people never even consider. Not only will her own life and Carly’s be irrevocably changed, she will have to contend with the outrage of a small Vermont community and come to terms with her lover’s new body–hoping against hope that her love will transcend the physical.
Pain Assessment and Pharmacologic Management, by highly renowned authors Chris Pasero and Margo McCaffery, is destined to become the definitive resource in pain management in adults. It provides numerous reproducible tables, boxes, and figures that can be used in clinical practice, and emphasizes the benefits of a multimodal analgesic approach throughout. In addition, Patient Medication Information forms for the most commonly used medications in each analgesic group can be copied and given to patients. This title is an excellent resource for nurses to become certified in pain management. - Presents best practices and evidence-based guidelines for assessing and managing pain most effectively with the latest medications and drug regimens. - Features detailed, step-by-step guidance on effective pain assessment to help nurses appropriately evaluate pain for each patient during routine assessments. - Provides reproducible tables, boxes, and figures that can be used in clinical practice. - Contains Patient Medication Information forms for the most commonly used medications in each analgesic group, to be copied and given to patients. - Offers the authors' world-renowned expertise in five sections: - Underlying Mechanisms of Pain and the Pathophysiology of Neuropathic Pain includes figures that clearly illustrate nociception and classification of pain by inferred pathology. - Assessment includes tools to assess patients who can report their pain as well as those who are nonverbal, such as the cognitively impaired and critically ill patients. Several pain-rating scales are translated in over 20 languages. - Nonnopioids includes indications for using acetaminophen or NSAIDs, and the prevention and treatment of adverse effects. - Opioids includes guidelines for opioid drug selection and routes of administration, and the prevention and treatment of adverse effects. - Adjuvant Analgesics presents different types of adjuvant analgesics for a variety of pain types, including persistent (chronic) pain, acute pain, neuropathic pain, and bone pain. Prevention and treatment of adverse effects is also covered. - Includes helpful Appendices that provide website resources and suggestions for the use of opioid agreements and for incorporating pain documentation into the electronic medical record. - Covers patients from young adults to frail older adults. - Provides evidence-based, practical guidance on planning and implementing pain management in accordance with current TJC guidelines and best practices. - Includes illustrations to clarify concepts and processes such as the mechanisms of action for pain medications. - Features spiral binding to facilitate quick reference.
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Post-mortem computed tomography (PMCT) is increasingly used in forensic pathology practice in many jurisdictions. Such imaging has expanded the capacity to evaluate skeletal trauma improving the visualisation, documentation and presentation of forensic findings. Typically when deceased persons are located and exhibit evidence of trauma, forensic pathologist, anthropologists and radiologists base their interpretations of the mechanism of trauma on their experience and understanding of the biomechanics of fractures as well as recognisable patterns of injury. In order to augment this process, An Atlas of Forensic Skeletal Trauma presents a range of de-identified adult and child skeletal trauma cases that occur in medico-legal contexts where the cause of death and mechanism of trauma are recorded. An Atlas of Forensic Skeletal Trauma includes comprehensive photographs and PMCT images as well as descriptive text. - Presents a valuable guide to the interpretation of skeletal trauma for practitioners and students of forensic anthropology, pathology and radiology - Provides coverage of skeletal trauma cases resulting from high and low velocity projectiles, low energy blunt force (e.g., assaults involving various implements, hangings, strangulations, falls), high energy blunt force (e.g., motor vehicle and aviation incidents), and more - Includes case studies with written and visual descriptions, discussions and up-to-date literature review
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