The vast array of libraries in the world bear mute witness to the truth of the 3000-year-old observation of King Solomon who stated " ... of making many books there is no end, and much study is a weariness of the flesh." Yet books are an essential written record of our lives and the progress of science and humanity. Here is another book to add to this huge collection, but, hopefully, not just another collection of pages, but rather a book with a specific purpose to aid in alleviating the "weariness of the flesh" that could arise from much studying of other journals and books in order to obtain the basic information contained herein. This book is about polymeric materials and biological activity, as the title notes. Polymeric materials, in the broad view taken here, would include not only synthetic polymers (e.g., polyethylene, polyvinyl chloride, polyesters, polyamides, etc.), but also the natural macromolecules (e.g., proteins, nucleic acids, polysaccharides) which compose natural tissues in humans, animals and plants. In the broad sense used here, biological activity is any type of such action whether it be in medication, pest control, plant-growth regu lation, and so on. In short, this book attempts to consider, briefly, the use of any type of polymeric material system with essentially any kind of biological activity.
The development and use of medical and dental materials are highly interdisciplinary endeavors which require expertise in chemistry, materials science, medicine and/or dentistry, mechanics and design engineering. The Symposium upon which this treatise is based was organized to bring members from these communities together to explore problems of mutual interest. The biomaterials which are used in medical or dental prostheses must not only exhibit structural stability and provide the desired function, but they must also perform over extended periods of time in the environment of the body. The latter is a very stringent requirement. The oral and other physiological environments are designed by nature to break down many organic substances. Also of importance is the requirement that materials used in the prosthesis not have a deleterious effect on body tissues. Most foreign (to the body) substances are somewhat toxic to human tissues; in fact, few factors are more limiting in the medical prosthesis field than the biocompatibility problem. Some of these problems and the attempts to solve them are discussed in this volume.
From the Preface This book attempts to delineate some of the more recent efforts at utilizing biotechnology in industry. For convenience, this book is divided into the following five sections: (1) Industrial Applications, (2) Polysaccharides and Lignins, (3) Spider Silks, (4) Protein-Based Systems, and (5) Miscellaneous Biotechnological Polymers. The division is intended for the convenience of the reader and not to depict any basic demarcation in biotechnology, which already spans much of our modern technology and appears poised to embark on a course aimed at extending its boundaries even further. One of the newest trends in science is the mimicking of nature using solutions provided in nature (such as elasticity) to produce materials with distinctive properties. The papers in this book are extensions of presentations given March 15-16, 1994, in San Diego, at the 207th National Meeting of the American Chemical Society during a symposium on "Industrial Biotechnological Polymers." This symposium was sponsored by the Biotechnology Secretariat and cosponsored by the A.C.S. Division of Polymeric Materials: Science and Engineering. The editors believe this book will make a lasting contribution to the field of biotechnological polymers.
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