The New York Times bestselling, “meticulously researched and absorbingly written” (The Washington Post) story of the trailblazers and the ordinary Americans on the front lines of the epic Apollo 11 moon mission. President John F. Kennedy astonished the world on May 25, 1961, when he announced to Congress that the United States should land a man on the Moon by 1970. No group was more surprised than the scientists and engineers at NASA, who suddenly had less than a decade to invent space travel. When Kennedy announced that goal, no one knew how to navigate to the Moon. No one knew how to build a rocket big enough to reach the Moon, or how to build a computer small enough (and powerful enough) to fly a spaceship there. No one knew what the surface of the Moon was like, or what astronauts could eat as they flew there. On the day of Kennedy’s historic speech, America had a total of fifteen minutes of spaceflight experience—with just five of those minutes outside the atmosphere. Russian dogs had more time in space than US astronauts. Over the next decade, more than 400,000 scientists, engineers, and factory workers would send twenty-four astronauts to the Moon. Each hour of space flight would require one million hours of work back on Earth to get America to the Moon on July 20, 1969. “A veteran space reporter with a vibrant touch—nearly every sentence has a fact, an insight, a colorful quote or part of a piquant anecdote” (The Wall Street Journal) and in One Giant Leap, Fishman has written the sweeping, definitive behind-the-scenes account of the furious race to complete one of mankind’s greatest achievements. It’s a story filled with surprises—from the item the astronauts almost forgot to take with them (the American flag), to the extraordinary impact Apollo would have back on Earth, and on the way we live today. From the research labs of MIT, where the eccentric and legendary pioneer Charles Draper created the tools to fly the Apollo spaceships, to the factories where dozens of women sewed spacesuits, parachutes, and even computer hardware by hand, Fishman captures the exceptional feats of these ordinary Americans. “It’s been 50 years since Neil Armstrong took that one small step. Fishman explains in dazzling form just how unbelievable it actually was” (Newsweek).
The Irish famine of the 1840s is the biggest humanitarian crisis in the United Kingdom's history. Within six years of the arrival of the potato blight in Ireland in 1845, more than a quarter of its residents had unexpectedly died or emigrated. Its population has not yet fully recovered since. Historians have struggled to explain why the British government decided to shut down its centrally organised relief efforts in 1847, long before the famine ended. Some have blamed the laissez-faire attitudes of the time for an inadequate response by the British government; others have alleged purposeful neglect and genocide. In contrast, this book uncovers a hidden narrative of the crisis, which links policy failure in Ireland to financial and political instability in Great Britain. More important than a laissez-faire ideology in hindering relief efforts for Ireland were the British government's lack of a Parliamentary majority from 1846, the financial crises of 1847, and a battle of ideas over monetary policy between proponents and opponents of financial orthodoxy. The high death toll in Ireland resulted from the British government's plans for intervention going awry, rather than being prematurely cancelled because of laissez-faire. This book is essential reading for scholars, students and anyone interested in Anglo-Irish relations, the history of financial crises, and why humanitarian-relief efforts can go wrong even with good intentions.
