An accessible guide that introduces students in all areas of life sciences to bioinformatics Basic Applied Bioinformatics provides a practical guidance in bioinformatics and helps students to optimize parameters for data analysis and then to draw accurate conclusions from the results. In addition to parameter optimization, the text will also familiarize students with relevant terminology. Basic Applied Bioinformatics is written as an accessible guide for graduate students studying bioinformatics, biotechnology, and other related sub-disciplines of the life sciences. This accessible text outlines the basics of bioinformatics, including pertinent information such as downloading molecular sequences (nucleotide and protein) from databases; BLAST analyses; primer designing and its quality checking, multiple sequence alignment (global and local using freely available software); phylogenetic tree construction (using UPGMA, NJ, MP, ME, FM algorithm and MEGA7 suite), prediction of protein structures and genome annotation, RNASeq data analyses and identification of differentially expressed genes and similar advanced bioinformatics analyses. The authors Chandra Sekhar Mukhopadhyay, Ratan Kumar Choudhary, and Mir Asif Iquebal are noted experts in the field and have come together to provide an updated information on bioinformatics. Salient features of this book includes: Accessible and updated information on bioinformatics tools A practical step-by-step approach to molecular-data analyses Information pertinent to study a variety of disciplines including biotechnology, zoology, bioinformatics and other related fields Worked examples, glossary terms, problems and solutions Basic Applied Bioinformatics gives students studying bioinformatics, agricultural biotechnology, animal biotechnology, medical biotechnology, microbial biotechnology, and zoology an updated introduction to the growing field of bioinformatics.
Using letters, diaries, and regimental newspapers to take us inside the minds of Civil War soldiers—black and white, Northern and Southern—as they fought and marched across a divided country, this unprecedented account is “an essential contribution to our understanding of slavery and the Civil War" (The Philadelphia Inquirer). In this unprecedented account, Chandra Manning With stunning poise and narrative verve, Manning explores how the Union and Confederate soldiers came to identify slavery as the central issue of the war and what that meant for a tumultuous nation. This is a brilliant and eye-opening debut and an invaluable addition to our understanding of the Civil War as it has never been rendered before.
From the author of What This Cruel War Was Over, a vivid portrait of the Union army’s escaped-slave refugee camps and how they shaped the course of emancipation and citizenship in the United States. Even before shots were fired at Fort Sumter, slaves recognized that their bondage was at the root of the war they knew was coming, and they began running to the Union army. By the war’s end, nearly half a million had taken refuge behind Union lines in improvised “contraband camps.” These were crowded and dangerous places, with conditions approaching those of a humanitarian crisis. Yet families and individuals—some 12 to 15 percent of the Confederacy’s slave population—took unimaginable risks to reach them, and they became the first places where many Northerners would come to know former slaves en masse, with reverberating consequences for emancipation, its progress, and the Reconstruction that followed. Drawing on records of the Union and Confederate armies, the letters and diaries of soldiers, transcribed testimonies of former slaves, and more, Chandra Manning allows us to accompany the black men, women, and children who sought out the Union army in hopes of achieving autonomy for themselves and their communities. Ranging from the stories of individuals to those of armies on the move to debates in the halls of Congress, Troubled Refuge probes the particular and deeply significant reality of the contraband camps: what they were really like and how former slaves and Union soldiers warily united there, forging a dramatically new but highly imperfect alliance between the government and African Americans. That alliance, which would outlast the war, helped destroy slavery and warded off the very acute and surprisingly tenacious danger of re-enslavement. It also raised, for the first time, humanitarian questions about refugees in wartime and legal questions about civil and military authority with which we still wrestle, as well as redefined American citizenship, to the benefit but also to the lasting cost of African Americans. Integrating a wealth of new findings, Manning casts in wholly original light what it was like to escape slavery, how emancipation happened, and how citizenship in the United States was transformed. This reshaping of hard structures of power would matter not only for slaves turned citizens, but for all Americans.
