This innovative case-based question-and-answer study guide to neuroradiology is geared to neurology and neurosurgery residents, medical students, and resident graduates preparing for the neurology and neuroradiology boards. The book presents 101 cases from adult neurology, pediatric neurology, and neurosurgery practice covering all major neuroradiology topics. Each case begins with one or more high-resolution images, a brief history, and questions, with answers and detailed explanations on the next page. Cases are presented in random order, rather than grouped by classification, so that readers will approach each case image with no prior clue to the diagnosis. The cases, questions, and answers will also be available on a companion Website.
Written by internationally eminent experts in cardiovascular imaging, this volume provides state-of-the-art information on the use of MRI and CT in the assessment of cardiac and vascular diseases. This third edition, now in four-color, reflects recent significant advances in cardiovascular MRI technology and the continuing emergence of multi-detector CT as an important diagnostic modality, particularly for ischemic heart disease. Seven new chapters have been added including chapters on anatomy, cardiovascular MR in infants/children, assessing myocardial viability, risk assessment in ischemic heart disease and MR guidance.
Schatzberg's Manual of Clinical Psychopharmacology is a meticulously researched, yet down-to-earth guide for practitioners prescribing psychotropic medications to individuals with psychiatric disorders or symptoms mandating treatment. The ninth edition offers up-to-date information on current drugs, interactions, side effects, and dosing guidelines, and retains the strengths and features that have made it a standard text for trainees and practicing clinicians. The authors also include a new chapter on important developments in laboratory-guided pharmacotherapy, including pharmacogenomic testing, neurocognitive testing, quantitative EEG, and neuroimaging. Although the book's primary purpose is to provide the reader-practitioner with basic and practical information regarding the many classes of psychiatric medications, the authors stress that understanding how to select and prescribe psychotropic medications does not obviate the basic need to comprehensively evaluate and understand psychiatric patients. Accordingly, the book draws on the authors' clinical experience, as well as on the scientific literature, resulting in an accessible, yet rigorous text. Features that have helped cement this book's reputation include: Coverage is not limited to long-standing and newly approved medications, but also includes agents that are likely to receive approval from the FDA in the near future, ensuring that the reader stays up-to-date. References are provided for key statements, and each chapter is then followed by a list of selected relevant articles and books for readers who want to go beyond the material presented, making for a leaner, more reader-friendly guide. Dozens of summary tables with key information on classes of psychotropics function as quick-reference guides, promoting learning and serving as convenient resources for overloaded clinicians. The appendix offers two kinds of suggested readings. The first, for clinicians, is invaluable to trainees, while the second, for patients and families, helps point clinicians to books aimed at a lay audience to supplement information provided to patients. Staying abreast of both new medications and promising treatment protocols is essential in this rapidly evolving field. Schatzberg's Manual of Clinical Psychopharmacology delivers authoritative information in a friendly, collegial style, ensuring that both students and practicing clinicians are equipped to provide a superior standard of care.
Coral reefs represent the most spectacular and diverse marine ecosystem on the planet as well as a critical source of income for millions of people. However, the combined effects of human activity have led to a rapid decline in the health of reefs worldwide, with many now facing complete destruction. Their world-wide deterioration and over-exploitation has continued and even accelerated in many areas since the publication of the first edition in 2009. At the same time, there has been a near doubling in the number of scientific papers that have been written in this short time about coral reef biology and the ability to acclimate to ocean warming and acidification. This new edition has been thoroughly revised and updated, incorporating the significant increase in knowledge gained over the last decade whilst retaining the book's focus as a concise and affordable overview of the field. The Biology of Coral Reefs provides an integrated overview of the function, physiology, ecology, and behaviour of coral reef organisms. Each chapter is enriched with a selection of 'boxes' on specific aspects written by internationally recognised experts. As with other books in the Biology of Habitats Series, the emphasis in this book is on the organisms that dominate this marine environment although pollution, conservation, climate change, and experimental aspects are also included. Indeed, particular emphasis is placed on conservation and management due to the habitat's critically endangered status. A global range of examples is employed which gives the book international relevance.
