Charles J. Link's Books

Practical Management of Pain E-Book

By: Honorio Benzon,James P. Rathmell,Christopher L. Wu,Dennis Turk,Charles E. Argoff,Robert W Hurley

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Practical Management of Pain E-Book

By: Honorio Benzon,James P. Rathmell,Christopher L. Wu,Dennis Turk,Charles E. Argoff,Robert W Hurley

For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. - Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. - Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. - Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. - Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. - Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. - Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. - Includes the latest guidelines on facet injections and safety of contrast agents. - Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

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Page Count

1520

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323711022

ISBN 13

9780323711029

Cancer Immunotherapy

Chapter 29. HyperAcute Vaccines: A Novel Cancer Immunotherapy

By: Gabriela R. Rossi,Nicholas N. Vahanian,W. Jay Ramsey,Charles J. Link

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Cancer Immunotherapy

Chapter 29. HyperAcute Vaccines: A Novel Cancer Immunotherapy

By: Gabriela R. Rossi,Nicholas N. Vahanian,W. Jay Ramsey,Charles J. Link

The hyperacute rejection of a xenotransplant is characterized by a complement-antibody mediated immune response dependent on αGal epitopes. Animal studies confirm that αGal epitopes expressed on allogeneic tumor vaccines elicit a potent T-cell-dependent antitumor immunity. Based on these immunologic reactions, we hypothesized that the hyperacute rejection mechanism could be exploited to alter antigen processing resulting in a novel therapeutic approach to treat human malignancies. Clinical trials data confirm that an immediate hypersensitivity response directed toward a vaccine composed of genetically modified allogeneic tumor cells expressing the xenoantigen αGal (HyperAcute vaccines) constitutes a polyvalent tumor cell vaccine with signs of clinical efficacy, concomitant to eliciting both a humoral IgG response as well as T-cell-mediated antitumor immunity. This conceptually innovative immunotherapy degrades tumoral immune escape and portends a promising genetic engineering tactic for the cost-effective development of a generally applicable human cancer vaccine principle with minimal toxicity. Encouraging results support additional clinical immunotherapy studies using HyperAcute vaccines.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059257

ISBN 13

9780128059258

Information Retrieval

Implementing and Evaluating Search Engines

By: Stefan Buttcher,Charles L. A. Clarke,Gordon V. Cormack

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Information Retrieval

Implementing and Evaluating Search Engines

By: Stefan Buttcher,Charles L. A. Clarke,Gordon V. Cormack

An introduction to information retrieval, the foundation for modern search engines, that emphasizes implementation and experimentation. Information retrieval is the foundation for modern search engines. This textbook offers an introduction to the core topics underlying modern search technologies, including algorithms, data structures, indexing, retrieval, and evaluation. The emphasis is on implementation and experimentation; each chapter includes exercises and suggestions for student projects. Wumpus—a multiuser open-source information retrieval system developed by one of the authors and available online—provides model implementations and a basis for student work. The modular structure of the book allows instructors to use it in a variety of graduate-level courses, including courses taught from a database systems perspective, traditional information retrieval courses with a focus on IR theory, and courses covering the basics of Web retrieval. In addition to its classroom use, Information Retrieval will be a valuable reference for professionals in computer science, computer engineering, and software engineering.

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Page Count

633

Publisher

MIT Press

Published Date

ISBN 10

0262288680

ISBN 13

9780262288682

The Project-State and Its Rivals

A New History of the Twentieth and Twenty-First Centuries

By: Charles S. Maier

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The Project-State and Its Rivals

A New History of the Twentieth and Twenty-First Centuries

By: Charles S. Maier

Charles Maier offers a new narrative of the long twentieth century, focused on institutions that shaped politics and societies: project-states, driven by democratic or authoritarian ideologies; capital; and advocates of apolitical values, such as health, human rights, and international law. In this we discern the unfolding of our own troubled time.

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Page Count

529

Publisher

Harvard University Press

Published Date

ISBN 10

0674290143

ISBN 13

9780674290143

Social Inequality

Forms, Causes, and Consequences

By: Heather M. Fitz Gibbon,Anne M. Nurse,Charles E. Hurst

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Social Inequality

Forms, Causes, and Consequences

By: Heather M. Fitz Gibbon,Anne M. Nurse,Charles E. Hurst

Like past editions, this tenth edition of Social Inequality: Forms, Causes, and Consequences is a user-friendly introduction to the study of social inequality. This book conveys the pervasiveness and extensiveness of social inequality in the United States within a comparative context, to show how inequality occurs, how it affects all of us, and what is being done about it. This edition benefits from a variety of changes that have significantly strengthened the text. The authors pay increased attention to disability, intersectionality, immigration, religion, and place. This edition also spotlights crime and the criminal justice system as well as health and the environment. The tenth edition includes a new chapter on policy alternatives and venues for social change.

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Page Count

564

Publisher

Routledge

Published Date

ISBN 10

1000007359

ISBN 13

9781000007350

Book's by Charles J. Link

Practical Management of Pain E-Book

Practical Management of Pain E-Book

Cancer Immunotherapy

Cancer Immunotherapy

Information Retrieval

Information Retrieval

The Project-State and Its Rivals

The Project-State and Its Rivals

Social Inequality

Social Inequality

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