Choon Kit Tang's Books

Biological DNA Sensor

Chapter 1. Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors

By: Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii

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Biological DNA Sensor

Chapter 1. Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors

By: Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii

In this chapter, we reflect on our early understanding of the immunogenic properties of dsDNA and give a chronological account of the journey we have taken to discover the individual cellular DNA sensors which have played important roles in mediating DNA induced inflammation.

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Elsevier Inc. Chapters

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ISBN 10

0128068744

ISBN 13

9780128068748

Biological DNA Sensor

Chapter 11. DNA Vaccine: Does it Target the Double Stranded-DNA Sensing Pathway?

By: Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii

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Biological DNA Sensor

Chapter 11. DNA Vaccine: Does it Target the Double Stranded-DNA Sensing Pathway?

By: Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii

Ideal vaccines are expected to give lifetime protection from infectious diseases, and if possible, from allergic diseases, autoimmune diseases and cancer. DNA vaccination was introduced two decades ago as a simple plasmid inoculation method with a capability of inducing both cellular and humoral immune responses. Recent studies have provided insights into the molecular mechanisms by which the double-stranded structure of DNA vaccine induces the activation of type-I interferon (IFN)-mediated innate immune responses via STING/TBK1 complex, similar to cytosolic double stranded DNA (dsDNA) recognition of immune cells. In this chapter, DNA vaccines and the current knowledge on their mechanism of action will be introduced. The possibilities of using this knowledge for improving immunogenicity of DNA vaccines in humans will then be discussed.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128068841

ISBN 13

9780128068847

Laboratory Tests for Unsaturated Soils

By: Eng-Choon Leong,Martin Wijaya

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Laboratory Tests for Unsaturated Soils

By: Eng-Choon Leong,Martin Wijaya

The testing of unsaturated soils requires greater care and effort than that of saturated soils. Although unsaturated soil mechanics has been embraced by geotechnical engineering, engineering practice has not yet caught up as the characterization of unsaturated soils is difficult and time-consuming, and made harder still by a lack of standards. Laboratory Tests for Unsaturated Soils collates test procedures to cover all laboratory tests for characterising unsaturated soils. It covers the background, theory, test procedures, and interpretation of test results. Each test procedure is broken down into simple stages and described in detail. The pitfalls of each test and the interpretation of the test results are explained. Test data and calculation methods are given, along with many numerical examples to illustrate the methods of interpretation and to offer the presentation of typical results. The book is especially useful for students and researchers who are new to the field and provides a practical handbook for engineering applications.

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Page Count

454

Publisher

CRC Press

Published Date

ISBN 10

1351600230

ISBN 13

9781351600231

Book's by Choon Kit Tang

Biological DNA Sensor

Biological DNA Sensor

Biological DNA Sensor

Biological DNA Sensor

Laboratory Tests for Unsaturated Soils

Laboratory Tests for Unsaturated Soils

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