2014 BMA Medical Book Awards Highly Commended in Pathology category! Muscle Biopsy: A Practical Approach gives you all of the unparalleled guidance necessary to effectively interpret and diagnose muscle biopsy specimens for the full range of diseases in both adults and children. Authored by Dr. Victor Dubowitz, internationally renowned figure in the field of muscle disease, this medical reference book takes an integrated approach to diagnosis and assessment of muscle biopsies that includes clinical, genetic, biochemical, and pathological features. It's the comprehensive, up-to-date coverage you need to evaluate muscle disorders with confidence "Overall, this is a well written and comprehensive textbook of muscle pathology that will be of invaluable assistance to laboratories reporting muscle pathology" Reviewed by The Bulletin of The Royal College of Pathologists, Jan 2015 Bridge the gap between clinical syndromes/disorders and their underlying pathologies with the guidance of muscle disease expert, Dr. Victor Dubowitz, who skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. Understand and apply expert techniques for obtaining a muscle biopsy, and familiarize yourself with the histochemical, histological, electron microscopical, and molecular appearance of normal muscle and the pathology of individual muscle disease. Read the entire contents and download all of the images online at Expert Consult. Apply all of the latest diagnostic techniques for neurodegenerative and genetic diseases with a brand-new chapter on myopathies associated with systemic disorders and aging, and use advanced techniques such as immunohistochemistry and immunoblotting to produce the most accurate diagnoses possible for a full range of muscle disorders. Stay current in practice with state-of-the-art coverage of genetic markers for individual conditions and antibodies used in immunocytochemical diagnosis. Understand the genetics of muscular dystrophies with absolute clarity through the use of brilliantly simple diagrams and tables, and compare your specimens to a wealth of superb color images capturing the full spectrum of muscle biopsy findings. Take advantage of international insights and fresh perspectives in muscle diseases and disorders from new author Dr. Anders Oldfors, from the Department of Pathology, University of Goteborg, Sweden.
For more than 45 years, Muscle Biopsy: A Practical Approach has offered, comprehensive, clinically-focused coverage of the acquisition, interpretation, and assessment of muscle biopsies – an area often only lightly covered in pathology texts. Taking an integrated approach that includes clinical, genetic, biochemical, and pathological features, the 5th Edition covers the full range of muscle disease in both adults and children. This highly illustrated, easy-to-use volume helps you navigate this challenging area, bridging the gap between clinical syndromes/disorders and their underlying pathologies. - Fully updated 5th edition of this internationally acclaimed classic in muscle pathology. - Written by internationally recognized world leaders in the field of muscle pathology. - Comprehensive coverage of histology, histochemistry, immunocytochemistry and electron microscopy in parallel with clinical and genetic advances. - Lavishly illustrated with over 600 full colour images. - Fully updated literature review. - Comprehensive update on the rapidly expanding field of neuromuscular disorders. - 4th edition Highly Commended in Pathology category of the prestigious 2014 BMA Medical Book Awards.
This issue of Clinics in Laboratory Medicine, Guest Edited by Caroline Astbury, PhD, FACMG, will focus on Cytogenetics, with topics including: Chronic lymphocytic leukemia; Acute lymphocytic leukemia; Acute myelogenous leukemia; Chronic myelogenous leukemia; Plasma cell myeloma; Lymphomas; Solid tumors; Myelodysplastic syndromes; SNP arrays in clinical practice; Prenatal arrays; FISH (including Paraffin-embedded (PET) FISH); New and old microdeletion and microduplication syndromes; Sex chromosome and sex chromosome abnormalities; Autosomal aneuploidy; Microarray-CGH interpretation and Genomic Integrity; Structural chromosome rearrangements and complex chromosome rearrangements; and UPD/imprinting.
This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.