This innovative case-based question-and-answer study guide to neuroradiology is geared to neurology and neurosurgery residents, medical students, and resident graduates preparing for the neurology and neuroradiology boards. The book presents 101 cases from adult neurology, pediatric neurology, and neurosurgery practice covering all major neuroradiology topics. Each case begins with one or more high-resolution images, a brief history, and questions, with answers and detailed explanations on the next page. Cases are presented in random order, rather than grouped by classification, so that readers will approach each case image with no prior clue to the diagnosis. The cases, questions, and answers will also be available on a companion Website .
A groundbreaking argument for why alien life will evolve to be much like life here on Earth We are all familiar with the popular idea of strange alien life wildly different from life on earth inhabiting other planets. Maybe it's made of silicon! Maybe it has wheels! Or maybe it doesn't. In The Equations of Life, biologist Charles S. Cockell makes the forceful argument that the laws of physics narrowly constrain how life can evolve, making evolution's outcomes predictable. If we were to find on a distant planet something very much like a lady bug eating something like an aphid, we shouldn't be surprised. The forms of life are guided by a limited set of rules, and as a result, there is a narrow set of solutions to the challenges of existence. A remarkable scientific contribution breathing new life into Darwin's theory of evolution, The Equations of Life makes a radical argument about what life can -- and can't -- be.
The collapse of historicism was not merely the demise of an academic tradition but signified a shift in the understanding of hermeneutics and metaphysics. Whereas earlier books have explored the rise and dominance of historicism within academic history, this is the first to trace its collapse and to show how it was shaped by larger philosophical and scientific concerns. Charles R. Bambach's lucid account of the demise of historicism within the context of German metaphysics provides a rich new perspective on the development of the young Heidegger's concept of "historicity" and on the origins of postmodern thought. Bambach reconstructs the methodological debates arising from a pervasive sense of crisis among German philosophers in the late nineteenth century. He details the divergent attempts by the Neo-Kantians, Nietzsche, and Dilthey to overcome the limitations of historical relativism. Heidegger's view of "historicity," Bambach shows, radically transforms the problematic of historicism into a discourse concerning the crisis of philosophical modernity.
In the early nineteenth century, the United States of America was far from united. The United States faced internal strife over the extent of governance and the rights of individual states. The United States’ relationship with their former colonial power was also uncertain. Britain impressed American sailors and supported Native Americans’ actions in the northwest and on the Canadian border. In the summer of 1812, President James Madison chose to go to war against Britain. War in the Chesapeake illustrates the causes for the War of 1812, the political impacts of the war on America, and the war effort in the Chesapeake Bay. The book examines the early war efforts, when both countries focused efforts on Canada and the Northwest front. Some historians claim Madison chose to go to war in an attempt to annex the neighboring British territories. The book goes on to discuss the war in the Chesapeake Bay. The British began their Chesapeake campaign in an effort to relieve pressure on their defenses in Canada. Rear Admiral George Cockburn led the resulting efforts, and began to terrorize the towns of the Chesapeake. From Norfolk to Annapolis, the British forces raided coastal towns, plundering villages for supplies and encouraging slaves to join the British forces. The British also actively campaigned against the large American frigates- seeing them as the only threat to their own naval superiority. War in the Chesapeake traces these British efforts on land and sea. It also traces the Americans’ attempts to arm and protect the region while the majority of the American regular forces fought on the Northwest front. In the summer campaign of 1814, the British trounced the Americans at Bladensburg, and burned Washington, D.C. Afterwards, the Baltimoreans shocked the British with a stalwart defense at Fort McHenry. The British leaders, Vice Admiral Sir Alexander Cochrane and Major General Robert Ross, did not expect strong resistance after their quick victories at Bladensburg. War in the Chesapeake tells the story of some of the earliest national heroes, including the defenders of Baltimore and naval leaders like John Rodgers and Stephen Decatur. The following December 1814, the United States and Britain signed the Treaty of Ghent, ending hostilities and returning North America to a peaceful status quo. The United States and neighboring Canada would not go to war on opposing sides again. The United States left the war slightly more unified and independent of the British.
Through this comprehensive Handbook, the reader will obtain a balanced and cohesive picture of the Early Church. It gives an overall view of the reception, transmission, and interpretation of the Bible in the life and thought of the Church during the first five centuries of Christianity. The print edition is available as a set of two volumes (9789004098152).
