The peripheral nervous system can be affected by malignancies involving different mechanisms. Neoplastic nerve lesion by compression, invasion, and infiltration is rare and occurs in particular in leukemia (neuroleukemiosis) and lymphoma (neurolymphomatosis). Its occurrence is much rarer in cancer, and even less so in sarcoma. The neoplastic infiltration of peripheral nerves by solid tumors is characterized by specific topographical sites such as the base of the skull, the ear, nose and throat region, and the cervico-brachial plexus as well as the lumbar and sacral plexus. Rarely malignant invasion affects the cranial nerves of the face where it can spread centripetally. Autonomic nerves and ganglia can also be affected. The retrograde spread of cancer in nerves is a bad prognostic sign. The clinical diagnosis is determined by tumor type, the pattern of involvement, and often pain.
Charcot–Marie–Tooth neuropathy (CMT) is a group of genetically heterogeneous disorders sharing a similar phenotype, characterized by wasting and weakness mainly involving the distal muscles of lower and upper limbs, variably associated with distal sensory loss and skeletal deformities. This chapter deals with dominantly transmitted CMT and related disorders, namely hereditary neuropathy with liability to pressure palsies (HNPP) and hereditary neuralgic amyotrophy (HNA). During the last 20 years, several genes have been uncovered associated with CMT and our understanding of the underlying molecular mechanisms has greatly improved. Consequently, a precise genetic diagnosis is now possible in the majority of cases, thus allowing proper genetic counseling. Although, unfortunately, treatment is still unavailable for all types of CMT, several cellular and animal models have been developed and some compounds have proved effective in these models. The first trials with ascorbic acid in CMT type 1A have been completed and, although negative, are providing relevant information on disease course and on how to prepare for future trials.
This book investigates the experiences of second- and third-generation Italians living in South Africa, exploring how nostalgia for Italy influences their sense of identity and belonging. The Italian community in South Africa is a unique diaspora, with a complex history, including roots in Italian colonial activities in Africa, and in World War II. This book looks at how the descendants of these early migrants take pride in being Italian and value the Italian language. They also ascribe much importance to their family roots, and have often created a romanticized image of Italy, mostly based on childhood vacation visits. The longing for an imaginary idealized version of Italy is closely linked to their wider search for a sense of identity and belonging against the backdrop of South African society, currently still grappling with its own multicultural identity. Interdisciplinary by design, this book draws on insights from both cultural studies and psychology in order to shine a light on an important and under-studied diasporic community. The book will be of interest to scholars from across migration studies and the Humanities in general. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
Grace ha settant’anni e possiede la più potente società finanziaria degli Stati Uniti. Nelle pieghe del suo passato, un segreto mai rivelato. Dopo la morte del marito, torna a New York per vendicare una violenza subita negli anni del college. Parte con due certezze: un indirizzo e il ricordo di un quadro. Troverà una città profondamente cambiata, ma il lampione all’angolo della 122ma strada, dove fu stuprata da giovane, è ancora lì. Per ottenere il suo scopo Grace sfrutterà tutte le armi a disposizione: soldi, astuzia, contatti con la malavita dell’Harlem spagnola. In un intreccio di strategie, negoziazioni, violenze e amori, il tempo presente sarà inclemente come quello passato e chiuderà il cerchio con un unico, potente interrogativo: fino a che punto può spingersi il desiderio di vendetta?
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