Indiana Jones meets Goosebumps in this chilling Creeptown adventure! When a mysterious force traps his class in a haunted museum, 12-year-old Arlo, a rising filmmaker, must abandon his script and become an action hero for real. But can he stop living bones? Don’t miss the fast-paced horror series kids are screaming about! Creeptown books combine fast plots, lovable characters and shocking late twists. Perfect for fans of R.L. Stine’s Goosebumps. Can you predict how the story will end? Praise for The Bone Taker: "Very entertaining … a nice mixture of adventure, humor, silliness, and drama." Say What? Blog "Quirky and fun … it will be some kids favorite book." Goodreads Reviewer "A cross between Goosebumps and Mr. Lemoncello with a little bit of Captain Underpants thrown in … it was totally ridiculous, but so much fun." BookSirens Reviewer
The Process of New Drug Discovery and Development presents a practical methodology for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It includes detailed discussions regarding the research process and presents critiques of the governmental regulatory aspects of pharmaceutical research. The author also addresses the controversy surrounding the use of animals in biomedical research and provides current information regarding the field of biotechnology, international drug research, and registration activities. The Process of New Drug Discovery and Development is an excellent "how to" text for pharmaceutical researchers, oncologists, biochemists, experimental biologists, and others involved in new drug research and development.
The first interpretive history that covers the antiwar movement in this country throughout the entire Vietnam era. Richly illustrated with compelling photographs of the times, the book chronicles the war struggle that provoked a struggle about America.
Environmental and Pollution Science, Third Edition, continues its tradition on providing readers with the scientific basis to understand, manage, mitigate, and prevent pollution across the environment, be it air, land, or water. Pollution originates from a wide variety of sources, both natural and man-made, and occurs in a wide variety of forms including, biological, chemical, particulate or even energy, making a multivariate approach to assessment and mitigation essential for success. This third edition has been updated and revised to include topics that are critical to addressing pollution issues, from human-health impacts to environmental justice to developing sustainable solutions. Environmental and Pollution Science, Third Edition is designed to give readers the tools to be able to understand and implement multi-disciplinary approaches to help solve current and future environmental pollution problems. - Emphasizes conceptual understanding of environmental systems and can be used by students and professionals from a diversity of backgrounds focusing on the environment - Covers many aspects critical to assessing and managing environmental pollution including characterization, risk assessment, regulation, transport and fate, and remediation or restoration - New topics to this edition include Ecosystems and Ecosystem Services, Pollution in the Global System, Human Health Impacts, the interrelation between Soil and Human Health, Environmental Justice and Community Engagement, and Sustainability and Sustainable Solutions - Includes color photos and diagrams, chapter questions and problems, and highlighted key words
The scientific and therapeutic implications of a new way of understanding a common disease. Depression has often been studied, but this multifaceted disease remains far from understood. Here, leading researchers present a major new view of the disorder that synthesizes multiple lines of scientific evidence from neurobiology, mindfulness, and genetics. A comprehensive mind-body approach to understanding, evaluating, and treating this disease.
Reviews recent studies on the mechanisms by which blood vessels are built, both during vascular embryonic vasculogenesis and angiogenesis during fetal development and during cyclical renewal and repair in adults. In vivo studies include the morphogenesis of primordial vascular networks and insights into growth factors from gene knockout studies in mice. A three- dimensional assay of endothelial cell invasion and capillary tube morphogenesis, and the rat aorta model of angiogenesis and its applications are among the in vitro studies. Computer models are described for the formation of netlike structures, tumor- induced angiogenesis, and other phenomena. Annotation copyrighted by Book News, Inc., Portland, OR
For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research.
Cellular and Molecular Targets for Chemoprevention provides comprehensive coverage of target mechanisms that have proved valuable in chemoprevention research, in addition to mechanisms that may prove valuable in the near future. The book discusses such topics as growth factor receptor modulation, cell-to-cell communication, differentiation modulation, antisense olgonucleotides, tumor suppressor genes, free radical scavengers, and polyamine synthesis inhibition. Cellular and Molecular Targets for Chemoprevention will be welcomed by scientists in all areas of cancer/chemoprevention research, pharmaceutical researchers, and advanced students.
Provides the latest QMRA methodologies to determine infection risk cause by either accidental microbial infections or deliberate infections caused by terrorism • Reviews the latest methodologies to quantify at every step of the microbial exposure pathways, from the first release of a pathogen to the actual human infection • Provides techniques on how to gather information, on how each microorganism moves through the environment, how to determine their survival rates on various media, and how people are exposed to the microorganism • Explains how QMRA can be used as a tool to measure the impact of interventions and identify the best policies and practices to protect public health and safety • Includes new information on genetic methods • Techniques use to develop risk models for drinking water, groundwater, recreational water, food and pathogens in the indoor environment
Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by pediatric infectious diseases. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention! Spend less time searching thanks to a consistent, easily-accessible format featuring revised high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Be prepared for the unexpected! A veritable "who's who" of global authorities provides practical knowledge to effectively diagnose and manage almost any infectious disease you may encounter. Quickly look up the answers you need by clinical presentation, pathogen, or type of host. Get expanded coverage for all types of infectious diseases including new chapters on infection related to pets and exotic animals, and tickborne infections. Apply the latest recommendations and treatments for emerging and re-emerging diseases including the H1N1 virus.
Ember McCoy, a young and stressed accountant, plans to spend Christmas alone at her family's lakeside cabin. But after a mysterious man offers his kindness and time, she begins to reassess her fast-paced world. Holding a star-shaped, stained-glass cookie up to the light, she makes a wish. Is the glistening candy-blue center a hopeful sign there may be more to her existence than the long work hours draining the joy from her life? Laiken Devere, an Ashrai water fairy, laments the passing of his grandmother and his future in the shadows of his older brothers. To honor his grandmother, he visits the human world above James Lake, asking the stars to reveal his destiny. But why would fate lead him to an impossible relationship with a human, especially the sorrowful young Ember he found by the lake? Does Ember and Laiken’s future together now rely on stained-glass secrets and star wishes?
This book offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the progression of tumors from different organ sites. The fate of the modification of adducts is discussed at the molecular level. The role that modifications in hot spots in oncogenes and supressor genes play at the molecular level and how these molecular modifications can lead to an explanation of molecular control in the formation of tumor phenotypes is also examined. Researchers in cell biology and toxicology, applied pharmacology, carcinogenesis, teratogenesis, mutagenesis, and molecular toxicology will find the book useful, interesting reading.
This book addresses possible analogies between cancer and developmental biology. An international group of experts provides a multidisciplinary approach, allowing biological or clinical scientists involved with cancer research to integrate specific information from diverse areas. Five concepts of cancer are presented, and developmental biology is reviewed at five levels. These are integrated in discussions of failure in organisation as a basis of cancer and its control. The book will be a valuable reference for both newcomers as well as experienced biological and clinical scientists. Features
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