This groundbreaking volume synthesizes the results of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, which yielded longitudinal data on more than 9,000 individuals. The authors trace how risk for depression, anxiety, eating disorders, antisocial behavior, alcoholism, and substance abuse emerges from the interplay of a variety of genetic and environmental influences. Major questions addressed include whether risk is disorder-specific, how to distinguish between correlational and causal genetic and evironmental factors, sex differences in risk, and how risk and protective factors interact over time. The book also summarizes the conceptual underpinnings of the study and describes key methodological challenges and innovations.
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Middle East can be bewildering, which is why we need to connect the dots that pull together the political, economic, diplomatic, military, cultural, and religious pieces of the puzzle. Professor Steven Carol slashes through the confusion with a topical approach, focusing on key issues such as the geographic features of the Middle East, demographics of the region, the influence of Islam, political processes, shifting alliances, war in the region, and the need for security. He also takes a careful look at perpetual negotiations, attempts to secure peace, and the role that the media play in how we view the region. His goal: to clarify the confusing nature of Middle East affairs and to combat the mistaken beliefs, misrepresentations, and outright fabrications about the region. In a bid to reclaim the truth, he shares basic principles, relying on factual supporting evidence to prove their validity. Seventy-eight maps and numerous tables make understanding complex topics easier. Whether you’re a student, educator, bureaucrat or politician, you’ll find insights based on facts in Understanding the Volatile and Dangerous Middle East.
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