A definitive guide to the science and history of constipation across the nation. Most Americans have had constipation symptoms at some point in their lives. Statistics show up to 30% of Americans are affected with chronic constipation. This number reaches 60% as we age. At any given time up to 100 million people in the United States experience constipation. During the pandemic, constipation and its related anorectal issues worsened because everyone was sitting at home. Constipation has affected humans throughout history. Some called it “civilization’s curse.” Dr. John Harvey Kellogg (yes, of Kellogg’s cereal fame) promoted cold cereal as a constipation cure. Today, we have more probiotics and diets than you can shake your tushy at, and social media has popularized the Blue Poop Challenge to diagnose gut health. But what does it all mean? After seeing thousands of patients in her practice as a colorectal surgeon, Dr. Fong realized that she was repeating the same information, sometimes twenty times a day. Yet, this information was not common knowledge. What was found on the Internet was confusing and conflicting, leaving people who Googled their symptoms with more questions than answers. As an academic clinician who has written peer-reviewed publications, Dr. Fong sought information beyond even what the medical textbooks taught her. Constipation Nation helps readers who would rather research information themselves before seeing a healthcare professional to troubleshoot their poop chute. Drawing from 200 evidence-based sources as well as historical texts, Dr. Fong addresses all aspects of constipation, combining medicine, physiology, anatomy, microbiology, nutrition, history, and social sciences to get to the bottom of it all to explain why we doo… and why we don’t.
A definitive guide to the science and history of constipation across the nation. Most Americans have had constipation symptoms at some point in their lives. Statistics show up to 30% of Americans are affected with chronic constipation. This number reaches 60% as we age. At any given time up to 100 million people in the United States experience constipation. During the pandemic, constipation and its related anorectal issues worsened because everyone was sitting at home. Constipation has affected humans throughout history. Some called it “civilization’s curse.” Dr. John Harvey Kellogg (yes, of Kellogg’s cereal fame) promoted cold cereal as a constipation cure. Today, we have more probiotics and diets than you can shake your tushy at, and social media has popularized the Blue Poop Challenge to diagnose gut health. But what does it all mean? After seeing thousands of patients in her practice as a colorectal surgeon, Dr. Fong realized that she was repeating the same information, sometimes twenty times a day. Yet, this information was not common knowledge. What was found on the Internet was confusing and conflicting, leaving people who Googled their symptoms with more questions than answers. As an academic clinician who has written peer-reviewed publications, Dr. Fong sought information beyond even what the medical textbooks taught her. Constipation Nation helps readers who would rather research information themselves before seeing a healthcare professional to troubleshoot their poop chute. Drawing from 200 evidence-based sources as well as historical texts, Dr. Fong addresses all aspects of constipation, combining medicine, physiology, anatomy, microbiology, nutrition, history, and social sciences to get to the bottom of it all to explain why we doo… and why we don’t.
This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature. - Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view - Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures - Features a large number of color figures which give information in a clear-and-concise way - Includes extensive references to review articles and primary literature - Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer
This two-volume text compiles the efforts of distinguished scientists nd focuses on the formation of free radicals, toxic effects of lipoperoxides, biological antioxidant protection against lipid peroxidation damage, and pathological implications of lipid peroxidation. This review also addresses vitamin E deficiency, carbon tetrachloride and ethanol poisoning, radiation damage, hyperbaric effects, tumors, aging, diabetes, liver degeneration, DNA damage, lipoprotein modification and artherosclerosis, multiple sclerosis, angiopathy, Parkinson's disease, lupus, and many other degenerative diseases. It is an excellent resource for biological chemist, cell biologists, and all who are interested in the pharmaceutical sciences.
A full-color, image-packed guide to developing highly persuasive content that attracts more customers than ever—all based on the latest brain science There’s an overlooked but critical scientific fact that every marketing profession needs to know: Many decisions start with attention, and it’s your job to grab the attention of every prospective customer as effectively as possible. But in this increasingly fast-paced, busy, and noisy world, how do you capture people’s attention, much less persuade them? To answer this question, cognitive neuroscientist Carmen Simon leverages insights gleaned from her use of advanced technologies to study where people look, for how long, what type of attention leads to memories, and what keeps the brain coming back for more, to determine the effectiveness of sales pitches, marketing materials, corporate presentations, training videos, and other business content. In Made You Look, Simon presents her four-part framework for effectively attracting the attention of customers and impacting their buying decision: • Automatic triggers: capture audience attention with the physical properties of an external stimulus • Guided action: guide your audience toward their internal thoughts and prompt them to focus on something rewarding • Introspection: orient their attention internally toward something they consider rewarding • Visual search: direct their attention externally toward what they consider rewarding Each section of Made You Look provides detailed guidelines you can use in your communication materials immediately. Attract attention and, as a result, influence memory and decisions with Made You Look, and lead your company to the top of your industry.
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