Reproductive technologies, says Thompson, are part of the increasing tendency to turn social problems into biomedical questions and can be used as a lens to see the resulting changes in the relations between science and society."--BOOK JACKET.
Reproductive technologies, says Thompson, are part of the increasing tendency to turn social problems into biomedical questions and can be used as a lens to see the resulting changes in the relations between science and society."--BOOK JACKET.
An examination of a decade and a half of political controversy, ethical debate, and scientific progress in stem cell research. After a decade and a half, human pluripotent stem cell research has been normalized. There may be no consensus on the status of the embryo—only a tacit agreement to disagree—but the debate now takes place in a context in which human stem cell research and related technologies already exist. In this book, Charis Thompson investigates the evolution of the controversy over human pluripotent stem cell research in the United States and proposes a new ethical approach for “good science.” Thompson traces political, ethical, and scientific developments that came together in what she characterizes as a “procurial” framing of innovation, based on concern with procurement of pluripotent cells and cell lines, a pro-cures mandate, and a proliferation of bio-curatorial practices. Thompson describes what she calls the “ethical choreography” that allowed research to go on as the controversy continued. The intense ethical attention led to some important discoveries as scientists attempted to “invent around” ethical roadblocks. Some ethical concerns were highly legible; but others were hard to raise in the dominant procurial framing that allowed government funding for the practice of stem cell research to proceed despite controversy. Thompson broadens the debate to include such related topics as animal and human research subjecthood and altruism. Looking at fifteen years of stem cell debate and discoveries, Thompson argues that good science and good ethics are mutually reinforcing, rather than antithetical, in contemporary biomedicine.
This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.
This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.
The ideal text for a two-semester graduate course on quantum mechanics. Fresh, comprehensive, and clear, it strikes the optimal balance between covering traditional material and exploring contemporary topics. Focusing on the probabilistic structure of quantum mechanics and the central role of symmetries to unify principles, this textbook guides readers through the logical development of the theory. Students will also learn about the more exciting and controversial aspects of quantum theory, with discussions on past interpretations and the current debates on cutting-edge concepts such as quantum information and entanglement, open quantum systems, and quantum measurement theory. The book has two types of content: Type A material is more elementary and is fully self-contained, functioning like a separate book within the book, while Type B content is at the level of a graduate course. Requiring minimal physics background, this textbook is appropriate for mathematics and engineering students, in addition to physicists. Introducing cutting-edge topics in the field, the book features about 150 concept-checking questions, 300 homework problems and a solutions manual.
Protein Folding aims to collect the most important information in the field of protein folding and probes the main principles that govern formation of the three-dimensional structure of a protein from a nascent polypeptide chain, as well as how the functional properties appear. This text is organized into three sections and consists of 15 chapters. After an introductory chapter where the main problems of protein folding are considered at the cellular level in the context of protein biosynthesis, the discussion turns to the conformation of native globular proteins. Definitions and rules of nomenclature are given, including the structural organization of globular proteins deduced from X-ray crystallographic data. Folding mechanisms are tentatively deduced from the observation of invariants in the architecture of folded proteins. The next chapters focus on the energetics of protein conformation and structure, indicating the principles of thermodynamic stability of the native structure, along with theoretical computation studies of protein folding, structure prediction, and folding simulation. The reader is also introduced to various experimental approaches; the reversibility of the unfolding-folding process; equilibrium and kinetic studies; and detection and characterization of intermediates in protein folding. This text concludes with a chapter dealing with problems specific to oligomeric proteins. This book is intended for research scientists, specialists, biochemists, and students of biochemistry and biology.
This book provides a comprehensive, authoritative, and contemporary discussion of the physiology and pathophysiology of the chest wall as well as an overview of the diagnostic and therapeutic modalities. It is an invaluable aid to clinical investigators.
Olive Mill Waste: Recent Advances for Sustainable Management addresses today's most relevant topics in olive oil industry sustainable management. Emphasizing recent advisable practices, the book explores the potential of reutilizing OMW to power the mill itself, the reuse of OMW as soil amendment, aerobic biological treatment of OMW and compost production, the case study of OMW within the biorefinery concept, the recovery of bioactive compounds from OMW, and their applications in food products and cosmetics. Recent research efforts have concluded that the successful management of OMW focuses on three main routes: (a) reuse of water, (b) reuse of polyphenols, and (c) reuse of nutrients. Following this consideration, the book covers sustainable practices in the olive oil industry, revealing opportunities for reutilizing the water of OMW within the process or as s soil amendment. At the same time, it explores all the possibilities of recovering polyphenols and reutilizing them in target products, such as foods and cosmetics. In addition, the book presents successful cases of industrial OMW valorization through real world experiences. - Covers the most recent advances in the field of olive mill waste management following sustainability principles - Fills the gap of transfer knowledge between academia and industry - Explores the advantages, disadvantages and real potential of processes and products in the market
This book explores a neglected feature of intellectual history and literature in the early modern period: the ways in which the body was theorized and represented as an intelligent cognitive agent, with desires, appetites, and understandings independent of the mind. It considers the works of early modern physicians, thinkers, and literary writers who explored the phenomenon of the independent and intelligent body. Charalampous rethinks the origin of dualism that is commonly associated with Descartes, uncovering hitherto unknown lines of reception regarding a form of dualism that understands the body as capable of performing complicated forms of cognition independently of the mind. The study examines the consequences of this way of thinking about the body for contemporary philosophy, theology, and medicine, opening up new vistas of thought against which to reassess perceptions of what literature can be thought and felt to do. Sifting and assessing this evidence sheds new light on a range of historical and literary issues relating to the treatment, perception, and representation of the human body. This book examines the notion of the thinking body across a wide range of genres, topics, and authors, including Montaigne’s Essays, Spenser’s allegorical poetry, Donne’s metaphysical poetry, tragic dramaturgy, Shakespeare, and Milton’s epic poetry and shorter poems. It will be essential for those studying early modern literature, cognition, and the body.