We are an integrated part of cosmos. The substance related to the astronomical concepts forms the subject matter of Astronomy. It broadly studies universe, solar system, planets, galaxies, meteoroids, asteroids and several other astronomical bodies, often thought to be of the status of celestial origin. Out of the occurrence of a fluke manifestation, one after the other resulting in the creation of life, species and humans. In modern times, Hubble Telescope revolutionised planetary studies and outlived its lifespan. What likely edge will James Webb have over Hubble Space Telescope which immensely enriched the human knowledge on Cosmos for about three decades? Acclaimed scientists have contributed towards evolving a convincing narrative. Often indisputable pieces of evidence and sometimes some intelligent hypothesis support it. A tiny dot became universe followed by the birth of the sun, moon, the earth, other planets, nebula, galaxy and milky ways, and living kingdom. Life evolved, flora and fauna developed. Five catastrophic extinctions occurred eliminating several species. This journey is laid on twelve hours on a clock. In due course, Homo sapiens developed who brought along intricacies like Environmental Degradation, Global Warming and Climate Change. What length of the queue will be created if we trace the lineage of our generation back to the first human that appeared to roam about on the earth? Narrative wavers from line, tracks the life and achievements of ancient civilisations, which laid the foundation stone for human societies, and got eliminated due to damage to the fine balance of environmental sustainability. This book refers to the ones like Indus valley civilisation, the master traders; the Sumerians, the pioneers in many fields; the mysterious Maya; and incredibly industrious Rapa Nui. All got exterminated. As scientists continue to turn up even more signs of collapsed civilisations, they are finding plenty of evidence that climate shifts are to blame to a considerable extent. Why and how? The narrative attempts to answer. The chronicle is before you which might engender a child-like fascination as you delve deeper and farther in it.
This examination of Sri Lanka's ethnic and religious minorities links the past with the present through a treatment of Sinhala-Buddhist fundamentalist development in the late nineteenth century and its hegemony in the late twentieth.
Our species is misnamed. Though sapiens defines human beings as "wise" what humans do especially well is to prospect the future. We are homo prospectus. In this book, Martin E. P. Seligman, Peter Railton, Roy F. Baumeister, and Chandra Sripada argue it is anticipating and evaluating future possibilities for the guidance of thought and action that is the cornerstone of human success. Much of the history of psychology has been dominated by a framework in which people's behavior is driven by past history (memory) and present circumstances (perception and motivation). Homo Prospectus reassesses this idea, pushing focus to the future front and center and opening discussion of a new field of Psychology and Neuroscience. The authors delve into four modes in which prospection operates: the implicit mind, deliberate thought, mind-wandering, and collective (social) imagination. They then explore prospection's role in some of life's most enduring questions: Why do people think about the future? Do we have free will? What is the nature of intuition, and how might it function in ethics? How does emotion function in human psychology? Is there a common causal process in different psychopathologies? Does our creativity change with age? In this remarkable convergence of research in philosophy, statistics, decision theory, psychology, and neuroscience, Homo Prospectus shows how human prospection fundamentally reshapes our understanding of key cognitive processes, thereby improving individual and social functioning. It aims to galvanize interest in this new science from scholars in psychology, neuroscience, and philosophy, as well as an educated public curious about what makes humanity what it is.
Increasingly, identities are the site for interdisciplinary initiatives and identity research is at the heart of many transdisciplinary research centres around the world. No single social science discipline 'owns' identity research which makes it a difficult topic to categorize. The SAGE Handbook of Identities systematizes this complex field by incorporating its interdisciplinary character to provide a comprehensive overview of its themes in contemporary research while still acknowledging the historical and philosophical significance of the concept of identity. Drawing on a global scholarship the Handbook has four parts: Part 1: Frameworks presents the main theoretical and methodological perspectives in identities research. Part 2: Formations covers the major formative forces for identities such as culture, globalisation, migratory patterns, biology and so on. Part 3: Categories reviews research on the core social categories which are central to identity such as ethnicity, gender, sexuality, disability and social class and intersections between these. Part 4: Sites and Context develops a series of case studies of crucial sites and contexts where identity is at stake such as social movements, relationships and family life, work-places and environments and citizenship.
This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules. This book is ideal for researchers of nanotechnology, materials science and biophysics.
It incorporates the changes that have occurred in endodontic theory and practice in terms of materials, concepts and protocols. The presentation of the concepts and techniques has also been revised.
This book addresses presents recent developments of novel planar inter digital sensors for food inspection. It covers the fundamentals of sensors, their design, modelling and simulations, fabrications, characterizations, experimental investigations and analyses. This book will be useful for the engineers and researchers especially higher undergraduate, postgraduate students as well as practitioners working on the development of Electromagnetic Sensors.
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. - Presents an overview of Diabetes Mellitus - Includes a discussion of various strategies and techniques adopted for oral delivery of insulin - Presents an update of research in the field
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