Com as alterações introduzidas pela Portaria n.º 271/2014, de 23 de dezembro, que aprovou os novos modelos de impressos relativos à Folha de Rosto e Anexos A, B, C, D e I. Inclui orientações para o preenchimento da Folha de Rosto e Anexos A, B, C, D, E, G, H, I, L, M, N, O, P e Q e exercícios resolvidos que simplificam a interpretação dos formulários. Esta edição de 2015 é um manual respeitante aos vários anexos que integram a IES/DA e que vem consolidar e complementar o trabalho anterior com novas orientações, de modo a apresentar um guia completo para o preenchimento da Folha de Rosto e Anexos A, B, C, D, E, G, H, I, L, M, N, O, P e Q. O Manual de preenchimento da IES/DA inclui agora notas explicativas para o correto preenchimento dos novos impressos, aprovados pela Portaria n.º 271/2014, de 23 de dezembro (Folha de Rosto e Anexos A, B, C, D e I), mas também para o preenchimento dos restantes anexos da declaração, mesmo não tendo sido alvo de atualização. Contém ainda um breve enquadramento fiscal, em sede de Imposto sobre o Rendimento das Pessoas Coletivas, das entidades que não exercem a título principal uma atividade comercial, industrial ou agrícola, dos não residentes sem estabelecimento estável, bem como das entidades sujeitas ao regime da transparência fiscal, entidades que se encontram obrigadas à entrega dos Anexos D, E e G, respetivamente. Inclui 8 exercícios resolvidos que simplificam a interpretação dos formulários e 18 quadros.
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules. - Summarizes the current advances in the use of permeability models in drug transport - Covers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood–brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applications - Updates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models
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