Particle or Wave is the first popular-level book to explain the origins and development of modern physical concepts about matter and the controversies surrounding them. The dichotomy between particle and wave reflects a dispute--whether the universe's most elementary building blocks are discrete or continuous in nature--originating in antiquity when philosophers first speculated about the makeup of the physical world. Charis Anastopoulos examines two of the earliest known theories about matter--the atomic theory, which attributed all physical phenomena to atoms and their motion in the void, and the theory of the elements, which described matter as consisting of the substances earth, air, fire, and water. He then leads readers up through the ages to the very frontiers of modern physics to reveal how these seemingly contradictory ideas still lie at the heart of today's continuing debates. Anastopoulos explores the revolutionary contributions of thinkers like Nicolas Copernicus, Isaac Newton, and Albert Einstein. He shows how Einstein's ideas about relativity unify opposing concepts by identifying matter with energy, and how quantum mechanics goes even further by postulating the coexistence of the particle and the wave descriptions. Anastopoulos surveys the latest advances in physics on the fundamental structure of matter, including the theories of quantum fields and elementary particles, and new cutting-edge ideas about the unification of all forces. This book reveals how the apparent contradictions of particle and wave reflect very different ways of understanding the physical world, and how they are pushing modern science to the threshold of new discoveries.
Learning in Morocco offers a rare look inside public education in the Middle East. While policymakers see a crisis in education based on demographics and financing, Moroccan high school students point to the effects of a highly politicized Arabization policy that has never been implemented coherently. In recent years, national policies to promote the use of Arabic have come into conflict with the demands of a neoliberal job market in which competence in French is still a prerequisite for advancement. Based on long-term research inside and outside classrooms, Charis Boutieri describes how students and teachers work within, or try to circumvent, the system, whose contradictory demands ultimately lead to disengagement and, on occasion, to students taking to the streets in protest.
Self-made shipping magnate Joseph Chance never planned on falling in love. He simply needed financing for a new business venture and a marriage of convenience provides it. Then he meets Tessa St. Croix, his future bride, and is instantly smitten. But when the angelic beauty reveals a life-changing secret on their wedding night, Joseph thinks maybe some dreams shouldn’t come true. He leaves England, reconciling himself to a detached, convenient marriage after all. Eleven months later, Tessa Chance has built a new life for herself in the heart of London. She’s learned her new husband's business and is determined to support herself and her responsibilities. When Joseph returns to London unexpectedly, nothing is as he imagined. His estranged wife has become the one person who can help him secure his company’s future, and her allure can tempt him still. Determined and hopeful, Tessa jumps at the chance to prove herself and justify the secret that tore them apart. Although bruised pride and broken hearts lie between them, Joseph and Tessa realize the love they once felt has never truly left. If they can learn to forgive each other, they’ll soon discover the truest love can heal all wounds.
An examination of a decade and a half of political controversy, ethical debate, and scientific progress in stem cell research. After a decade and a half, human pluripotent stem cell research has been normalized. There may be no consensus on the status of the embryo—only a tacit agreement to disagree—but the debate now takes place in a context in which human stem cell research and related technologies already exist. In this book, Charis Thompson investigates the evolution of the controversy over human pluripotent stem cell research in the United States and proposes a new ethical approach for “good science.” Thompson traces political, ethical, and scientific developments that came together in what she characterizes as a “procurial” framing of innovation, based on concern with procurement of pluripotent cells and cell lines, a pro-cures mandate, and a proliferation of bio-curatorial practices. Thompson describes what she calls the “ethical choreography” that allowed research to go on as the controversy continued. The intense ethical attention led to some important discoveries as scientists attempted to “invent around” ethical roadblocks. Some ethical concerns were highly legible; but others were hard to raise in the dominant procurial framing that allowed government funding for the practice of stem cell research to proceed despite controversy. Thompson broadens the debate to include such related topics as animal and human research subjecthood and altruism. Looking at fifteen years of stem cell debate and discoveries, Thompson argues that good science and good ethics are mutually reinforcing, rather than antithetical, in contemporary biomedicine.
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