The ultimate goal of cancer chemoprevention research and development is the identification of pharmaceutical or dietary constituents that will prevent cancer. Cancer Chemoprevention presents the proceedings of a large workshop on cancer chemoprevention that highlights the latest knowledge in the field, in addition to issues and ideas concerning future directions. Retinoids, sulfur compounds, and a large number of many naturally occurring cancer inhibitors in the diet are discussed, including green tea, garlic constituents, citrus fruit oils, and beans and seeds containing protease inhibitors. Compounds that may prevent the formation of carcinogens in food are covered, and the mechanisms by which chemical or dietary agencts produce cancer inhibitors are discussed.
Charles Griswold has written a comprehensive philosophical study of Smith's moral and political thought. Griswold sets Smith's work in the context of the Enlightenment and relates it to current discussions in moral and political philosophy. Smith's appropriation as well as criticism of ancient philosophy, and his carefully balanced defence of a liberal and humane moral and political outlook, are also explored. This 1999 book is a major philosophical and historical reassessment of a key figure in the Enlightenment that will be of particular interest to philosophers and political and legal theorists, as well as historians of ideas, rhetoric, and political economy.
Significantly revised and updated, the new edition of this highly regarded reference on the shoulder continues to impress. A multitude of leading international authorities—30% new to this 4th edition—present today’s most comprehensive, in-depth view of the current state of shoulder practice, all in a beautifully illustrated, full-color 2-volume masterwork. They deliver the most up-to-date coverage of shoulder function and dysfunction, along with practical approaches for patient evaluation and balanced discussions of treatment alternatives—open and arthroscopic, surgical and nonsurgical. Greatly expanded and visually enhanced coverage of arthroscopy, as well as many new chapters, provide expert guidance on the latest minimally invasive approaches. New “Critical Points summary boxes highlight key technical tips and pearls, and two DVDs deliver new videos that demonstrate how to perform open and arthroscopic procedures. And now, as an Expert Consult title, this thoroughly updated 4th edition comes with access to the complete fully searchable contents online, as well as videos of arthroscopic procedures from the DVDs—enabling you to consult it rapidly from any computer with an Internet connection. Includes tips and pearls from leaders in the field, as well as their proven and preferred methods. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Provides a balance between open and arthroscopic techniques so you can chose the right procedures for each patient. Includes the entire contents of the book online, fully searchable, as well as procedural videos from the DVDs, for quick, easy anywhere access. Features 30% new expert contributors and new chapters, including Effectiveness Evaluation and the Shoulder, Revision of Rotator Cuff Problems, Management of Complications of Rotator Cuff Surgery, Management of Infected Shoulder Prosthesis, and others, providing you with abundant fresh insights and new approaches. Provides new and expanded material on the management of advanced arthritis and CTA, infected arthroplasty, procedures to manage the stiff shoulder, and much more keeping you on the cusp of the newest techniques. Offers enhanced coverage of shoulder arthroscopy, including basic and advanced techniques and complications, for expert advice on all of the latest minimally invasive approaches. Devotes an entire new chapter to research frontiers to keep you apprised of what’s on the horizon. Incorporates “Critical Points summary boxes that highlight key technical tips and pearls. Uses a new full-color design for optimal visual guidance of arthroscopic views and procedures. Presents new videos on arthroscopic procedures on 2 DVDs to help you master the latest techniques.
Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by pediatric infectious diseases. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention! Spend less time searching thanks to a consistent, easily-accessible format featuring revised high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Be prepared for the unexpected! A veritable "who's who" of global authorities provides practical knowledge to effectively diagnose and manage almost any infectious disease you may encounter. Quickly look up the answers you need by clinical presentation, pathogen, or type of host. Get expanded coverage for all types of infectious diseases including new chapters on infection related to pets and exotic animals, and tickborne infections. Apply the latest recommendations and treatments for emerging and re-emerging diseases including the H1N1 virus.
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.