Buy a new version of this textbook and receive access to the Connected eBook on Casebook Connect, including lifetime access to the online ebook with highlight, annotation, and search capabilities. Access also includes an outline tool and other helpful resources. Connected eBooks provide what you need most to be successful in your law school classes. A user-friendly introduction to real estate law and the market factors that shape basic transactions, providing accessible coverage, enriching practice applications, structured perfectly for a one-semester course on real estate transactions. This concise and user-friendly casebook provides students with the tools necessary to understand real estate transactions in a real-world market setting. Real Estate Transactions is accessible to students with no prior background in real estate or business and coverage includes many real property and contract law materials tested on the Bar Exam. Multiple practice applications are included in every chapter to provide a bridge to “real world” law practice and preparation for assessments of lawyering skills (like the MPT). It also features cases and materials that reveal ethical and professional responsibility issues that allow students to see professional ethics in a real-world context. This integrated approach to explaining the market and ethical constraints on transactional real estate lawyers includes clear and concise explanations on each topic. New to the Sixth Edition: Two new co-authors: Andrea J. Boyack and James J. Kelly, Jr. Updated cases and text, including material on recent legal developments. Discussions of impactful current events, including the long-term impacts of the COVID-19 pandemic. Updated materials on market changes affecting real estate. New and improved problems in every chapter. Material on the evolving concerns about social justice. Professors will benefit from: Practice application problems that increase in difficulty with each section. Structured to balance theory and practice by emphasizing what successful transaction lawyers do daily. Multiple assessment opportunities allow for flexible grading approaches, enable students to demonstrate mastery of the material prior to the final exam, and can generate written responses that provide important information about student learning.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Need the go-to reference on adult bone and joint injuries? Get the definitive guide on fracture treatment, written by the world’s top orthopaedic surgeons: Rockwood and Green’s Fractures in Adults. This fully updated and expanded 8th edition offers up-to-the-minute research and recommendations from more than 80 leading orthopaedic experts from around the world. An essential resource on fractures for every orthopaedic surgeon or resident.. Features: NEW chapters on: Management of the Geriatric or Elderly Patient; Management of Bone Defects;; Psychological Aspect of Trauma NEW authors from countries including India, China, Columbia, Greece, and Denmark NEW 10 new full length videos added to the video library. All videos feature easy navigation so you can go directly to specific steps in the procedure, or watch the entire procedure from start to finish Pearls and Pitfalls and preventive measures listed for all procedures NEW Time-saving outline template for easy quick-reference “Before the Case” checklists of all necessary equipment for each surgical procedure Preferred Technique section provides algorithms explaining each author’s choice of preferred procedure Full-color operative photos, tables, x-rays, diagrams, and more than 500 line drawings of surgical procedures
Peat: Industrial Chemistry and Technology explores the chemistry and chemical technology of peat as a chemical feedstock. The processes that generate peat chemicals, such as solvent extraction and acid hydrolysis, are discussed. Some of the more important implications of peat use for humans and nature are also pointed out. This book describes alternative technologies for each of the major organic components of peat, including solvent extraction of peat bitumens; decolorization and oxidation of peat waxes; acid hydrolysis of unfractionated peat; and coke production. Other chapters discuss chemical characterization and analysis of peat; composition and hydrolysis of peat carbohydrates; composition of peat hydrolysates intended for yeast production; production of organic chemicals by peat hydrolysis; and scale of peat chemical operations. The final chapter examines the ecological and other environmental factors affecting the chemical technology of peat. This monograph will be a useful source of information for chemists, engineers, and managers interested in the industrial potential of peat as a chemical feedstock.
This exhaustive reference includes new chapters and pedagogical features, as well as—for the first time—content on managing fragility factures. To facilitate fast, easy absorption of the material, this edition has been streamlined and now includes more tables, charts, and treatment algorithms than ever before. Experts in their field share their experiences and offer insights and guidance on the latest technical developments for common orthopaedic procedures, including their preferred treatment options.
Historians often view early modern Ireland as a testing ground for subsequent British colonial adventures further afield. McGrath argues against this passive view, suggesting that Ireland played an enthusiastic role in the establishment and expansion of the first British Empire. He focuses on two key areas of empire-building: finance and defence.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis—the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer—opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response—the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.
The scientific world and modern society today is experiencing the dawning of an era of herbal medicine. Extensive research has shown that aromatic plants are important anti-inflammatory, antioxidant, anti aging and immune boosting delectable foods, with the magic and miracle to boost our immune system providing us with extended and an improved quality of life. Apart from making bland recipes into welcoming or interesting victories, herbs and spices have stirred the minds of the research community to look deeper into its active components from a functional perspective. It is essential to present the scientific and medicinal aspect of herbs and spices together with the analysis of constituents, its medicinal application, toxicology and its physiological effects. Herbs and spices with high levels of antioxidants are in great demand as they tend to promote health and prevent diseases naturally assuring increased safety and reliability for consumers. Herbs and spices are not only known for taste and flavor, but today research has opened up a new realm in which the antioxidant properties of these aromatic plants provide preservation for foods and health benefits for consumers who look forward to concrete scientific research to guide them further and explore herbal medicine. The aim of this book is to create awareness in society about the reliability of medicinal properties of certain herbs and spices through scientific and scholarly research.