Age-related macular degeneration (AMD) is a degenerative condition that begins in Bruch’s membrane and progresses to involve the retinal pigment epithelium and ultimately, overlying photoreceptors. The only required etiologic factor is age, and AMD is regarded as the leading cause of blindness in individuals over 65 years. AMD results from variable contributions of age, environment, and genetic predisposition. Many loci are linked to AMD—in the vast majority of cases, the disease is associated with polymorphisms within these genes, rather than mutations that ablate gene function. The etiologic complexity of AMD is reflected by the paucity of animal models that entirely replicate the human disease. In this review, we compare the salient anatomy of the primate and rodent retina, particularly in the light of AMD pathology. Next, prevailing hypotheses explaining how AMD may develop are discussed. These include the role of complement activation and macrophage chemotaxis in AMD, molecular mechanisms of choroidal neovascularization, and the roles of oxidative damage and lipid metabolism. An overview of spontaneous and induced non-human primate models is given, and relevant mouse models are described in the context of each pathogenetic mechanism.
Drawing on extensive interviews with artists and their assistants as well as close readings of artworks, Jones explains that much of the major work of the 1960s was compelling precisely because it was "mainstream" - central to the visual and economic culture of its time.
This book marks an important contribution to colonial and postcolonial studies in its clarification of the African discourse of consciousness and its far-reaching analyses of a literature of animism. It will be of great interest to scholars in many fields including literary and critical theory, philosophy, anthropology, politics and psychoanalysis.
Thoroughly revised and updated, Exploring Bioinformatics: A Project-Based Approach, Second Edition is intended for an introductory course in bioinformatics at the undergraduate level. Through hands-on projects, students are introduced to current biological problems and then explore and develop bioinformatic solutions to these issues. Each chapter presents a key problem, provides basic biological concepts, introduces computational techniques to address the problem, and guides students through the use of existing web-based tools and software solutions. This progression prepares students to tackle the On-Your-Own Project, where they develop their own software solutions. Topics such as antibiotic resistance, genetic disease, and genome sequencing provide context and relevance to capture student interest.
Winner of the Ethel Wilson Fiction Prize and shortlisted for the Governor-General's Award for fiction and the Commonwealth Writer's Prize, Caroline Adderson's short fiction collection travels far and wide. From adolescent brothers marooned at an indifferent relatives cottage, to a Depression-era Ukrainian immigrant reading the drought-parched skies above Palliser's Triangle, to two friends trying to make sense of feminism in the eighties, Adderson captures her characters' cadences, conflicts, and consolations, their individual burdens and the mysteries they share. Adventurous, often funny, and impeccably researched, these stories chart their lives with compassion and intelligence.
Addressing the question of how neoliberal ideology has served to conflate the radical left with extremism, this book examines how the Arab left has asserted itself in the context of authoritarianism and Islamic extremism during and after the Arab uprisings. It examines how the Arab cultural left has offered a critique of the signifying practices of political hegemonies in the region and argues that though creative expression as constituted in the very language of the Arab uprisings, it has put forward its own alternatives Using a wide array of texts and sources, both Arab and non-Arab, the opening chapters of the book identify how ethical and radical values pertaining to sociality are co-opted by political leaders in the Middle East and turned into jargon. Later chapters outline resistance to this co-option through a poetics of inter-subjectivity that takes structures of feeling into account, ranging from disappointment, despair and distrust, to dignity, solidarity and reconfigured senses of the sacred. In showing how psychological and affective states relate to signifying practices, the book offers an original conceptual framework for differentiating 'radicalization' from the creative radicalism of the Arab avant-garde.
Between 1600 and 1800 around 4,000 Catholic women left England for a life of exile in the convents of France, Flanders, Portugal and America. These closed communities offered religious contemplation and safety, but also provided an environment of concentrated female intellectualism. The nuns’ writings from this time form a unique resource.
Through examination of the functions of language and cross-cultural readings of literature - from African queer reading to postcolonial Shakespeare - Rooney explores current ideas of performativity in literature and language, and negotiates a path between feminist theory’s common pitfalls of essentialism and constructivism.
This book emphasizes the indivual's personal responsibility for wellness by presenting general (core) and current health information to guide decision-making. The focus of the text is to present health topics, including cultural, racial, ethnic and gender diversity, identify risk factors and give students useful and sensible suggestions to reduce their risk for preventable diseases and conditions in order to achieve optimal levels of wellness for themselves, friends and family. Filled with practical advice, stimulating discussion questions and self-assessment exercises, this text takes an applied approach and empowers students to take control of their own health. Concentrated emphasis on health issues as they relate to various cultural differences make this text one of the most up-to-date resources for health-related culture, gender, ethnic and age issues.
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