The first ever publication of J.R.R. Tolkien’s final writings on Middle-earth, covering a wide range of subjects and perfect for those who have read and enjoyed The Silmarillion, The Lord of the Rings, Unfinished Tales, and The History of Middle-earth, and want to learn more about Tolkien’s magnificent world. It is well known that J.R.R. Tolkien published The Hobbit in 1937 and The Lord of the Rings in 1954–5. What may be less known is that he continued to write about Middle-earth in the decades that followed, right up until the years before his death in 1973. For him, Middle-earth was part of an entire world to be explored, and the writings in The Nature of Middle-earth reveal the journeys that he took as he sought to better understand his unique creation. From sweeping themes as profound as Elvish immortality and reincarnation, and the Powers of the Valar, to the more earth-bound subjects of the lands and beasts of Númenor, the geography of the Rivers and Beacon-hills of Gondor, and even who had beards! This new collection, which has been edited by Carl F. Hostetter, one of the world’s leading Tolkien experts, is a veritable treasure-trove offering readers a chance to peer over Professor Tolkien’s shoulder at the very moment of discovery: and on every page, Middle-earth is once again brought to extraordinary life.
The first ever publication of J.R.R. Tolkien’s final writings on Middle-earth, covering a wide range of subjects and perfect for those who have read and enjoyed The Silmarillion, The Lord of the Rings, Unfinished Tales, and The History of Middle-earth, and want to learn more about Tolkien’s magnificent world. It is well known that J.R.R. Tolkien published The Hobbit in 1937 and The Lord of the Rings in 1954–5. What may be less known is that he continued to write about Middle-earth in the decades that followed, right up until the years before his death in 1973. For him, Middle-earth was part of an entire world to be explored, and the writings in The Nature of Middle-earth reveal the journeys that he took as he sought to better understand his unique creation. From sweeping themes as profound as Elvish immortality and reincarnation, and the Powers of the Valar, to the more earth-bound subjects of the lands and beasts of Númenor, the geography of the Rivers and Beacon-hills of Gondor, and even who had beards! This new collection, which has been edited by Carl F. Hostetter, one of the world’s leading Tolkien experts, is a veritable treasure-trove offering readers a chance to peer over Professor Tolkien’s shoulder at the very moment of discovery: and on every page, Middle-earth is once again brought to extraordinary life.
A Study in the Rise of Religion among the Germans of the West, Based on the History of the Evangelischer Kirchenverein des Westens (Evangelical Church Society of the West) 1840-1866
A Study in the Rise of Religion among the Germans of the West, Based on the History of the Evangelischer Kirchenverein des Westens (Evangelical Church Society of the West) 1840-1866
Since its original release in 1939, Carl Schneider's The German Church on the American Frontier has been the premier published resource on the unique "Evangelischer Kirchenverein des Westens" (Evangelical Church Society of the West), 1840-66, which later assumed a wider denominational identity as the German Evangelical Synod of North America, the church of the Niebuhr family. Known eventually as the Evangelical Synod of North America, the group's ecumenical and irenic heritage contributed to mergers that resulted in the Evangelical and Reformed Church, 1934-1957, and thereafter in the United Church of Christ.
High Risk Pregnancy examines the full range of challenges in general obstetrics, medical complications of pregnancy, prenatal diagnosis, fetal disease, and management of labor and delivery. Drs. David James, Philip J. Steer, Carl P. Weiner, Bernard Gonik, Caroline Crowther, and Stephen Robson present an evidence-based approach to the available management options, equipping you with the most appropriate strategy for each patient. This comprehensive reference features the fully searchable text online at www.expertconsult.com, as well as more than 100 videos of imaging and monitoring. giving you easy access to the resources you need to manage high risk pregnancies. Prepare for clinical challenges and save time in addressing them thanks to expert advice on treatment options from international contributors. Find and apply the information you need quickly and easily through a consistent organization and at-a-glance summary boxes that discuss evidence-based management options. Access the fully searchable text online at www.expertconsult.com, along with links to Medline. View over 140 videos of detailed fetal imaging and monitoring that aid in diagnoses. Tap into recent developments in treatment and management in four new chapters—Global Maternal & Perinatal Health Issues; Recurrent Pregnancy Loss; Surveillance of the Fetus and its Indications; and Training for Obstetric Emergencies. Apply new evidence-based management options to treat genetic and constitutional factors leading to a high-risk pregnancy (such as diabetes, obesity, hypertension, and cardiac disease) through new and expanded coverage of these increasingly common presentations. Reference pregnancy-relevant laboratory values with an updated and comprehensive appendix on "Normal Values in Pregnancy." Effectively manage patients newly diagnosed with hematologic and immunologic malignancies, and explore the available drug options. Confirm your diagnoses with greater confidence thanks to full-color images throughout the text.
Logically organized and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, is your #1 resource for details on how virtually all of today's drugs and herbal supplements interact with pregnancy and lactation. More than just a dosing manual, this unique title by Dr. Carl P. Weiner fully explains whether each drug is FDA-approved for use by expecting or nursing mothers, is known to be safe for use, or is known to pose a danger. With up-to-date coverage of nearly 2,000 substances, it provides the thorough details you need to choose the most effective course of treatment. - Uses a consistent, easy-to-follow format for each substance: generic and trade name • class • indications • mechanism of action • dosage, with contraindications and cautions • maternal considerations • fetal considerations • drug interactions • breastfeeding safety • references • and summary information. - Describes over-the-counter drugs and alternative medications as well as prescription drugs. - Uses an eye-catching icon to highlight known teratogens. - Includes international drug names to give this reference a global perspective. - Features new letter thumb tabs for easier navigation. - Includes dozens of new drugs and thorough updates throughout. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Rhabdomyosarcoma is one of the most common malignant solid tumors of children and adolescents. This book provides a comprehensive review of current knowledge and addresses the many complex issues in the diagnosis and treatment of the tumor. It represents the results of 15 years of research by the Intergroup Rabdomyosarcoma Study, which is a large, multi-national, collaborative project that has made significant progress in elucidating the epidemiological, biological, and clinical characteristics of these malignancies. All researchers, pediatricians, and other physicians who work with Rhabdomyosarcoma will find an incredible amount of valuable information in this book.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.
Thyroid cancer is cancer of the thyroid gland. These may be of many types including papillary, follicular, Hurthle cell (aka oxyphilic or oncocytic), or medullary cancers. Surgery plays an important role in treating these cancers. The thyroid concentrates iodine and so is extremely sensitive to the effects of various radioactive isotopes of iodine produced by nuclear fission. These radioactive isotopes increase the chances of developing cancer, though thyroid cancer can develop even without any exposure to radioactivity. Some evidence suggests that insufficient or excessive dietary iodine may also increase the risk for thyroid cancer. This book presents the latest research in this field.
2019 PEN/E.O. Wilson Literary Science Writing Award Finalist "Science book of the year"—The Guardian One of New York Times 100 Notable Books for 2018 One of Publishers Weekly's Top Ten Books of 2018 One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018 One of Science Friday's Best Science Books of 2018 “Extraordinary”—New York Times Book Review "Magisterial"—The Atlantic "Engrossing"—Wired "Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-Tribune Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities... But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.
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