Provide optimal anesthetic care to your young patients with A Practice of Anesthesia in Infants and Children, 5th Edition, by Drs. Charles J. Cote, Jerrold Lerman, and Brian J. Anderson. 110 experts representing 10 different countries on 6 continents bring you complete coverage of the safe, effective administration of general and regional anesthesia to infants and children - covering standard techniques as well as the very latest advances. Find authoritative answers on everything from preoperative evaluation through neonatal emergencies to the PACU. Get a free laminated pocket reference guide inside the book! Quickly review underlying scientific concepts and benefit from expert information on preoperative assessment and anesthesia management, postoperative care, emergencies, and special procedures. Stay on the cutting edge of management of emergence agitation, sleep-disordered breathing and postoperative vomiting; the use of new devices such as cuffed endotracheal tubes and new airway devices; and much more. Familiarize yourself with the full range of available new drugs, including those used for premedication and emergence from anesthesia. Benefit from numerous new figures and tables that facilitate easier retention of the material; new insights from neonatologists and neonatal pharmacologists; quick summaries of each chapter; and more than 1,000 illustrations that clarify key concepts. Access the entire text online, fully searchable, at www.expertconsult.com, plus an extensive video library covering simulation, pediatric airway management, burn injuries, ultra-sound guided regional anesthesia, and much more; and new online-only sections, tables and figures.
Covering everything from preoperative evaluation to neonatal emergencies to the PACU, A Practice of Anesthesia in Infants and Children, 6th Edition, features state-of-the-art advice on the safe, effective administration of general and regional anesthesia to young patients. It reviews underlying scientific information, addresses preoperative assessment and anesthesia management in detail, and provides guidelines for postoperative care, emergencies, and special procedures. Comprehensive in scope and thoroughly up to date, this 6th Edition delivers unsurpassed coverage of every key aspect of pediatric anesthesia. - Includes a laminated pocket reference guide inside with essential, practical information. - Features key references at the end of each chapter that provide a quick summary for review. - Presents must-know information on standards, techniques, and the latest advances in pediatric anesthesia from global experts. - Provides access to a video library of 70 pediatric anesthesia procedures – 35 are new! Videos include demonstrations on managing the difficult pediatric airway, cardiac assist devices in action, new positioning devices, management of burn injuries, and many demonstrations of ultra-sound guided regional anesthesia blocks and techniques. - Features extensive revisions of all chapters with many new contributors, and numerous new figures and tables throughout. - Introduces new drugs such as those used to premedicate children and facilitate emergence from anesthesia, plus an up-to-date discussion of the drug approval process and detailed information on opioid safety for children with obstructive sleep. - Includes new chapters on pharmacogenomic implications of drugs in children and the anesthetic implications when caring for children with cancer. - Offers up-to-date information on the management of emergence agitation, sleep-disordered breathing, neonatal and pediatric emergencies, and the obese child and bariatric surgery. - The Essentials chapters, with extensive input from pediatrician experts, provide the latest information concerning hematology, pulmonology, oncology, hepatology, nephrology, and neurology. - Contains significant updates on perioperative fluid management, pharmacology, intravenous anesthesia and target controlled infusions, cystic fibrosis, new interventional devices for children with congenital heart defects, cardiopulmonary resuscitation, simulation in pediatric anesthesia, and much more. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Addresses US military professionalism and the revisions, modifications and changes necessary to respond to the changed domestic and strategic environments of the new world order.
Praise for previous editions: “An excellent resource for both student midwives and qualified staff alike.” (Alison James, Midwifery Lecturer, Plymouth University) "A lovely book with a lot of practical advice and easy to navigate. (Jayne Samples, Midwifery Lecturer, University of Huddersfield) This fully revised and updated third edition of The Midwife’s Labour and Birth Handbook is a practical and accessible guide to midwifery care. It addresses important questions such as: Why are women being pressured into caesarean section for breech presentation when the evidence is equivocal? If a baby needs assisted ventilation breaths at birth, why not bring the ambubag to the baby and leave the cord intact so the baby can benefit from the extra maternal oxygen supply? Why is skin-to-skin contact at birth so rarely offered to preterm babies when there is evidence of benefit? This well-regarded text promotes normality and woman-centred care, using research, evidence-based guidelines and anecdotal accounts from women. It challenges practice and guidelines which are biased or based on poor evidence. Guidance is offered on how to deal with difficult, sometimes controversial, situations. The Midwife's Labour and Birth Handbook 3rd edition is an essential guide for both student midwives and experienced practising midwives. New to this edition: Full colour photographs including a kneeling breech birth Suturing diagrams to assist left-handed midwives. Expanded chapters on slow progress in labour and malposition/malpresentations, including a rare photograph of a face presentation birth.