Drawing on comprehensive analyses of all of Sophocles' plays, on structuralist anthropology, and on other extensive work on myth and tragedy, Charles Segal examines Sophocles both as a great dramatic poet and as a serious thinker. He shows how Sophoclean tragedy reflects the human condition in its constant and tragic struggle for order and civilized life against the ever-present threat of savagery and chaotic violence, both within society and within the individual. Tragedy and Civilization begins with a study of these themes and then proceeds to detailed discussions of each of the seven plays. For this edition Segal also provides a new preface discussing recent developments in the study of Sophocles.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
This book differs from its predecessor, Lieb & Mattis Mathematical Physics in One Dimension, in a number of important ways. Classic discoveries which once had to be omitted owing to lack of space ? such as the seminal paper by Fermi, Pasta and Ulam on lack of ergodicity of the linear chain, or Bethe's original paper on the Bethe ansatz ? can now be incorporated. Many applications which did not even exist in 1966 (some of which were originally spawned by the publication of Lieb & Mattis) are newly included. Among these, this new book contains critical surveys of a number of important developments: the exact solution of the Hubbard model, the concept of spinons, the Haldane gap in magnetic spin-one chains, bosonization and fermionization, solitions and the approach to thermodynamic equilibrium, quantum statistical mechanics, localization of normal modes and eigenstates in disordered chains, and a number of other contemporary concerns.
The seventh edition of The Economics of European Integration provides students with an accessible presentation of the facts, theories and controversies that are driving rapid change at the heart of Europe. This new edition covers crucial updates on the impact of Brexit and Covid-19 and offers an expert analysis of the contemporary status of integration within the European Union. Key Features and Updates •Wide range of learning features including boxed examples and illustrations, end of chapter summaries, self-assessment questions and essay questions. •Fully updated to include new discussions and examples such as the new budget which has significant implications on European bonds, immigration, and climate change. •Two new chapters highlighting the impact of both Brexit and Covid-19 on the EU. •An Online Learning Centre with Lecture Outlines, PowerPoint Presentations, and an Image Library. Richard Baldwin is Professor of International Economics at the Graduate Institute, Geneva, having been a visiting professor at Oxford and MIT. He is Editor-in-Chief and founder of VoxEU.org since 2007 and he advises governments around the world on globalisation and integration issues having served in the Bush (Sr) White House in 1990-91. Charles Wyplosz is Professor Emeritus of International Economics at the Graduate Institute in Geneva where he also served as Director of the International Centre for Money and Banking Studies. He is a Fellow of CEPR and of the European Economic Association, as well as a Founding Managing Editor of the Economic Policy journal.
This publication, a collection of 174 papers, encompasses the fundamental and intricate photochemistry and electron transfer of flavins and flavoproteins, the mechanisms associated with enzymes utilising flavins (such as dehydrogenases, reductases, oxidases, monooxygenases, synthases, peroxidases), the three-dimensional structures of flavoproteins and flavoenzymes and the emerging role of flavins and flavoproteins in medicine. Flavins and Flavoproteins 1996 continues the series which has appeared every three years since 1965. Presented are overviews of key areas of flavin research, coupled with the most recent understanding of the chemistry/photochemistry of flavins and the structure/function relationship of numerous proteins/enzymes that use flavins as essential cofactors. Key Features: Detailed studies on the structure and mechanism of flavoenzymes are reported together with newly discovered medical aspects; New research of high quality with extensive data, figures and bibliographies; The interaction of flavins with other electron carriers such as the cytochromes, metals, and non-heme iron centres is investigated with a variety of spectrophotometric techniques; NMR and crystallography studies have provided new three-dimensional structures of several flavoenzymes and flavoproteins; Numerous papers on an extensive number of flavoenzymes and complex flavoproteins are presented.
Featuring over 600 full-color illustrations, the Third Edition of this definitive reference provides comprehensive, current, and authoritative coverage of the entire spectrum of urologic surgical pathology. The book emphasizes diagnostic morphology and includes clinical-pathologic correlations. This thoroughly updated edition clarifies histologic variants of prognostic value in urinary bladder cancers and prostate carcinomas and identifies tumor markers useful in both diagnosis and post-therapy management of cancer patients. Also included are current diagnostic criteria for urothelial carcinomas, the latest TNM staging of urogenital organ malignancies, and up-to-date renal tumor classifications, including cytogenetic, immunohistochemical, and morphologic correlations. A companion Website will offer the fully searchable text and an image bank.
Benign prostatic hyperplasia and the resulting lower urinary tract symptoms is a major part of almost any urologist’s clinical practice. Due to the high prevalence of the disease in our aging population, new concepts and treatments are constantly entering the marketplace. Differences in patient preferences and desired outcomes require the practicing urologist to understand not only the pathophysiology of the disease but how specific treatments may be better suited for some patients and not others. This issue will address the current concepts and treatments available to urologists.
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