In Travelers' Diarrhea, 2e, a team of medical experts brings you up-to-date on the pathogenesis and state-of-the-art management of travelers' diarrhea. Selected for their expertise in infectious diseases, the contributors also relate a thorough history of travelers' diarrhea, a basic understanding of the discipline, and a look at the future. Substantial understanding of the risks of acquiring travelers' diarrhea exists and we continue to learn about differences in host susceptibility.Updated information on the growing area of travelers' diarrhea is included. .
Minimize complications with Creasy and Resnik's Maternal-Fetal Medicine.This medical reference book puts the most recent advances in basic science, clinical diagnosis, and management at your fingertips, equipping you with the up-to date evidence-based guidelines and knowledge you need to ensure the best possible outcomes in maternal-fetal medicine. "... Creasy & Resnik's Maternal-Fetal Medicine: Principles and Practice remains an authoritative reference book for clinical residents, fellows and practicing specialists in Maternal-Fetal Medicine." Reviewed by Ganesh Acharya , Feb 2015 Apply today's best practices in maternal-fetal medicine with an increased emphasis on evidence-based medicine. Find dependable, state-of-the-art answers to any clinical question with comprehensive coverage of maternal-fetal medicine from the foremost researchers and practitioners in obstetrics, gynecology and perinatology. Take advantage of the most recent diagnostic advances with a new section on Obstetrical Imaging, complemented by online ultrasound clips as well as cross references and links to genetic disorder databases. Stay on top of rapidly evolving maternal-fetal medicine through new chapters on Recurrent Spontaneous Abortion, Stillbirth, Patient Safety, Maternal Mortality, and Substance Abuse, as well as comprehensive updates on the biology of parturition, fetal DNA testing from maternal blood, fetal growth, prenatal genetic screening and diagnosis, fetal cardiac malformations and arrhythmias, thyroid disease and pregnancy, management of depression and psychoses during pregnancy and the puerperium, and much more. Access the complete contents online at Expert Consult. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Minimize complications with Creasy and Resnik's Maternal-Fetal Medicine. This medical reference book puts the most recent advances in basic science, clinical diagnosis, and management at your fingertips, equipping you with the up-to date evidence-based guidelines and knowledge you need to ensure the best possible outcomes in maternal-fetal medicine. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Apply today’s best practices in maternal-fetal medicine with an increased emphasis on evidence-based medicine. Find dependable, state-of-the-art answers to any clinical question with comprehensive coverage of maternal-fetal medicine from the foremost researchers and practitioners in obstetrics, gynecology and perinatology. Take advantage of the most recent diagnostic advances with a new section on Obstetrical Imaging, complemented by online ultrasound clips as well as cross references and links to genetic disorder databases. Stay on top of rapidly evolving maternal-fetal medicine through new chapters on Recurrent Spontaneous Abortion, Stillbirth, Patient Safety, Maternal Mortality, and Substance Abuse, as well as comprehensive updates on the biology of parturition, fetal DNA testing from maternal blood, fetal growth, prenatal genetic screening and diagnosis, fetal cardiac malformations and arrhythmias, thyroid disease and pregnancy, management of depression and psychoses during pregnancy and the puerperium, and much more. Access the complete contents online at Expert Consult.
Drawing on detailed design, construction and financial histories of six prominent performing arts buildings with budgets ranging from £3.4 million to over £100 million, Geometry and Atmosphere presents unique and valuable insights into the complex process of building for the arts. Of interest to architects, urban designers and those involved in theatre studies, this book will also be useful to other sectors where public money is spent on major building projects.
This history is enriched with personal recollections and reminiscences. Its pages are filled with the names of those individuals who settled, or helped in some way to establish the County, as well as those who are remembered for various other reasons. The fifty-four illustrations include Wise County’s commonwealth attorneys, from the first (1856) to the twenty-first (1935).
This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1955.
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